Ankara Üniversitesi Veteriner Fakültesi Dergisi
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Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats

Yıl 2017, Cilt: 64 Sayı: 4, 241 - 248, 01.12.2017

Laçine AKSOY Zeyneb ASLAN

https://doi.org/10.1501/Vetfak_0000002805

Öz

Antioxidative and nephroprotective effects of royal jelly against ethylene glycol induced renal injury were examined
in this study. Five groups of rats were used. Rats in Group 1 served as control. Rats in Group 2 received ethylene glycol (1%) in
drinking water, while those in Group 3 received 100 mg/kg of royal jelly through oral gavage. Group 4 served as protective group and
received ethylene glycol 1% in drinking water and 100 mg/kg of royal jelly administered. Group 5 served as treatment group and
received ethylene glycol 1% in the drinking water for the initial 15 days, followed by 100 mg/kg of royal jelly administered last 15
days. Oxidative stress was induced by ethylene glycol. Royal jelly was found to reduce renal damage with measured BUN and CREA
(creatinine) levels. It was considered that royal jelly has positive effects on antioxidant system and decreased effects on lipid
peroxidation. Royal jelly may have positive nephroprotective effects on the injury induced by ethylene glycol exposure. Particularly,
the effects observed in the treatment group were remarkable.

Anahtar Kelimeler

Antioxidant, calcium oxalate, ethylene glycol, nephropathy, royal jelly

Kaynakça

  • Aebi H (1974): Methods of Enzymatic Analysis, Catalase. Academic Press, New York, NY, USA.
  • Ashok P, Koti CB, Vishwanathswamy AHM (2010): Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. Indian J Pharmacol, 42, 380-383.
  • Atmani F, Slimani Y, Mimouni M, et al. (2004): Prophylaxis of calcium oxalate stones by Herniaria hirsuta on experimentally induced nephrolithiasis in rats. BJU Int, 92, 137-140.
  • Azab KS, Bashandy M, Salem M, et al. (2011): Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats. N Am J Med Sci, 3, 268- 276.
  • Beutler E, Dubon O, Kelly BM (1963): Improved method for the determination of blood glutathione. J Lab Clin Med, 61, 882-888.
  • Bradford MM (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-254.
  • Brouwers EMW, Ebert R, Beetsma J (1987): Behavioural and physiological aspects of nurse bees in relation to the composition of larval food during caste differentiation in the honeybee. J Apic Res, 26, 11-23.
  • Caudarella R, Vescini F (2009): Urinary citrate and renal stone disease: The preventive role of alkali citrate treatment. Arch Ital Urol Androl, 81,182-187.
  • Cemek M, Aymelek F, Büyükokuroğlu ME, et al. (2010): Protective potential of Royal Jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels. Food Chem Toxicol, 48, 2827-2832.
  • Chen YH, Liu HP, Chen HY, et al. (2011): Ethylene glycol induces calcium oxalate crystal deposition in Malpighian tubules: A Drosophila model for nephrolithiasis/ urolithiasis. Kidney Int, 80, 369-377.
  • Cihan YB, Öztürk A, Gökalp SS (2013): Protective role of royal jelly against radiation- induced oxidative stress in rats. Int J Hematol Oncol, 23, 79-87.
  • El-Nekeety AA, El-Kholy W, Abbas NF, et al. (2007): Efficacy of royal jelly against the oxidative stress of fumonisin in rats. Toxicon, 50, 256-269.
  • Eraslan G, Kanbur M, Silici S (2007): Evaluation of propolis effects on some biochemical parameters in rats treated with sodium fluoride. Pest Biochem Physiol, 88, 273-283.
  • Erel Ö (2004): A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem, 37, 112-119.
  • Erel Ö (2005): A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38, 1103- 1111.
  • Favus MJ (1989): Familial forms of hypercalciuria. J Urol, 141, 719-722.
  • Gupta RK, Patel AK, Shah N, et al. (2014): Oxidative stress and antioxidants in disease and cancer: A review. Asian Pac J Cancer Prev, 15, 4405-4409.
  • Hamilton RW, Gardner LB, Penn AS, et al. (1972): Acute tubular myoglobinuria. Ann Intern Med, 77, 77-82. by exercise-induced
  • Hosseinzadeh H, Khooei AR, Khashayarmanesh Z, et al. (2010): Antiurolithiatic activity of Pinus Eldarica Medw. Fruits aqueous extract in rats. Urol J, 7, 233-237.
  • Huang HS, Ma MC, Chen CF, et al. (2003): Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones. Urology, 62, 1123-1128.
  • Iannuzzi J (1990): Royal Jelly: Mystery food. Am Bee J, 130, 587-589.
  • Jain SK, McVie R, Duett J, et al. (1989): Erythrocyte membrane lipid peroxidation and glycolylated hemoglobin in diabetes. Diabetes, 38, 1539-1543.
  • Khan S (2005): Hyperoxaluria-induced oxidative stress and antioxidants for renal protection. Urol Res, 33, 349- 357.
  • Kubo T, Sasaki M, Nakamura J, et al. (1996): Change in the expression of hypopharyngeal gland proteins of the worker honeybees (Apis mellifera L.) with age and/or role. J Biochem, 119, 291-295.
  • Kurzer F, Senderson PM (1956): Urea in the history of organic chemistry. J Chem Educ, 33, 452-459.
  • Lercker G, Capella P, Conte LS, et al. (1981): Components of Royal Jelly: Identification of the organic acids. Lipids, 16, 912-919.
  • Lerolle N, Lantz B, Paillard F, et al. (2002): Risk factors for nephrolithiasis in patients with familial idiopathic hypercalciuria. Am J Med, 113, 99-103.
  • McMartin K (2009): Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning? Clin Toxicol, 47, 859-869.
  • Miranda KM, Espey MG, Wink DA (2001): A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide, 5, 62-71.
  • Neroev VV, Arkhipova MM (2003): Retinal ischemia and nitric oxide. Vestn Ross Akad Med Nauk, 5, 37-40.
  • Ohkawa H, Ohishi N, Yagi K (1979): Assay for lipid peroxides in animals and tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351-358.
  • Pavel CI, Mărghitaş LA, Bobiş O, et al. (2011): Biological activities of royal jelly. Scientific Papers. J Anim Sci Biotechnol, 44, 108-118.
  • Rubiolo JA, Mithieux G, Vega FV (2008): Resveratrol protects primary rat hepatocytes against oxidative stress damage: Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur J Pharmacol, 591, 66-72.
  • Thomas MJ (2000): The role of free radicals and antioxidants. Nutrition, 16, 716-718.
  • Yasui T, Fujita K, Sato M, et al. (1999): The effect of takusha, a kampo medicine, on renal stone formation and osteopontin expression in a rat urolithiasis model. Urol Res, 27, 194-199.
  • Young IS, Woodside JW (2001): Antioxidants in health and disease. J Clin Pathol, 54, 176-186.
  • Zheng HQ, Hu FL, Dietemann V (2011): Changes in composition of royal jelly harvested at different times: Consequences for quality standards. Apidologie, 42, 39-47. Geliş tarihi: 27.10.2015 / Kabul tarihi : 15.12.2016 Address for correspondence: Assoc. Prof. Dr. Laçine AKSOY Afyon Kocatepe Universitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, 03200, Afyonkarahisar, Türkiye e- mail: lacinetur@aku.edu.tr

