Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2022, Cilt: 6 Sayı: 2, 98 - 104, 31.08.2022
https://doi.org/10.30704/http-www-jivs-net.1137848

Öz

Destekleyen Kurum

Selçuk Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü

Proje Numarası

19202049

Teşekkür

Çalışmamda bana yol gösteren kıymetli hocam Tufan KEÇECİ'ye ve her zaman yanımda olan eşime teşekkür ederim.

Kaynakça

  • Antonious, G. F. (2018). Capsaicinoids and vitamins in hot pepper and their role in disease therapy. In Capsaicin and its human therapeutic development. IntechOpen.
  • Abdel-Salam O. M. (2007). Modulation of visceral nociception, inflammation and gastric mucosal injury by cinnarizine. Drug target insights, 2, 29–38.
  • Abdel-Salam, O. M., Abdel-Rahman, R. F., Sleem, A. A., & Farrag, A. R. (2012). Modulation of lipopolysaccharide-induced oxidative stress by capsaicin. Inflammopharmacology, 20(4), 207–217. https://doi.org/10.1007/s10787-011-0101-9
  • Baek, Y. M., Hwang, H. J., Kim, S. W., Hwang, H. S., Lee, S. H., Kim, J. A., & Yun, J. W. (2008). A comparative proteomic analysis for capsaicin-induced apoptosis between human hepatocarcinoma (HepG2) and human neuroblastoma (SK-N-SH) cells. Proteomics, 8(22), 4748–4767. https://doi.org/10.1002/pmic.200800094
  • Brzezińska-Slebodzińska E. (2003). Influence of hypothyroidism on lipid peroxidation, erythrocyte resistance and antioxidant plasma properties in rabbits. Acta veterinaria Hungarica, 51(3), 343–351. https://doi.org/10.1556/AVet.51.2003.3.9
  • Cano-Europa, C., Vanessa, B., Margarita, F., & Rocio, O. (2012). The Relationship Between Thyroid States, Oxidative Stress and Cellular Damage. In V. I. Lushchak, & D. V. Gospodaryov (Eds.), Oxidative Stress and Diseases. IntechOpen. https://doi.org/10.5772/35082
  • Cebeci, E., Alibaz-Oner, F., Usta, M., Yurdakul, S., & Erguney, M. (2012). Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in patients with subclinical hypothyroidism. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 60(1), 23–28. https://doi.org/10.2310/JIM.0b013e31823581dd
  • Chaudhary, A., Gour, J. K., & Rizvi, S. I. (2022). Capsaicin has potent anti-oxidative effects in vivo through a mechanism which is non-receptor mediated. Archives of physiology and biochemistry, 128(1), 141–147. https://doi.org/10.1080/13813455.2019.1669056
  • Coria, M. J., Pastrán, A. I., & Gimenez, M. S. (2009). Serum oxidative stress parameters of women with hypothyroidism. Acta bio-medica : Atenei Parmensis, 80(2), 135–139.
  • Deraz, H. A., Shoukry, A., Bakr H. G., Shalaby, S. M., (2016). Lipid peroxidationand antioxidant statusin overt and subclinical hypothyroidism, International Journal of Advanced Research , 4, 6, 322-332.
  • Erdamar, H., Demirci, H., Yaman, H., Erbil, M. K., Yakar, T., Sancak, B., Elbeg, S., Biberoğlu, G., & Yetkin, I. (2008). The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clinical chemistry and laboratory medicine, 46(7), 1004–1010. https://doi.org/10.1515/CCLM.2008.183
  • Gluvic, Z. M., Obradovic, M. M., Sudar-Milovanovic, E. M., Zafirovic, S. S., Radak, D. J., Essack, M. M., Bajic, V. B., Takashi, G., & Isenovic, E. R. (2020). Regulation of nitric oxide production in hypothyroidism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 124, 109881. https://doi.org/10.1016/j.biopha.2020.109881
  • Gomathi, K.G., Khan, N., & Basha, S.A. (2016). Total antioxidant status and lipid parameters among patients of hypothyroidism. Gulf Medıcal Journal, 1, 2, 46-50.
  • Guerrero, A., Pamplona, R., Portero-Otín, M., Barja, G., & López-Torres, M. (1999). Effect of thyroid status on lipid composition and peroxidation in the mouse liver. Free radical biology & medicine, 26(1-2), 73–80. https://doi.org/10.1016/s0891-5849(98)00173-7
  • Kandır, S. (2015). Ratlarda Deneysel Hipotiroidizm ve Hipertiroidizmin Kan Plazmasında Bazı Serbest Radikal ve Antioksidan Sistem Parametreleri Üzerine Etkileri. Selçuk Üniversitesi Sağlık Bilimleri Enstitüsü Veteriner Fizyoloji, Doktora Tezi, KONYA.
  • Kempaiah, R. K., & Srinivasan, K. (2004b). Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver in high-fat-fed rats. Annals of nutrition & metabolism, 48(5), 314–320. https://doi.org/10.1159/000081198
  • Konukoglu, D., Ercan, M., & Hatemi, H. (2002). Plasma viscosity in female patients with hypothyroidism: effects of oxidative stress and cholesterol. Clinical hemorheology and microcirculation, 27(2), 107–113.
  • Kumari, S., Sandhya, G.K., Gowda, K., (2011). Oxidative stress in hypo and hyperthyroidism. Al Ameen J Med Sci, 4, 1, 49-53. Li, W., Yang, H., Lu, Y., (2019). Capsaicin alleviates lipid metabolism disorder in high beef fat-fed mice. Journal of Functional Foods, 60, 103444.
