Araştırma Makalesi
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Yıl 2020, Cilt 67, Sayı 1, 33 - 40, 26.12.2019
https://doi.org/10.33988/auvfd.563491

Öz

Kaynakça

  • Agarwal R, Kharya MD, Shrivastava R (1979): Antimicrobial and anthelmintic activities of the essential oil of Nigella sativa Linn. IJEB, 17, 1264-1265.
  • Akhtar AH, Ahmed KD, Gilani SN, et al. (1996): Antiulcer effects of aqueous extract of Nigella sativa and Pongamia pinnata in rats. Fitoterapia, 3, 195-199.
  • Aliyeva E, Umur S, Zafer E, et al. (2004): The effect of polylactide membranes on the levels of reactive oxygen species in periodontal flaps during wound healing. Biomaterials, 25, 4633 – 4637.
  • Arici M, Sagdic O, Gecgel U (2005): Antibacterial effect of Turkish black cumin (Nigella sativa L.) oils. Grasas y Aceites, 56, 259-262.
  • Atiyeh BS, Costagliola M, Hayek SN, et al. (2007): Effect of silver on burn wound infection control and healing: Review of the literature. BURNS, 33, 139-148.Baboir BM (1978): Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med, 298, 629–668.
  • Benrath J, Zimmermann M, Gillardon F (1995): Substance P and nitric oxide mediate wound healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation. Neurosci Lett, 200, 17-20.
  • Buege JA, Aust SD (1978): Microsomal lipid peroxidation. Methods Enzymol, 52, 302 - 310.
  • Bulgrin JP, Shabani M, Chakravarthy D, et al. (1995): Nitric oxide synthesis is suppressed in steroid-impaired and diabetic wounds. Wounds, 7, 48-57.
  • Burits M, Bucar F (2000): Antioxidant activity of Nigella sativa essential oil. Phytotherapy Research, 14, 323-328.
  • Denk H, Künzele H, Plenk H, et al. (1989): Romeis Mikroskopische Technik. 17. Neubearbeitete Auflage. 439 - 450. Urban und Schwarzenberg, Wien, München Baltimore.
  • Diegelmann RF, Evans MC (2004): Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci, 9, 283-289.
  • Dorsett-Martin WA (2004): Rat models of skin wound healing: A Review. Wound Rep Reg, 12, 591-599.
  • Durmus AS, Han MC, Yaman I (2009): Comparative evaluation of collagenase and silver sulfadiazine on burned wound healing in rats. Fırat University Veterinary Journal of Health Sciences, 23, 135-139.
  • Engin A (2004): Yara iyileşmesi. 266-277. In: İ Sayek (Ed), Temel Cerrahi. Güneş Kitabevi, Ankara.
  • Freeman BA, Crapo JD (1982): Biology of disease: free radicals and tissue injury. Laboratory Investigation, 47, 412 - 424.
  • Gibson-Corley KN, Olivier AK, Meyerholz DK (2013): Principles for valid histopathologic scoring in research. Vet Pathol, 50, 1007-1015.
  • Gubta A, Singh RL, Roghubir R (2002): Antioxidant status during cutaneous wound healing in immunocompromised rats. Mol Cell Biochem, 241, 1-7.
  • Houghton PJ, Zarka R, Heras B, et al. (1995): Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med, 61, 33-36.
  • Meral I, Yener Z, Kahraman T, et al. (2001): Effect of Nigella sativa on Glucose Concentration, Lipid Peroxidation, Anti‐Oxidant Defence System and Liver Damage in Experimentally‐Induced Diabetic Rabbits. VMS Veterinary Medicine and Science, 48, 593-599.
  • Miranda KM, Espey MG, Wink AD (2001): A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide, 5, 62 - 71.
  • Musalmah M, Fairuz AH, Gapor MT, et al. (2002): Effect of Vitamin E on plasma malondialdehyde, antioxidant enzyme levels and the rates of wound closures during wound healing in normal and diabetic rats. Asia Pac J Clin Nutr, 11, S448-51.
  • Özyurt H, Irmak MK, Akyol Ö, et al. (2001): Caffeic acid phenethyl ester changes the indices of oxidative stress in the serum of rats with renal ischemia-reperfusion injury. Cell Biochem Funct, 19, 259-63.
  • Pham-Huy LA, He H, Pham-Huy C (2008): Free Radicals, Antioxidants in Disease and Health. IJBS, 4, 89-96.
  • Schaffer MR, Tantry M, Efron PA, et al. (1997): Diabetes impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery, 121, 513-9.
  • Serarslan G, Altuğ ME, Kontaş T (2007): Kafeik Asid Fenetil Ester'in insizyonel Yara Modelinde Plazma Lipid Peroksidasyonu, Antioksidan Durum ve Nitrik Oksit Seviyesi Üzerine Etkisi. Türkderm, 41, 11-4.
  • Sidhu GS, Mani H, Gaddipatti JP et al. (1999): Curcumin enhances wound healing in streptozotocin-induced diabetic rats and genetically diabetic mice. Wound Rep Reg, 7, 362 – 374.
  • Thiem B, Grosslinka O (2003): Antimicrobial activity of Rubus chamaemorus leaves. Fitoterapia, 75, 93 – 95.
  • Worthen DR, Ghosheh OA, Crooks PA (1998): The invitro anti-tumor activity of some crude and purified components of the black seed, Nigella sativa L. Anticancer Research, 18, 1527-1532.
  • Yaman I, Durmus AS, Ceribaşı S, et al. (2010): Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats. Veterinarni Medicina, 12, 619-624.
  • Yaman I, Balıkçı E (2010): Protective effects of Nigella sativa against gentamicin-induced nephrotoxicity in rats. Experimental and Toxicologic Pathology, 62, 183-190.
  • Yamasaki K, Edington HDJ, McClosky C, et al. (1998): Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest, 101, 967-71.

Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats

Yıl 2020, Cilt 67, Sayı 1, 33 - 40, 26.12.2019
https://doi.org/10.33988/auvfd.563491

Öz

The present study was undertaken to evaluate of Nigella sativa oil (NSO) and zinc-silver cream in a rat model of wound healing by means of clinical appearance, histopathology, oxidative stress parameters, and biomechanical tests. The rats were divided into three groups, each having twenty animals. Group 1 served as a control having wound. Other two groups received either NS oil or zinc-silver cream in addition to the wound.  The study was initiated after the animals rested for 2 weeks for acclimation. Blood samples were collected from 10 randomly selected animals from each group at days 0, 3, 7 and 14 for oxidative stress measurements. Differences among groups for blood lipid peroxidation and antioxidant values were determined with respect to biochemical oxidative stress results (P<0.01). Wound sites of 10 animals from each group were allocated for histopathological examinations, and those of the remaining 10 animals from each group were used in biomechanical testing. Histopathological examination revealed that epithelization occurred in all groups. Inflammatory response with an intensive vascularization was present in the samples of the silver group (P<0.01). Consequently, zinc-silver group has differed positively in terms of biochemical and biomechanical and histological aspects compared to other groups for wound healing and oxidative stress.

Kaynakça

  • Agarwal R, Kharya MD, Shrivastava R (1979): Antimicrobial and anthelmintic activities of the essential oil of Nigella sativa Linn. IJEB, 17, 1264-1265.
  • Akhtar AH, Ahmed KD, Gilani SN, et al. (1996): Antiulcer effects of aqueous extract of Nigella sativa and Pongamia pinnata in rats. Fitoterapia, 3, 195-199.
  • Aliyeva E, Umur S, Zafer E, et al. (2004): The effect of polylactide membranes on the levels of reactive oxygen species in periodontal flaps during wound healing. Biomaterials, 25, 4633 – 4637.
  • Arici M, Sagdic O, Gecgel U (2005): Antibacterial effect of Turkish black cumin (Nigella sativa L.) oils. Grasas y Aceites, 56, 259-262.
  • Atiyeh BS, Costagliola M, Hayek SN, et al. (2007): Effect of silver on burn wound infection control and healing: Review of the literature. BURNS, 33, 139-148.Baboir BM (1978): Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med, 298, 629–668.
  • Benrath J, Zimmermann M, Gillardon F (1995): Substance P and nitric oxide mediate wound healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation. Neurosci Lett, 200, 17-20.
  • Buege JA, Aust SD (1978): Microsomal lipid peroxidation. Methods Enzymol, 52, 302 - 310.
  • Bulgrin JP, Shabani M, Chakravarthy D, et al. (1995): Nitric oxide synthesis is suppressed in steroid-impaired and diabetic wounds. Wounds, 7, 48-57.
  • Burits M, Bucar F (2000): Antioxidant activity of Nigella sativa essential oil. Phytotherapy Research, 14, 323-328.
  • Denk H, Künzele H, Plenk H, et al. (1989): Romeis Mikroskopische Technik. 17. Neubearbeitete Auflage. 439 - 450. Urban und Schwarzenberg, Wien, München Baltimore.
  • Diegelmann RF, Evans MC (2004): Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci, 9, 283-289.
