Evcil Güvercinlerde Deksmedetomidin ve Deksmedetomidin-Ketamin Kombinasyonunun Anestezik Özel-likleri ile Reversal Bir Ajan Olarak Atipamezolün Değerlendirilmesi
Öz
Bu çalışmanın amacı evcil güvercinlerde (Columba livia) deksmedetomidin ve ketaminin tek başına ve deksme-detomidin-ketamin kombinasyonunun anestezik etkinliğini ve α2 adrenerjik antagonisti atipamezolün etkilerini belir-lemektir. DX grubuna deksmedetomidin (80 μg/kg), K grubuna ketamin (100 mg/kg) tek başına, DXK grubuna ise deks-medetomidin (40 μg/kg) ve ketamin (50 mg/kg) art arda kasiçi (IM) yolla uygulandı. Anestezi derinliği ile kardiyopulmo-ner bulgular enjeksiyon öncesinden (T0) 60. dakikaya (T60) kadar izlendi. T60'da IM yolla atipamezol, deksmedetomi-dinin 4 katı dozda DX (320 μg/kg) ve DXK gruplarına (160 μg/kg) enjekte edildi. DX grubundaki güvercinlerde yalnızca minimal seviyede sedasyon ile bradikardi ve solunum sayısında ani düşme görüldü (P<0.05). DXK grubunda kardiyo-pulmoner değerler DX grubuna göre daha az etkilendi. DXK grubunda atipamezol enjeksiyonundan 22.47±0.64 dk sonra tüm güvercinler ayaktaydı. Sonuç olarak deksmedetomidin (80 μg/kg) güvercinlerde tek başına kullanılmamalı, kullanım mecburiyetinde kardiyopulmoner parametreler perianestezik olarak dikkatle takip edilmelidir. Deksmedetomi-din (40 μg/kg) ve ketamin (50 mg/kg) orta seviyede anestezi gerektiren klinik uygulamalarda kullanılabilir. Atipamezol güvercinlerde deksmedetomidinin dört katı dozda güvenle kullanılabilir.
Anahtar Kelimeler
Kaynakça
- Antisedan [package insert]. Orion Pharma, Espoo, Finland, https://www2.zoetisus.com/content/_assets/docs/Petcare/antisedan-pi.pdf 2022; Ac-cessed Date: 19.03.2022.
- Association of Veterinary Anaesthetists (AVA) Autumn Meeting 2004. Wild animal immobilisation. Vienna. https://www.ava.eu.com/wpcontent/uploads/2015/09/AVATrainingDayProc-Vienna2004.pdf. Accessed Date: 03.04 2022.
- Atalan G, Uzun M, Demirkan I, Yildiz S, Cenesiz M. Effect of medetomidine‐butorphanol‐ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal temperature of domestic pigeons. J Vet Med A Physiol Pathol Clin Med 2002; 49(6): 281-5.
- Azizpour A, Hassani Y. Clinical evaluation of general anaesthesia in pigeons using a combination of ketamine and diazepam. J S Afr Vet Assoc 2012; 83(1): 1-4.
- Baek C, Kim S, Jang JW, Jung Y, Choi GJ, Shim S, Yun S, Seo K, Song YK, Kim SJ, Seo JM. Investigation of stereotactic surgery for avian brain stimulation by a fully implanted wireless system. Neurosurg Focus 2020; 49(1): 1-8.
- Doss G, Mans C. Avian sedation. J Avian Med Surg 2021; 35(3): 253-68.
- Duranni UF, Khan MA, Ahmed SS. Comparative efficacy (sedative and anaesthetic) of detomidine, ketamine and detomidine-ketamine cocktail in pigeons (Columba livia). Pak Vet J 2008; 28(3): 115-8. Duranni UF, Ashraf M, Khan MA. A comparison of the clinical effects associated with xylazine, ketamine, and a xylazine-ketamine cocktail in pigeons (Columba livia). Turk J Vet Anim Sci 2009; 33(5): 413-7. Gunkel C, Lafortune M. Current techniques in avian anesthesia. In Seminars in Avian and Exotic Pet Medicine (Vol. 14, No. 4). WB Saunders USA 2005; pp. 263-76. Hawkins MG, Pascoe PJ. Cagebirds. West G, Heard D, Caulkett N, eds. Zoo animal and Wildlife Im-mobilization and Anesthesia. First Edition. UK: Blackwell Publishing, 2007; pp. 269-97. Hawkins MG, Paul-Murphy J. Avian analgesia. Vet Clin North Am Exot Anim Pract 2011; 14(1): 61-80.
