Natural products and
anti-inflammatory agents including cyclooxygenase-2 (COX-2) inhibitors which is
a type of nonsteroidal anti-inflammatory drugs (NSAIDs) are highly considerable
interest for the prevention of carcinogenesis. The objective of this study is
to evaluate the oxidative status of colitis-associated cancer induced by azoxymethane
(AOM)/dextran sulfate sodium (DSS), and the effects of COX-2 inhibitor in mice.
Totally 40 mice were randomized and divided to four groups. All animals except
control and Cox-2 inhibitor alone group received AOM/DSS to establish
colitis-associated cancer model as reported elsewhere. COX-2 preferential
inhibitor meloxicam was used to minimize side effects such as gastrointestinal
hemorrhage. Meloxicam were used (5mg/kg, intraperitoneal) three times a week
with meloxicam alone and AOM/DSS + meloxicam group. Superoxide dismutase (SOD),
Glutathione peroxidase (GPx), Malondialdehyde (MDA) and Advanced Oxidation
Protein Products (AOPP) which all of them are oxidative stress markers were
measured by spectrophotometrically. The combination treatment of Meloxicam and
AOM/DSS significantly increased (P< 0.05) SOD activities in mice. GPx
activities were found significantly increased (P< 0.05) in Meloxicam and
AOM/DSS combinations or alone. There were no differences between the control
and treatment groups of MDA levels. AOPP levels of Meloxicam and AOM/DSS
combination group were found higher than the other groups. Meloxicam and /or
AOM/DSS treatment not caused lipid peroxidations, but increased the antioxidant
enzymes and Advanced Oxidation Protein Products levels.
Azoxymethane, colon cancer, COX-2, dextran sulfate sodium, oxidative stress
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Cerrahi |
Bölüm | Makaleler |
Yazarlar |
|
Yayımlanma Tarihi | 9 Eylül 2019 |
Yayınlandığı Sayı | Yıl 2019Cilt: 66 Sayı: 4 |
Bibtex | @araştırma makalesi { auvfd521040, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2019}, volume = {66}, number = {4}, pages = {351 - 356}, doi = {10.33988/auvfd.521040}, title = {Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice}, key = {cite}, author = {Kısmalı, Görkem and Üner, Aykut Göktürk and Meral, Öğünç and Alpay, Merve and Salmanoğlu, Berrin and Ülker Çakır, Dilek and Kosova, Funda and Sel, Tevhide} } |
APA | Kısmalı, G. , Üner, A. G. , Meral, Ö. , Alpay, M. , Salmanoğlu, B. , Ülker Çakır, D. , Kosova, F. & Sel, T. (2019). Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 66 (4) , 351-356 . DOI: 10.33988/auvfd.521040 |
MLA | Kısmalı, G. , Üner, A. G. , Meral, Ö. , Alpay, M. , Salmanoğlu, B. , Ülker Çakır, D. , Kosova, F. , Sel, T. "Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 66 (2019 ): 351-356 <http://vetjournal.ankara.edu.tr/tr/pub/issue/47708/521040> |
Chicago | Kısmalı, G. , Üner, A. G. , Meral, Ö. , Alpay, M. , Salmanoğlu, B. , Ülker Çakır, D. , Kosova, F. , Sel, T. "Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice". Ankara Üniversitesi Veteriner Fakültesi Dergisi 66 (2019 ): 351-356 |
RIS | TY - JOUR T1 - Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice AU - GörkemKısmalı, Aykut GöktürkÜner, ÖğünçMeral, MerveAlpay, BerrinSalmanoğlu, DilekÜlker Çakır, FundaKosova, TevhideSel Y1 - 2019 PY - 2019 N1 - doi: 10.33988/auvfd.521040 DO - 10.33988/auvfd.521040 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 351 EP - 356 VL - 66 IS - 4 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.521040 UR - https://doi.org/10.33988/auvfd.521040 Y2 - 2019 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice %A Görkem Kısmalı , Aykut Göktürk Üner , Öğünç Meral , Merve Alpay , Berrin Salmanoğlu , Dilek Ülker Çakır , Funda Kosova , Tevhide Sel %T Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice %D 2019 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 66 %N 4 %R doi: 10.33988/auvfd.521040 %U 10.33988/auvfd.521040 |
ISNAD | Kısmalı, Görkem , Üner, Aykut Göktürk , Meral, Öğünç , Alpay, Merve , Salmanoğlu, Berrin , Ülker Çakır, Dilek , Kosova, Funda , Sel, Tevhide . "Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice". Ankara Üniversitesi Veteriner Fakültesi Dergisi 66 / 4 (Eylül 2019): 351-356 . https://doi.org/10.33988/auvfd.521040 |
AMA | Kısmalı G. , Üner A. G. , Meral Ö. , Alpay M. , Salmanoğlu B. , Ülker Çakır D. , Kosova F. , Sel T. Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice. Ankara Univ Vet Fak Derg. 2019; 66(4): 351-356. |
Vancouver | Kısmalı G. , Üner A. G. , Meral Ö. , Alpay M. , Salmanoğlu B. , Ülker Çakır D. , Kosova F. , Sel T. Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2019; 66(4): 351-356. |
IEEE | G. Kısmalı , A. G. Üner , Ö. Meral , M. Alpay , B. Salmanoğlu , D. Ülker Çakır , F. Kosova ve T. Sel , "Oxidative status of colitis-associated cancer model induced by azoxymethane /dextran sulfate sodium and the effects of COX-2 inhibitor in mice", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 66, sayı. 4, ss. 351-356, Eyl. 2019, doi:10.33988/auvfd.521040 |