Ratlarda etilen glikolün indüklediği nefropatide arı sütünün nefroprotektif ve antioksidatif etkileri

Yıl 2017, Cilt: 64 Sayı: 4, 241 - 248, 01.12.2017

Laçine AKSOY Zeyneb ASLAN

https://doi.org/10.1501/Vetfak_0000002805

Öz

Bu çalışmada ratlarda etilen glikolün oluşturduğu renal hasara karşı arı sütünün antioksidatif etkileri incelendi. Ratlardan 5 çalışma grubu oluşturuldu. 1. grup kontrol grubu olarak belirlendi. 2. gruptaki ratlara etilen glikol, içme suyunda (%1 oranında) verildi. 3. gruptaki ratlara her gün oral gavajla 100 mg/kg arı sütü verildi. 4. grup koruyucu grup olarak belirlendi ve 30 gün boyunca içme suyunda etilen glikol (%1) verilirken, oral gavajla 100 mg/kg arı sütü verildi. 5. grup tedavi edici grup olarak belirlendi ve çalışmanın ilk 15 günü etilen glikol (%1) içme suyunda, son 15 gün 100 mg/kg arı sütü oral gavajla verildi. Etilen glikolün oksidatif stresi indüklediği görülmüştür. Ölçülen BUN ve CREA (kreatinin) düzeylerinden arı sütünün böbrek hasarını azalttığı bulundu. Arı sütünün antioksidatif sistemi desteklediği, lipid peroksidasyonunu azaltıcı etki gösterdiği düşünülmektedir. Etilen glikol maruziyetiyle oluşturulan hasara karşı arı sütünün olumlu etkileri olduğu söylenebilir. Arı sütü uygulamasıyla tedavi edici grupta elde edilen sonuçlar özellikle dikkat çekicidir

