The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows

Mushap Kuru

Araştırma Makalesi

İneklerde akut septik mastitis ve klinik mastitisin kan serumu mineral düzeylerine etkisi

Yıl 2018, Cilt: 15 Sayı: 1, 11 - 16, 15.04.2018

Mushap Kuru

Öz

Bu çalışmada, akut septik mastitisli (ASM) ve klinik mastitisli (KM) ineklerde serum Na, K, Ca, Mg, Zn, Cu ve Fe

düzeylerinin belirlenmesi amaçlandı. Çalışmada 3-5 yaş arası 80 adet inek kullanıldı ve 4 grup (ASM, n=20; KM, n=20;

Kontrol1, K1=20, ASM ve KM’li ahırların sağlıklı hayvanları; Kontrol2, K2=20, ASM ve KM şikayeti olmayan ahırların

sağlıklı hayvanları) oluşturuldu. Gruplardan alınan kan serumu örneklerinde atomik absorbsiyon spektrofotometre ile

Na, K, Ca, Mg, Zn, Cu ve Fe düzeyleri belirlendi. Ayrıca tüm gruplara glutaraldehyde (GLA) testi yapıldı. Ölçüm sonuçlarına

göre Na, K, Ca ve Cu düzeylerinin tüm gruplarda benzer olduğu saptandı (P>0.05). Mg düzeyinin ASM grubunda

K1 ve K2’ye göre daha düşük olduğu (sırasıyla P<0.05, P<0.001) belirlendi. Zn düzeyinin ise ASM ve KM’li hayvanlarda

kontrol gruplarına göre daha düşük düzeyde olduğu saptandı (P<0.01). Fe konsantrasyonunun ise ASM grubunda

diğer gruplara göre istatistiksel olarak daha düşük düzeyde tespit edildi (P<0.001). GLA testi ASM ve KM gruplarında

pozitif, kontrol gruplarında ise negatif olarak bulundu. Sonuç olarak, akut septik mastitiste Mg, Zn ve Fe düzeylerinde

düşüş saptandı. Klinik mastitiste ise yalnızca Mg ve Zn düzeylerinin düştüğü belirlendi. Na, K, Ca ve Cu değerlerinin

ise etkilenmediği görüldü. Ayrıca mastitis tedavisinde Mg, Zn ve Fe gibi minerallerin uygulaması faydalı olabilir.

