Tamoxifen (TAM) is one of selective estrogen
receptor modulators used in breast cancer treatment and prevention. The objective of this study was
to determine whether or not insulin-like growth factor-I (IGF-1) and its
receptor (IGF-1R), has any role in the effect mechanism of TAM on the ovary.
Experimentally, animals were divided into three groups as control group (n=
20), low dose TAM treatment group (0.5 mg/mouse/day, n= 20) and high dose TAM
treatment group (1.5 mg/mouse/day, n= 20). TAM was injected 0.5 and 1.5
mg/mouse/day for 5 days. Ovarian sections were used to examine the general
structure by trichrome staining method and to determine IGF-1 and IGF-1R
expressions by immunohistochemical staining method. After the experiment, the
presence of atretic follicles and small cystic structures in the TAM-treated
animals was determined. Also, antral follicles and the corpus luteum were much
less in the high dose TAM group than in the control. TAM did not change the
expression of IGF-1 in granulosa cells, but increased the expression of IGF-1R.
In TAM groups, IGF-1 and IGF-1R expression were increased in oocytes of
follicles and in interstitial cells depending on TAM doses. However, while
IGF-1 expression was unchanged in the corpus luteum, decreased in treatment
group. TAM generally stimulated IGF-1 and IGF-1R expression in a dose-dependent
manner. The results suggest that IGF-1 signaling pathway is involved in the
mechanism of action of TAM on the ovary. We may assert that it may be useful to
use IGF-1 signaling pathway regulators to adjust the effects of TAM on the
ovary.
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Cerrahi |
Bölüm | Makaleler |
Yazarlar |
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Yayımlanma Tarihi | 9 Eylül 2019 |
Yayınlandığı Sayı | Yıl 2019Cilt: 66 Sayı: 4 |
Bibtex | @araştırma makalesi { auvfd498411, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2019}, volume = {66}, number = {4}, pages = {343 - 350}, doi = {10.33988/auvfd.498411}, title = {The effect of tamoxifen on IGF signaling pathway in the mouse ovary}, key = {cite}, author = {Asmaz, Ender Deniz and Zık, Berrin} } |
APA | Asmaz, E. D. & Zık, B. (2019). The effect of tamoxifen on IGF signaling pathway in the mouse ovary . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 66 (4) , 343-350 . DOI: 10.33988/auvfd.498411 |
MLA | Asmaz, E. D. , Zık, B. "The effect of tamoxifen on IGF signaling pathway in the mouse ovary" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 66 (2019 ): 343-350 <http://vetjournal.ankara.edu.tr/tr/pub/issue/47708/498411> |
Chicago | Asmaz, E. D. , Zık, B. "The effect of tamoxifen on IGF signaling pathway in the mouse ovary". Ankara Üniversitesi Veteriner Fakültesi Dergisi 66 (2019 ): 343-350 |
RIS | TY - JOUR T1 - The effect of tamoxifen on IGF signaling pathway in the mouse ovary AU - Ender DenizAsmaz, BerrinZık Y1 - 2019 PY - 2019 N1 - doi: 10.33988/auvfd.498411 DO - 10.33988/auvfd.498411 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 343 EP - 350 VL - 66 IS - 4 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.498411 UR - https://doi.org/10.33988/auvfd.498411 Y2 - 2019 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi The effect of tamoxifen on IGF signaling pathway in the mouse ovary %A Ender Deniz Asmaz , Berrin Zık %T The effect of tamoxifen on IGF signaling pathway in the mouse ovary %D 2019 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 66 %N 4 %R doi: 10.33988/auvfd.498411 %U 10.33988/auvfd.498411 |
ISNAD | Asmaz, Ender Deniz , Zık, Berrin . "The effect of tamoxifen on IGF signaling pathway in the mouse ovary". Ankara Üniversitesi Veteriner Fakültesi Dergisi 66 / 4 (Eylül 2019): 343-350 . https://doi.org/10.33988/auvfd.498411 |
AMA | Asmaz E. D. , Zık B. The effect of tamoxifen on IGF signaling pathway in the mouse ovary. Ankara Univ Vet Fak Derg. 2019; 66(4): 343-350. |
Vancouver | Asmaz E. D. , Zık B. The effect of tamoxifen on IGF signaling pathway in the mouse ovary. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2019; 66(4): 343-350. |
IEEE | E. D. Asmaz ve B. Zık , "The effect of tamoxifen on IGF signaling pathway in the mouse ovary", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 66, sayı. 4, ss. 343-350, Eyl. 2019, doi:10.33988/auvfd.498411 |