This experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed
intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper. In this study
individually housed thirty-six male Sprague-Dawley rats were used. Animals were randomly divided into six groups; control, copper
sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper
sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip)
and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage). The study
demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper
group (P<0.01). Propolis and flunixin meglumine administration significantly decreased MDA levels in the kidney and liver tissues,
and serum TNF-α levels (P<0.001). Propolis supplementation to rats who were also treated with copper significantly increased the
superoxide dismutase, catalase and reduced glutathione activities (P<0.001). Flunixin meglumine and propolis treatments decreased
the copper-induced degenerative and necrotic changes with the apoptotic cells in the liver and kidney tissues. In conclusion, propolis
appeared to ameliorate the adverse effects on feed intake, liver and kidney tissues seeing in the copper treatment and, apparently caused
by the copper toxicity, by scavenging the free radicals and increasing activity of antioxidants.
Antioxidant status, copper, flunixin meglumine, histological changes, propolis
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Hekimlik |
Bölüm | Araştırma Makalesi |
Yazarlar |
|
Yayımlanma Tarihi | 9 Kasım 2018 |
Yayınlandığı Sayı | Yıl 2018Cilt: 65 Sayı: 4 |
Bibtex | @araştırma makalesi { auvfd635499, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2018}, volume = {65}, number = {4}, pages = {395 - 406}, doi = {10.1501/Vetfak\_0000002873}, title = {The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats}, key = {cite}, author = {Tatlı Seven, Pınar and Gül Baykalır, Burcu and Parlak Ak, Tuba and Seven, İsmail and Başak, Neşe and Yaman, Mine} } |
APA | Tatlı Seven, P. , Gül Baykalır, B. , Parlak Ak, T. , Seven, İ. , Başak, N. & Yaman, M. (2018). The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 65 (4) , 395-406 . DOI: 10.1501/Vetfak_0000002873 |
MLA | Tatlı Seven, P. , Gül Baykalır, B. , Parlak Ak, T. , Seven, İ. , Başak, N. , Yaman, M. "The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 65 (2018 ): 395-406 <http://vetjournal.ankara.edu.tr/tr/pub/issue/49588/635499> |
Chicago | Tatlı Seven, P. , Gül Baykalır, B. , Parlak Ak, T. , Seven, İ. , Başak, N. , Yaman, M. "The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 65 (2018 ): 395-406 |
RIS | TY - JOUR T1 - The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats AU - PınarTatlı Seven, BurcuGül Baykalır, TubaParlak Ak, İsmailSeven, NeşeBaşak, MineYaman Y1 - 2018 PY - 2018 N1 - doi: 10.1501/Vetfak_0000002873 DO - 10.1501/Vetfak_0000002873 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 395 EP - 406 VL - 65 IS - 4 SN - 1300-0861-1308-2817 M3 - doi: 10.1501/Vetfak_0000002873 UR - https://doi.org/10.1501/Vetfak_0000002873 Y2 - 2017 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats %A Pınar Tatlı Seven , Burcu Gül Baykalır , Tuba Parlak Ak , İsmail Seven , Neşe Başak , Mine Yaman %T The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats %D 2018 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 65 %N 4 %R doi: 10.1501/Vetfak_0000002873 %U 10.1501/Vetfak_0000002873 |
ISNAD | Tatlı Seven, Pınar , Gül Baykalır, Burcu , Parlak Ak, Tuba , Seven, İsmail , Başak, Neşe , Yaman, Mine . "The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 65 / 4 (Kasım 2018): 395-406 . https://doi.org/10.1501/Vetfak_0000002873 |
AMA | Tatlı Seven P. , Gül Baykalır B. , Parlak Ak T. , Seven İ. , Başak N. , Yaman M. The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats. Ankara Univ Vet Fak Derg. 2018; 65(4): 395-406. |
Vancouver | Tatlı Seven P. , Gül Baykalır B. , Parlak Ak T. , Seven İ. , Başak N. , Yaman M. The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2018; 65(4): 395-406. |
IEEE | P. Tatlı Seven , B. Gül Baykalır , T. Parlak Ak , İ. Seven , N. Başak ve M. Yaman , "The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 65, sayı. 4, ss. 395-406, Kas. 2018, doi:10.1501/Vetfak_0000002873 |