  • Mancini, A., Festa, R., Di Donna, V., Leone, E., Littarru, G. P., Silvestrini, A., Meucci, E., & Pontecorvi, A. (2010). Hormones and antioxidant systems: role of pituitary and pituitary-dependent axes. Journal of endocrinological investigation, 33(6), 422–433. https://doi.org/10.1007/BF03346615
  • Manjunatha, H., & Srinivasan, K. (2007). Hypolipidemic and antioxidant effects of curcumin and capsaicin in high-fat-fed rats. Canadian journal of physiology and pharmacology, 85(6), 588–596. https://doi.org/10.1139/y07-044
  • Messarah, M., Boulakoud, M. S., Boumendjel, A., Abdennour, C., & El Feki, A. (2007). The impact of thyroid activity variations on some oxidizing-stress parameters in rats. Comptes rendus biologies, 330(2), 107–112. https://doi.org/10.1016/j.crvi.2006.11.004
  • Messarah, M., Boumendjel, A., Chouabia, A., Klibet, F., Abdennour, C., Boulakoud, M. S., & Feki, A. E. (2010). Influence of thyroid dysfunction on liver lipid peroxidation and antioxidant status in experimental rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 62(3), 301–310. https://doi.org/10.1016/j.etp.2009.04.009
  • Messarah, M., Saoudi, M., Boumendjel, A., Boulakoud, M. S., & Feki, A. E. (2011). Oxidative stress induced by thyroid dysfunction in rat erythrocytes and heart. Environmental toxicology and pharmacology, 31(1), 33–41. https://doi.org/10.1016/j.etap.2010.09.003
  • Mogulkoc, R., Baltaci, A. K., Aydin, L., Oztekin, E., & Sivrikaya, A. (2005). The effect of thyroxine administration on lipid peroxidation in different tissues of rats with hypothyroidism. Acta physiologica Hungarica, 92(1), 39–46. https://doi.org/10.1556/APhysiol.92.2005.1.6
  • Nanda, N., Bobby, Z., Hamide, A., Koner, B. C., & Sridhar, M. G. (2007). Association between oxidative stress and coronary lipid risk factors in hypothyroid women is independent of body mass index. Metabolism: clinical and experimental, 56(10), 1350–1355. https://doi.org/10.1016/j.metabol.2007.05.015
  • Rondeel, J. M., de Greef, W. J., Klootwijk, W., & Visser, T. J. (1992). Effects of hypothyroidism on hypothalamic release of thyrotropin-releasing hormone in rats. Endocrinology, 130(2), 651–656. https://doi.org/10.1210/endo.130.2.1733713 Salama, A. F., Tousson, E., Ibrahim, W., & Hussein, W. M. (2013). Biochemical and histopathological studies of the PTU-induced hypothyroid rat kidney with reference to the ameliorating role of folic acid. Toxicology and industrial health, 29(7), 600–608. https://doi.org/10.1177/0748233711432577
  • Santi, A., Duarte, M. M., Moresco, R. N., Menezes, C., Bagatini, M. D., Schetinger, M. R., & Loro, V. L. (2010). Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism. Clinical chemistry and laboratory medicine, 48(11), 1635–1639. https://doi.org/10.1515/CCLM.2010.309
  • Schwartz, E. S., Lee, I., Chung, K., & Mo Chung, J. (2008). Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. Pain, 138(3), 514–524. https://doi.org/10.1016/j.pain.2008.01.029
  • Tenorio-Velázquez, V. M., Barrera, D., Franco, M., Tapia, E., Hernández-Pando, R., Medina-Campos, O. N., & Pedraza-Chaverri, J. (2005). Hypothyroidism attenuates protein tyrosine nitration, oxidative stress and renal damage induced by ischemia and reperfusion: effect unrelated to antioxidant enzymes activities. BMC nephrology, 6, 12. https://doi.org/10.1186/1471-2369-6-12
  • Torun, A. N., Kulaksizoglu, S., Kulaksizoglu, M., Pamuk, B. O., Isbilen, E., & Tutuncu, N. B. (2009). Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism. Clinical endocrinology, 70(3), 469–474. https://doi.org/10.1111/j.1365-2265.2008.03348.x
  • Venditti, P., & Di Meo, S. (2006). Thyroid hormone-induced oxidative stress. Cellular and molecular life sciences : CMLS, 63(4), 414–434. https://doi.org/10.1007/s00018-005-5457-9
  • Yazıcı, C. (2019). Hipotiroidizm Oluşturulan Ratlarda Koenzim Q10'un Kan Plazması Nitrik Oksit ve Total Antioksidan Kapasite Düzeyleri Üzerine Etkisi. Selçuk Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, KONYA.
  • Zhang, L., Fang, G., Zheng, L., Chen, Z., & Liu, X. (2013a). The hypocholesterolemic effect of capsaicinoids in ovariectomized rats fed with a cholesterol-free diet was mediated by inhibition of hepatic cholesterol synthesis. Food & function, 4(5), 738–744. https://doi.org/10.1039/c3fo30321g
  • Zhang, L., Fang, G., Zheng, L., Chen, Z., & Liu, X. (2013b). Hypocholesterolemic effect of capsaicinoids in rats fed diets with or without cholesterol. Journal of agricultural and food chemistry, 61(18), 4287–4293. https://doi.org/10.1021/jf304471t
  • Zhang, L., Zhou, M., Fang, G., Tang, Y., Chen, Z. and Liu, X. (2013c), Hypocholesterolemic effect of capsaicinoids by increased bile acids excretion in ovariectomized rats. Mol. Nutr. Food Res., 57: 1080-1088. https://doi.org/10.1002/mnfr.201200716

