Research Article
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Year 2019, Volume: 66 Issue: 4, 357 - 361, 09.09.2019

Duygu Mutluay , Yukiko Yamazaki Kanani Hokutan Charles J Rosser Hideki Furuya

https://doi.org/10.33988/auvfd.533634

Abstract

References

  • 1. Aflalo ED, Sod-Moriah UA, Potashnik G, et al (2005): Expression of plasminogen activators in preimplantation rat embryos developed in vivo and in vitro. Reprod Biol Endocrinol, 3, 7.
  • 2. Astedt B, Lindoff C, Lecander I (1998): Significance of the plasminogen activator inhibitor of placental type (PAI-2) in pregnancy. Semin Thromb Hemost, 24, 431-435.
  • 3. Balsara RD, Ploplis VA (2008): Plasminogen activator inhibitor-1: the double-edged sword in apoptosis. Thromb Haemost, 100, 1029-1036.
  • 4. Brenner B (2004): Haemostatic changes in pregnancy. Thromb Res, 114, 409-414.
  • 5. Canipari R, Strickland S (1985): Plasminogen activator in the rat ovary. Production and gonadotropin regulation of the enzyme in granulosa and thecal cells. J Biol Chem, 260, 5121-5125.
  • 6. Carmeliet P, Kieckens L, Schoonjans L, et al (1993): Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J Clin Invest, 92, 2746-2755.
  • 7. Collen D (1980): On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. Thromb Haemost, 43, 77-89.
  • 8. Dougherty KM, Pearson JM, Yang AY, et al (1999): The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival. Proc Natl Acad Sci USA, 96, 686-691.
  • 9. Fang H, Placencio VR, DeClerck YA (2012): Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function. J Natl Cancer Inst, 104, 1470-1484.
  • 10. Feinberg RF, Kao LC, Haimowitz JE, et al (1989): Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Lab Investig J Tech Methods Pathol, 61, 20-26.
  • 11. Feng Q, Liu Y, Liu K, et al (2000): Expression of urokinase, plasminogen activator inhibitors and urokinase receptor in pregnant rhesus monkey uterus during early placentation. Placenta, 21, 184-193.
  • 12. Giacoia EG, Miyake M, Lawton A, et al (2014): PAI-1 leads to G1-phase cell-cycle progression through cyclin D3/cdk4/6 upregulation. Mol Cancer Res, 12, 322-334.
  • 13. Giacoia EG, Miyake M, Goodison S, et al (2013): Targeting plasminogen activator inhibitor-1 inhibits angiogenesis and tumor growth in a human cancer xenograft model. Mol Cancer Ther, 12, 2697-2708.
  • 14. Hellgren M (2003): Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost, 29, 125-130.
  • 15. Hofmann GE, Glatstein I, Schatz F, Heller D, et al (1994): Immunohistochemical localization of urokinase-type plasminogen activator and the plasminogen activator inhibitors 1 and 2 in early human implantation sites. Am J Obstet Gynecol, 170, 671-676.
  • 16. Huarte J, Belin D, Vassalli JD (1985): Plasminogen activator in mouse and rat oocytes: induction during meiotic maturation. Cell, 43, 551-558.
  • 17. Huarte J, Vassalli, JD, Belin D, et al (1993): Involvement of the plasminogen activator/plasmin proteolytic cascade in fertilization. Dev Biol, 157, 539-46.
  • 18. Kaufmann P, Black S, Huppertz B (2003): Endovascular trophoblast invasion: Implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod, 69, 1-7.
  • 19. Lee CC, Huang TS (2005): Plasminogen activator inhibitor-1: the expression, biological functionsand effects on tumorigenesis and tumor cell adhesion and migration. J Cancer Mol, 1, 25-36. 20. Lijnen HR (2005): Pleiotropic functions of plasminogen activator inhibitor- 1. J Thromb Haemost, 3, 35-45. 21. Liu YX (2004): Plasminogen activator/plasminogen activator inhibitors in ovarian physiology. Front Biosci, 9, 3356-3373. 22. Markiewski MM, Nilsson B, Ekdahl KN, et al (2007): Complement and coagulation: strangers or partners in crime? Trends Immunol, 28, 184-192. 23. Mashiko S, Kitatani K, Toyoshima M, et al (2015): Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer. Cancer Biol Ther, 16, 253-260. 24. Mehta BN, Nath N, Chimote N (2014): Periodicity in the levels of serum plasminogen activator inhibitor-1 is a robust prognostic factor for embryo implantation and clinical pregnancy in ongoing IVF cycles. J Hum Reprod Sci, 7, 198-205. 25. Mutluay D (2016): Distribution of primitive endoderm and epiblast lineage specific factors in late stage blastocysts. Slov Vet Res, 53, 211-217. 26. Mutluay D, Oner H (2017) The Abelson tyrosine kinase (c-Abl) localization in preimplantation mouse development. Rom J Morphol Embryol, 58, 1385-1391. 27. Pihusch M, Pihusch V, Holler E (2005): Plasminogen activator inhibitor-1: A review. J Lab Med, 29, 403-411. 28. Placencio VR, DeClerck YA (2015): Plasminogen Activator Inhibitor-1 in Cancer: Rationale and Insight for Future Therapeutic Testing. Cancer Res, 75, 2969-2974. 29. Pyke C, Kristensen P, Ralfkiaer E, Eriksen J, Danø K (1991): The plasminogen activation system in human colon cancer: messenger RNA for the inhibitor PAI-1 is located in endothelial cells in the tumor stroma. Cancer Res, 51, 4067-4071. 30. Saksela, O, Rifkin DB (1988): Cell-associated plasminogen activation: Regulation and physiological functions. Annu Rev Cell Biol, 4, 93-126. 31. Sappino AP, Huarte J, Belin D, et al (1989): Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos. J Cell Biol, 109, 2471-2479. 32. Soares MJ, Chakraborty D, Kubota K, et al (2014): Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy. Int J Dev Biol, 58, 247-259. 33. Ye Y, Vattai A, Zhang X, et al (2017): Role of plasminogen activator inhibitor type 1 in pathologies of female reproductive diseases. Int J Mol Sci, 18, pii: E1651. 34. Zhang X, Rutledge J, Khamsi F, et al (1992): Release of tissue-type plasminogen activator by activated rat eggs and its possible role in the zona reaction. Mol Reprod Dev, 32, 28-32.

