Evaluation of cord blood ischemia modified albumin and mean platelet volume in infants of preeclamptic mothers
Öz
Aim: Oxidative stress (OS) is a known cause of placental dysfunction, thus may be causally related to preeclampsia and
small for gestational age infant (SGA). We aimed to investigate cord blood ischemia-modified albumin (IMA) and mean
platelet volüme (MPV) levels in neonates born to mothers with preeclampsia and correlate the determined levels with
beeing SGA.
Material and Method: A prospective controlled study was conducted. Fifty infants of mothers with preeclampsia, 40
healthy neonates of healthy mothers were included. Cord blood IMA and MPV levels were measured in infants of
mothers with preeclampsia. The role of cord blood IMA levels to predict beeing SGA was also investigated.
Results: Cord blood IMA and MPV levels of infants of preeclamptic mothers were significantly higher compared to
controls. Serum IMA levels were significantly higher in SGA infants compared to appropirate for gestational age (AGA)
infants (p=0.018), however MPV levels were similar in both groups (p=0.735).
Conclusion: According to this study cord blood IMA and MPV levels may be considered useful as a simple measure of
OS status in infants of mothers with preeclampsia. However, further studies with larger samples will be necessary to
determine usefulness of these markers in clinical practice.
Anahtar Kelimeler
oxidative stress ischemia modified albumin newborn preeclampcia
Kaynakça
- Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of preeclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol 2011; 25:391-403.
- Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 2013; 170:1-7.
- Hung TH, Burton GJ. Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia. Taiwan J Obstet Gynecol 2006; 45:189-200.
- Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Bio Reprod 2003; 69: 1-7.
- Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998; 179:1359-1375.
- Bar–Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia- a priliminary report. J Emerg Med 2000; 19:311-315.
- Ustün Y, Engin Ustün Y, Oztürk O, Alanbay I, Yaman H. Ischemia- modified albümin as an oxidative stress marker in preeclampsia. J Matern Fetal Neonatal Med 2011; 24:418-421.
- Reddy VS, Duggina P, Vedhantam M, Manne M, Varma N, Nagaram S. Maternal serum and fetal cord blood ischemia modified albümin concentrations in normal pregnancy and preeclampsia: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2018: 31:3255-3266.
- Noris P, Melazzini F, Balduini CL. New roles for mean platelet volüme measurement in the clinical practice? Platelets 2016; 27:607-612.
- Reese JA, Peck JD, Yu Z, Scordino TA, Deschamps DR, Mclntosh JJ, et al. Platelet sequestration and consumption in the placental intervillous space contributr to lower platelet counts during pregnancy. Am J Hematol 2019; 94:E8-E11.
- ACOG Practice Bulletin No. 202:Gestational Hypertension and Preeclampsia. Obstet Gynecol 2019; 133:1.
- Gioia S, Piazze J, Anceschi MM, Cerekja A, Alberini A, Giancotti A, et al. Mean platelet volume: association with adverse neonatal outcome. Platelets 2007; 18: 284-288.
- Alkholy E, Farag E, Behery M, Ibrahim M. The significance of platelet count, mean platelet volume and platelet width distribution in preeclampsia. Al-Azhar Assiut Medical Journal 2013; 11:200-214.
- Usher R, McClean F. Intrauterine growth of live born Caucasian infants born between 25 and 44 weeks of gestation. J Pediatr 1969; 74:901-910.
- Abboud H, Labreuche J, Meseguer E, Lavallee PC, Simon O, Olivot JM, et al. Ischemia modified albümin in acute stroke. Cerebrovasc Dis 2007; 23:216-220.
- van Rijn BB, Franx A, Sikkema JM, van Rijn HJ, Bruinse HW, Voorbij HA. Ischemia modiefied albümin in normal pregnancy and preeclampsia. Hypertens Pregnancy 2008; 27:159-167.
