Complex clinical symptoms such as ulcerative skin lesions, destructive mucosal inflammation, and disseminated
visceral infection can reveal in leishmaniasis. The conventional drugs are toxic and expensive. In addition, patients receive a long
treatment with these drugs which have adverse effects and unfortunately there are some limitations during the treatment. The aim of
this study is to investigate the in vitro anti-leishmanial activities of four different extracts of Sarcopoterium spinosum against
Leishmania tropica. Initially, different concentrations of ethanol, methanol, n-hexane, and water extracts of S. spinosum were incubated
with L. tropica promastigotes. After 72 hours of incubation, the growth of L. tropica promastigotes was significantly inhibited and the
percentage of inhibition ranged between 42.8 and 100 %. Among these extracts, the most efficient growth inhibition (100 %) was
obtained with methanol extract (at a dose of 50 µg/ml). In conclusion, S. spinosum may be a potential source for the development of
novel therapeutic agents to treat L. tropica infection.
Anti-leishmanial activity in vitro Leishmania tropica Sarcopoterium spinosum
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Cerrahi |
Bölüm | Araştırma Makalesi |
Yazarlar | |
Yayımlanma Tarihi | 9 Kasım 2018 |
Yayımlandığı Sayı | Yıl 2018Cilt: 65 Sayı: 4 |