Anahtar Kelimeler

Akute septik mastitis, inek, klinik mastitis, mineraller

Kaynakça

1. Atakisi O, Oral H, Atakisi E, Merhan O, Pancarci SM, Ozcan A, Marasli S, Polat B, Colak A, Kaya S. Subclinical mastitis causes alterations in nitric oxide, total oxidant and antioxidant capacity in cow milk. Res Vet Sci 2010; 89(1): 10-3.
2. Atroshi F, Parantainen J, Sankari S, Järvinen M, Lindberg LA, Saloniemi H. Changes in inflammation-related blood constituents of mastitic cows. Vet Res 1996; 27(2): 125-32.
3. Bleul U, Sacher K, Corti S, Braun U. Clinical findings in 56 cows with toxic mastitis. Vet Rec 2006; 159(20): 677-9
4. Blowey R, Edmondson P. Mastitis Control in Dairy Herds. Second Edition. Gloucester: CABI, 2010; p. 5-59.
5. Bullen JJ. The significance of iron in infection. Rev Infect Dis 1981; 3(6): 1127-38.
6. Chirase NK, Hutcheson DP, Thompson GB. Feed intake, rectal temperature, and serum mineral concentrations of feedlot cattle fed zinc oxide or zinc methionine and challenged with infectious bovine rhinotracheitis virus. J Anim Sci 1991; 69(10): 4137-45.
7. Edmonson AJ, Lean IJ, Weaver LD, Farver T, Webster G. A body condition scoring chart for Holstein dairy cows. J Dairy Sci 1989; 72(1): 68-8.
8. El Zubeir IE, ElOwni OA, Mohamed G. Effect of mastitis on macro-minerals of bovine milk and blood serum in Sudan. J S Afr Vet Assoc 2005; 76(1): 22-5.
9. Erskine RJ, Bartlett PC. Serum concentrations of copper, iron, and zinc during Escherichia coli-induced mastitis. J Dairy Sci 1993; 76(2): 408-13.
10. Green M. Toxic mastitis in cattle. In Practice 1998; 20(3): 128-33.
11. Green MJ, Cripps PJ, Green LE. Prognostic indicators for toxic mastitis in dairy cows. Vet Rec 1998; 143(5): 127-30.
12. Hershko C, Cook JD, Finch CA. Storage iron kinetics. VI. The effect of inflammation on iron exchange in the rat. Br J Haematol 1974; 28(1): 67-75.
13. Karademir B. Effect of intraperitoneal exudate existing upon the total and differential leukocyte count in cattle with traumatic reticuloperitonitis. Kafkas Univ Vet Fak Derg 2005; 11(2): 159-61.
14. Karademir B. Evaluation of glutaraldehyde test in traumatic reticuloperitonitis in cattle. Indian Vet J 2006; 83(9): 996-8.
15. Karademir B. Comparisons of some sample preparation methods for blood-serum copper and zinc at atomic absorption spectrometer. Kafkas Univ Vet Fak Derg 2007; 13(1): 61-6.
16. Karademir B. Effect of stress induced by vaccination on blood plasma copper, zinc, potassium and magnesium. Kafkas Univ Vet Fak Derg 2007; 13(1): 49-54.
17. Karademir B. Effects of fluoride ingestion on serum levels of the trace minerals Co, Mo, Cr, Mn and Li in adult male mice. Fluoride 2010; 43(3): 174-8.
18. Karademir B, Eseceli H, Kart A. The effect of oral levothyroxine sodium on serum Zn, Fe, Ca and Mg levels during acute copper sulfate toxication in rabbits. J Anim Vet Adv 2010; 9(2): 240-7.
19. Karademir B. Effects of oral zinc sulfate applications at different pH (ascorbic acid, vinegar of graps and distillated water) on serum zinc levels in rabbits. Ankara Üniv Vet Fak Derg 2011; 58(1): 11-6.
20. Liberg P. Glutaraldehyde and formol-gel tests in bovine traumatic peritonitis. Acta Vet Scand 1981; 22(1): 78-84.
21. Lohuis JA, Kremer W, Schukken YH, Smit JA, Verheijden JH, Brand A, Van Miert AS. Growth of Escherichia coli in whole and skim milk from endotoxin-induced mastitic quarters: In vitro effects of deferoxamine, zinc and iron supplementation. J Dairy Sci 1988; 71(10): 2772-81.
22. Menzies FD, McBride SH, McDowell SW, McCoy MA, McConnell W, Bell C. Clinical and laboratory findings in cases of toxic mastitis in cows in Northern Ireland. Vet Rec 2000; 147(5): 123-8.
23. Menzies FD, Gordon AW, McBride SH, Goodall EA. Risk factors for toxic mastitis in cows. Vet Rec 2003; 152(11): 319-22.
24. Middleton JR, Luby CD, Viera L, Tyler JW, Casteel S. Short communication: Influence of Staphylococcus aureus intramammary infection on serum copper, zinc, and iron concentrations. J Dairy Sci 2004; 87(4): 976-9.
25. Naresh R, Dwivedi SK, Dey S, Swarup D. Zinc, copper and cobalt concentration in blood during inflammation of the mammary gland in dairy cows. Asian-Aust J Anim Sci 2001; 14(4): 564-6.
26. Oral H, Çolak A, PolatB, Cengiz M, Cengiz S, Baştan A, Kaya S. The effectiveness of the Aloe vera therapy for the treatment of subclinical mastitis in dairy cows. Erciyes Üniv Vet Fak Derg 2014; 11(3): 157-61.
27. Oral H, Öğün M, Kuru M, Kaya S. Evaluation of certain oxidative stress parameters in heifers that were administered short term PRID. Kafkas Univ Vet Fak Derg 2015; 21(4): 569-73.
28. O'Rourke D. Nutrition and udder health in dairy cows: A review. Ir Vet J 2009; 62(Suppl 4): 15-20.
29. Orr CL, Hutcheson DP, Grainger RB, Cummins JM, Mock RE. Serum copper, zinc, calcium and phosphorus concentrations of calves stressed by bovine respiratory disease and infectious bovine rhinotracheitis. J Anim Sci 1990; 68(9): 2893-900.
30. Ranjan R, Swarup D, Naresh R, Patra RC. Enhanced erythrocytic lipid peroxides and reduced plasma ascorbic acid, and alteration in blood trace elements level in dairy cows with mastitis. Vet Res Commun 2009; 29(1): 27-34.
31. Rişvanlı A, Türköz Y, Kalkan C, Çetin H. An investigation on the serum levels of biochemical variables in the cows with clinical mastitis. FÜ Sağlık Bil Derg 1999; 13(2): 131-4.
32. Rişvanlı A, Kaygusuzoğlu E, Çetin H, Öcal H. A study on the some electrolyte levels and mineral substances in blood sera of cows with clinical and subclinical mastitis. YYÜ Vet Fak Derg 2000; 11(1): 61-5.
33. Sadeghian S, Kojouri G, Eftekhari Z, Khadivar F, Bashiri A. Study of blood levels of electrolytes of infected cattle with healthy cattle. Intern J Appl Res Vet Med 2011; 9(2): 204-10.
34. Şimşek H, Aksakal M. The effect of vitamin E on some biochemical values in cows with subclinical mastitis. YYÜ Vet Fak Derg 2005; 16(1): 37-40.
35. Spears JW, Weiss WP. Role of antioxidants and trace elements in health and immunity of transition dairy cows. Vet J 2008; 176(1): 70-6.
36. Verheijden JH, van Miert AS, Schotman AJ, van Duin CT. Plasma zinc and iron concentrations as measurements for evaluating the influence of endotoxin-neutralizing agents in Escherichia coli endotoxin-induced mastitis. Am J Vet Res 1982; 43(4): 724-8.
37. Yıldız H, Kaygusuzoğlu E. Investigation of Ca, Zn, Mg, Fe and Cu concentrations in blood and milk of cows with negative and positive CMT results. Bull Vet Inst Pulawy 2005; 49(2): 209-13.