- Heard D. Anesthesia. Speer BL. ed. In: Current Therapy in Avian Medicine and Surgery. First Edition. USA: Elsevier, Inc 2016; pp. 601-15.
- Hornak S, Liptak T, Ledecky V, Hromada R, Bilek J, Mazensky D, Petrovic V. A preliminary trial of the sedation induced by intranasal administration of midazolam alone or in combination with dexme-detomidine and reversal by atipamezole for a short-term ımmobilization in pigeons. Vet Anaesth Analg 2014; 42(2): 192-6.
- Jerolmack C. Animal practices, ethnicity, and community: The Turkish pigeon handlers of Berlin. Am Sociol Rev 2007; 72(6): 874-94.
- Kamiloglu A, Atalan G, Kamiloglu NN. Comparison of intraosseous and intramuscular drug administration for induction of anaesthesia in domestic pigeons. Res Vet Sci 2008; 85(1): 171-5.
- Korbel R. Comporative investigations on inhalation anaesthesia with isoflurane (Forence) and sevoflurane (Sevorane) in racing pigeons (Columba livia Gmel, 1789, Var. Domestica) and presentation of a reference anaesthesia protocol for birds. Tierarztl Prax Ausg K Kleintiere Heimtiere 1998; 26(3): 211-23.
- Lennox AM. Sedation as an alternative to general anesthesia in pet birds. In Proceedings of the Association of Avian Veterinarians, Seattle; USA 2001; pp. 289-92.
- Lichtenberger M, Lennox A. Critical care. Speer BL. ed. In Current Therapy in Avian Medicine and Surgery. First Edition. USA: Elsevier, Inc 2016; pp. 582-8.
- Ludders JW. Comparative anesthesia and analgesia of birds. Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. eds. In: Veterinary Anesthesia and Analgesia The Fifth Edition. USA: John Wiley & Sons, Inc. 2015; pp. 800-16.
- Lumeij JT, Deenik JW. Medetomidine-ketamine and diazepam-ketamine anesthesia in racing pigeons (Columba Livia Domestica) A comparative study. J Avian Med Surg 2003; 17(4): 191-6.
- Mans C. Sedation and analgesia in birds 2017, https://www.isvma.org/wpcontent/uploads/2017/10/AVIAN_SEDATION_ANALGESIA_Birds-1.pdf; Accessed Date: 15.05. 2022.
- Martel A, Doss GA, Mans C. Evaluation of the effects of intramuscular injection volume on midazolam-butorphanol induced sedation in domestic pigeons (Columba livia). J Exot Pet Med 2021; 37: 3-7.
- Memon AM, Kaka U, Umer M, , Kamboh AA, Behan AA, Janyaro H, Goh YM, Kalhoro AB, Abu J, Bhutto KR, Maqbool A. Benefits of incorporating atipamezole in medetomidine-ketamine anaesthe-sia in pigeons. Pak J Zool 2021; 53(6): 1-8.
- Pan SY, Liu G, Lin JH, Jin YP. Efficacy and safety of dexmedetomidine premedication in balanced anesthesia: A systematic review and meta-analysis in dogs. Animals 2021; 11(11): 3254-70.
- Pollock CG, Schumacher J, Orosz SE, Ramsay EC. Sedative effects of medetomidine in pigeons (Columba livia). J Avian Med Surg 2001; 15(2): 95-100.
- Posner LP. Sedatives and tranquilizers. Riviere JE, Papich MG. eds. In: Veterinary Pharmacology and Therapeutics USA: John Wiley Sons, Inc 2018; pp. 324-68.
- Report from the Commission to the European an Parliament and the Council (EC): 2019 Report on the Statistics on the Use of Animals for Scientific Purposes in the Member States of the European Union in 2015-2017.www.op.europa.eu/en/publication-detail/-/publication/04a890d4-47ff-11eab81b 01aa75ed71a1; Accessed Date: 02.05. 2022.
- Sandmeier P. Evaluation of medetomidine for short-term immobilization of domestic pigeons (Columba livia) and Amazon parrots (Amazona Species), J Avian Med Surg 2000; 14: 8-14.
