Öz
In this study, it is aimed to evaluate the bone metabolism, biochemical and haematological changes of cats with chronic renal failure. 22 female cats aging between 3-12 years with Chronic Renal Failure (CRF) and for control group 10 clinicaly healty female cats aging nearly the same with the patients constituted the research’s animal material. Urine samples densities were determined and assayed for the presence of protein. Blood count and total protein, urea, creatinine, sodium, potassium, calcium, phosphorus, osteocalcine, total ALP and bone ALP assays have been made in blood and samples of these animals. Serum osteocalcine values were found under detection limits (
Anahtar Kelimeler
Biochemical findings cat chronic renal failure haematological findings
Kaynakça
- Bilgili H, Orhun S (2002): The research of the changes on joint tissues radiological and histopathologically on an experimental osteoarthritis performed on rabbit stifle joint. Turk J Vet Surg, 8, 8-12.
- Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994): Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. New Eng J Med, 331, 889-895.
- Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1996): Rabbit articular cartilage defects treated with autologous cultured chondrocytes. Clin Orthop, 326, 270-283.
- Buckwalter JA, Mankin HJ (1997): Articular cartilage. Part II: Degeneration and osteoarthritis, repair, regeneration, and transplantation. J Bone Joint Surg, 79A, 612-627.
- Cook JL, Kreeger JM, Payne JT, Tomlinson JL (2002): Effects of EGF, FGF, and PDGF on canine chondrocytes in three-dimensional culture. Vet Comp Orthop Traumatol, 10, 210-213.
- Fortier LA, Nixon AJ, Mohammed HO, Lust G (1997): Altered biological activity of equine chondrocytes cultured in a three-dimensional fibrin matrix and supplemented with transforming growth factor β–1. Am J Vet Res, 58, 66-70.
- Fortier LA, Nixon AJ, Williams J, Cable CS (1998): Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells. Am J Vet Res, 59, 1182-1187.
- Gillogly SD, Voight M, Blackburn T (1998): Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation. J O S P T, 28, 241-251.
- Jackson DW, Simon TM (1999): Tissue engineering principles in orthopaedic surgery. Clin Orthop, 376, 31- 45.
- Kim W, Mooney D, Vacanti JP, Upton J, Ibarra C, Vacanti CA (1996): chondrocytes stored at 4°C. Tissue Eng, 2, 75-81.
- Messner K, Gillquist J (1996): Cartilage repair: A critical review. Acta Orthop Scand, 67, 523-529.
- Noguchi T, Oka M, Fujino M, Neo M, Yamamuro T (1994): Repair of osteochondral defects with grafts or cultured chondrocytes: comparison of allografts and isografts. Clin Orthop Rel Res, 302, 251-258.
- Tunay S, Bilgili H, Yıldız C, Yanmış İ, Solakoğlu C, Gür E (2002): The use of intraarticular hyaluronic acid on the treatment of experimental osteoarthritis: Radiological and histopathological study on rabbit stifle joint. Turk J Vet Anim Sci, 26, 939-947.
- Wakitani S, Kimura T, Hirooka A, Ochl T, Yoneda M, Yasui N, Owaki H, Ono K (1989): Repair of rabbit articular surfaces with allograft chondrocytes embedded in collage gel. J Bone Joint Surg, 71B, 74-80.
- Yaylaoğlu MB, Yıldız C, Korkusuz F, Hasırcı V (1999): A novel osteochondral implant. Biomaterials, 20, 1513-1520.
- Yıldız C, Bahçe M, Başbozkurt M, Uğur G, Oğuz E, Deveci S, Gür E (1997): Cultured chondrocytes in monolayer system. Turk J Bone Joint Surg, 3, 88-93.
- Yıldız C, Bahçe M, Şehirlioglu A, Tunay S, Erler K, Başbozkurt M, Gür E (1998): Injectable Chondrocyte. Acta Orthop Trauma Turc, 2, 78-85.
- Yıldız C, Yaylaoglu MB, Korkusuz F, Başbozkurt M, Hasırcı V (1999): Calcium phosphate loaded lyophilized collagen graft material for induction of chondrocytes. J Bone Joint Surg, 81A, 64.
- Yıldız C, Bilgili H, Bahçe M, Başbozkurt M, Aslanbey D, Gür E (1999): An experimental study of chondrocyte cell culture from cartilage tissue of rabbit shoulder joint. Turk J Vet Surg, 5, 20-23.
- Yıldız C, Bilgili H, Bahçe M, Başbozkurt M, Aslanbey D, Gür E (2000): Two different in-vitro methods for chondrocyte proliferation: An experimental study on rabbit stifle joint cartilage. Turk J Vet Surg, 6, 47-51.