The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows

Yıl 2018, Cilt: 15 Sayı: 1, 11 - 16, 15.04.2018

Mushap Kuru

Öz

The purpose of this
study is to identify serum Na, K, Ca, Mg, Zn, Cu and Fe levels in cows with
acute septic mastitis (ASM) and clinical mastitis (CM). The study consisted 80
cows between the ages of three and five in four groups (ASM, n=20; CM, n=20;
Control-1 C1=20, healthy cows, together with ASM or CM cows; Control-2, C2=20,
healthy cows, without ASM or CM cows). Serum Na, K, Ca, Mg, Zn, Cu and Fe
levels were determined by using atomic absorption spectrophotometry. The Mg
levels were lower in the ASM group compared to C1 and C2 groups (P<0.05, and
P<0.001 respectively). Zn levels in the ASM and CM animals were lower than
those in control groups (P<0.01). Fe concentrations that of the ASM group
were found to be statistically lower than in the other groups (P<0.001). The
glutaraldehyde (GLA) test was positive in the ASM and CM groups but negative in
the control groups. In conclusion, lower levels of Mg, Zn and Fe were found with
acute septic mastitis. In clinical mastitis, on the other hand, only the Mg and
Zn levels were low. Na, K, Ca and Cu values were not affected. It may also be
beneficial to apply minerals such as Mg, Zn and Fe in mastitis treatment.