  • Dorsett-Martin WA (2004): Rat models of skin wound healing: A Review. Wound Rep Reg, 12, 591-599.
  • Durmus AS, Han MC, Yaman I (2009): Comparative evaluation of collagenase and silver sulfadiazine on burned wound healing in rats. Fırat University Veterinary Journal of Health Sciences, 23, 135-139.
  • Engin A (2004): Yara iyileşmesi. 266-277. In: İ Sayek (Ed), Temel Cerrahi. Güneş Kitabevi, Ankara.
  • Freeman BA, Crapo JD (1982): Biology of disease: free radicals and tissue injury. Laboratory Investigation, 47, 412 - 424.
  • Gibson-Corley KN, Olivier AK, Meyerholz DK (2013): Principles for valid histopathologic scoring in research. Vet Pathol, 50, 1007-1015.
  • Gubta A, Singh RL, Roghubir R (2002): Antioxidant status during cutaneous wound healing in immunocompromised rats. Mol Cell Biochem, 241, 1-7.
  • Houghton PJ, Zarka R, Heras B, et al. (1995): Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med, 61, 33-36.
  • Meral I, Yener Z, Kahraman T, et al. (2001): Effect of Nigella sativa on Glucose Concentration, Lipid Peroxidation, Anti‐Oxidant Defence System and Liver Damage in Experimentally‐Induced Diabetic Rabbits. VMS Veterinary Medicine and Science, 48, 593-599.
  • Miranda KM, Espey MG, Wink AD (2001): A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide, 5, 62 - 71.
  • Musalmah M, Fairuz AH, Gapor MT, et al. (2002): Effect of Vitamin E on plasma malondialdehyde, antioxidant enzyme levels and the rates of wound closures during wound healing in normal and diabetic rats. Asia Pac J Clin Nutr, 11, S448-51.
  • Özyurt H, Irmak MK, Akyol Ö, et al. (2001): Caffeic acid phenethyl ester changes the indices of oxidative stress in the serum of rats with renal ischemia-reperfusion injury. Cell Biochem Funct, 19, 259-63.
  • Pham-Huy LA, He H, Pham-Huy C (2008): Free Radicals, Antioxidants in Disease and Health. IJBS, 4, 89-96.
  • Schaffer MR, Tantry M, Efron PA, et al. (1997): Diabetes impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery, 121, 513-9.
  • Serarslan G, Altuğ ME, Kontaş T (2007): Kafeik Asid Fenetil Ester'in insizyonel Yara Modelinde Plazma Lipid Peroksidasyonu, Antioksidan Durum ve Nitrik Oksit Seviyesi Üzerine Etkisi. Türkderm, 41, 11-4.
  • Sidhu GS, Mani H, Gaddipatti JP et al. (1999): Curcumin enhances wound healing in streptozotocin-induced diabetic rats and genetically diabetic mice. Wound Rep Reg, 7, 362 – 374.
  • Thiem B, Grosslinka O (2003): Antimicrobial activity of Rubus chamaemorus leaves. Fitoterapia, 75, 93 – 95.
  • Worthen DR, Ghosheh OA, Crooks PA (1998): The invitro anti-tumor activity of some crude and purified components of the black seed, Nigella sativa L. Anticancer Research, 18, 1527-1532.
  • Yaman I, Durmus AS, Ceribaşı S, et al. (2010): Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats. Veterinarni Medicina, 12, 619-624.
  • Yaman I, Balıkçı E (2010): Protective effects of Nigella sativa against gentamicin-induced nephrotoxicity in rats. Experimental and Toxicologic Pathology, 62, 183-190.
  • Yamasaki K, Edington HDJ, McClosky C, et al. (1998): Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest, 101, 967-71.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Hekimlik
Bölüm Makaleler
Yazarlar

