Öz
A clinical, hematological and pathological study was carried out on a bovine case of diabetes mellitus (DM) presenting clinical sings of polydipsia, polyuria, glycosuria, hyperglycemia, progressive emaciation and decreased milk yield. The body temperature, heart and respiratory rates were in normal range. Also there was no significant change in hematological values. Prior to slaughter; blood and urine samples were taken twice 48 hour interval from the cow. At necropsy, liver was pale and enlarged. Multiple small white foci were observed on the cortical area of the kidneys. Lung edema and foamy exudates in the lumen of the trachea and bronchus was present. At the gross examination pancreas was in normal appearance. Histopathologically reduced number and size were observed at the pancreatic islet localized in all pancreatic lobes. Decreased cell number observed in the Langerhans islets. Vacuolization and degenerations at the beta cells were commonly seen. Immunohistochemical study of pancreatic tissue revealed a marked reduction in the concentration and distribution of insulin, proinsulin, and amylin, but an increase in glucagon secreted cells. According to the clinical, histopathological and immunohistochemical findings, a combination of diabetes mellitus and multiorgan damage were diagnosed in a cow
Anahtar Kelimeler
Kaynakça
- Braun U, Gansohr B, Seidel M, Dumelin J, Wenger B, Schade B, Pospischil A (2008): Diabetes mellitus in a goat. SAT, 150, 608-612.
- Capen CC (2001): Endocrine System. 279-323. In: Thomson’s Special Veterinary Pathology. Third Edition, Mosby, Inc., Missouri.
- Charles J (2007): Pancreas. 389-424. In: MG Maxie (Ed), Jubb, Kennedy and Palmer's Pathology of Domestic Animals, Elsevier Limited, Philadeplphia.
- Ciobotaru E (2013): Spontaneous Diabetes Mellitus in Animals. 271-296. In: OO Oluwafemi (Ed), Diabetes Mellitus - Insights and Perspectives. InTech, Rijeka, Croatia.
- Clark Z (2003): Diabetes mellitus in a 6-month-old Charolais heifer calf. Can Vet J, 44, 921-922.
- Elliott J, Fowden AL, Callingham BA, Sharman DF, Silver M (1991): Physiological and Pathological Influences on Sheep Blood-Plasma Amineoxidase-effect of Pregnancy and Experimental Alloxan-induced Diabetes-mellitus. Res Vet Sci, 50, 334-339.
- Giri JK, Magdesian KG, Gaffney PM (2011): Insulin- dependent diabetes mellitus associated with presumed autoimmune polyendocrine syndrome in a mare. Can Vet J, 52, 506-512.
- Gould AC (1981): Diabetes mellitus in cattle. Vet Rec, 109, 539.
- Jones TC, Hunt RD, King NW (1997): Veterinary Pathology. Williams and Wilkins, Maryland.
- Koneko JJ, Rhode EA (1964): Diabetes mellitus in a cow. JAVMA, 144, 367-373.
- Molitch ME (1990): Diabetes mellitus. 136. In: Walker HK, Hall WD and Hurst JW (Eds), Clinical Methods: The History, Physical, and Laboratory Examinations. Boston, Butterworths.
- Mostaghni K, Ivoghli B (1977): Diabetes mellitus in the bovine. Cornell Vet, 67,24–28.
- Nazifi T, Karimi A, Ghasrodashti R (2004): Diabetes mellitus and fatty liver in a cow: case report. Comp Clin Path, 13, 82-85.
- Radostits OM, Gay CC, Hinchcliff KW, Constable PD (2008): Bovine virus diarrhea, mucosal disease. 1248– 1277. Bovine pestivirus disease complex. In: Veterinary Medicine: A Textbook of Diseases of Cattle, Horses, Sheep, Pigs, and Goats, 10th edn. Saunders Elsevier, Philadelphia.
- Stogdale L (1986): Definition of diabetes mellitus. Cornell Vet, 76, 156-174.
- Taniyama H, Shirakawa T, Furuoka H, Osame S, Kitamura N, Miyazawa K (1993): Spontaneous Diabetes mellitus in Young Cattle: Histologic, immunohistochemical, and electron microscopic studies of the islet of Langerhans. Vet Pathol, 30, 46-54.
- Unger RH, Foster DW (1998): Diabetes mellitus. 973- 1059. In: Wilson JD, Foster DW, Kronenberg HM, et al, (Eds). Williams Textbook of Endocrinology, WB Saunders, Philadelphia.
- Van Metre DC (2009): Diseases of the renal system. 925- 971. In: Smith, BP (Ed), Large Animal Internal Medicine. Mosby, Elsevier, St. Louis.
