Ankara Üniversitesi Veteriner Fakültesi Dergisi
Araştırma Makalesi
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Yıl 2020, Cilt: 67 Sayı: 2, 121 - 125, 03.03.2020

Nazlı ERCAN Murat YÜKSEL Mustafa KOÇKAYA

https://doi.org/10.33988/auvfd.492765

Öz

Kaynakça

  • 1. Aebi H (1984): Catalase in vitro. Methods Enzymol, 105, 121-6.
  • 2. Aydın İ, Bülbül A, Avcı GE, et al (2009): Serum oxidative status and adenosine deaminase activity in dogs with transmissible venereal tumour. Bull Vet Inst Pulawy, 53, 771- 774.
  • 3. Baştan A, Baki Acar D, Cengiz M (2008): Uterine and ovarian metastasis of transmissible venereal tumour in a bitch. Turk J Vet Anim Sci, 32, 65-66.
  • 4. Dinçer Y, Akçay T, Kural AR, et al (2011): Evaluation of 8-hydroxy-2'-deoxyguanosine concentration and antioxidant enzyme activities in bladder cancer patients. Turkiye Klinikleri J Med Sci, 31, 553-558.
  • 5. Durak I, Yurtaslanı Z, Canbolat O, et al (1993): A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin Chim Acta, 214,103-104.
  • 6. Ercan N, Fidancı UR (2012): Piyodermalı köpeklerde 8-hidroksi-2’-deoksiguanozin (8-OHdG) düzeyleri. Ankara Üniv Vet Fak Derg, 59, 163-168.
  • 7. Fraga C, Shigenaga M, Park J, et al (1990): Oxidative damage to DNA during aging: 8-Hydroxy-2’-deoxyguanosine in rat organ DNA urine. Proc Natl Acad Sci, 87, 4533-4537.
  • 8. Gencer M, Ceyla E, Aksoy A, et al (2005): Oksidatif stres benign ve malign akciğer hastalıklarının ayırıcı tanısında belirteç olabilir mi? Akciğer Arşivi, 6, 89-92.
  • 9. Haliwell B (2007): Oxidative stress and cancer: have we moved forward? Biochem J, 401, 1-11.
  • 10. Hattori Y, Nishigori C, Tanaka T, et al (1996): 8-hydroxy-2’-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol, 107, 733-737.
  • 11. Janero DR (1990): Malondialdehyde and thiobarbituric acid-reactivy as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med, 9, 515-540.
  • 12. Jayasri K, Padmaja K, Saibaba M (2016): Altered oxidative stress and carbohydrate metabolism in canine mammary tumors. Veterinary world, 9, 1489.
  • 13. Kumaraguruparan R, Balachandran C, Manohar BM, et al (2005): Altered oxidant-antioxidant profile in canine mammary tumours, Vet Res Commun, 29, 287-96.
  • 14. Lin H, Jenner A, Ong C, et al (2004): A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2’-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extraction. Biochem J, 380, 541-548.
  • 15. Macotpet A, Suksawat F, Sukon P, et al (2013): Oxidative stress in cancer-bearing dogs assessed by measuring serum malondialdehyde. BMC Vet Res, 9, 101.
  • 16. Martinis B, Bianchi M (2002): Methodology for urinary 8-hydroxy-2’-deoxyguanosine analysis by HPLC with electrochemical detection. Pharmacol Res, 46, 129-131.
  • 17. Matsufuji H, Ochi H, Shibamoto T (2006): Formation and inhibition of genotoxic malonaldehyde from DNA oxidation controlled with EDTA. Food Chem Toxicol, 44, 236-241.
  • 18. Nak D, Mısırlıoğlu D, Nak Y, et al (2004): Bir köpekte meme metastazlı transmissible venereal tümör olgusu. Vet Bil Derg, 20, 99-102.
  • 19. Paglia DE, WN Valentine (1967): Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med, 70, 158-169.
  • 20. Pilger A, Ivancsits S, Germadnik D, et al (2002): Urinary excretion of 8-hydroxy-2’-deoxyguanosine measured by high-performance liquid chromatography with electrochemical detection. J Chromatogr B, 778, 393-401.
  • 21. SPSS (2014): IBM SPSS Statistics for Windows, ver¬sion 22.00. SPSS Inc., Chicago, IL.
  • 22. Strakova A, Murchison EP (2014): The changing global distribution and prevalence of canine transmissible venereal tumour. BMC Vet Res, 10, 168.
  • 23. Sun Y, Oberley LW, Li Y (1988): A simple method for clinical assay of superoxide dismutase. Clin Chem, 34, 497-500.
  • 24. Tanja P, Alenka NS, Butinar J, et al (2008): Antioxidant status in canine cancer patients. Acta Vet Beograd, 58, 275-286.
  • 25. Tüközkan N, Erdamar H, Seven I (2006): Measurement of total malondialdehyde in plasma and tissues by high-performance liquid chromatography and thiobarbituric acid assay. Fırat Tıp Derg, 11, 88-92.
  • 26. Urso ML, Clarkson PM (2003): Oxidative stress, exercise and antioxidant supplementation. Toxicology, 189, 41-54.
  • 27. Welsh JS (2011). Contagious Cancer. The Oncologist, 16, 1-4.
  • 28. Winter JL, Barber LG., Freeman L, et al (2009): Antioxidant status and biomarkers of oxidative stress in dogs with Lymphoma. J Vet Intern Med, 23, 311-316.
  • 29. Wiseman H, Kaur H, Halliwell B (1995): DNA damage and cancer: measurement and mechanism. Cancer Letters, 93, 113-120.
  • 30. Wu LL, Chiou CC, Chang PY, et al (2004): Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics Clin Chim Acta, 339, 1-9.
  • 31. Zhang F, Stott WT, Clark AJ, et al (2007): Quantitation of 8-hydroxydeoxyguanosine in DNA by liquid chromatography/positive atmospheric pressure photoionization tandem mass spectrometry. Rapid Commun Mass Spectrom, 21, 3949-3955.

Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour

Yıl 2020, Cilt: 67 Sayı: 2, 121 - 125, 03.03.2020

Nazlı ERCAN Murat YÜKSEL Mustafa KOÇKAYA

https://doi.org/10.33988/auvfd.492765

Öz

Canine transmissible venereal tumour (TVT) is a contagious cancer and sexually transmitted one dog to another by allogenic transfer of living cancer cells. The aim of this study is to examine the relationship between antioxidative metabolism and venereal tumour at Kangal Dogs and to show the size of oxidative damage it causes through 8-hydroxy-2’deoxyguanosine (8-OHdG). The materials of this study included the blood sera of 15 Kangal Dogs with TVT, and as a control group of 15 healthy Kangal Dogs. The sera levels of 8-OHdG were determined by competitive enzyme linked immunosorbent assay (ELISA) method. The level of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) which are antioxidative enzymes were investigated by spectrophotometric methods as described. Serum 8-OHdG and MDA levels of dogs with TVT were found to be significantly increased compared to the control group (P<0.001). The levels of GPx were statistically different (P<0.05). In the light of the findings, which are obtained in this study, the transmissible venereal tumour, which is an infectious and treatable type of cancer, can lead to new studies that may be caused by oxidant-antioxidant metabolism.

Anahtar Kelimeler

antioxidant enzymes, Kangal dog, transmissible venereal tumour, 8-OHdG

Kaynakça

  • 1. Aebi H (1984): Catalase in vitro. Methods Enzymol, 105, 121-6.
  • 2. Aydın İ, Bülbül A, Avcı GE, et al (2009): Serum oxidative status and adenosine deaminase activity in dogs with transmissible venereal tumour. Bull Vet Inst Pulawy, 53, 771- 774.
  • 3. Baştan A, Baki Acar D, Cengiz M (2008): Uterine and ovarian metastasis of transmissible venereal tumour in a bitch. Turk J Vet Anim Sci, 32, 65-66.
  • 4. Dinçer Y, Akçay T, Kural AR, et al (2011): Evaluation of 8-hydroxy-2'-deoxyguanosine concentration and antioxidant enzyme activities in bladder cancer patients. Turkiye Klinikleri J Med Sci, 31, 553-558.
  • 5. Durak I, Yurtaslanı Z, Canbolat O, et al (1993): A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin Chim Acta, 214,103-104.
  • 6. Ercan N, Fidancı UR (2012): Piyodermalı köpeklerde 8-hidroksi-2’-deoksiguanozin (8-OHdG) düzeyleri. Ankara Üniv Vet Fak Derg, 59, 163-168.
  • 7. Fraga C, Shigenaga M, Park J, et al (1990): Oxidative damage to DNA during aging: 8-Hydroxy-2’-deoxyguanosine in rat organ DNA urine. Proc Natl Acad Sci, 87, 4533-4537.
  • 8. Gencer M, Ceyla E, Aksoy A, et al (2005): Oksidatif stres benign ve malign akciğer hastalıklarının ayırıcı tanısında belirteç olabilir mi? Akciğer Arşivi, 6, 89-92.
  • 9. Haliwell B (2007): Oxidative stress and cancer: have we moved forward? Biochem J, 401, 1-11.
  • 10. Hattori Y, Nishigori C, Tanaka T, et al (1996): 8-hydroxy-2’-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol, 107, 733-737.
  • 11. Janero DR (1990): Malondialdehyde and thiobarbituric acid-reactivy as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med, 9, 515-540.