Evaluation of the Anesthetic Properties of Dexmedetomidine and Dexmedetomidine-Ketamine Combination and the Properties of Atipamezole as a Reversal Agent in Domestic Pigeons
Öz
The aim of this study was to determine the anesthetic efficacy of dexmedetomidine and ketamine alone and dexmedetomidine-ketamine combination and the effects of α2 adrenergic reversal atipamezole in domestic pigeons (Columba livia). In DX group, dexmedetomidine (80 μg/kg), in K group, ketamine (100 mg/kg) alone, in DXK group, dexmedetomidine (40 μg/kg) and ketamine (50 mg/kg) consecutively were administered intramuscularly (IM). Anesthetic depth and cardiopulmonary symptoms were monitored starting from the pre-injection moment (T0) till the 60th minute (T60). At T60, atipamezole at a dosage 4 times that of dexmedetomidine was injected intramuscularly to the DX group (320 μg/kg) and the DXK group (160 μg/kg). In the DX group, only minimal sedation, bradycardia, and a sudden drop in respiratory rate were seen (P<0.05). The cardiopulmonary parameter values in the DXK group were affected to a less-er extent compared to the DK group. In the DXK group, 22.47±0.64 minutes after atipamezole injection, all pigeons were on their feet. As a result, it was concluded that dexmedetomidine (80 μg/kg) alone should not be used in pigeons, and if it is needed to be used, cardiopulmonary parameters should be carefully monitored peri-anesthetically. Dexmedetomidine (40 μg/kg) and ketamine (50 mg/kg) can be used in clinical practices that require a moderate level of anesthesia. Atipamezole can safely be used at 4 times the dosage of dexmedetomidine in pigeons.
Anahtar Kelimeler
Kaynakça
- Antisedan [package insert]. Orion Pharma, Espoo, Finland, https://www2.zoetisus.com/content/_assets/docs/Petcare/antisedan-pi.pdf 2022; Ac-cessed Date: 19.03.2022.
- Association of Veterinary Anaesthetists (AVA) Autumn Meeting 2004. Wild animal immobilisation. Vienna. https://www.ava.eu.com/wpcontent/uploads/2015/09/AVATrainingDayProc-Vienna2004.pdf. Accessed Date: 03.04 2022.
- Atalan G, Uzun M, Demirkan I, Yildiz S, Cenesiz M. Effect of medetomidine‐butorphanol‐ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal temperature of domestic pigeons. J Vet Med A Physiol Pathol Clin Med 2002; 49(6): 281-5.
- Azizpour A, Hassani Y. Clinical evaluation of general anaesthesia in pigeons using a combination of ketamine and diazepam. J S Afr Vet Assoc 2012; 83(1): 1-4.
- Baek C, Kim S, Jang JW, Jung Y, Choi GJ, Shim S, Yun S, Seo K, Song YK, Kim SJ, Seo JM. Investigation of stereotactic surgery for avian brain stimulation by a fully implanted wireless system. Neurosurg Focus 2020; 49(1): 1-8.
- Doss G, Mans C. Avian sedation. J Avian Med Surg 2021; 35(3): 253-68.
- Duranni UF, Khan MA, Ahmed SS. Comparative efficacy (sedative and anaesthetic) of detomidine, ketamine and detomidine-ketamine cocktail in pigeons (Columba livia). Pak Vet J 2008; 28(3): 115-8. Duranni UF, Ashraf M, Khan MA. A comparison of the clinical effects associated with xylazine, ketamine, and a xylazine-ketamine cocktail in pigeons (Columba livia). Turk J Vet Anim Sci 2009; 33(5): 413-7. Gunkel C, Lafortune M. Current techniques in avian anesthesia. In Seminars in Avian and Exotic Pet Medicine (Vol. 14, No. 4). WB Saunders USA 2005; pp. 263-76. Hawkins MG, Pascoe PJ. Cagebirds. West G, Heard D, Caulkett N, eds. Zoo animal and Wildlife Im-mobilization and Anesthesia. First Edition. UK: Blackwell Publishing, 2007; pp. 269-97. Hawkins MG, Paul-Murphy J. Avian analgesia. Vet Clin North Am Exot Anim Pract 2011; 14(1): 61-80.