Anahtar Kelimeler

Acute septic mastitis, clinical mastitis, cow, minerals

Kaynakça

1. Atakisi O, Oral H, Atakisi E, Merhan O, Pancarci SM, Ozcan A, Marasli S, Polat B, Colak A, Kaya S. Subclinical mastitis causes alterations in nitric oxide, total oxidant and antioxidant capacity in cow milk. Res Vet Sci 2010; 89(1): 10-3.
2. Atroshi F, Parantainen J, Sankari S, Järvinen M, Lindberg LA, Saloniemi H. Changes in inflammation-related blood constituents of mastitic cows. Vet Res 1996; 27(2): 125-32.
3. Bleul U, Sacher K, Corti S, Braun U. Clinical findings in 56 cows with toxic mastitis. Vet Rec 2006; 159(20): 677-9
4. Blowey R, Edmondson P. Mastitis Control in Dairy Herds. Second Edition. Gloucester: CABI, 2010; p. 5-59.
5. Bullen JJ. The significance of iron in infection. Rev Infect Dis 1981; 3(6): 1127-38.
6. Chirase NK, Hutcheson DP, Thompson GB. Feed intake, rectal temperature, and serum mineral concentrations of feedlot cattle fed zinc oxide or zinc methionine and challenged with infectious bovine rhinotracheitis virus. J Anim Sci 1991; 69(10): 4137-45.
7. Edmonson AJ, Lean IJ, Weaver LD, Farver T, Webster G. A body condition scoring chart for Holstein dairy cows. J Dairy Sci 1989; 72(1): 68-8.
8. El Zubeir IE, ElOwni OA, Mohamed G. Effect of mastitis on macro-minerals of bovine milk and blood serum in Sudan. J S Afr Vet Assoc 2005; 76(1): 22-5.
9. Erskine RJ, Bartlett PC. Serum concentrations of copper, iron, and zinc during Escherichia coli-induced mastitis. J Dairy Sci 1993; 76(2): 408-13.
10. Green M. Toxic mastitis in cattle. In Practice 1998; 20(3): 128-33.
11. Green MJ, Cripps PJ, Green LE. Prognostic indicators for toxic mastitis in dairy cows. Vet Rec 1998; 143(5): 127-30.
12. Hershko C, Cook JD, Finch CA. Storage iron kinetics. VI. The effect of inflammation on iron exchange in the rat. Br J Haematol 1974; 28(1): 67-75.
13. Karademir B. Effect of intraperitoneal exudate existing upon the total and differential leukocyte count in cattle with traumatic reticuloperitonitis. Kafkas Univ Vet Fak Derg 2005; 11(2): 159-61.
14. Karademir B. Evaluation of glutaraldehyde test in traumatic reticuloperitonitis in cattle. Indian Vet J 2006; 83(9): 996-8.
15. Karademir B. Comparisons of some sample preparation methods for blood-serum copper and zinc at atomic absorption spectrometer. Kafkas Univ Vet Fak Derg 2007; 13(1): 61-6.
16. Karademir B. Effect of stress induced by vaccination on blood plasma copper, zinc, potassium and magnesium. Kafkas Univ Vet Fak Derg 2007; 13(1): 49-54.
17. Karademir B. Effects of fluoride ingestion on serum levels of the trace minerals Co, Mo, Cr, Mn and Li in adult male mice. Fluoride 2010; 43(3): 174-8.
18. Karademir B, Eseceli H, Kart A. The effect of oral levothyroxine sodium on serum Zn, Fe, Ca and Mg levels during acute copper sulfate toxication in rabbits. J Anim Vet Adv 2010; 9(2): 240-7.
19. Karademir B. Effects of oral zinc sulfate applications at different pH (ascorbic acid, vinegar of graps and distillated water) on serum zinc levels in rabbits. Ankara Üniv Vet Fak Derg 2011; 58(1): 11-6.
20. Liberg P. Glutaraldehyde and formol-gel tests in bovine traumatic peritonitis. Acta Vet Scand 1981; 22(1): 78-84.
21. Lohuis JA, Kremer W, Schukken YH, Smit JA, Verheijden JH, Brand A, Van Miert AS. Growth of Escherichia coli in whole and skim milk from endotoxin-induced mastitic quarters: In vitro effects of deferoxamine, zinc and iron supplementation. J Dairy Sci 1988; 71(10): 2772-81.
22. Menzies FD, McBride SH, McDowell SW, McCoy MA, McConnell W, Bell C. Clinical and laboratory findings in cases of toxic mastitis in cows in Northern Ireland. Vet Rec 2000; 147(5): 123-8.
23. Menzies FD, Gordon AW, McBride SH, Goodall EA. Risk factors for toxic mastitis in cows. Vet Rec 2003; 152(11): 319-22.
24. Middleton JR, Luby CD, Viera L, Tyler JW, Casteel S. Short communication: Influence of Staphylococcus aureus intramammary infection on serum copper, zinc, and iron concentrations. J Dairy Sci 2004; 87(4): 976-9.
25. Naresh R, Dwivedi SK, Dey S, Swarup D. Zinc, copper and cobalt concentration in blood during inflammation of the mammary gland in dairy cows. Asian-Aust J Anim Sci 2001; 14(4): 564-6.
26. Oral H, Çolak A, PolatB, Cengiz M, Cengiz S, Baştan A, Kaya S. The effectiveness of the Aloe vera therapy for the treatment of subclinical mastitis in dairy cows. Erciyes Üniv Vet Fak Derg 2014; 11(3): 157-61.
27. Oral H, Öğün M, Kuru M, Kaya S. Evaluation of certain oxidative stress parameters in heifers that were administered short term PRID. Kafkas Univ Vet Fak Derg 2015; 21(4): 569-73.
28. O'Rourke D. Nutrition and udder health in dairy cows: A review. Ir Vet J 2009; 62(Suppl 4): 15-20.
29. Orr CL, Hutcheson DP, Grainger RB, Cummins JM, Mock RE. Serum copper, zinc, calcium and phosphorus concentrations of calves stressed by bovine respiratory disease and infectious bovine rhinotracheitis. J Anim Sci 1990; 68(9): 2893-900.
30. Ranjan R, Swarup D, Naresh R, Patra RC. Enhanced erythrocytic lipid peroxides and reduced plasma ascorbic acid, and alteration in blood trace elements level in dairy cows with mastitis. Vet Res Commun 2009; 29(1): 27-34.
31. Rişvanlı A, Türköz Y, Kalkan C, Çetin H. An investigation on the serum levels of biochemical variables in the cows with clinical mastitis. FÜ Sağlık Bil Derg 1999; 13(2): 131-4.
32. Rişvanlı A, Kaygusuzoğlu E, Çetin H, Öcal H. A study on the some electrolyte levels and mineral substances in blood sera of cows with clinical and subclinical mastitis. YYÜ Vet Fak Derg 2000; 11(1): 61-5.
33. Sadeghian S, Kojouri G, Eftekhari Z, Khadivar F, Bashiri A. Study of blood levels of electrolytes of infected cattle with healthy cattle. Intern J Appl Res Vet Med 2011; 9(2): 204-10.
34. Şimşek H, Aksakal M. The effect of vitamin E on some biochemical values in cows with subclinical mastitis. YYÜ Vet Fak Derg 2005; 16(1): 37-40.
35. Spears JW, Weiss WP. Role of antioxidants and trace elements in health and immunity of transition dairy cows. Vet J 2008; 176(1): 70-6.
36. Verheijden JH, van Miert AS, Schotman AJ, van Duin CT. Plasma zinc and iron concentrations as measurements for evaluating the influence of endotoxin-neutralizing agents in Escherichia coli endotoxin-induced mastitis. Am J Vet Res 1982; 43(4): 724-8.
37. Yıldız H, Kaygusuzoğlu E. Investigation of Ca, Zn, Mg, Fe and Cu concentrations in blood and milk of cows with negative and positive CMT results. Bull Vet Inst Pulawy 2005; 49(2): 209-13.