The effect of capsaicin on TBARS and TAS in rats with hypothyroidism

Yıl 2022, Cilt: 6 Sayı: 2, 98 - 104, 31.08.2022
https://doi.org/10.30704/http-www-jivs-net.1137848

Öz

In this study, capsaicin was administered to rats with experimental hypothyroidism. İt was aimed to determine the changes in plasma levels of thiobarbituric acid reactive substances (TBARS), which are indicators of oxidative stress, and total antioxidant capacity (TAS), which is one of the components of antioxidant defence mechanisms. A total of 32 healthy male Wistar Albino rats weighing 300-350 g, approximately 12 weeks old, were used as animal material in the study. Rats were divided into four equal groups control (K), Capsaicin (C), Hypothyroid (H) and capsaicin + Hypothyroid (CH). During the 30-day trial period, (10mg / kg / day) capsaicin was administered to the rats in group C by oral gavage per animal. In group H, 6-n-propyl-2-thiouracil (PTU) was added daily to their drinking water at 0.05% weight/volume (W/V). In the CH group, 10 mg/kg/day of capsaicin was administered by oral gavage method and 0.05% weight / volume (W / V) of PTU was added to drinking water. At the end of the application, we obtained plasma and serum samples from the subjects in the groups under general anaesthesia (thiopental anaesthesia, 40 mg/kg) and by taking sufficient amount of blood from the heart by cardiac puncture. We determined thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), free T3 (fT3), total thyroxine (TT4) and free T4 (fT4) levels from serum samples, and TBARS and TAS levels from plasma samples. In conclusion, in the light of the data obtained in this study, we determined that lipid peroxidation and oxidative stress occur in hypothyroidism. However, we concluded that the application of capsaicin is partially sufficient to maintain the oxidant/antioxidant balance.

