Öz
It is known that the kidney size is related to body height, body surface area and body weight. In the present study we propose the volume fraction approach of stereological methods that eliminate the effects of body size over the quantitative evaluation of cortex, medulla and pelvis of kidney. Kidneys were removed from 20 Kivircik sheeps and their volumes were measured using the Archimedean principle. The total volume and volume of its components and the volume fraction of cortex, medulla and the pelvis were estimated stereologically. The mean kidney volumes were 61.3±12.7cm3 and 59.7±12.8cm3, using the Archimedean and the Cavalieri principles, respectively. The obtained values were not found to be significantly different (p>0.05). The kidney was composed of 69.7±3.0% cortex, 27.1±2.9% medulla and 3.2±0.7% pelvis. Our results show that the stereological method applied in this study provides unbiased data about the volumetric characteristics of kidney and can be used on physical section of the evaluation of the volume and volume fractions of kidney and its subcomponents
Anahtar Kelimeler
Cavalieri principle renal cortex renal medulla renal pelvis stereology
Kaynakça
- Basoglu A, Buyukkarabacak Y, Sahin B, Kaplan S (2007): Volumetric evaluation of the lung expansion following resection: a stereological study. Eur J Cardiothorac Surg, 31, 512-517.
- Beech DJ, Roche ED, Sibbons PD, Rossdale PD, Ousey JC (2000): Stereological estimation of volume-weighted mean glomerular volume from arbitrary sections of the equine kidney. J Anat, 197, 307-311.
- Bertram JF (1995): Analyzing renal glomeruli with the new stereology. Int Rev Cytol, 161, 111-172.
- Bertram JF (2001): Counting in the kidney. Kidney Int, 59, 792-796.
- Brenner BM, Garcia DL, Anderson S (1988): Glomeruli and blood pressure: Less of one, more the other? Am J Hypertens, 1, 335-347.
- Brenner BM, Chertow GM (1993): Congenital oligonephropathy: An inborn cause of adult hypertension and progressive renal injury? Curr Opin Nephrol Hypertens, 2, 691-695.
- Cheung CM, Shurrab AE, Buckley DL, Hegarty J, Middleton RJ, Mamtora H, Kalra PA (2006): MR- derived renal morphology and renal function in patients with atherosclerotic renovascular disease. Kidney Int, 69, 715-722.
- Coulam CH, Bouley DM, Sommer FG (2002): Measurement of renal volumes with contrast-enhanced MRI. J Magn Reson Imaging, 15, 174-179.
- Glaser JR, Glaser EM (2000): Stereology, morphometry and mapping: the whole is greater than the sum of its parts. J Chem Neuroanat, 20, 115-126.
- Gundersen HJ, Jensen EB (1987): The efficiency of systematic sampling in stereology and its prediction. J Microsc, 147, 229-263.
- Gundersen HJG, Bendtsen TF, Korbo L, Marcussen N, Móller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sórensen FB, Vesterby A, West MJ (1988): Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS, 96, 379-394.
- Gundersen HJ, Jensen EB, Kieu K, Nielsen J (1999): The efficiency of systematic sampling in stereology- reconsidered. J Microsc, 193, 199-211.
- Hanstede JG, Gerrits PO (1983): The effects of embedding in water-soluble plastics on the final dimensions of liver sections. J Microsc, 131, 79-86.
- Howard CV, Reed MG (1998): Unbiased stereology. Three-dimensional measurement in microscopy. Bios Oxford, 55-68.
- Kim YS, Moon JI, Kim DK, Kim SI, Park K (2001): Ratio of donor kidney weight to recipient bodyweight as an index of graft function. Lancet, 357, 1180-1181.
- Lane PH, Belsha CW, Plummer J, Steinhardt GF, Lynch RE, Wood EG (1998): Relationship of renal size, body size, and blood pressure in children. Pediatr Nephrol, 12, 35-39.
- Mattfeldt T, Gottfried HW, Wolter H, Schmidt V, Kestler HA, Mayer J (2003): Classification of prostatic carcinoma with artificial neural networks using comparative genomic hybridization and quantitative stereological data. Pathol Res Pract, 199, 773-784.
