Letter to Editor
Year 2011,
Volume: 58 Issue: 3, 161 - 165, 01.09.2011
Abstract
Bovine cutaneous papillomatosis caused by a bovine papillomavirus, is a common skin disease in Turkey. The aim of the present study was to describe the clinical, histopathological and immunohistochemical aspects of naturally occurring bovine cutaneous papillomatosis.A total of 82 Holstein cattle (9.5%), aged between 5 and 24 months, were diagnosed as cutaneous papilloma by clinical examination. The percentage of papilloma and papillomatosis in male and female was found in 7.3% and 14.8%, respectively. The cauliflower-like growths of varying sizes (0.5-11 cm) were mostly located on the head (63.2%). Histopathology revealed various degrees of acanthosis and hyperkeratosis in all neoplasms. Immunohistochemical (IHC) examination with antibodies against proliferating cell nuclear antigen (PCNA) and Ki-67 were detected in the basal layer of the epidermis and connective tissue. Bovine papillomavirus (BPV-1) antigens were detected in the basal layer. In conclusion, it was decided that the BPV-1, PCNA and Ki-67 antibodies were very useful markers in the diagnosis of bovine cutaneous papilloma
Keywords
References
- Atasever A, Cam Y, Atalay O (2005): Bir sığır sürüsünde deri papillomatosis olguları. Ankara Univ Vet Fak Derg, 52, 197–200.
- Barrett TL, Smith KJ, Hodge JJ, Butler R, Hall FW, Skelton HG (1997): Immunohistochemical nuclear staining for p53, PCNA, and Ki-67 in different histologic variants basal cell carcinoma. J Am Acad Dermatol, 37, 430-7
- Blood DC, Radostits OM (1989): Veterinary medicine. A textbook of the diseases of cattle, sheep, pigs, goats and horses. 7th edn., Bailliere Tindall, London.
- Borku MK, Atalay O, Kibar M, Çam Y, Atasever A (2007): Ivermectin is an effective treatment for bovine cutaneous papillomatosis. Res Vet Sci, 83, 360–363.
- Brugal G (1995): Quantitative microscopy and tumour cell proliferation. Bul Cancer 82, 511-517.
- Campo MS (2002): Animal models of papillomavirus pathogenesis. Virus Res, 89, 249-261.
- Campo MS (1998): Persistent infection by bovine papillomavirus. 503-516. In: R Ahmed, ISY Chen, (Eds), Persistent Viral Infections, Wiley.
- Campo, MS, Jarrett WF, O’neil W, Baron RJ (1994): Latent papillomavirus infection in cattle. Res Vet Sci, 56, 151–157.
- Dinç DA (1995): Papillomatozis. 41-45. In: Evcil Hayvanlarda Memenin Deri Hastalıkları, Dolaşım Bozukluklari ve Operasyonlari. Konya, Ülkü Matbaası.
- Emhmad AO, Levkut M, Levkutova´ M, Revajova´ V, Ondrejka R, Benı´sˇek Z (1997): Immunohistochemistry of the progressive and regressive stages of bovine papillomatosis. Acta Veterinaria Brno, 66, 245–248.
- Goldschmidt MH, Hendrick MJ. (2002). Tumors of the skin and soft tissues. 47-117.. In DJ Meuten (eds), Tumors in domestic animals. 4th edn., Iowa State Pres, Ames.
- Hargis AM (1995): Cutaneous Neoplasia. 504-509. In: Thomson’s Special Veterinary Pathology. Carlton WW, McGavin MD (eds), 2nd edn., Mosby, Philadelphia, London, Sydney, Tokyo.
- Hatipoglu F, Ozdemir O, Kıran MM (2009): Detection of argyrophil nucleolar organizer regions (AgNORs) and proliferating cell nuclear antigen (PCNA) in epithelial skin tumours from domestic animals. Revue Méd. Vét, 160, 477-483.
- Jelinek F, Tachezy R (2005): Cutaneous papillomatosis in cattle. J Comp Pathol, 132, 70–81.
- Jones TC, Hunt RD, King NW (1997): Bovine cutaneous papillomatosis. 252. Veterinary Pathology, 6th edn., Williams & Wilkins, A Waverly Company, Philadelphia, london, Tokyo, Sydney.
- Karademir N, Güvenç T, Yarım M, Orman MM, Gülbahar MY (1996): Comparison of agnors staining and pcna immunostaing methods, and mitotic index scores in intracutaneous cornifying epithelioma and squamous cell carcinoma. Ankara Univ Vet Fak Derg, 43, 281-285.
- Kawahira K (1999): Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) in malignant and nonmalignant skin diseases. Arch Dermatol Res, 291, 413–418.