  • 12. Jayasri K, Padmaja K, Saibaba M (2016): Altered oxidative stress and carbohydrate metabolism in canine mammary tumors. Veterinary world, 9, 1489.
  • 13. Kumaraguruparan R, Balachandran C, Manohar BM, et al (2005): Altered oxidant-antioxidant profile in canine mammary tumours, Vet Res Commun, 29, 287-96.
  • 14. Lin H, Jenner A, Ong C, et al (2004): A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2’-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extraction. Biochem J, 380, 541-548.
  • 15. Macotpet A, Suksawat F, Sukon P, et al (2013): Oxidative stress in cancer-bearing dogs assessed by measuring serum malondialdehyde. BMC Vet Res, 9, 101.
  • 16. Martinis B, Bianchi M (2002): Methodology for urinary 8-hydroxy-2’-deoxyguanosine analysis by HPLC with electrochemical detection. Pharmacol Res, 46, 129-131.
  • 17. Matsufuji H, Ochi H, Shibamoto T (2006): Formation and inhibition of genotoxic malonaldehyde from DNA oxidation controlled with EDTA. Food Chem Toxicol, 44, 236-241.
  • 18. Nak D, Mısırlıoğlu D, Nak Y, et al (2004): Bir köpekte meme metastazlı transmissible venereal tümör olgusu. Vet Bil Derg, 20, 99-102.
  • 19. Paglia DE, WN Valentine (1967): Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med, 70, 158-169.
  • 20. Pilger A, Ivancsits S, Germadnik D, et al (2002): Urinary excretion of 8-hydroxy-2’-deoxyguanosine measured by high-performance liquid chromatography with electrochemical detection. J Chromatogr B, 778, 393-401.
  • 21. SPSS (2014): IBM SPSS Statistics for Windows, ver¬sion 22.00. SPSS Inc., Chicago, IL.
  • 22. Strakova A, Murchison EP (2014): The changing global distribution and prevalence of canine transmissible venereal tumour. BMC Vet Res, 10, 168.
  • 23. Sun Y, Oberley LW, Li Y (1988): A simple method for clinical assay of superoxide dismutase. Clin Chem, 34, 497-500.
  • 24. Tanja P, Alenka NS, Butinar J, et al (2008): Antioxidant status in canine cancer patients. Acta Vet Beograd, 58, 275-286.
  • 25. Tüközkan N, Erdamar H, Seven I (2006): Measurement of total malondialdehyde in plasma and tissues by high-performance liquid chromatography and thiobarbituric acid assay. Fırat Tıp Derg, 11, 88-92.
  • 26. Urso ML, Clarkson PM (2003): Oxidative stress, exercise and antioxidant supplementation. Toxicology, 189, 41-54.
  • 27. Welsh JS (2011). Contagious Cancer. The Oncologist, 16, 1-4.
  • 28. Winter JL, Barber LG., Freeman L, et al (2009): Antioxidant status and biomarkers of oxidative stress in dogs with Lymphoma. J Vet Intern Med, 23, 311-316.
  • 29. Wiseman H, Kaur H, Halliwell B (1995): DNA damage and cancer: measurement and mechanism. Cancer Letters, 93, 113-120.
  • 30. Wu LL, Chiou CC, Chang PY, et al (2004): Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics Clin Chim Acta, 339, 1-9.
  • 31. Zhang F, Stott WT, Clark AJ, et al (2007): Quantitation of 8-hydroxydeoxyguanosine in DNA by liquid chromatography/positive atmospheric pressure photoionization tandem mass spectrometry. Rapid Commun Mass Spectrom, 21, 3949-3955.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm Araştırma Makalesi
Yazarlar