- Mattfeldt T, Trijic D, Gotffried HW, Kestler HA (2004): Incidental carcinoma of the prostate: clinicopat- hological, stereological and immunohistochemical findings studied with logistic regression and self-organizing feature maps. BJU Int, 93, 284-290.
- Mazonakis M, Karampekios S, Damilakis J, Voloudaki A, Gourtsoyiannis N (2004): Stereological estimation of total intracranial volume on CT images. Eur Radiol, 14, 1285-1290.
- Miller PL, Meyer TW (1990): Effects of tissue preparation on glomerular volume and capillary structure in the rat. Lab Invest, 63, 862-866.
- Mounier-Vehier C, Lions C, Devos P, Jaboureck O, Willoteaux S, Carre A, Beregi JP (2002): Cortical thickness: an early morphological marker of atherosclerotic renal disease. Kidney Int, 61, 591-598.
- Mounier-Vehier C, Lions C, Jaboureck O, Devos P, Haulon S, Wibaux M, Carre A, Beregi JP (2002): Parenchymal consequences of fibromuscular dysplasia renal artery stenosis. Am J Kidney Dis, 40, 1138-1145.
- Nawaratne S, Brien JE, Seeman E, Fabiny R, Zalcberg J, Cosolo W, Angus P, Morgan DJ (1998): Relationships among liver and kidney volumes, lean body mass and drug clearance. J Clin Pharmacol, 46, 447-452.
- Odaci E, Sahin B, Sonmez OF, Kaplan S, Bas O, Bilgic S, Bek Y, Ergür H (2003): Rapid estimation of the vertebral body volume: a combination of the Cavalieri principle and computed tomography images. Eur J Radiol, 48, 316-326.
- Odaci E, Kaplan S, Sahin B, Bas O, Gevrek F, Aygün D, Ünal B, Sönmez OF, Colakoglu S, Bilgic S (2004): Effects of low-dose oxcarbazepine administration on developing cerebellum in newborn rat: A stereological study. Neurosci Res Commun, 31, 28-36.
- Poggio ED, Hila S, Stephany B, Fatica R, Krishnamurthi V, del Bosque C, Goldfarb D, Herts B, Dennis VW, Heeger PS, Braun W (2006): Donor kidney volume and outcomes following live donor kidney transplantation. Am J Transplant, 6, 616-624.
- Sahin B, Aslan H, Unal B, Canan S, Bilgic S, Kaplan S, Tumkaya L (2001): Brain volume of the lamb, rat and bird do not show hemispheric asymmetry: A stereological study. Image Anal Stereol, 20, 9-13.
- Sahin B, Alper T, Kökcü A, Malatyalioglu E, Kosif R (2003a): Estimation of the amniotic fluid volume using the Cavalieri method on ultrasound images. Int J Gynecol Obstet, 82, 25-30.
- Sahin B, Emirzeoglu M, Uzun A, Incesu L, Bek Y, Bilgic S, Kaplan S (2003b): Unbiased estimation of the liver volume by the Cavalieri principle using magnetic resonance images. Eur J Radiol, 47, 164-167.
- Schmidt IM, Molgaard C, Main KM, Michaelsen KF (2001): Effect of gender and lean body mass on kidney size in healthy 10-year-old children. Pediatr Nephrol, 16, 366- 370.
- Troell S, Berg U, Johansson B, Wikstad I (1988): Comparison between renal parenchymal sonographic volume, renal parenchymal urographic area, glomerular filtration rate and renal plasma flow in children. Scand J Urol Nephrol, 22, 207-214.
- Weibel ER, Knight BW (1964): A morphometric study on the thickness of the pulmonary air-blood barrier. J Cell Biol, 21, 367-384.
