Research Article
Year 2025,
Accepted Papers, 1 - 9
Abstract
Project Number
IR.UMA.REC.1402.099
References
- Amorati R, Foti MC, Valgimigli L (2013): Antioxidant activity of essential oils. J Agric Food Chem, 61, 10835–10847.
- AOAC (2000): Method 973.18. Official methods of analysis. Association of Official Analytical Chemists, International, Gaithersburg, MD, USA.
- Asghari M, Abdi-Benemar H, Maheri-Sis N, et al (2021): Effects of emulsified essential oils blend on performance, blood metabolites, oxidative status and intestinal microflora of suckling calves. Anim Feed Sci Technol, 277, 114954.
- Baskara AP, Ariyadi B, Dono ND, et al (2020): The Potential use of essential oil nanoemulsion as a novel alternative to antibiotics in poultry production‐A review. Iran J Appl Anim Sci, 10, 203-212.
- Chen H, Davidson PM, Zhong Q (2014): Impacts of sample preparation methods on solubility and antilisterial characteristics of essential oil components in milk. Appl Environ Microbiol, 80, 907-916.
- Chen X, Shang S, Yan F, et al (2023): Antioxidant activities of essential oils and their major components in scavenging free radicals, inhibiting lipid oxidation and reducing cellular oxidative stress. Molecules, 28, 4559.
- Costa DC, Costa HS, Gonçalves Albuquerque T, et al (2015): Advances in phenolic compounds analysis of aromatic plants and their potential applications. Trends Food Sci Technol, 45, 336-354
- Da Costa S, Basri M, Shamsudin N, et al (2014): Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application. J Chem, 2014, 1-8.
- Dadkhah A, Fatemi F, Rasooli A, et al (2018): Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture. Pharm Biol, 56, 495-504.
- Donsi F, Annuanziata M, Sessa M, et al (2011): Nano-encapsulation of essential oils to enhance their antimicrobial activity in foods. Food Sci Technol, 44, 1908–1914.
- Farzaei MH, Bahramsoltani R, Ghobadi A, et al (2017): Pharmacological activity of Mentha longifolia and its phytoconstituents. J Tradit Chin Med, 37, 710-20.
- Favaretto JA, Alba DF, Marchiori MS, et al (2020): Supplementation with a blend based on micro-encapsulated carvacrol, thymol, and cinnamaldehyde in lambs feed inhibits immune cells and improves growth performance. Livest Sci, 240, 104144.
- Fazeli-Nasab B, Fooladvand Z (2016): A review on Iranian Carum copticum (L.): composition and biological activities. European J Med Plants, 12, 1-8.
- Ghadimian S, Esmaeili F (2016): Chemical composition of the essential oils of Carum copticum. J Essent Oil-Bear Plants, 19, 1834-1836.
- Jaiswal M, Dudhe R, Sharma PK (2015): Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech, 5, 123–127.
- Khalili B, Abdi-benemar H, Seifdavati J, et al (2024): Micellized conjugated linoleic acid as an immune modifier feed additive for suckling calves. Ankara Univ Vet Fak Derg, 71, 445-52.
- Khan MA, Lee HJ, Lee WS, et al (2007): Starch source evaluation in calf starter: I. feed consumption, body weight gain, structural growth, and blood metabolites in Holstein calves. J Dairy Sci, 90, 5259- 5268.
- Kozics K, Srancikova A, Sedlackova E, et al (2017): Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells. Neoplasma, 64, 485-93.
- Kuyumcu F, Aycan A (2018): Evaluation of oxidative stress levels and antioxidant enzyme activities in burst fractures. Med Sci Monit, 24, 225-234.
- Li J, Lei J, He L, et al (2019): Evaluation and monitoring of superoxide dismutase (SOD) activity and its clinical significance in gastric cancer: a systematic review and meta-analysis. Med Sci Moni, 25, 2032-2042.
- Liew SN, Utra U, Alias AK, et al (2020): Physical, morphological and antibacterial properties of lime essential oil nanoemulsions prepared via spontaneous emulsification method. LWT, 128, 109388.
- Lowe GL, Sutherland MA, Waas JR, et al (2019): Physiological and behavioral responses as indicators for early disease detection in dairy calves. J Dairy Sci, 102, 5389-5402.
- Mahmudul Hasan KM, Tamanna N, Anwarul Haque M (2018): Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed. Food Sci Hum Wellness, 7, 77-82.