Toplam 37 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Bölüm	Araştırma Makalesi
Yazarlar	Mushap Kuru
Yayımlanma Tarihi	15 Nisan 2018
Gönderilme Tarihi	6 Eylül 2016
Kabul Tarihi	22 Kasım 2016
Yayımlandığı Sayı	Yıl 2018 Cilt: 15 Sayı: 1

Kaynak Göster

APA	Kuru, M. (2018). The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 15(1), 11-16.
AMA	Kuru M. The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows. Erciyes Üniv Vet Fak Derg. Nisan 2018;15(1):11-16.
Chicago	Kuru, Mushap. “The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 15, sy. 1 (Nisan 2018): 11-16.
EndNote	Kuru M (01 Nisan 2018) The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 15 1 11–16.
IEEE	M. Kuru, “The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows”, Erciyes Üniv Vet Fak Derg, c. 15, sy. 1, ss. 11–16, 2018.
ISNAD	Kuru, Mushap. “The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 15/1 (Nisan 2018), 11-16.
JAMA	Kuru M. The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows. Erciyes Üniv Vet Fak Derg. 2018;15:11–16.
MLA	Kuru, Mushap. “The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, c. 15, sy. 1, 2018, ss. 11-16.
Vancouver	Kuru M. The Effect on Serum Mineral Levels of Acute Septic Mastitis and Clinical Mastitis in Cows. Erciyes Üniv Vet Fak Derg. 2018;15(1):11-6.

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