Anahtar Kelimeler

Antioksidan, arı sütü, etilen glikol, kalsiyum okzalat, nefropati

Kaynakça

  • Aebi H (1974): Methods of Enzymatic Analysis, Catalase. Academic Press, New York, NY, USA.
  • Ashok P, Koti CB, Vishwanathswamy AHM (2010): Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. Indian J Pharmacol, 42, 380-383.
  • Atmani F, Slimani Y, Mimouni M, et al. (2004): Prophylaxis of calcium oxalate stones by Herniaria hirsuta on experimentally induced nephrolithiasis in rats. BJU Int, 92, 137-140.
  • Azab KS, Bashandy M, Salem M, et al. (2011): Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats. N Am J Med Sci, 3, 268- 276.
  • Beutler E, Dubon O, Kelly BM (1963): Improved method for the determination of blood glutathione. J Lab Clin Med, 61, 882-888.
  • Bradford MM (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-254.
  • Brouwers EMW, Ebert R, Beetsma J (1987): Behavioural and physiological aspects of nurse bees in relation to the composition of larval food during caste differentiation in the honeybee. J Apic Res, 26, 11-23.
  • Caudarella R, Vescini F (2009): Urinary citrate and renal stone disease: The preventive role of alkali citrate treatment. Arch Ital Urol Androl, 81,182-187.
  • Cemek M, Aymelek F, Büyükokuroğlu ME, et al. (2010): Protective potential of Royal Jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels. Food Chem Toxicol, 48, 2827-2832.
  • Chen YH, Liu HP, Chen HY, et al. (2011): Ethylene glycol induces calcium oxalate crystal deposition in Malpighian tubules: A Drosophila model for nephrolithiasis/ urolithiasis. Kidney Int, 80, 369-377.
  • Cihan YB, Öztürk A, Gökalp SS (2013): Protective role of royal jelly against radiation- induced oxidative stress in rats. Int J Hematol Oncol, 23, 79-87.
  • El-Nekeety AA, El-Kholy W, Abbas NF, et al. (2007): Efficacy of royal jelly against the oxidative stress of fumonisin in rats. Toxicon, 50, 256-269.
  • Eraslan G, Kanbur M, Silici S (2007): Evaluation of propolis effects on some biochemical parameters in rats treated with sodium fluoride. Pest Biochem Physiol, 88, 273-283.
  • Erel Ö (2004): A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem, 37, 112-119.
  • Erel Ö (2005): A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38, 1103- 1111.
  • Favus MJ (1989): Familial forms of hypercalciuria. J Urol, 141, 719-722.
  • Gupta RK, Patel AK, Shah N, et al. (2014): Oxidative stress and antioxidants in disease and cancer: A review. Asian Pac J Cancer Prev, 15, 4405-4409.
  • Hamilton RW, Gardner LB, Penn AS, et al. (1972): Acute tubular myoglobinuria. Ann Intern Med, 77, 77-82. by exercise-induced
  • Hosseinzadeh H, Khooei AR, Khashayarmanesh Z, et al. (2010): Antiurolithiatic activity of Pinus Eldarica Medw. Fruits aqueous extract in rats. Urol J, 7, 233-237.
  • Huang HS, Ma MC, Chen CF, et al. (2003): Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones. Urology, 62, 1123-1128.
  • Iannuzzi J (1990): Royal Jelly: Mystery food. Am Bee J, 130, 587-589.
  • Jain SK, McVie R, Duett J, et al. (1989): Erythrocyte membrane lipid peroxidation and glycolylated hemoglobin in diabetes. Diabetes, 38, 1539-1543.
  • Khan S (2005): Hyperoxaluria-induced oxidative stress and antioxidants for renal protection. Urol Res, 33, 349- 357.
  • Kubo T, Sasaki M, Nakamura J, et al. (1996): Change in the expression of hypopharyngeal gland proteins of the worker honeybees (Apis mellifera L.) with age and/or role. J Biochem, 119, 291-295.
  • Kurzer F, Senderson PM (1956): Urea in the history of organic chemistry. J Chem Educ, 33, 452-459.
  • Lercker G, Capella P, Conte LS, et al. (1981): Components of Royal Jelly: Identification of the organic acids. Lipids, 16, 912-919.
  • Lerolle N, Lantz B, Paillard F, et al. (2002): Risk factors for nephrolithiasis in patients with familial idiopathic hypercalciuria. Am J Med, 113, 99-103.
  • McMartin K (2009): Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning? Clin Toxicol, 47, 859-869.
  • Miranda KM, Espey MG, Wink DA (2001): A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide, 5, 62-71.
  • Neroev VV, Arkhipova MM (2003): Retinal ischemia and nitric oxide. Vestn Ross Akad Med Nauk, 5, 37-40.
  • Ohkawa H, Ohishi N, Yagi K (1979): Assay for lipid peroxides in animals and tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351-358.
  • Pavel CI, Mărghitaş LA, Bobiş O, et al. (2011): Biological activities of royal jelly. Scientific Papers. J Anim Sci Biotechnol, 44, 108-118.
  • Rubiolo JA, Mithieux G, Vega FV (2008): Resveratrol protects primary rat hepatocytes against oxidative stress damage: Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur J Pharmacol, 591, 66-72.
  • Thomas MJ (2000): The role of free radicals and antioxidants. Nutrition, 16, 716-718.
  • Yasui T, Fujita K, Sato M, et al. (1999): The effect of takusha, a kampo medicine, on renal stone formation and osteopontin expression in a rat urolithiasis model. Urol Res, 27, 194-199.
  • Young IS, Woodside JW (2001): Antioxidants in health and disease. J Clin Pathol, 54, 176-186.
  • Zheng HQ, Hu FL, Dietemann V (2011): Changes in composition of royal jelly harvested at different times: Consequences for quality standards. Apidologie, 42, 39-47. Geliş tarihi: 27.10.2015 / Kabul tarihi : 15.12.2016 Address for correspondence: Assoc. Prof. Dr. Laçine AKSOY Afyon Kocatepe Universitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, 03200, Afyonkarahisar, Türkiye e- mail: lacinetur@aku.edu.tr