Localization of plasminogen activator inhibitor type 1 and 2 in preimplantation mouse development in vitro

Year 2019, Volume: 66 Issue: 4, 357 - 361, 09.09.2019

Duygu Mutluay , Yukiko Yamazaki Kanani Hokutan Charles J Rosser Hideki Furuya

https://doi.org/10.33988/auvfd.533634

Abstract

Plasminogen activator
inhibitor type 1 (PAI-1) and type 2 (PAI-2) are the major endogenous inhibitors
of fibrinolysis, or thrombolysis, as it is effective in blocking the conversion
of plasminogen to plasmin. In mammalian embryos, both PAI-1 and PAI-2 proteins
are expressed in the trophoblasts during and after implantation, suggesting
their critical roles in implantation and placentation during pregnancy.
However, it remains unclear how both proteins localize in the early stage
embryos before implantation. In this
study, 2 cell stage embryos were flushed from the oviducts and cultured to
specified stages in medium at 37 ̊C in a 5% CO2 incubator. Embryos
were fixed and double immunostained with anti-PAI-1 and anti- PAI-2 antibody.
We determined the critical expression and localization patterns of PAI-1 and
PAI-2 proteins in murine preimplantation embryos at 2 cell, 8 cell, morula and
blastocyst stages by using confocal laser scanning microscope. We found that
PAI-1 and PAI-2 constantly express in the embryos during preimplantation
development, and these proteins localize in both the cytoplasm and the nucleus
of each blastomere regardless of their developmental stage. Our results suggest
that PAI-1 and PAI-2 proteins may play roles in
early embryonic development before implantation.