- Mandal S, DebMandal M (2016): Essential Oils in Food Preservation, Flavor and Safety, 1st Ed, 825-834. Department of Nutrition and Dietetics, King’s College London, London, UK.
- McGill MR (2016): The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J, 15, 817-828.
- Moore K, Roberts LJ (1998): Measurement of lipid peroxidation. Free Radic Res, 2, 659-671.
- Mueller K, Blum NM, Kluge H, et al (2012): Influence of broccoli extract and various essential oils on performance and expression of xenobiotic and antioxidant enzymes in broiler chickens. Br J Nutr, 108, 588-602.
- Nhung NT, Chansiripornchai N, Carrique-Mas JJ (2017): Antimicrobial Resistance in Bacterial Poultry Pathogens: A Review. Front Vet Sci, 4, 126.
- Oh J, Wall EH, Bravo DM, et al (2017): Host-mediated effects of phytonutrients in ruminants: a review. J Dairy Sci, 100, 5974–5983.
- Pawar MM, Kamra DN, Chaudhary LC, et al (2019): Nutrient’s utilization, methane emission, immune function, blood metabolites and performance of buffalo calves fed Trachyspermum copticum seed oil. Indian J Anim Sci, 89, 63–67.
- Rezaei Sarteshnizi F, Abdi-Benemar H, Seifdavati J, et al (2020): Influence of spray-dried rumen fluid supplementation on performance, blood metabolites and cytokines in suckling Holstein calves. Animal, 14, 1849-56.
- Rostami R, Eslamifar Z, Nazemi S, et al (2022): The effect of thyme essential oil on liver ınjuries caused by renal ıschemia‐reperfusion in Rats. Biomed Res Int, 2022, 2988334.
- Salazar LFL, Nero LA, Campos-Galvao MEM, et al (2019): Effect of selected feed additives to improve growth and health of dairy calves. PLoS One, 14, e0216066.
- Sandner G, Heckmann M, Weghuber J (2020): Immunomodulatory activities of selected essential oils. Biomolecules, 10, 1139.
- SAS Institute (2003): SAS User’s Guide: Statistics, Release 9.1. SAS Inst, Inc, Cary, NC.
- Selmi S, Jallouli M, Gharbi N, et al (2015): Hepatoprotective and renoprotective effects of lavender (Lavandula stoechas L.) essential oils against malathion-induced oxidative stress in young male mice. J Med Food, 18, 1103-11.
- Sundararajan B, Moola AK, Vivek K, et al (2018): Formulation of nanoemulsion from leaves essential oil of Ocimum basilicum L. and its antibacterial, antioxidant and larvicidal activities (Culex quinquefasciatus). Microb Pathog, 125, 475-485.
- Van Soest PJ, Robertson JB, Lewis BA (1991): Methods for dietary fiber, neutral detergent fiber and non-starch polysaccharides in relation to animal nutrition. J Dairy Sci, 74, 3583-3597.
- Vizioli J, Salzet M (2003): Antimicrobial peptides: new weapons to control parasitic infections? Trends Parasitol, 19, 32-40
- Volpato A, Crecencio RB, Tomasi T, et al (2019): Phytogenic as feed additive for suckling dairy calves’ has a beneficial effect on animal health and performance. An Acad Bras Ciênc, 91, e20180747.
Effect of nanomicelles of Thymus vulgaris, Carum copticum, Mentha longifolia, and Lavandula angustifolia essential oils on the performance and health status of suckling calves
Abstract
This study investigated the effects of nanomicelles of four essential oils on functional and antioxidant parameters of 48 male Holstein newborn calves. The calves were assigned to six groups and monitored over a 46-day period. The groups included one control group and five treatment groups, each receiving 400 mg of a specific nanomicellized essential oil (NEO) – Thymus vulgaris (TNEO), Carum copticum (CNEO), Mentha longifolia (MNEO), Lavandula angustifolia (LNEO) – or a blend of all four (BNEO), administered daily via 8 ml of milk emulsion. No significant differences in average daily weight gain (ADG) were observed among the groups during days 0-14 and 14-32. However, during days 32-46, calves supplemented with TNEO and LNEO showed significantly higher ADG (P=0.004). Calves receiving LNEO exhibited significantly higher blood concentrations of total protein (P=0.022) and albumin (P=0.046) compared to both the control and other treatment groups. Alanine aminotransferase (ALT) levels were lower in the TNEO, LNEO, MNEO, and BNEO groups compared to the control (P=0.012). Blood glutathione peroxidase (GPx) (P=0.009) and superoxide dismutase (SOD) (P=0.001) activities were elevated in the TNEO and BNEO groups. Malondialdehyde (MDA) concentrations were reduced in all NEO-supplemented groups, with the lowest levels observed in the TNEO group (P=0.009). Although the control group exhibited the lowest total antioxidant capacity (TAC), no significant differences were detected among the NEO-treated groups. Overall, these findings suggest that nanomicellized essential oils of Lavandula angustifolia and Thymus vulgaris confer the most notable benefits to suckling calves, enhancing weight gain, feed consumption, blood parameters, and oxidative stress markers.