- Heard D. Anesthesia. Speer BL. ed. In: Current Therapy in Avian Medicine and Surgery. First Edition. USA: Elsevier, Inc 2016; pp. 601-15.
- Hornak S, Liptak T, Ledecky V, Hromada R, Bilek J, Mazensky D, Petrovic V. A preliminary trial of the sedation induced by intranasal administration of midazolam alone or in combination with dexme-detomidine and reversal by atipamezole for a short-term ımmobilization in pigeons. Vet Anaesth Analg 2014; 42(2): 192-6.
- Jerolmack C. Animal practices, ethnicity, and community: The Turkish pigeon handlers of Berlin. Am Sociol Rev 2007; 72(6): 874-94.
- Kamiloglu A, Atalan G, Kamiloglu NN. Comparison of intraosseous and intramuscular drug administration for induction of anaesthesia in domestic pigeons. Res Vet Sci 2008; 85(1): 171-5.
- Korbel R. Comporative investigations on inhalation anaesthesia with isoflurane (Forence) and sevoflurane (Sevorane) in racing pigeons (Columba livia Gmel, 1789, Var. Domestica) and presentation of a reference anaesthesia protocol for birds. Tierarztl Prax Ausg K Kleintiere Heimtiere 1998; 26(3): 211-23.
- Lennox AM. Sedation as an alternative to general anesthesia in pet birds. In Proceedings of the Association of Avian Veterinarians, Seattle; USA 2001; pp. 289-92.
- Lichtenberger M, Lennox A. Critical care. Speer BL. ed. In Current Therapy in Avian Medicine and Surgery. First Edition. USA: Elsevier, Inc 2016; pp. 582-8.
- Ludders JW. Comparative anesthesia and analgesia of birds. Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. eds. In: Veterinary Anesthesia and Analgesia The Fifth Edition. USA: John Wiley & Sons, Inc. 2015; pp. 800-16.
- Lumeij JT, Deenik JW. Medetomidine-ketamine and diazepam-ketamine anesthesia in racing pigeons (Columba Livia Domestica) A comparative study. J Avian Med Surg 2003; 17(4): 191-6.
- Mans C. Sedation and analgesia in birds 2017, https://www.isvma.org/wpcontent/uploads/2017/10/AVIAN_SEDATION_ANALGESIA_Birds-1.pdf; Accessed Date: 15.05. 2022.
- Martel A, Doss GA, Mans C. Evaluation of the effects of intramuscular injection volume on midazolam-butorphanol induced sedation in domestic pigeons (Columba livia). J Exot Pet Med 2021; 37: 3-7.
- Memon AM, Kaka U, Umer M, , Kamboh AA, Behan AA, Janyaro H, Goh YM, Kalhoro AB, Abu J, Bhutto KR, Maqbool A. Benefits of incorporating atipamezole in medetomidine-ketamine anaesthe-sia in pigeons. Pak J Zool 2021; 53(6): 1-8.
- Pan SY, Liu G, Lin JH, Jin YP. Efficacy and safety of dexmedetomidine premedication in balanced anesthesia: A systematic review and meta-analysis in dogs. Animals 2021; 11(11): 3254-70.
- Pollock CG, Schumacher J, Orosz SE, Ramsay EC. Sedative effects of medetomidine in pigeons (Columba livia). J Avian Med Surg 2001; 15(2): 95-100.
- Posner LP. Sedatives and tranquilizers. Riviere JE, Papich MG. eds. In: Veterinary Pharmacology and Therapeutics USA: John Wiley Sons, Inc 2018; pp. 324-68.
- Report from the Commission to the European an Parliament and the Council (EC): 2019 Report on the Statistics on the Use of Animals for Scientific Purposes in the Member States of the European Union in 2015-2017.www.op.europa.eu/en/publication-detail/-/publication/04a890d4-47ff-11eab81b 01aa75ed71a1; Accessed Date: 02.05. 2022.
- Sandmeier P. Evaluation of medetomidine for short-term immobilization of domestic pigeons (Columba livia) and Amazon parrots (Amazona Species), J Avian Med Surg 2000; 14: 8-14.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Nisan 2024 |
| Gönderilme Tarihi | 3 Ağustos 2023 |
| Kabul Tarihi | 3 Ekim 2023 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 21 Sayı: 1 |
Kaynak Göster
https://dergipark.org.tr/tr/download/journal-file/20610
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