The present study was undertaken to evaluate of Nigella sativa oil (NSO) and zinc-silver cream in a rat model of wound healing by means of clinical appearance, histopathology, oxidative stress parameters, and biomechanical tests. The rats were divided into three groups, each having twenty animals. Group 1 served as a control having wound. Other two groups received either NS oil or zinc-silver cream in addition to the wound. The study was initiated after the animals rested for 2 weeks for acclimation. Blood samples were collected from 10 randomly selected animals from each group at days 0, 3, 7 and 14 for oxidative stress measurements. Differences among groups for blood lipid peroxidation and antioxidant values were determined with respect to biochemical oxidative stress results (P<0.01). Wound sites of 10 animals from each group were allocated for histopathological examinations, and those of the remaining 10 animals from each group were used in biomechanical testing. Histopathological examination revealed that epithelization occurred in all groups. Inflammatory response with an intensive vascularization was present in the samples of the silver group (P<0.01). Consequently, zinc-silver group has differed positively in terms of biochemical and biomechanical and histological aspects compared to other groups for wound healing and oxidative stress.
Nigella sativa oil, Oxidative stress, rat, wound healing, zinc-silver
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Hekimlik |
Bölüm | Makaleler |
Yazarlar |
|
Yayımlanma Tarihi | 26 Aralık 2019 |
Yayınlandığı Sayı | Yıl 2020, Cilt 67, Sayı 1 |
Bibtex | @araştırma makalesi { auvfd563491, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2019}, volume = {67}, number = {1}, pages = {33 - 40}, doi = {10.33988/auvfd.563491}, title = {Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats}, key = {cite}, author = {Kumandaş, Ali and Karslı, Birkan and Kürüm, Aytül and Çınar, Miyase and Elma, Ertuğrul} } |
APA | Kumandaş, A. , Karslı, B. , Kürüm, A. , Çınar, M. & Elma, E. (2019). Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 67 (1) , 33-40 . DOI: 10.33988/auvfd.563491 |
MLA | Kumandaş, A. , Karslı, B. , Kürüm, A. , Çınar, M. , Elma, E. "Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2019 ): 33-40 <http://vetjournal.ankara.edu.tr/tr/pub/issue/48774/563491> |
Chicago | Kumandaş, A. , Karslı, B. , Kürüm, A. , Çınar, M. , Elma, E. "Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2019 ): 33-40 |
RIS | TY - JOUR T1 - Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats AU - AliKumandaş, BirkanKarslı, AytülKürüm, MiyaseÇınar, ErtuğrulElma Y1 - 2019 PY - 2019 N1 - doi: 10.33988/auvfd.563491 DO - 10.33988/auvfd.563491 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 33 EP - 40 VL - 67 IS - 1 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.563491 UR - https://doi.org/10.33988/auvfd.563491 Y2 - 2019 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats %A Ali Kumandaş , Birkan Karslı , Aytül Kürüm , Miyase Çınar , Ertuğrul Elma %T Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats %D 2019 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 67 %N 1 %R doi: 10.33988/auvfd.563491 %U 10.33988/auvfd.563491 |
ISNAD | Kumandaş, Ali , Karslı, Birkan , Kürüm, Aytül , Çınar, Miyase , Elma, Ertuğrul . "Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 / 1 (Aralık 2019): 33-40 . https://doi.org/10.33988/auvfd.563491 |
AMA | Kumandaş A. , Karslı B. , Kürüm A. , Çınar M. , Elma E. Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats. Ankara Univ Vet Fak Derg. 2019; 67(1): 33-40. |
Vancouver | Kumandaş A. , Karslı B. , Kürüm A. , Çınar M. , Elma E. Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2019; 67(1): 33-40. |
IEEE | A. Kumandaş , B. Karslı , A. Kürüm , M. Çınar ve E. Elma , "Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 67, sayı. 1, ss. 33-40, Ara. 2019, doi:10.33988/auvfd.563491 |