- Lu S, Tiekso J, Hietanen S, Syrjaènen K, Havu VK, Syrjaènen S (1999): Expression of cell-cycle proteins p53, p21 (WAF-1), PCNA and Ki-67 in benign, premalignant and malignant skin lesions with implicated HPV involvement. Acta Derm Venereol, 79, 268-273
- Luna LG (1968). Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. 32–241. McGraw-Hill Book Company, New York.
- Ndarathi CM, Mbuthia PG (1994): Individual bovine- specific and species-specific autogenous vaccine in treatment of bovine cutaneous papillomatosis. Indian J Anim Sci, 64, 218-221.
- Nicholls PK, Stanley MA (2000): The immunology of animal papillomaviruses. Vet Immunol Immunopathol, 73, 101–127.
- Niwa Y (1995):Demonstration of oncogene, E7 region of 18 type HPV in the skin lesions of patients with severe, treatment-resistant atopic dermatitis (abstract, in Japanese). J Jpn Soc Cancer Ther, 30,1226.
- Olson C (1993): Papillomatosis in cattle. 430–431. In: Howard, J.L. (ed), Current Veterinary Therapy 3 & Food Animal Practice. W. B. Saunders Company, Philadelphia, London, Tokyo.
- Olson C, Olson RO, Hubbard-Van Stelle S (1992): Variations of response of cattle to experimentally induced viral papillomatosis. J Am Vet Med Assoc, 201, 56–62.
- Otter A, Leonard D (2003): Fibropapillomatosis outbreak in calves. Vet Rec, 1, 570–571.
- Rosai J (1996): Ackerman's surgical pathology. 47-48. 8th edn., St Louis, C.V. Mosby Co.
- Smith BP (1996): Papillomatosis (Warts, Fibropapillomas). 1417-1418. In: Large Animal Internal Medicine & Diseases of Horses, Cattle, Sheep, and Goats. Smith BP (Eds). 2nd edn., Mosby-Year Book, Inc. Boston, New York, Philadelphia, London, Tokyo.
- Theilen G, Wheeldon EB, East N, Madewell B, Lancaster WD, Munn R (1985): Goat papillomatosis. Am J Vet Res, 46, 2519-2526.
- The Merck Veterinary Manual (2008): Papillomas. http://www.merckvetmanual.com/mvm/index.jsp?cfile=ht m/bc/72214.htm
Year 2011,
Volume: 58 Issue: 3, 161 - 165, 01.09.2011
Abstract
Bovine papillomavirusun neden olduğu deri papillomatozisi ülkemizde sığırların yaygın bir deri hastalığıdır. Bu çalışmanın amacı doğal olarak oluşmuş sığır deri papillomatozisinde klinik, histopatolojik ve immunohistokimyasal bulguların değerlendirilmesidir. 5 ile 24 ay arasında değişen 82 adet Holstein sığıra (% 9,5) klinik olarak deri papillomu tanısı konuldu. Papilloma ve papillomatozisin erkek ve dişi hayvanlar arasında görülme yüzde oranı sırasıyla %7,3 ve %14,8 olarak belirlendi. Çeşitli boyutlarda (0,5–11 cm) karnabahar görünümündeki üremelerin çoğunlukla baş bölgesinde (%63,2) yerleşim gösterdiği belirlendi. Tümörlerde mikroskobik olarak değişen derecelerde akantozis ve hiperkeratoz saptandı. İmmunohistokimyasal boyamalarda epidermisin bazal katmanında ve bağ dokuda PCNA ve Ki-67 pozitif reaksiyonlar tespit edildi. Bovine papillomavirus antijenleri bazal katmanda belirlendi. Sonuç olarak BPV-1, PCNA ve Ki-67 primer antikorlarının sığır deri papillomunun tanısında önemli markırlar olduğuna karar verildi
Keywords
References
- Atasever A, Cam Y, Atalay O (2005): Bir sığır sürüsünde deri papillomatosis olguları. Ankara Univ Vet Fak Derg, 52, 197–200.
- Barrett TL, Smith KJ, Hodge JJ, Butler R, Hall FW, Skelton HG (1997): Immunohistochemical nuclear staining for p53, PCNA, and Ki-67 in different histologic variants basal cell carcinoma. J Am Acad Dermatol, 37, 430-7
- Blood DC, Radostits OM (1989): Veterinary medicine. A textbook of the diseases of cattle, sheep, pigs, goats and horses. 7th edn., Bailliere Tindall, London.
- Borku MK, Atalay O, Kibar M, Çam Y, Atasever A (2007): Ivermectin is an effective treatment for bovine cutaneous papillomatosis. Res Vet Sci, 83, 360–363.
- Brugal G (1995): Quantitative microscopy and tumour cell proliferation. Bul Cancer 82, 511-517.
- Campo MS (2002): Animal models of papillomavirus pathogenesis. Virus Res, 89, 249-261.
- Campo MS (1998): Persistent infection by bovine papillomavirus. 503-516. In: R Ahmed, ISY Chen, (Eds), Persistent Viral Infections, Wiley.
