Journal of Istanbul Veterinary Sciences

Öz

Given developing data and knowledge everyday, science related novelty within the Veterinary Internal
Medicine shine like a star. A star is born; immunostimulation via probiotherapy and/or fecal microbiota
transplantation. As an important component of the latter branch, Veterinary Dermatology has changed
within the last 10 years and shifted to another West side of the story. Understanding gut-brain-skin axis,
our mind has been shifted to determine gastroenterology and dermatology is somewhat like famous
twosomes such as ‘Blues brothers’ or ‘Metin Akpınar-Zeki Alasya’. The gut and skin, as an important
components of gastroenterology and dermatology, highl vascularized and entirely innervated organs with
neuroendocrine and immune participation, are aberrantly in association with purpose and function. Both
organs are crucial for maintaining physiological homeostasis. Available data presented closely acquainted,
bifacial relationship between the gut and skin. Apart from several research possessing a link for
gastrointestinal health to skin homeostasis/allostasis. Gastrointestinal and dermatological disorders are
interlocked, oftenly allergy, histamin intolerance and gastrointestinal signs are accompanied by cutaneous
manifestations, in relation with the gut microbiome. In this presentation the gut microbiome’s contribution
to gastrointestinal and skin disorders along with pathogenesis (i.e. gut-brain- skin axis) intestinal barrier
functioning, leaky gut, disbiosis and unbalanced microbiota), analytic methodology (16 s rRna analysis,
significance of phylum, class, order, family, genus detection to those of gut microbiota), , treatment
options will be discussed. Interestingly the participation of fecal microbiota transplantation and altered
calendar probiotic treatment will be discussed in detail. The author (from his large archive) will be
presenting case series of atopic dermatitis along with pruritic dermatoses, which were succesfully treated.