Project Number
IR.UMA.REC.1402.099
References
- Amorati R, Foti MC, Valgimigli L (2013): Antioxidant activity of essential oils. J Agric Food Chem, 61, 10835–10847.
- AOAC (2000): Method 973.18. Official methods of analysis. Association of Official Analytical Chemists, International, Gaithersburg, MD, USA.
- Asghari M, Abdi-Benemar H, Maheri-Sis N, et al (2021): Effects of emulsified essential oils blend on performance, blood metabolites, oxidative status and intestinal microflora of suckling calves. Anim Feed Sci Technol, 277, 114954.
- Baskara AP, Ariyadi B, Dono ND, et al (2020): The Potential use of essential oil nanoemulsion as a novel alternative to antibiotics in poultry production‐A review. Iran J Appl Anim Sci, 10, 203-212.
- Chen H, Davidson PM, Zhong Q (2014): Impacts of sample preparation methods on solubility and antilisterial characteristics of essential oil components in milk. Appl Environ Microbiol, 80, 907-916.
- Chen X, Shang S, Yan F, et al (2023): Antioxidant activities of essential oils and their major components in scavenging free radicals, inhibiting lipid oxidation and reducing cellular oxidative stress. Molecules, 28, 4559.
- Costa DC, Costa HS, Gonçalves Albuquerque T, et al (2015): Advances in phenolic compounds analysis of aromatic plants and their potential applications. Trends Food Sci Technol, 45, 336-354
- Da Costa S, Basri M, Shamsudin N, et al (2014): Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application. J Chem, 2014, 1-8.
- Dadkhah A, Fatemi F, Rasooli A, et al (2018): Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture. Pharm Biol, 56, 495-504.
- Donsi F, Annuanziata M, Sessa M, et al (2011): Nano-encapsulation of essential oils to enhance their antimicrobial activity in foods. Food Sci Technol, 44, 1908–1914.
- Farzaei MH, Bahramsoltani R, Ghobadi A, et al (2017): Pharmacological activity of Mentha longifolia and its phytoconstituents. J Tradit Chin Med, 37, 710-20.
- Favaretto JA, Alba DF, Marchiori MS, et al (2020): Supplementation with a blend based on micro-encapsulated carvacrol, thymol, and cinnamaldehyde in lambs feed inhibits immune cells and improves growth performance. Livest Sci, 240, 104144.
- Fazeli-Nasab B, Fooladvand Z (2016): A review on Iranian Carum copticum (L.): composition and biological activities. European J Med Plants, 12, 1-8.
- Ghadimian S, Esmaeili F (2016): Chemical composition of the essential oils of Carum copticum. J Essent Oil-Bear Plants, 19, 1834-1836.
- Jaiswal M, Dudhe R, Sharma PK (2015): Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech, 5, 123–127.
- Khalili B, Abdi-benemar H, Seifdavati J, et al (2024): Micellized conjugated linoleic acid as an immune modifier feed additive for suckling calves. Ankara Univ Vet Fak Derg, 71, 445-52.
- Khan MA, Lee HJ, Lee WS, et al (2007): Starch source evaluation in calf starter: I. feed consumption, body weight gain, structural growth, and blood metabolites in Holstein calves. J Dairy Sci, 90, 5259- 5268.
- Kozics K, Srancikova A, Sedlackova E, et al (2017): Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells. Neoplasma, 64, 485-93.
- Kuyumcu F, Aycan A (2018): Evaluation of oxidative stress levels and antioxidant enzyme activities in burst fractures. Med Sci Monit, 24, 225-234.