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Diğer ID JA97FH42DV
Bölüm Araştırma Makalesi
Yazarlar

Laçine AKSOY
Afyon Kocatepe University, Faculty of Science and Arts, Department of Chemistry, Afyonkarahisar, Turkey.

Zeyneb ASLAN
Afyon Kocatepe University, Faculty of Science and Arts, Department of Chemistry, Afyonkarahisar, Turkey.

Yayımlanma Tarihi 1 Aralık 2017
Yayınlandığı Sayı Yıl 2017Cilt: 64 Sayı: 4

Kaynak Göster

Bibtex @editöre mektup { auvfd525924, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2017}, volume = {64}, number = {4}, pages = {241 - 248}, doi = {10.1501/Vetfak\_0000002805}, title = {Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats}, key = {cite}, author = {Aksoy, Laçine and Aslan, Zeyneb} }
APA Aksoy, L. & Aslan, Z. (2017). Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 64 (4) , 241-248 . DOI: 10.1501/Vetfak_0000002805
MLA Aksoy, L. , Aslan, Z. "Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 64 (2017 ): 241-248 <http://vetjournal.ankara.edu.tr/tr/pub/issue/43284/525924>
Chicago Aksoy, L. , Aslan, Z. "Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 64 (2017 ): 241-248
RIS TY - JOUR T1 - Ratlarda etilen glikolün indüklediği nefropatide arı sütünün nefroprotektif ve antioksidatif etkileri AU - LaçineAksoy, ZeynebAslan Y1 - 2017 PY - 2017 N1 - doi: 10.1501/Vetfak_0000002805 DO - 10.1501/Vetfak_0000002805 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 241 EP - 248 VL - 64 IS - 4 SN - 1300-0861-1308-2817 M3 - doi: 10.1501/Vetfak_0000002805 UR - https://doi.org/10.1501/Vetfak_0000002805 Y2 - 2023 ER -
EndNote %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats %A Laçine Aksoy , Zeyneb Aslan %T Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats %D 2017 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 64 %N 4 %R doi: 10.1501/Vetfak_0000002805 %U 10.1501/Vetfak_0000002805
ISNAD Aksoy, Laçine , Aslan, Zeyneb . "Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 64 / 4 (Aralık 2017): 241-248 . https://doi.org/10.1501/Vetfak_0000002805
AMA Aksoy L. , Aslan Z. Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats. Ankara Univ Vet Fak Derg. 2017; 64(4): 241-248.
Vancouver Aksoy L. , Aslan Z. Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2017; 64(4): 241-248.
IEEE L. Aksoy ve Z. Aslan , "Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 64, sayı. 4, ss. 241-248, Ara. 2017, doi:10.1501/Vetfak_0000002805