Öz
Böbrek büyüklüğünün, vücut yüksekliği, vücut yüzey alanı ve vücut ağırlığı ile ilişkili olduğu bilinmektedir. Yapılan bu çalışmada, korteks, medulla ve böbrek pelvisinin rakamsal değerlendirilmesi üzerinde vücut büyüklüğünün etkilerini elimine etmek amacı ile, stereolojik metodlardan hacimsel oran yaklaşımı kullanılmıştır. Materyal olarak 20 adet Kıvırcık koyunundan elde edilen böbreklerin hacmi Arşimed prensibi kullanılarak ölçülmüştür. Ayrıca bu böbreklerin toplam hacmi ve korteks, medulla ve pelvis bölümlerinin hacmi stereolojik olarak tahmin edilmiştir. Arşimed ve Cavalier metodları kullanılarak elde edilen ortalama böbrek hacimleri sırası ile, 61.3±12.7 cm3 ve 59.7±12.8 cm3 olarak ölçülmüştür. Elde edilen veriler istatistiki olarak önemli bulunmamıştır (p>0,05). Böbrek, %69.7±3.0 korteks, %27.1±2.9 medulla ve %3.2±0.7 pelvis’den oluşmaktadır. Sonuçlarımız gösterir ki, bu çalışmada kullanılan stereolojik metodlar, böbreğin hacimsel karakteristikleri hakkında ön yargısız bilgi sağlar ve böbrek hacmi, hacimsel oranları ve alt bölümlerinin değerlendirilmesinde kullanılabilir
Anahtar Kelimeler
Cavalier prensibi cortex renalis medulla renalis pelvis renalis stereoloji
Kaynakça
- Basoglu A, Buyukkarabacak Y, Sahin B, Kaplan S (2007): Volumetric evaluation of the lung expansion following resection: a stereological study. Eur J Cardiothorac Surg, 31, 512-517.
- Beech DJ, Roche ED, Sibbons PD, Rossdale PD, Ousey JC (2000): Stereological estimation of volume-weighted mean glomerular volume from arbitrary sections of the equine kidney. J Anat, 197, 307-311.
- Bertram JF (1995): Analyzing renal glomeruli with the new stereology. Int Rev Cytol, 161, 111-172.
- Bertram JF (2001): Counting in the kidney. Kidney Int, 59, 792-796.
- Brenner BM, Garcia DL, Anderson S (1988): Glomeruli and blood pressure: Less of one, more the other? Am J Hypertens, 1, 335-347.
- Brenner BM, Chertow GM (1993): Congenital oligonephropathy: An inborn cause of adult hypertension and progressive renal injury? Curr Opin Nephrol Hypertens, 2, 691-695.
- Cheung CM, Shurrab AE, Buckley DL, Hegarty J, Middleton RJ, Mamtora H, Kalra PA (2006): MR- derived renal morphology and renal function in patients with atherosclerotic renovascular disease. Kidney Int, 69, 715-722.
- Coulam CH, Bouley DM, Sommer FG (2002): Measurement of renal volumes with contrast-enhanced MRI. J Magn Reson Imaging, 15, 174-179.
- Glaser JR, Glaser EM (2000): Stereology, morphometry and mapping: the whole is greater than the sum of its parts. J Chem Neuroanat, 20, 115-126.
- Gundersen HJ, Jensen EB (1987): The efficiency of systematic sampling in stereology and its prediction. J Microsc, 147, 229-263.
- Gundersen HJG, Bendtsen TF, Korbo L, Marcussen N, Móller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sórensen FB, Vesterby A, West MJ (1988): Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS, 96, 379-394.
- Gundersen HJ, Jensen EB, Kieu K, Nielsen J (1999): The efficiency of systematic sampling in stereology- reconsidered. J Microsc, 193, 199-211.
- Hanstede JG, Gerrits PO (1983): The effects of embedding in water-soluble plastics on the final dimensions of liver sections. J Microsc, 131, 79-86.
- Howard CV, Reed MG (1998): Unbiased stereology. Three-dimensional measurement in microscopy. Bios Oxford, 55-68.
- Kim YS, Moon JI, Kim DK, Kim SI, Park K (2001): Ratio of donor kidney weight to recipient bodyweight as an index of graft function. Lancet, 357, 1180-1181.
- Lane PH, Belsha CW, Plummer J, Steinhardt GF, Lynch RE, Wood EG (1998): Relationship of renal size, body size, and blood pressure in children. Pediatr Nephrol, 12, 35-39.