Proje Numarası

19202049

Kaynakça

  • Antonious, G. F. (2018). Capsaicinoids and vitamins in hot pepper and their role in disease therapy. In Capsaicin and its human therapeutic development. IntechOpen.
  • Abdel-Salam O. M. (2007). Modulation of visceral nociception, inflammation and gastric mucosal injury by cinnarizine. Drug target insights, 2, 29–38.
  • Abdel-Salam, O. M., Abdel-Rahman, R. F., Sleem, A. A., & Farrag, A. R. (2012). Modulation of lipopolysaccharide-induced oxidative stress by capsaicin. Inflammopharmacology, 20(4), 207–217. https://doi.org/10.1007/s10787-011-0101-9
  • Baek, Y. M., Hwang, H. J., Kim, S. W., Hwang, H. S., Lee, S. H., Kim, J. A., & Yun, J. W. (2008). A comparative proteomic analysis for capsaicin-induced apoptosis between human hepatocarcinoma (HepG2) and human neuroblastoma (SK-N-SH) cells. Proteomics, 8(22), 4748–4767. https://doi.org/10.1002/pmic.200800094
  • Brzezińska-Slebodzińska E. (2003). Influence of hypothyroidism on lipid peroxidation, erythrocyte resistance and antioxidant plasma properties in rabbits. Acta veterinaria Hungarica, 51(3), 343–351. https://doi.org/10.1556/AVet.51.2003.3.9
  • Cano-Europa, C., Vanessa, B., Margarita, F., & Rocio, O. (2012). The Relationship Between Thyroid States, Oxidative Stress and Cellular Damage. In V. I. Lushchak, & D. V. Gospodaryov (Eds.), Oxidative Stress and Diseases. IntechOpen. https://doi.org/10.5772/35082
  • Cebeci, E., Alibaz-Oner, F., Usta, M., Yurdakul, S., & Erguney, M. (2012). Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in patients with subclinical hypothyroidism. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 60(1), 23–28. https://doi.org/10.2310/JIM.0b013e31823581dd
  • Chaudhary, A., Gour, J. K., & Rizvi, S. I. (2022). Capsaicin has potent anti-oxidative effects in vivo through a mechanism which is non-receptor mediated. Archives of physiology and biochemistry, 128(1), 141–147. https://doi.org/10.1080/13813455.2019.1669056
  • Coria, M. J., Pastrán, A. I., & Gimenez, M. S. (2009). Serum oxidative stress parameters of women with hypothyroidism. Acta bio-medica : Atenei Parmensis, 80(2), 135–139.
  • Deraz, H. A., Shoukry, A., Bakr H. G., Shalaby, S. M., (2016). Lipid peroxidationand antioxidant statusin overt and subclinical hypothyroidism, International Journal of Advanced Research , 4, 6, 322-332.
  • Erdamar, H., Demirci, H., Yaman, H., Erbil, M. K., Yakar, T., Sancak, B., Elbeg, S., Biberoğlu, G., & Yetkin, I. (2008). The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clinical chemistry and laboratory medicine, 46(7), 1004–1010. https://doi.org/10.1515/CCLM.2008.183
  • Gluvic, Z. M., Obradovic, M. M., Sudar-Milovanovic, E. M., Zafirovic, S. S., Radak, D. J., Essack, M. M., Bajic, V. B., Takashi, G., & Isenovic, E. R. (2020). Regulation of nitric oxide production in hypothyroidism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 124, 109881. https://doi.org/10.1016/j.biopha.2020.109881
  • Gomathi, K.G., Khan, N., & Basha, S.A. (2016). Total antioxidant status and lipid parameters among patients of hypothyroidism. Gulf Medıcal Journal, 1, 2, 46-50.