Nazlı ERCAN
Sivas Cumhuriyet University, Faculty of Veterinary Medicine, Department of Biochemistry
0000-0003-3542-3743
Türkiye

Murat YÜKSEL
Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynecology
0000-0001-6634-0559
Türkiye

Mustafa KOÇKAYA
Sivas Cumhuriyet University, Faculty of Veterinary Medicine, Department of Physiology
0000-0001-5173-0853
Türkiye

Yayımlanma Tarihi 3 Mart 2020
Yayınlandığı Sayı Yıl 2020Cilt: 67 Sayı: 2

Kaynak Göster

Bibtex @araştırma makalesi { auvfd492765, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2020}, volume = {67}, number = {2}, pages = {121 - 125}, doi = {10.33988/auvfd.492765}, title = {Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour}, key = {cite}, author = {Ercan, Nazlı and Yüksel, Murat and Koçkaya, Mustafa} }
APA Ercan, N. , Yüksel, M. & Koçkaya, M. (2020). Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 67 (2) , 121-125 . DOI: 10.33988/auvfd.492765
MLA Ercan, N. , Yüksel, M. , Koçkaya, M. "Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2020 ): 121-125 <http://vetjournal.ankara.edu.tr/tr/pub/issue/52756/492765>
Chicago Ercan, N. , Yüksel, M. , Koçkaya, M. "Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2020 ): 121-125
RIS TY - JOUR T1 - Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour AU - NazlıErcan, MuratYüksel, MustafaKoçkaya Y1 - 2020 PY - 2020 N1 - doi: 10.33988/auvfd.492765 DO - 10.33988/auvfd.492765 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 121 EP - 125 VL - 67 IS - 2 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.492765 UR - https://doi.org/10.33988/auvfd.492765 Y2 - 2019 ER -
EndNote %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour %A Nazlı Ercan , Murat Yüksel , Mustafa Koçkaya %T Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour %D 2020 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 67 %N 2 %R doi: 10.33988/auvfd.492765 %U 10.33988/auvfd.492765
ISNAD Ercan, Nazlı , Yüksel, Murat , Koçkaya, Mustafa . "Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 / 2 (Mart 2020): 121-125 . https://doi.org/10.33988/auvfd.492765
AMA Ercan N. , Yüksel M. , Koçkaya M. Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour. Ankara Univ Vet Fak Derg. 2020; 67(2): 121-125.
Vancouver Ercan N. , Yüksel M. , Koçkaya M. Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2020; 67(2): 121-125.
IEEE N. Ercan , M. Yüksel ve M. Koçkaya , "Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 67, sayı. 2, ss. 121-125, Mar. 2020, doi:10.33988/auvfd.492765