Öz
Çok su içme, çok idrar yapma, ilerleyen zayıflama ve süt veriminde azalma şikayetleri ile kliniğe getirilen diyabetli bir inekte klinik, hematolojik ve patolojik incelemeler yapıldı. Hayvanın vücut ısısı, kalp ve solunum sayıları normal sınırlar içerisindeydi. Ayrıca hemogram muayenede de önemli bir bulguya rastlanmadı. İnek kesime gitmeden önce 48 saat arayla 2 defa kan ve idrar numunesi toplandı. Nekropside, karaciğer büyümüş ve soluk renkliydi. Böbreklerin kortikal bölgelerinde çok sayıda beyaz renkli ve küçük odak saptandı. Akciğerlerde ödem, trahea ve bronş lumenlerinde köpüklü eksudat vardı. Dış bakıda pankreas normal görünümdeydi. Histopatolojik incelemede bütün pankreatik loplarda pankreatik adacık sayısı ve boyutunda azalma gözlendi. Langerhans adacıklarında hücre sayısının azaldığı saptandı. Genel olarak beta hücrelerinde vakuolizasyon ve dejenerasyonlar sıklıkla dikkati çekti. Pankreatik dokunun immunohistokimyasal muayenesinde insülin, proinsülin ve amilin sentezleyen hücrelerde belirgin bir azalma olduğu, buna karşın glukagon sentezleyen hücrelerde bir artış olduğu gözlendi. Klinik, histopatolojik ve immunohistokimyasal bulgulara dayanarak diabetes mellitus ve çoklu organ hasarı teşhisi konuldu
Anahtar Kelimeler
Kaynakça
- Braun U, Gansohr B, Seidel M, Dumelin J, Wenger B, Schade B, Pospischil A (2008): Diabetes mellitus in a goat. SAT, 150, 608-612.
- Capen CC (2001): Endocrine System. 279-323. In: Thomson’s Special Veterinary Pathology. Third Edition, Mosby, Inc., Missouri.
- Charles J (2007): Pancreas. 389-424. In: MG Maxie (Ed), Jubb, Kennedy and Palmer's Pathology of Domestic Animals, Elsevier Limited, Philadeplphia.
- Ciobotaru E (2013): Spontaneous Diabetes Mellitus in Animals. 271-296. In: OO Oluwafemi (Ed), Diabetes Mellitus - Insights and Perspectives. InTech, Rijeka, Croatia.
- Clark Z (2003): Diabetes mellitus in a 6-month-old Charolais heifer calf. Can Vet J, 44, 921-922.
- Elliott J, Fowden AL, Callingham BA, Sharman DF, Silver M (1991): Physiological and Pathological Influences on Sheep Blood-Plasma Amineoxidase-effect of Pregnancy and Experimental Alloxan-induced Diabetes-mellitus. Res Vet Sci, 50, 334-339.
- Giri JK, Magdesian KG, Gaffney PM (2011): Insulin- dependent diabetes mellitus associated with presumed autoimmune polyendocrine syndrome in a mare. Can Vet J, 52, 506-512.
- Gould AC (1981): Diabetes mellitus in cattle. Vet Rec, 109, 539.
- Jones TC, Hunt RD, King NW (1997): Veterinary Pathology. Williams and Wilkins, Maryland.
- Koneko JJ, Rhode EA (1964): Diabetes mellitus in a cow. JAVMA, 144, 367-373.
- Molitch ME (1990): Diabetes mellitus. 136. In: Walker HK, Hall WD and Hurst JW (Eds), Clinical Methods: The History, Physical, and Laboratory Examinations. Boston, Butterworths.
- Mostaghni K, Ivoghli B (1977): Diabetes mellitus in the bovine. Cornell Vet, 67,24–28.
- Nazifi T, Karimi A, Ghasrodashti R (2004): Diabetes mellitus and fatty liver in a cow: case report. Comp Clin Path, 13, 82-85.
- Radostits OM, Gay CC, Hinchcliff KW, Constable PD (2008): Bovine virus diarrhea, mucosal disease. 1248– 1277. Bovine pestivirus disease complex. In: Veterinary Medicine: A Textbook of Diseases of Cattle, Horses, Sheep, Pigs, and Goats, 10th edn. Saunders Elsevier, Philadelphia.
- Stogdale L (1986): Definition of diabetes mellitus. Cornell Vet, 76, 156-174.
- Taniyama H, Shirakawa T, Furuoka H, Osame S, Kitamura N, Miyazawa K (1993): Spontaneous Diabetes mellitus in Young Cattle: Histologic, immunohistochemical, and electron microscopic studies of the islet of Langerhans. Vet Pathol, 30, 46-54.
- Unger RH, Foster DW (1998): Diabetes mellitus. 973- 1059. In: Wilson JD, Foster DW, Kronenberg HM, et al, (Eds). Williams Textbook of Endocrinology, WB Saunders, Philadelphia.
- Van Metre DC (2009): Diseases of the renal system. 925- 971. In: Smith, BP (Ed), Large Animal Internal Medicine. Mosby, Elsevier, St. Louis.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Diğer ID | JA58UP47NN |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2016 |
| Yayımlandığı Sayı | Yıl 2016Cilt: 63 Sayı: 1 |