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Association of the FTO gene with obesity and cancer in dogs

Yıl 2023, Cilt: 7 Sayı: 3, 118 - 131, 31.12.2023
https://doi.org/10.30704/http-www-jivs-net.1349652

Öz

Nowadays, obesity is one of the most serious problems that significantly affect health in both human and animal populations. Fat mass and obesity-associated gene (FTO), increases the risk of obesity and other metabolic diseases such as cancer, with taking part in many complex molecular pathways. On the other hand, environmental and genetic factors cause changes in FTO gene variants and expression levels, which result in phenotypic differences. Advanced knowledge on the genetic basis of human FTO gene and its association with cancer and obesity, has paved the way for the investigation of FTO gene in animals as well. In this review, we summarized current state of knowledge about the FTO gene, which is considered as an important marker of obesity in humans, as well as obesity, cancer and the association of FTO polymorphisms with these diseases in dogs by considering humans with other animal species. Understanding the molecular background of the FTO gene in dogs will be leading to the development of individual treatment methods and prediction of possible phenotypic effects in other species.

Kaynakça

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Yıl 2023, Cilt: 7 Sayı: 3, 118 - 131, 31.12.2023
https://doi.org/10.30704/http-www-jivs-net.1349652

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Kaynakça

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  • Ozer, A., & Bruick, R. K. (2007). Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?. Nature chemical biology, 3(3), 144-153.
  • Peters, T., Ausmeier, K., & Rüther, U. (1999). Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mammalian genome, 10 (10), 983-986.
  • Phillips, C. M. (2013). Nutrigenetics and metabolic disease: current status and implications for personalised nutrition. Nutrients, 5(1), 32-57.
  • Pierce, B. L., Austin, M. A., & Ahsan, H. (2011). Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data. Cancer Causes & Control, 22, 877-883.
  • Popović, A. M., Huđek Turković, A., Žuna, K., Bačun-Družina, V., Rubelj, I., & Matovinović, M. (2023). FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences. Food Technology and Biotechnology, 61(1), 14-26.
  • Wu, Q., Saunders, R. A., Szkudlarek-Mikho, M., de la Serna, I., & Chin, K.V. (2010). The obesity-associated Fto gene is a transcriptional coactivator. Biochemical and biophysical research communications, 401(3), 390-395. Ricci, R., & Bevilacqua, F. (2012). The potential role of leptin and adiponectin in obesity: a comparative review. The Veterinary Journal, 191(3), 292-298.
  • Robbens, S., Rouzé, P., Cock, J. M., Spring, J., Worden, A. Z., & Van de Peer, Y. (2008). The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae. Journal of Molecular Evolution, 66, 80-84.
  • Robertson, I. D. (2003). The association of exercise, diet and other factors with owner-perceived obesity in privately owned dogs from metropolitan Perth, WA. Preventive veterinary medicine, 58(1-2), 75-83.
  • Ronkainen, J., Huusko, T. J., Soininen, R., Mondini, E., Cinti, F., Mäkelä, K. A., Kovalainen, M., Herzig, K. H., Järvelin, M. R., Sebert, S., Savolainen, M. J., & Salonurmi, T. (2015). Fat mass-and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue. Scientific reports, 5(1), 9233.
  • Russell, M. A., & Morgan, N. G. (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clinical Science, 120(9), 403-413.
  • Sarfstein, R., Friedman, Y., Attias-Geva, Z., Fishman, A., Bruchim, I., & Werner, H. (2013). Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or-independent manners. PloS one, 8(4), e61537.
  • Scuteri, A., Sanna, S., Chen, W. M., Uda, M., Albai, G., Strait, J., Najjar, S., Nagaraja, R., Orrú, M., Usala, G., Dei, M., Lai, S., Maschio, A., Busonero, F., Mulas, A., Cao, A., Lakatta, E., & Abecasis, G. R. (2007). Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS genetics, 3(7), e115.
  • Sebert, S. P., Hyatt, M. A., Chan, L. L. Y., Yiallourides, M., Fainberg, H. P., Patel, N., Sharkey, D., Stephenson, T., Rhind, R. M., Bell, R. C., Budge, H., Gardner, D. S., & Symonds, M. E. (2010). Influence of prenatal nutrition and obesity on tissue specific fat mass and obesity-associated (FTO) gene expression. Reproduction, 139(1), 265-274.
  • Song, R. B., Vite, C. H., Bradley, C. W., & Cross, J. R. (2013). Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight. Journal of veterinary internal medicine, 27(5), 1143-1152.
  • Speakman, J. R., Rance, K. A., & Johnstone, A. M. (2008). Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity, 16(8), 1961-1965.