- Mattfeldt T, Gottfried HW, Wolter H, Schmidt V, Kestler HA, Mayer J (2003): Classification of prostatic carcinoma with artificial neural networks using comparative genomic hybridization and quantitative stereological data. Pathol Res Pract, 199, 773-784.
- Mattfeldt T, Trijic D, Gotffried HW, Kestler HA (2004): Incidental carcinoma of the prostate: clinicopat- hological, stereological and immunohistochemical findings studied with logistic regression and self-organizing feature maps. BJU Int, 93, 284-290.
- Mazonakis M, Karampekios S, Damilakis J, Voloudaki A, Gourtsoyiannis N (2004): Stereological estimation of total intracranial volume on CT images. Eur Radiol, 14, 1285-1290.
- Miller PL, Meyer TW (1990): Effects of tissue preparation on glomerular volume and capillary structure in the rat. Lab Invest, 63, 862-866.
- Mounier-Vehier C, Lions C, Devos P, Jaboureck O, Willoteaux S, Carre A, Beregi JP (2002): Cortical thickness: an early morphological marker of atherosclerotic renal disease. Kidney Int, 61, 591-598.
- Mounier-Vehier C, Lions C, Jaboureck O, Devos P, Haulon S, Wibaux M, Carre A, Beregi JP (2002): Parenchymal consequences of fibromuscular dysplasia renal artery stenosis. Am J Kidney Dis, 40, 1138-1145.
- Nawaratne S, Brien JE, Seeman E, Fabiny R, Zalcberg J, Cosolo W, Angus P, Morgan DJ (1998): Relationships among liver and kidney volumes, lean body mass and drug clearance. J Clin Pharmacol, 46, 447-452.
- Odaci E, Sahin B, Sonmez OF, Kaplan S, Bas O, Bilgic S, Bek Y, Ergür H (2003): Rapid estimation of the vertebral body volume: a combination of the Cavalieri principle and computed tomography images. Eur J Radiol, 48, 316-326.
- Odaci E, Kaplan S, Sahin B, Bas O, Gevrek F, Aygün D, Ünal B, Sönmez OF, Colakoglu S, Bilgic S (2004): Effects of low-dose oxcarbazepine administration on developing cerebellum in newborn rat: A stereological study. Neurosci Res Commun, 31, 28-36.
- Poggio ED, Hila S, Stephany B, Fatica R, Krishnamurthi V, del Bosque C, Goldfarb D, Herts B, Dennis VW, Heeger PS, Braun W (2006): Donor kidney volume and outcomes following live donor kidney transplantation. Am J Transplant, 6, 616-624.
- Sahin B, Aslan H, Unal B, Canan S, Bilgic S, Kaplan S, Tumkaya L (2001): Brain volume of the lamb, rat and bird do not show hemispheric asymmetry: A stereological study. Image Anal Stereol, 20, 9-13.
- Sahin B, Alper T, Kökcü A, Malatyalioglu E, Kosif R (2003a): Estimation of the amniotic fluid volume using the Cavalieri method on ultrasound images. Int J Gynecol Obstet, 82, 25-30.
- Sahin B, Emirzeoglu M, Uzun A, Incesu L, Bek Y, Bilgic S, Kaplan S (2003b): Unbiased estimation of the liver volume by the Cavalieri principle using magnetic resonance images. Eur J Radiol, 47, 164-167.
- Schmidt IM, Molgaard C, Main KM, Michaelsen KF (2001): Effect of gender and lean body mass on kidney size in healthy 10-year-old children. Pediatr Nephrol, 16, 366- 370.
- Troell S, Berg U, Johansson B, Wikstad I (1988): Comparison between renal parenchymal sonographic volume, renal parenchymal urographic area, glomerular filtration rate and renal plasma flow in children. Scand J Urol Nephrol, 22, 207-214.
- Weibel ER, Knight BW (1964): A morphometric study on the thickness of the pulmonary air-blood barrier. J Cell Biol, 21, 367-384.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Diğer ID | JA93DY93GS |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Aralık 2009 |
| Yayımlandığı Sayı | Yıl 2009Cilt: 56 Sayı: 4 |