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Determination of Asemetacin in Drugs by Flow-Injection Analysis Technique Using UV Detector

Yıl 2019, Cilt: 12 Sayı: 2, 1008 - 1017, 31.08.2019
https://doi.org/10.18185/erzifbed.536965

Öz

In this study, a flow-injection analysis (FIA) system with UV-detection
is described for the direct determination of Acemetacin, which is
antiinflammatory-analgesic drug used for the treatment of rheumatic diseases.
The best suitable carrier solvent system was found to be 2 mM NaOH prepared in
ethanol :water (20:80, v/v). Using a flow-rate of 1,2 mL min-1 and
wavelength of 280,8 nm, the linear response was obtained for Acemetacin in the
range of 1,2×10-5‒5,8×10-5 M (5,0‒24,1 μg mL-1)
with a detection limit of 1,6×10-6 M
(0,7 μg mL-1). The proposed method was successfully applied to the
determination of Acemetacin in commercial capsules and results were compared by
a simple UV-spectrophotometric method developed in this study.

Kaynakça

  • Brooks, P.M., Day, R.O., 1991. ′′Nonsteroidal antiinflammatory drugs - differences and similarities′′, The New England Journal of Medicine, 324, 1716-1725.
  • Castro, B, Gameiro, P., Lima, J.L.F.C., Matos, C., Reis, S., 2001.′′Interaction of drugs with hexadecylphosphocholine micelles. Derivative spectroscopy, acid-base and solubility studies′′, Materials Science and Engineering C, 18(1-2), 71-7.
  • Duffy, C.P., Elliott, C.J., O′Connor, R.A., Heenan, M.M., Coyle, S., Cleary, I.M., Kavanagh, K., Verhaegen, S., O′Loughlin, C.M., Nicamhlaoibh, R., Clynes, .M. 1998. ′′Enhancement of chemotherapeutic drug toxicity to human tumour cells in vitro by a subset of non-steroidal anti-inflammatory drugs (NSAIDs)′′, European Journal of Cancer, 34(8), 1250-1259.
  • Escuder-Gilabert, L., Martin-Biosca, Y., Sagrado, S., Villanueva-Camanas, R.M., Medina-Hermandez, M.J., 2002. ′′Quality control of pharmaceuticals containing non-steroidal anti-inflammatory drugs by micellar liquid chromatography′′, Chromatohraphia, 55, 283-288.
  • Hoffmann, O., Klaushofer, K., Koller, K. 1985. ′′Prostaglandin –related bone resorption in cultured neonatal Mouse calvaria: Evaluation of biopotency of nonsteroidal anti-inflammatory drugs′′, Prostaglandins, 30 (5), 857-866.
  • Ibrahim, H., Boyer, A., Bouajila, J., Couderc, F., Nepveu, F., 2007. ′′Determination of non-steroidal anti-inflammatory drugs in pharmaceuticals and human serum by dual-mode gradient HPLC and fluorescence detection′′, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 857(1), 59-66.
  • Jones, R.W., Collins, A.J., Notarianni, L.J., Sedman, E., 1991. ′′The comparative pharmacokinetics of acemetacin in young subjects and elderly patients′′, British Journal of Clinical Pharmacology, 31, 543-545.
  • Kayaalp, O. 2002 ′′Rasyonel tedavi yönünden tıbbi farmakoloji′′ 10. Baskı. Hacettepe-Taş Kitapçılık Ltd.Şti., Ankara, 960-994.
  • Krull, I.S., Swartz, M., 1999. ′′Analytical method development and validation fort he academic researcher′′, Analytical Letters , 32 (6), 1067-1080.
  • Martínez-Algaba, C., Escuder-Gilabert, L., Sagrado, S., Villanueva-Camañas, R.M., Medina-Hernández, M.J., 2004. ′′Comparison between sodium dodecylsulphate and cetyltrimethylammonium bromide as mobile phases in the micellar liquid chromatography determination of non-steroidal anti-inflammatory drugs in pharmaceuticals′′, Journal of Pharmaceutical and Biomedical Analysis, 36(2), 393-399.
  • Notarianni, L.J., Collins, A. 1987. ′′Method forthe determination of acemetacin a non-steroidal anti-inflammatory drug in plasma by high –performans liquid chromatography′′, J of Chromatography. 413, 305-308.
  • Özbakan, H., Murat Palabiyik, I., Gökhan Çaǧlayan, M., Onur, F., 2009. ′′Spectrophotometric and liquid chromatographic determination of acemetacin in pharmaceutical formulations′′, Turkish Journal of Pharmaceutical Sciences, 6(3), 163-176.
  • Palacios, J.L., Arcos, J., Batanero, P.S. 1988. ′′Electrochemical behaviour of acemetacin′′, Journal of Pharmaceutical and Biomedical Analysis, 6, 963-968.
  • Paraskevas D.T., Demetrius G.T., 1991.′′Review of recent applications of flow injection spectrophotometry to pharmaceutical analysis′′, Analytica Chimica Acta 588, 1-9.
  • Reguera, C., Ortiz, M.C., Arcos, M. J. 2002. ′′Differantial pulse voltammetric simultaneous determination of four anti-inflammatory drugs by using soft modelling′′, Electroanalysis. 14(24), 699-1706.
  • Saul, P.A., Korlipara, K. 1991. ′′Acemetacin and indometacin in the treatment of rheumayoid-arthritis a double-blind comparative study in general practice′′, Current Medical Research and Opinion, 12, 332-341.
  • Schöllnhommer, G., Dell, H.D., Doersing, K., Kamp, R. 1985. ′′Quanitative determination of acemetacin and its metabolite indometacin in blood and plasma by column liquid chromatography′′, Journal of Chromatography B: Biomedical Sciences and Applications,375, 331-338.
  • Yuan, Y., Sun, N., Yan, H., Han, D., Row, K.H., 2016. ′′Determination of indometacin and acemetacin in human urine via reduced graphene oxide - based pipette tip solid-phase extraction coupled to HPLC′′, Microchimica Acta, 183(2), 799-804.
  • Zhang, Z.-J., Zhuang, Y.-F., Ju, H.-X., 2004.′′Flow injection chemiluminescent detection of acemetacin in KMnO4 - Na2SO3 system′′, Yaoxue Xuebao, 39(11), 925-928.