- Li J, Lei J, He L, et al (2019): Evaluation and monitoring of superoxide dismutase (SOD) activity and its clinical significance in gastric cancer: a systematic review and meta-analysis. Med Sci Moni, 25, 2032-2042.
- Liew SN, Utra U, Alias AK, et al (2020): Physical, morphological and antibacterial properties of lime essential oil nanoemulsions prepared via spontaneous emulsification method. LWT, 128, 109388.
- Lowe GL, Sutherland MA, Waas JR, et al (2019): Physiological and behavioral responses as indicators for early disease detection in dairy calves. J Dairy Sci, 102, 5389-5402.
- Mahmudul Hasan KM, Tamanna N, Anwarul Haque M (2018): Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed. Food Sci Hum Wellness, 7, 77-82.
- Mandal S, DebMandal M (2016): Essential Oils in Food Preservation, Flavor and Safety, 1st Ed, 825-834. Department of Nutrition and Dietetics, King’s College London, London, UK.
- McGill MR (2016): The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J, 15, 817-828.
- Moore K, Roberts LJ (1998): Measurement of lipid peroxidation. Free Radic Res, 2, 659-671.
- Mueller K, Blum NM, Kluge H, et al (2012): Influence of broccoli extract and various essential oils on performance and expression of xenobiotic and antioxidant enzymes in broiler chickens. Br J Nutr, 108, 588-602.
- Nhung NT, Chansiripornchai N, Carrique-Mas JJ (2017): Antimicrobial Resistance in Bacterial Poultry Pathogens: A Review. Front Vet Sci, 4, 126.
- Oh J, Wall EH, Bravo DM, et al (2017): Host-mediated effects of phytonutrients in ruminants: a review. J Dairy Sci, 100, 5974–5983.
- Pawar MM, Kamra DN, Chaudhary LC, et al (2019): Nutrient’s utilization, methane emission, immune function, blood metabolites and performance of buffalo calves fed Trachyspermum copticum seed oil. Indian J Anim Sci, 89, 63–67.
- Rezaei Sarteshnizi F, Abdi-Benemar H, Seifdavati J, et al (2020): Influence of spray-dried rumen fluid supplementation on performance, blood metabolites and cytokines in suckling Holstein calves. Animal, 14, 1849-56.
- Rostami R, Eslamifar Z, Nazemi S, et al (2022): The effect of thyme essential oil on liver ınjuries caused by renal ıschemia‐reperfusion in Rats. Biomed Res Int, 2022, 2988334.
- Salazar LFL, Nero LA, Campos-Galvao MEM, et al (2019): Effect of selected feed additives to improve growth and health of dairy calves. PLoS One, 14, e0216066.
- Sandner G, Heckmann M, Weghuber J (2020): Immunomodulatory activities of selected essential oils. Biomolecules, 10, 1139.
- SAS Institute (2003): SAS User’s Guide: Statistics, Release 9.1. SAS Inst, Inc, Cary, NC.
- Selmi S, Jallouli M, Gharbi N, et al (2015): Hepatoprotective and renoprotective effects of lavender (Lavandula stoechas L.) essential oils against malathion-induced oxidative stress in young male mice. J Med Food, 18, 1103-11.
- Sundararajan B, Moola AK, Vivek K, et al (2018): Formulation of nanoemulsion from leaves essential oil of Ocimum basilicum L. and its antibacterial, antioxidant and larvicidal activities (Culex quinquefasciatus). Microb Pathog, 125, 475-485.
- Van Soest PJ, Robertson JB, Lewis BA (1991): Methods for dietary fiber, neutral detergent fiber and non-starch polysaccharides in relation to animal nutrition. J Dairy Sci, 74, 3583-3597.
- Vizioli J, Salzet M (2003): Antimicrobial peptides: new weapons to control parasitic infections? Trends Parasitol, 19, 32-40
- Volpato A, Crecencio RB, Tomasi T, et al (2019): Phytogenic as feed additive for suckling dairy calves’ has a beneficial effect on animal health and performance. An Acad Bras Ciênc, 91, e20180747.
There are 40 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Food Hygiene and Technology |
| Journal Section | Research Article |
| Authors | |
| Project Number | IR.UMA.REC.1402.099 |
| Early Pub Date | June 13, 2025 |
| Publication Date | |
| Submission Date | February 20, 2025 |
| Acceptance Date | May 26, 2025 |
| Published in Issue | Year 2025Accepted Papers |