- Campo, MS, Jarrett WF, O’neil W, Baron RJ (1994): Latent papillomavirus infection in cattle. Res Vet Sci, 56, 151–157.
- Dinç DA (1995): Papillomatozis. 41-45. In: Evcil Hayvanlarda Memenin Deri Hastalıkları, Dolaşım Bozukluklari ve Operasyonlari. Konya, Ülkü Matbaası.
- Emhmad AO, Levkut M, Levkutova´ M, Revajova´ V, Ondrejka R, Benı´sˇek Z (1997): Immunohistochemistry of the progressive and regressive stages of bovine papillomatosis. Acta Veterinaria Brno, 66, 245–248.
- Goldschmidt MH, Hendrick MJ. (2002). Tumors of the skin and soft tissues. 47-117.. In DJ Meuten (eds), Tumors in domestic animals. 4th edn., Iowa State Pres, Ames.
- Hargis AM (1995): Cutaneous Neoplasia. 504-509. In: Thomson’s Special Veterinary Pathology. Carlton WW, McGavin MD (eds), 2nd edn., Mosby, Philadelphia, London, Sydney, Tokyo.
- Hatipoglu F, Ozdemir O, Kıran MM (2009): Detection of argyrophil nucleolar organizer regions (AgNORs) and proliferating cell nuclear antigen (PCNA) in epithelial skin tumours from domestic animals. Revue Méd. Vét, 160, 477-483.
- Jelinek F, Tachezy R (2005): Cutaneous papillomatosis in cattle. J Comp Pathol, 132, 70–81.
- Jones TC, Hunt RD, King NW (1997): Bovine cutaneous papillomatosis. 252. Veterinary Pathology, 6th edn., Williams & Wilkins, A Waverly Company, Philadelphia, london, Tokyo, Sydney.
- Karademir N, Güvenç T, Yarım M, Orman MM, Gülbahar MY (1996): Comparison of agnors staining and pcna immunostaing methods, and mitotic index scores in intracutaneous cornifying epithelioma and squamous cell carcinoma. Ankara Univ Vet Fak Derg, 43, 281-285.
- Kawahira K (1999): Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) in malignant and nonmalignant skin diseases. Arch Dermatol Res, 291, 413–418.
- Lu S, Tiekso J, Hietanen S, Syrjaènen K, Havu VK, Syrjaènen S (1999): Expression of cell-cycle proteins p53, p21 (WAF-1), PCNA and Ki-67 in benign, premalignant and malignant skin lesions with implicated HPV involvement. Acta Derm Venereol, 79, 268-273
- Luna LG (1968). Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. 32–241. McGraw-Hill Book Company, New York.
- Ndarathi CM, Mbuthia PG (1994): Individual bovine- specific and species-specific autogenous vaccine in treatment of bovine cutaneous papillomatosis. Indian J Anim Sci, 64, 218-221.
- Nicholls PK, Stanley MA (2000): The immunology of animal papillomaviruses. Vet Immunol Immunopathol, 73, 101–127.
- Niwa Y (1995):Demonstration of oncogene, E7 region of 18 type HPV in the skin lesions of patients with severe, treatment-resistant atopic dermatitis (abstract, in Japanese). J Jpn Soc Cancer Ther, 30,1226.
- Olson C (1993): Papillomatosis in cattle. 430–431. In: Howard, J.L. (ed), Current Veterinary Therapy 3 & Food Animal Practice. W. B. Saunders Company, Philadelphia, London, Tokyo.
- Olson C, Olson RO, Hubbard-Van Stelle S (1992): Variations of response of cattle to experimentally induced viral papillomatosis. J Am Vet Med Assoc, 201, 56–62.
- Otter A, Leonard D (2003): Fibropapillomatosis outbreak in calves. Vet Rec, 1, 570–571.
- Rosai J (1996): Ackerman's surgical pathology. 47-48. 8th edn., St Louis, C.V. Mosby Co.
- Smith BP (1996): Papillomatosis (Warts, Fibropapillomas). 1417-1418. In: Large Animal Internal Medicine & Diseases of Horses, Cattle, Sheep, and Goats. Smith BP (Eds). 2nd edn., Mosby-Year Book, Inc. Boston, New York, Philadelphia, London, Tokyo.
- Theilen G, Wheeldon EB, East N, Madewell B, Lancaster WD, Munn R (1985): Goat papillomatosis. Am J Vet Res, 46, 2519-2526.
- The Merck Veterinary Manual (2008): Papillomas. http://www.merckvetmanual.com/mvm/index.jsp?cfile=ht m/bc/72214.htm
There are 29 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA49KP22FA |
| Journal Section | Research Article |
| Authors | |
| Publication Date | September 1, 2011 |
| Published in Issue | Year 2011Volume: 58 Issue: 3 |