The present study was undertaken to
evaluate of Nigella sativa oil (NSO)
and zinc-silver cream in a rat model of
wound healing by means of clinical appearance, histopathology, oxidative stress
parameters, and biomechanical tests. The rats were divided into three groups, each having twenty
animals. Group 1 served as a control having wound. Other two groups received
either NS oil or zinc-silver cream in addition to the wound. The study was initiated after the animals rested for
2 weeks for acclimation. Blood samples were collected from 10 randomly selected animals from
each group at days 0, 3, 7 and 14 for oxidative stress measurements. Differences among groups for blood lipid peroxidation and
antioxidant values were determined with respect to biochemical oxidative stress
results (P<0.01). Wound sites of 10 animals from each
group were allocated for histopathological examinations, and those of the
remaining 10 animals from each group were used in biomechanical testing. Histopathological examination
revealed that epithelization occurred in all groups. Inflammatory
response with an intensive vascularization was present in the samples of the silver group (P<0.01).
Consequently, zinc-silver group has differed positively in terms of
biochemical and biomechanical and histological aspects compared to other groups for
wound healing and oxidative stress.
Nigella sativa oil Oxidative stress rat wound healing zinc-silver
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Cerrahi |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 26 Aralık 2019 |
Yayımlandığı Sayı | Yıl 2020Cilt: 67 Sayı: 1 |