Keywords

Embryo development PAI-1 PAI-2 preimplantation

References

  • 1. Aflalo ED, Sod-Moriah UA, Potashnik G, et al (2005): Expression of plasminogen activators in preimplantation rat embryos developed in vivo and in vitro. Reprod Biol Endocrinol, 3, 7.
  • 2. Astedt B, Lindoff C, Lecander I (1998): Significance of the plasminogen activator inhibitor of placental type (PAI-2) in pregnancy. Semin Thromb Hemost, 24, 431-435.
  • 3. Balsara RD, Ploplis VA (2008): Plasminogen activator inhibitor-1: the double-edged sword in apoptosis. Thromb Haemost, 100, 1029-1036.
  • 4. Brenner B (2004): Haemostatic changes in pregnancy. Thromb Res, 114, 409-414.
  • 5. Canipari R, Strickland S (1985): Plasminogen activator in the rat ovary. Production and gonadotropin regulation of the enzyme in granulosa and thecal cells. J Biol Chem, 260, 5121-5125.
  • 6. Carmeliet P, Kieckens L, Schoonjans L, et al (1993): Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J Clin Invest, 92, 2746-2755.
  • 7. Collen D (1980): On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. Thromb Haemost, 43, 77-89.
  • 8. Dougherty KM, Pearson JM, Yang AY, et al (1999): The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival. Proc Natl Acad Sci USA, 96, 686-691.
  • 9. Fang H, Placencio VR, DeClerck YA (2012): Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function. J Natl Cancer Inst, 104, 1470-1484.
  • 10. Feinberg RF, Kao LC, Haimowitz JE, et al (1989): Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Lab Investig J Tech Methods Pathol, 61, 20-26.
  • 11. Feng Q, Liu Y, Liu K, et al (2000): Expression of urokinase, plasminogen activator inhibitors and urokinase receptor in pregnant rhesus monkey uterus during early placentation. Placenta, 21, 184-193.
  • 12. Giacoia EG, Miyake M, Lawton A, et al (2014): PAI-1 leads to G1-phase cell-cycle progression through cyclin D3/cdk4/6 upregulation. Mol Cancer Res, 12, 322-334.
  • 13. Giacoia EG, Miyake M, Goodison S, et al (2013): Targeting plasminogen activator inhibitor-1 inhibits angiogenesis and tumor growth in a human cancer xenograft model. Mol Cancer Ther, 12, 2697-2708.
  • 14. Hellgren M (2003): Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost, 29, 125-130.
  • 15. Hofmann GE, Glatstein I, Schatz F, Heller D, et al (1994): Immunohistochemical localization of urokinase-type plasminogen activator and the plasminogen activator inhibitors 1 and 2 in early human implantation sites. Am J Obstet Gynecol, 170, 671-676.
  • 16. Huarte J, Belin D, Vassalli JD (1985): Plasminogen activator in mouse and rat oocytes: induction during meiotic maturation. Cell, 43, 551-558.
  • 17. Huarte J, Vassalli, JD, Belin D, et al (1993): Involvement of the plasminogen activator/plasmin proteolytic cascade in fertilization. Dev Biol, 157, 539-46.
  • 18. Kaufmann P, Black S, Huppertz B (2003): Endovascular trophoblast invasion: Implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod, 69, 1-7.
  • 19. Lee CC, Huang TS (2005): Plasminogen activator inhibitor-1: the expression, biological functionsand effects on tumorigenesis and tumor cell adhesion and migration. J Cancer Mol, 1, 25-36. 20. Lijnen HR (2005): Pleiotropic functions of plasminogen activator inhibitor- 1. J Thromb Haemost, 3, 35-45. 21. Liu YX (2004): Plasminogen activator/plasminogen activator inhibitors in ovarian physiology. Front Biosci, 9, 3356-3373. 22. Markiewski MM, Nilsson B, Ekdahl KN, et al (2007): Complement and coagulation: strangers or partners in crime? Trends Immunol, 28, 184-192. 23. Mashiko S, Kitatani K, Toyoshima M, et al (2015): Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer. Cancer Biol Ther, 16, 253-260. 24. Mehta BN, Nath N, Chimote N (2014): Periodicity in the levels of serum plasminogen activator inhibitor-1 is a robust prognostic factor for embryo implantation and clinical pregnancy in ongoing IVF cycles. J Hum Reprod Sci, 7, 198-205. 25. Mutluay D (2016): Distribution of primitive endoderm and epiblast lineage specific factors in late stage blastocysts. Slov Vet Res, 53, 211-217. 26. Mutluay D, Oner H (2017) The Abelson tyrosine kinase (c-Abl) localization in preimplantation mouse development. Rom J Morphol Embryol, 58, 1385-1391. 27. Pihusch M, Pihusch V, Holler E (2005): Plasminogen activator inhibitor-1: A review. J Lab Med, 29, 403-411. 28. Placencio VR, DeClerck YA (2015): Plasminogen Activator Inhibitor-1 in Cancer: Rationale and Insight for Future Therapeutic Testing. Cancer Res, 75, 2969-2974. 29. Pyke C, Kristensen P, Ralfkiaer E, Eriksen J, Danø K (1991): The plasminogen activation system in human colon cancer: messenger RNA for the inhibitor PAI-1 is located in endothelial cells in the tumor stroma. Cancer Res, 51, 4067-4071. 30. Saksela, O, Rifkin DB (1988): Cell-associated plasminogen activation: Regulation and physiological functions. Annu Rev Cell Biol, 4, 93-126. 31. Sappino AP, Huarte J, Belin D, et al (1989): Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos. J Cell Biol, 109, 2471-2479. 32. Soares MJ, Chakraborty D, Kubota K, et al (2014): Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy. Int J Dev Biol, 58, 247-259. 33. Ye Y, Vattai A, Zhang X, et al (2017): Role of plasminogen activator inhibitor type 1 in pathologies of female reproductive diseases. Int J Mol Sci, 18, pii: E1651. 34. Zhang X, Rutledge J, Khamsi F, et al (1992): Release of tissue-type plasminogen activator by activated rat eggs and its possible role in the zona reaction. Mol Reprod Dev, 32, 28-32.
There are 22 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Articles
Authors