  • Speakman, J. R., Van Acker, A., & Harper, E. J. (2003). Age‐related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy. Aging cell, 2(5), 265-275.
  • Stratigopoulos, G., Padilla, S. L., LeDuc, C. A., Watson, E., Hattersley, A. T., McCarthy, M. I., Zeltser, L. M., Chung, W. K., & Leibel, R. L. (2008). Regulation of Fto/Ftm gene expression in mice and humans. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 294(4), R1185-R1196.
  • Switonski, M., & Mankowska, M. (2013). Dog obesity–the need for identifying predisposing genetic markers. Research in veterinary science, 95(3), 831-836.
  • Tan, A., Dang, Y., Chen, G., & Mo, Z. (2015). Overexpression of the fat mass and obesity associated gene (FTO) in breast cancer and its clinical implications. International journal of clinical and experimental pathology, 8(10), 13405.
  • Tang, H., Dong, X., Hassan, M., Abbruzzese, J. L., & Li, D. (2011). Body Mass Index and Obesity-and Diabetes-Associated Genotypes and Risk for Pancreatic CancerObesity-Related Genes Modify Pancreatic Cancer Risk. Cancer epidemiology, biomarkers & prevention, 20(5), 779-792.
  • Tanofsky-Kraff, M., Han, J C., Anandalingam, K., Shomaker, L. B., Columbo, K. M., Wolkoff, L. E., Kozlosky, M., Elliott, C., Ranzenhofer, L. M., Roza, C. A., Yanovski, S. Z., & Yanovski, J. A. (2009). The FTO gene rs9939609 obesity-risk allele and loss of control over eating. The American journal of clinical nutrition, 90(6), 1483-1488.
  • The GenoMEL Consortium. (2013). A variant in FTO shows association with melanoma risk not due to BMI. Nature Genetics, 45, 428–432.
  • Timpson, N. J., Emmett, P. M., Frayling, T. M., Rogers, I., Hattersley, A. T., McCarthy, M. I., & Davey Smith, G. (2008). The fat mass–and obesity-associated locus and dietary intake in children. The American journal of clinical nutrition, 88 (4), 971-978.
  • Tsai, K. L., Clark, L. A., & Murphy, K. E. (2007). Understanding hereditary diseases using the dog and human as companion model systems. Mammalian Genome, 18, 444-451.
  • Tung, Y. C. L., Ayuso, E., Shan, X., Bosch, F., O'Rahilly, S., Coll, A. P., & Yeo, G. S. (2010). Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PloS one, 5(1), e8771.
  • Vail, D. M., & Macewen, E. G. (2000). Spontaneously occurring tumors of companion animals as models for human cancer. Cancer investigation, 18 (8), 781-792.
  • Hoeven, F. V. D., Schimmang, T., Volkmann, A., Mattei, M. G., Kyewski, B., & Rüther, U. (1994). Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). Development, 120(9), 2601-2607.
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  • Wåhlén, K., Sjölin, E., & Hoffstedt, J. (2008). The common rs9939609 gene variant of the fat mass-and obesity-associated gene FTO is related to fat cell lipolysis. Journal of lipid research, 49(3), 607-611.
  • Wang, S., Liu, S., Yuan, T., & Sun, X. (2021). Genetic effects of FTO gene insertion/deletion (InDel) on fat-tail measurements and growth traits in Tong sheep. Animal biotechnology, 32(2), 229-239.
  • Wardle, J., Llewellyn, C., Sanderson, S., & Plomin, R. (2009). The FTO gene and measured food intake in children. International journal of obesity, 33(1), 42-45.
  • Wei, J., Liu, F., Lu, Z., Fei, Q., Ai, Y., He, P. C., Shi, H., Cui, X., Su, R., Klungland, A., Jia, G., Chen, J., & He, C. (2018). Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm. Molecular cell, 71(6), 973-985.
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  • Zhang, B., Li, Y., Li, L., Chen, M., Zhang, C., Zuo, X. B., Zhou, F. S., Liang, B., Zhu, J., Li, P., Huang, Z., Xuan, H., Li, W., & Chen, Z. D. (2014). Association study of susceptibility loci with specific breast cancer subtypes in Chinese women. Breast cancer research and treatment, 146, 503-514.
  • Zhang, G. W., Gao, L., Chen, S. Y., Zhao, X. B., Tian, Y. F., Wang, X., Deng, X. S., & Lai, S. J. (2013). Single nucleotide polymorphisms in the FTO gene and their association with growth and meat quality traits in rabbits. Gene, 527(2), 553-557.
  • Zielke, L. G., Bortfeldt, R. H., Reissmann, M., Tetens, J., Thaller, G., & Brockmann, G. A. (2013). Impact of variation at the FTO locus on milk fat yield in Holstein dairy cattle. PLoS One, 8(5), e63406.
Toplam 110 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Bilimleri (Diğer)
Bölüm Derleme Makaleler
Yazarlar

Dina Bedik 0000-0002-4088-3827

Gizem Kırmızıoğlu 0000-0002-6422-0139

Iraz Akış 0000-0001-7330-103X

Yayımlanma Tarihi 31 Aralık 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 7 Sayı: 3

Kaynak Göster

APA Bedik, D., Kırmızıoğlu, G., & Akış, I. (2023). Association of the FTO gene with obesity and cancer in dogs. Journal of Istanbul Veterinary Sciences, 7(3), 118-131. https://doi.org/10.30704/http-www-jivs-net.1349652

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