- Yıldız C, Bahçe M, Deveci S, Bilgili H, İde T, Tunay S, Başbozkurt M, Gür E (2001): Autologous chondrocyte transplantation (An experimental study in rabbit knee joints). Turk J Arthrop Arthros Surg, 12, 75-82. Geliş tarihi: 14.06.2005 / Kabul tarihi: 22.07.2005
Öz
Araştırmada, kronik böbrek yetmezliği (KBY) gözlenen kedilerde hematolojik ve biyokimyasal değişikliklerin incelenmesi ve bulguların hastalığın derecelendirilmesinde kullanılması amaçlanmıştır. KBY tespit edilen ve yaşları 3-12 arasında değişen 22 dişi kedi ile aynı yaşlarda ve klinik olarak sağlıklı görünen 10 dişi kedi (kontrol) araştırmanın hayvan materyalini oluşturmuştur. Hayvanlara ait idrar örneklerinde protein varlığı ve dansite; kan örneklerinde hemoglobin, hematokrit değer, alyuvar ve akyuvar sayıları ile akyuvarların % dağılımları; serum örneklerinde ise toplam protein, üre, kreatinin, sodyum, potasyum, kalsiyum, fosfor, osteokalsin (OC), toplam ALP (t-ALP) ve kemik spesifik ALP (k-ALP) değerleri ölçülmüştür. KBY’li kedilerde poliüri, idrar dansitesinde düşüş, azotemi, hipokalemi, hiponatremi, hiperfosfatemi, hiperproteinemi, normositik normokromik anemi ve akyuvar artışı saptanmış; serum osteokalsin değerleri hasta ve kontrol grupta ölçüm sınırlarının altında (
Anahtar Kelimeler
Biyokimyasal belirtiler hematolojik belirtiler kedi kronik böbrek yetmezliği
Kaynakça
- Bilgili H, Orhun S (2002): The research of the changes on joint tissues radiological and histopathologically on an experimental osteoarthritis performed on rabbit stifle joint. Turk J Vet Surg, 8, 8-12.
- Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994): Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. New Eng J Med, 331, 889-895.
- Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1996): Rabbit articular cartilage defects treated with autologous cultured chondrocytes. Clin Orthop, 326, 270-283.
- Buckwalter JA, Mankin HJ (1997): Articular cartilage. Part II: Degeneration and osteoarthritis, repair, regeneration, and transplantation. J Bone Joint Surg, 79A, 612-627.
- Cook JL, Kreeger JM, Payne JT, Tomlinson JL (2002): Effects of EGF, FGF, and PDGF on canine chondrocytes in three-dimensional culture. Vet Comp Orthop Traumatol, 10, 210-213.
- Fortier LA, Nixon AJ, Mohammed HO, Lust G (1997): Altered biological activity of equine chondrocytes cultured in a three-dimensional fibrin matrix and supplemented with transforming growth factor β–1. Am J Vet Res, 58, 66-70.
- Fortier LA, Nixon AJ, Williams J, Cable CS (1998): Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells. Am J Vet Res, 59, 1182-1187.
- Gillogly SD, Voight M, Blackburn T (1998): Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation. J O S P T, 28, 241-251.
- Jackson DW, Simon TM (1999): Tissue engineering principles in orthopaedic surgery. Clin Orthop, 376, 31- 45.
- Kim W, Mooney D, Vacanti JP, Upton J, Ibarra C, Vacanti CA (1996): chondrocytes stored at 4°C. Tissue Eng, 2, 75-81.
- Messner K, Gillquist J (1996): Cartilage repair: A critical review. Acta Orthop Scand, 67, 523-529.
- Noguchi T, Oka M, Fujino M, Neo M, Yamamuro T (1994): Repair of osteochondral defects with grafts or cultured chondrocytes: comparison of allografts and isografts. Clin Orthop Rel Res, 302, 251-258.
- Tunay S, Bilgili H, Yıldız C, Yanmış İ, Solakoğlu C, Gür E (2002): The use of intraarticular hyaluronic acid on the treatment of experimental osteoarthritis: Radiological and histopathological study on rabbit stifle joint. Turk J Vet Anim Sci, 26, 939-947.
- Wakitani S, Kimura T, Hirooka A, Ochl T, Yoneda M, Yasui N, Owaki H, Ono K (1989): Repair of rabbit articular surfaces with allograft chondrocytes embedded in collage gel. J Bone Joint Surg, 71B, 74-80.
- Yaylaoğlu MB, Yıldız C, Korkusuz F, Hasırcı V (1999): A novel osteochondral implant. Biomaterials, 20, 1513-1520.
- Yıldız C, Bahçe M, Başbozkurt M, Uğur G, Oğuz E, Deveci S, Gür E (1997): Cultured chondrocytes in monolayer system. Turk J Bone Joint Surg, 3, 88-93.
- Yıldız C, Bahçe M, Şehirlioglu A, Tunay S, Erler K, Başbozkurt M, Gür E (1998): Injectable Chondrocyte. Acta Orthop Trauma Turc, 2, 78-85.
- Yıldız C, Yaylaoglu MB, Korkusuz F, Başbozkurt M, Hasırcı V (1999): Calcium phosphate loaded lyophilized collagen graft material for induction of chondrocytes. J Bone Joint Surg, 81A, 64.
- Yıldız C, Bilgili H, Bahçe M, Başbozkurt M, Aslanbey D, Gür E (1999): An experimental study of chondrocyte cell culture from cartilage tissue of rabbit shoulder joint. Turk J Vet Surg, 5, 20-23.
- Yıldız C, Bilgili H, Bahçe M, Başbozkurt M, Aslanbey D, Gür E (2000): Two different in-vitro methods for chondrocyte proliferation: An experimental study on rabbit stifle joint cartilage. Turk J Vet Surg, 6, 47-51.
- Yıldız C, Bahçe M, Deveci S, Bilgili H, İde T, Tunay S, Başbozkurt M, Gür E (2001): Autologous chondrocyte transplantation (An experimental study in rabbit knee joints). Turk J Arthrop Arthros Surg, 12, 75-82. Geliş tarihi: 14.06.2005 / Kabul tarihi: 22.07.2005
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Veteriner Cerrahi |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Haziran 2006 |
| Yayımlandığı Sayı | Yıl 2006Cilt: 53 Sayı: 2 |