  • Guerrero, A., Pamplona, R., Portero-Otín, M., Barja, G., & López-Torres, M. (1999). Effect of thyroid status on lipid composition and peroxidation in the mouse liver. Free radical biology & medicine, 26(1-2), 73–80. https://doi.org/10.1016/s0891-5849(98)00173-7
  • Kandır, S. (2015). Ratlarda Deneysel Hipotiroidizm ve Hipertiroidizmin Kan Plazmasında Bazı Serbest Radikal ve Antioksidan Sistem Parametreleri Üzerine Etkileri. Selçuk Üniversitesi Sağlık Bilimleri Enstitüsü Veteriner Fizyoloji, Doktora Tezi, KONYA.
  • Kempaiah, R. K., & Srinivasan, K. (2004b). Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver in high-fat-fed rats. Annals of nutrition & metabolism, 48(5), 314–320. https://doi.org/10.1159/000081198
  • Konukoglu, D., Ercan, M., & Hatemi, H. (2002). Plasma viscosity in female patients with hypothyroidism: effects of oxidative stress and cholesterol. Clinical hemorheology and microcirculation, 27(2), 107–113.
  • Kumari, S., Sandhya, G.K., Gowda, K., (2011). Oxidative stress in hypo and hyperthyroidism. Al Ameen J Med Sci, 4, 1, 49-53. Li, W., Yang, H., Lu, Y., (2019). Capsaicin alleviates lipid metabolism disorder in high beef fat-fed mice. Journal of Functional Foods, 60, 103444.
  • Mancini, A., Festa, R., Di Donna, V., Leone, E., Littarru, G. P., Silvestrini, A., Meucci, E., & Pontecorvi, A. (2010). Hormones and antioxidant systems: role of pituitary and pituitary-dependent axes. Journal of endocrinological investigation, 33(6), 422–433. https://doi.org/10.1007/BF03346615
  • Manjunatha, H., & Srinivasan, K. (2007). Hypolipidemic and antioxidant effects of curcumin and capsaicin in high-fat-fed rats. Canadian journal of physiology and pharmacology, 85(6), 588–596. https://doi.org/10.1139/y07-044
  • Messarah, M., Boulakoud, M. S., Boumendjel, A., Abdennour, C., & El Feki, A. (2007). The impact of thyroid activity variations on some oxidizing-stress parameters in rats. Comptes rendus biologies, 330(2), 107–112. https://doi.org/10.1016/j.crvi.2006.11.004
  • Messarah, M., Boumendjel, A., Chouabia, A., Klibet, F., Abdennour, C., Boulakoud, M. S., & Feki, A. E. (2010). Influence of thyroid dysfunction on liver lipid peroxidation and antioxidant status in experimental rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 62(3), 301–310. https://doi.org/10.1016/j.etp.2009.04.009
  • Messarah, M., Saoudi, M., Boumendjel, A., Boulakoud, M. S., & Feki, A. E. (2011). Oxidative stress induced by thyroid dysfunction in rat erythrocytes and heart. Environmental toxicology and pharmacology, 31(1), 33–41. https://doi.org/10.1016/j.etap.2010.09.003
  • Mogulkoc, R., Baltaci, A. K., Aydin, L., Oztekin, E., & Sivrikaya, A. (2005). The effect of thyroxine administration on lipid peroxidation in different tissues of rats with hypothyroidism. Acta physiologica Hungarica, 92(1), 39–46. https://doi.org/10.1556/APhysiol.92.2005.1.6
  • Nanda, N., Bobby, Z., Hamide, A., Koner, B. C., & Sridhar, M. G. (2007). Association between oxidative stress and coronary lipid risk factors in hypothyroid women is independent of body mass index. Metabolism: clinical and experimental, 56(10), 1350–1355. https://doi.org/10.1016/j.metabol.2007.05.015