Akış-Enjeksiyon Analiz Tekniği ile UV Dedektör Kullanılarak İlaçlarda Asemetasin Tayini

Yıl 2019, Cilt: 12 Sayı: 2, 1008 - 1017, 31.08.2019
https://doi.org/10.18185/erzifbed.536965

Öz

Bu çalışmada romatizma
tedavisinde kullanılan antiinflamatuvar-analjezik etkili ilaçlardan Asemetasin
bileşiğinin doğrudan tayininde UV-dedektörlü akış-enjeksiyon analiz (FIA)
tekniği tanımlanmıştır. En uygun taşıyıcı çözücünün, etanol:su (20:80, h/h) içerisinde
hazırlanan 2 mM NaOH olduğu saptanmıştır. Akış hızı olarak 1,2 mL dak-1
ve çalışma dalga boyu olarak 280,8 nm değerleri kullanıldığında Asemetasin için
1,2×10-5‒5,8×10-5 M (5,0‒24,1 μg mL-1)derişim
aralığında, 1,6×10-6 M (0,7 μg mL-1) gözlenebilirlik
sınırına
sahip
doğrusal bir aralık elde edilmiştir. Önerilen yöntem, bu bileşiği içeren
ticari kapsül ilaç şekline başarıyla uygulanmış ve sonuçlar bu çalışmada
geliştirilen basit bir UV-spektrofotometrik yöntemle karşılaştırılmıştır.