Duygu Mutluay 0000-0003-3286-130X

Yukiko Yamazaki 0000-0001-5089-1487

Kanani Hokutan 0000-0003-1494-2392

Charles J Rosser 0000-0002-6052-4223

Hideki Furuya 0000-0002-9536-8662

Publication Date September 9, 2019
Published in Issue Year 2019Volume: 66 Issue: 4

Cite

APA Mutluay, D., Yamazaki, Y., Hokutan, K., Rosser, C. J., et al. (2019). Localization of plasminogen activator inhibitor type 1 and 2 in preimplantation mouse development in vitro. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 66(4), 357-361. https://doi.org/10.33988/auvfd.533634
AMA Mutluay D, Yamazaki Y, Hokutan K, Rosser CJ, Furuya H. Localization of plasminogen activator inhibitor type 1 and 2 in preimplantation mouse development in vitro. Ankara Univ Vet Fak Derg. September 2019;66(4):357-361. doi:10.33988/auvfd.533634
Chicago Mutluay, Duygu, Yukiko Yamazaki, Kanani Hokutan, Charles J Rosser, and Hideki Furuya. “Localization of Plasminogen Activator Inhibitor Type 1 and 2 in Preimplantation Mouse Development in Vitro”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 66, no. 4 (September 2019): 357-61. https://doi.org/10.33988/auvfd.533634.
EndNote Mutluay D, Yamazaki Y, Hokutan K, Rosser CJ, Furuya H (September 1, 2019) Localization of plasminogen activator inhibitor type 1 and 2 in preimplantation mouse development in vitro. Ankara Üniversitesi Veteriner Fakültesi Dergisi 66 4 357–361.
IEEE D. Mutluay, Y. Yamazaki, K. Hokutan, C. J. Rosser, and H. Furuya, “Localization of plasminogen activator inhibitor type 1 and 2 in preimplantation mouse development in vitro”, Ankara Univ Vet Fak Derg, vol. 66, no. 4, pp. 357–361, 2019, doi: 10.33988/auvfd.533634.
ISNAD Mutluay, Duygu et al. “Localization of Plasminogen Activator Inhibitor Type 1 and 2 in Preimplantation Mouse Development in Vitro”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 66/4 (September 2019), 357-361. https://doi.org/10.33988/auvfd.533634.
JAMA Mutluay D, Yamazaki Y, Hokutan K, Rosser CJ, Furuya H. Localization of plasminogen activator inhibitor type 1 and 2 in preimplantation mouse development in vitro. Ankara Univ Vet Fak Derg. 2019;66:357–361.
MLA Mutluay, Duygu et al. “Localization of Plasminogen Activator Inhibitor Type 1 and 2 in Preimplantation Mouse Development in Vitro”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 66, no. 4, 2019, pp. 357-61, doi:10.33988/auvfd.533634.
Vancouver Mutluay D, Yamazaki Y, Hokutan K, Rosser CJ, Furuya H. Localization of plasminogen activator inhibitor type 1 and 2 in preimplantation mouse development in vitro. Ankara Univ Vet Fak Derg. 2019;66(4):357-61.