  • Rondeel, J. M., de Greef, W. J., Klootwijk, W., & Visser, T. J. (1992). Effects of hypothyroidism on hypothalamic release of thyrotropin-releasing hormone in rats. Endocrinology, 130(2), 651–656. https://doi.org/10.1210/endo.130.2.1733713 Salama, A. F., Tousson, E., Ibrahim, W., & Hussein, W. M. (2013). Biochemical and histopathological studies of the PTU-induced hypothyroid rat kidney with reference to the ameliorating role of folic acid. Toxicology and industrial health, 29(7), 600–608. https://doi.org/10.1177/0748233711432577
  • Santi, A., Duarte, M. M., Moresco, R. N., Menezes, C., Bagatini, M. D., Schetinger, M. R., & Loro, V. L. (2010). Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism. Clinical chemistry and laboratory medicine, 48(11), 1635–1639. https://doi.org/10.1515/CCLM.2010.309
  • Schwartz, E. S., Lee, I., Chung, K., & Mo Chung, J. (2008). Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. Pain, 138(3), 514–524. https://doi.org/10.1016/j.pain.2008.01.029
  • Tenorio-Velázquez, V. M., Barrera, D., Franco, M., Tapia, E., Hernández-Pando, R., Medina-Campos, O. N., & Pedraza-Chaverri, J. (2005). Hypothyroidism attenuates protein tyrosine nitration, oxidative stress and renal damage induced by ischemia and reperfusion: effect unrelated to antioxidant enzymes activities. BMC nephrology, 6, 12. https://doi.org/10.1186/1471-2369-6-12
  • Torun, A. N., Kulaksizoglu, S., Kulaksizoglu, M., Pamuk, B. O., Isbilen, E., & Tutuncu, N. B. (2009). Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism. Clinical endocrinology, 70(3), 469–474. https://doi.org/10.1111/j.1365-2265.2008.03348.x
  • Venditti, P., & Di Meo, S. (2006). Thyroid hormone-induced oxidative stress. Cellular and molecular life sciences : CMLS, 63(4), 414–434. https://doi.org/10.1007/s00018-005-5457-9
  • Yazıcı, C. (2019). Hipotiroidizm Oluşturulan Ratlarda Koenzim Q10'un Kan Plazması Nitrik Oksit ve Total Antioksidan Kapasite Düzeyleri Üzerine Etkisi. Selçuk Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, KONYA.
  • Zhang, L., Fang, G., Zheng, L., Chen, Z., & Liu, X. (2013a). The hypocholesterolemic effect of capsaicinoids in ovariectomized rats fed with a cholesterol-free diet was mediated by inhibition of hepatic cholesterol synthesis. Food & function, 4(5), 738–744. https://doi.org/10.1039/c3fo30321g
  • Zhang, L., Fang, G., Zheng, L., Chen, Z., & Liu, X. (2013b). Hypocholesterolemic effect of capsaicinoids in rats fed diets with or without cholesterol. Journal of agricultural and food chemistry, 61(18), 4287–4293. https://doi.org/10.1021/jf304471t
  • Zhang, L., Zhou, M., Fang, G., Tang, Y., Chen, Z. and Liu, X. (2013c), Hypocholesterolemic effect of capsaicinoids by increased bile acids excretion in ovariectomized rats. Mol. Nutr. Food Res., 57: 1080-1088. https://doi.org/10.1002/mnfr.201200716
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm Araştırma Makaleleri
Yazarlar

Fatih Ertekin 0000-0002-2528-7859

Tufan Keçeci 0000-0002-6479-3025

Proje Numarası 19202049
Yayımlanma Tarihi 31 Ağustos 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 6 Sayı: 2

Kaynak Göster

APA Ertekin, F., & Keçeci, T. (2022). The effect of capsaicin on TBARS and TAS in rats with hypothyroidism. Journal of Istanbul Veterinary Sciences, 6(2), 98-104. https://doi.org/10.30704/http-www-jivs-net.1137848

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