Kaynakça

  • Brooks, P.M., Day, R.O., 1991. ′′Nonsteroidal antiinflammatory drugs - differences and similarities′′, The New England Journal of Medicine, 324, 1716-1725.
  • Castro, B, Gameiro, P., Lima, J.L.F.C., Matos, C., Reis, S., 2001.′′Interaction of drugs with hexadecylphosphocholine micelles. Derivative spectroscopy, acid-base and solubility studies′′, Materials Science and Engineering C, 18(1-2), 71-7.
  • Duffy, C.P., Elliott, C.J., O′Connor, R.A., Heenan, M.M., Coyle, S., Cleary, I.M., Kavanagh, K., Verhaegen, S., O′Loughlin, C.M., Nicamhlaoibh, R., Clynes, .M. 1998. ′′Enhancement of chemotherapeutic drug toxicity to human tumour cells in vitro by a subset of non-steroidal anti-inflammatory drugs (NSAIDs)′′, European Journal of Cancer, 34(8), 1250-1259.
  • Escuder-Gilabert, L., Martin-Biosca, Y., Sagrado, S., Villanueva-Camanas, R.M., Medina-Hermandez, M.J., 2002. ′′Quality control of pharmaceuticals containing non-steroidal anti-inflammatory drugs by micellar liquid chromatography′′, Chromatohraphia, 55, 283-288.
  • Hoffmann, O., Klaushofer, K., Koller, K. 1985. ′′Prostaglandin –related bone resorption in cultured neonatal Mouse calvaria: Evaluation of biopotency of nonsteroidal anti-inflammatory drugs′′, Prostaglandins, 30 (5), 857-866.
  • Ibrahim, H., Boyer, A., Bouajila, J., Couderc, F., Nepveu, F., 2007. ′′Determination of non-steroidal anti-inflammatory drugs in pharmaceuticals and human serum by dual-mode gradient HPLC and fluorescence detection′′, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 857(1), 59-66.
  • Jones, R.W., Collins, A.J., Notarianni, L.J., Sedman, E., 1991. ′′The comparative pharmacokinetics of acemetacin in young subjects and elderly patients′′, British Journal of Clinical Pharmacology, 31, 543-545.
  • Kayaalp, O. 2002 ′′Rasyonel tedavi yönünden tıbbi farmakoloji′′ 10. Baskı. Hacettepe-Taş Kitapçılık Ltd.Şti., Ankara, 960-994.
  • Krull, I.S., Swartz, M., 1999. ′′Analytical method development and validation fort he academic researcher′′, Analytical Letters , 32 (6), 1067-1080.
  • Martínez-Algaba, C., Escuder-Gilabert, L., Sagrado, S., Villanueva-Camañas, R.M., Medina-Hernández, M.J., 2004. ′′Comparison between sodium dodecylsulphate and cetyltrimethylammonium bromide as mobile phases in the micellar liquid chromatography determination of non-steroidal anti-inflammatory drugs in pharmaceuticals′′, Journal of Pharmaceutical and Biomedical Analysis, 36(2), 393-399.
  • Notarianni, L.J., Collins, A. 1987. ′′Method forthe determination of acemetacin a non-steroidal anti-inflammatory drug in plasma by high –performans liquid chromatography′′, J of Chromatography. 413, 305-308.
  • Özbakan, H., Murat Palabiyik, I., Gökhan Çaǧlayan, M., Onur, F., 2009. ′′Spectrophotometric and liquid chromatographic determination of acemetacin in pharmaceutical formulations′′, Turkish Journal of Pharmaceutical Sciences, 6(3), 163-176.
  • Palacios, J.L., Arcos, J., Batanero, P.S. 1988. ′′Electrochemical behaviour of acemetacin′′, Journal of Pharmaceutical and Biomedical Analysis, 6, 963-968.
  • Paraskevas D.T., Demetrius G.T., 1991.′′Review of recent applications of flow injection spectrophotometry to pharmaceutical analysis′′, Analytica Chimica Acta 588, 1-9.
  • Reguera, C., Ortiz, M.C., Arcos, M. J. 2002. ′′Differantial pulse voltammetric simultaneous determination of four anti-inflammatory drugs by using soft modelling′′, Electroanalysis. 14(24), 699-1706.
  • Saul, P.A., Korlipara, K. 1991. ′′Acemetacin and indometacin in the treatment of rheumayoid-arthritis a double-blind comparative study in general practice′′, Current Medical Research and Opinion, 12, 332-341.
  • Schöllnhommer, G., Dell, H.D., Doersing, K., Kamp, R. 1985. ′′Quanitative determination of acemetacin and its metabolite indometacin in blood and plasma by column liquid chromatography′′, Journal of Chromatography B: Biomedical Sciences and Applications,375, 331-338.
  • Yuan, Y., Sun, N., Yan, H., Han, D., Row, K.H., 2016. ′′Determination of indometacin and acemetacin in human urine via reduced graphene oxide - based pipette tip solid-phase extraction coupled to HPLC′′, Microchimica Acta, 183(2), 799-804.
  • Zhang, Z.-J., Zhuang, Y.-F., Ju, H.-X., 2004.′′Flow injection chemiluminescent detection of acemetacin in KMnO4 - Na2SO3 system′′, Yaoxue Xuebao, 39(11), 925-928.
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Gülşah Saydan Kanberoğlu

Erol Şener

Muzaffer Tuncel Bu kişi benim

Zühre Şentürk

Yayımlanma Tarihi 31 Ağustos 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 12 Sayı: 2

Kaynak Göster

APA Saydan Kanberoğlu, G., Şener, E., Tuncel, M., Şentürk, Z. (2019). Akış-Enjeksiyon Analiz Tekniği ile UV Dedektör Kullanılarak İlaçlarda Asemetasin Tayini. Erzincan University Journal of Science and Technology, 12(2), 1008-1017. https://doi.org/10.18185/erzifbed.536965