Ali KUMANDAŞ> (Sorumlu Yazar)
KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF SURGERY
0000-0002-7679-2126
Türkiye


Birkan KARSLI>
KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF SURGERY
0000-0003-4208-3134
Türkiye


Aytül KÜRÜM>
KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF HISTOLOGY
0000-0002-0170-0231
Türkiye


Miyase ÇINAR>
KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF BIOCHEMISTRY
0000-0003-3806-9938
Türkiye


Ertuğrul ELMA Bu kişi benim
KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF SURGERY
0000-0001-8795-6512
Türkiye

Yayımlanma Tarihi 26 Aralık 2019
Yayınlandığı Sayı Yıl 2020, Cilt 67, Sayı 1

Kaynak Göster

Bibtex @araştırma makalesi { auvfd563491, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2019}, volume = {67}, number = {1}, pages = {33 - 40}, doi = {10.33988/auvfd.563491}, title = {Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats}, key = {cite}, author = {Kumandaş, Ali and Karslı, Birkan and Kürüm, Aytül and Çınar, Miyase and Elma, Ertuğrul} }
APA Kumandaş, A. , Karslı, B. , Kürüm, A. , Çınar, M. & Elma, E. (2019). Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 67 (1) , 33-40 . DOI: 10.33988/auvfd.563491
MLA Kumandaş, A. , Karslı, B. , Kürüm, A. , Çınar, M. , Elma, E. "Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2019 ): 33-40 <http://vetjournal.ankara.edu.tr/tr/pub/issue/48774/563491>
Chicago Kumandaş, A. , Karslı, B. , Kürüm, A. , Çınar, M. , Elma, E. "Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2019 ): 33-40
RIS TY - JOUR T1 - Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats AU - AliKumandaş, BirkanKarslı, AytülKürüm, MiyaseÇınar, ErtuğrulElma Y1 - 2019 PY - 2019 N1 - doi: 10.33988/auvfd.563491 DO - 10.33988/auvfd.563491 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 33 EP - 40 VL - 67 IS - 1 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.563491 UR - https://doi.org/10.33988/auvfd.563491 Y2 - 2019 ER -
EndNote %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats %A Ali Kumandaş , Birkan Karslı , Aytül Kürüm , Miyase Çınar , Ertuğrul Elma %T Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats %D 2019 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 67 %N 1 %R doi: 10.33988/auvfd.563491 %U 10.33988/auvfd.563491
ISNAD Kumandaş, Ali , Karslı, Birkan , Kürüm, Aytül , Çınar, Miyase , Elma, Ertuğrul . "Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 / 1 (Aralık 2019): 33-40 . https://doi.org/10.33988/auvfd.563491
AMA Kumandaş A. , Karslı B. , Kürüm A. , Çınar M. , Elma E. Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats. Ankara Univ Vet Fak Derg. 2019; 67(1): 33-40.
Vancouver Kumandaş A. , Karslı B. , Kürüm A. , Çınar M. , Elma E. Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2019; 67(1): 33-40.
IEEE A. Kumandaş , B. Karslı , A. Kürüm , M. Çınar ve E. Elma , "Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 67, sayı. 1, ss. 33-40, Ara. 2019, doi:10.33988/auvfd.563491