- Ozdemir ÖM, Ozdemir E, Enli Y, Oztekin O, Ergin H. Ischemia modified albümin in preterm infants born to mothers with preeclampsia. Pediatr Int 2018; 60:553-559.
- Delic R, Stefanovic M. Statistical regression model of standard and new laboratory markers and its usefulness in prediction of preeclampsia. J Matern Fetal Nenatal Med 2014; 27:388-392.
- Iacovidou N, Briana DD, Boutsikou M, Liosi S, Baka S, Boutsikou T, et al. Cord Blood Ischemia-Modified Albumin Levels in Normak and Intrauterine Growth Restricted Pregnancies. Mediators Inflamm 2008; 2008:1-5.
- Bellos I, Fitrou G, Pergialiotis V, Papantoniou N, Daskalakis G. Mean Platelet volume values in preeclampsia: a systematic review and metaanalysis.Pregnancy Hypertens 2018; 13:174-180.
- Marumoto Y, Kaibara M, Murata T. Hemorheological studies on platelet counts and size in normal pregnancy and pregnancies with preeclampsia and IUGR. Nippon Sanka Fujinka Gakkai Zasshi 1989: 41:1380-1386.
- Cekmez F, Tanju IA, Canpolat FE, Aydinoz S, Aydemir G, Karademir F, et al. Mean Platelet volume in very preterm infants: a predictor of morbidities? Eur Rev Med Pharmacol Sci 2013; 17:134-137.
Preeklamptik annelerin bebeklerinde kordon kanı iskemi modifiye albümin düzeyleri ve ortalama trombosit hacminin değerlendirilmesi
Öz
Amaç: Oksidatif stres (OS), plasental disfonksiyonun bilinen bir nedenidir, bu nedenle preeklampsi ve gestasyon haftasına
göre düşük doğum ağırlığı ile nedensel olarak ilişkili olabilir. Preeklampsili annelerden doğan yenidoğanlarda kordon
kanı iskemi modifiye albumin (İMA) ve ortalama trombosit hacmi (MPV) düzeylerini araştırmayı ve belirlenen düzeylerin
gestasyon haftasına göre düşük doğum ağırlığı ile ilişkisini değerlendirmeyi amaçladık.
Gereç ve Yöntem: Prospektif kontrollü olan bu çalışmaya annesinde preeklampsi olan 50 bebek ve sağlıklı annelerin 40
sağlıklı yenidoğanı dahil edildi. Preeklampsili annelerin bebeklerinde kordon kanı İMA ve MPV düzeyleri ölçüldü. Kordon
kanı İMA düzeylerinin gestasyon haftasına göre düşük doğum ağırlığı olma durumunu öngörmedeki rolü de araştırıldı.
Bulgular: Preeklamptik annelerin bebeklerinin kordon kanı İMA ve MPV düzeyleri kontrollere göre anlamlı derecede yüksekti.
Serum İMA düzeyleri gestasyon haftasına göre düşük doğum ağırlığı olan bebeklerde, doğum ağırlığı gestasyonel yaşa uygun
(AGA) bebeklere göre anlamlı olarak yüksekti (p=0,018), ancak MPV düzeyleri her iki grupta da benzerdi (p=0,735).
Sonuç: Bu çalışmaya göre, preeklamptik annelerin bebeklerinde kord kanı İMA ve MPV düzeylerinin OS durumunun basit
bir ölçümü olarak yararlı olduğu düşünülebilir. Bununla birlikte, bu belirteçlerin klinik pratikteki yararlılığını belirlemek için
daha büyük örneklemli daha ileri çalışmalar gerekli olacaktır.
Anahtar Kelimeler
oksidatif stres iskemi modifiye albümin yenidoğan preeklampsi
Kaynakça
- Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of preeclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol 2011; 25:391-403.
- Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 2013; 170:1-7.
- Hung TH, Burton GJ. Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia. Taiwan J Obstet Gynecol 2006; 45:189-200.
- Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Bio Reprod 2003; 69: 1-7.
- Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998; 179:1359-1375.
- Bar–Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia- a priliminary report. J Emerg Med 2000; 19:311-315.
- Ustün Y, Engin Ustün Y, Oztürk O, Alanbay I, Yaman H. Ischemia- modified albümin as an oxidative stress marker in preeclampsia. J Matern Fetal Neonatal Med 2011; 24:418-421.
- Reddy VS, Duggina P, Vedhantam M, Manne M, Varma N, Nagaram S. Maternal serum and fetal cord blood ischemia modified albümin concentrations in normal pregnancy and preeclampsia: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2018: 31:3255-3266.
- Noris P, Melazzini F, Balduini CL. New roles for mean platelet volüme measurement in the clinical practice? Platelets 2016; 27:607-612.
- Reese JA, Peck JD, Yu Z, Scordino TA, Deschamps DR, Mclntosh JJ, et al. Platelet sequestration and consumption in the placental intervillous space contributr to lower platelet counts during pregnancy. Am J Hematol 2019; 94:E8-E11.
- ACOG Practice Bulletin No. 202:Gestational Hypertension and Preeclampsia. Obstet Gynecol 2019; 133:1.
- Gioia S, Piazze J, Anceschi MM, Cerekja A, Alberini A, Giancotti A, et al. Mean platelet volume: association with adverse neonatal outcome. Platelets 2007; 18: 284-288.
- Alkholy E, Farag E, Behery M, Ibrahim M. The significance of platelet count, mean platelet volume and platelet width distribution in preeclampsia. Al-Azhar Assiut Medical Journal 2013; 11:200-214.
- Usher R, McClean F. Intrauterine growth of live born Caucasian infants born between 25 and 44 weeks of gestation. J Pediatr 1969; 74:901-910.
- Abboud H, Labreuche J, Meseguer E, Lavallee PC, Simon O, Olivot JM, et al. Ischemia modified albümin in acute stroke. Cerebrovasc Dis 2007; 23:216-220.
- van Rijn BB, Franx A, Sikkema JM, van Rijn HJ, Bruinse HW, Voorbij HA. Ischemia modiefied albümin in normal pregnancy and preeclampsia. Hypertens Pregnancy 2008; 27:159-167.
- Ozdemir ÖM, Ozdemir E, Enli Y, Oztekin O, Ergin H. Ischemia modified albümin in preterm infants born to mothers with preeclampsia. Pediatr Int 2018; 60:553-559.
- Delic R, Stefanovic M. Statistical regression model of standard and new laboratory markers and its usefulness in prediction of preeclampsia. J Matern Fetal Nenatal Med 2014; 27:388-392.
- Iacovidou N, Briana DD, Boutsikou M, Liosi S, Baka S, Boutsikou T, et al. Cord Blood Ischemia-Modified Albumin Levels in Normak and Intrauterine Growth Restricted Pregnancies. Mediators Inflamm 2008; 2008:1-5.
- Bellos I, Fitrou G, Pergialiotis V, Papantoniou N, Daskalakis G. Mean Platelet volume values in preeclampsia: a systematic review and metaanalysis.Pregnancy Hypertens 2018; 13:174-180.
- Marumoto Y, Kaibara M, Murata T. Hemorheological studies on platelet counts and size in normal pregnancy and pregnancies with preeclampsia and IUGR. Nippon Sanka Fujinka Gakkai Zasshi 1989: 41:1380-1386.
- Cekmez F, Tanju IA, Canpolat FE, Aydinoz S, Aydemir G, Karademir F, et al. Mean Platelet volume in very preterm infants: a predictor of morbidities? Eur Rev Med Pharmacol Sci 2013; 17:134-137.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Çocuk Sağlığı ve Hastalıkları |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Aralık 2021 |
| Kabul Tarihi | 29 Aralık 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 3 Sayı: 4 |
