Canine transmissible venereal tumour (TVT) is a contagious cancer and sexually transmitted one dog to another by allogenic transfer of living cancer cells. The aim of this study is to examine the relationship between antioxidative metabolism and venereal tumour at Kangal Dogs and to show the size of oxidative damage it causes through 8-hydroxy-2’deoxyguanosine (8-OHdG). The materials of this study included the blood sera of 15 Kangal Dogs with TVT, and as a control group of 15 healthy Kangal Dogs. The sera levels of 8-OHdG were determined by competitive enzyme linked immunosorbent assay (ELISA) method. The level of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) which are antioxidative enzymes were investigated by spectrophotometric methods as described. Serum 8-OHdG and MDA levels of dogs with TVT were found to be significantly increased compared to the control group (P<0.001). The levels of GPx were statistically different (P<0.05). In the light of the findings, which are obtained in this study, the transmissible venereal tumour, which is an infectious and treatable type of cancer, can lead to new studies that may be caused by oxidant-antioxidant metabolism.
antioxidant enzymes, Kangal dog, transmissible venereal tumour, 8-OHdG
Birincil Dil | İngilizce |
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Konular | Veteriner Cerrahi |
Bölüm | Araştırma Makalesi |
Yazarlar |
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Yayımlanma Tarihi | 3 Mart 2020 |
Yayınlandığı Sayı | Yıl 2020Cilt: 67 Sayı: 2 |
Bibtex | @araştırma makalesi { auvfd492765, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2020}, volume = {67}, number = {2}, pages = {121 - 125}, doi = {10.33988/auvfd.492765}, title = {Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour}, key = {cite}, author = {Ercan, Nazlı and Yüksel, Murat and Koçkaya, Mustafa} } |
APA | Ercan, N. , Yüksel, M. & Koçkaya, M. (2020). Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 67 (2) , 121-125 . DOI: 10.33988/auvfd.492765 |
MLA | Ercan, N. , Yüksel, M. , Koçkaya, M. "Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2020 ): 121-125 <https://vetjournal.ankara.edu.tr/tr/pub/issue/52756/492765> |
Chicago | Ercan, N. , Yüksel, M. , Koçkaya, M. "Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 (2020 ): 121-125 |
RIS | TY - JOUR T1 - Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour AU - NazlıErcan, MuratYüksel, MustafaKoçkaya Y1 - 2020 PY - 2020 N1 - doi: 10.33988/auvfd.492765 DO - 10.33988/auvfd.492765 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 121 EP - 125 VL - 67 IS - 2 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.492765 UR - https://doi.org/10.33988/auvfd.492765 Y2 - 2019 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour %A Nazlı Ercan , Murat Yüksel , Mustafa Koçkaya %T Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour %D 2020 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 67 %N 2 %R doi: 10.33988/auvfd.492765 %U 10.33988/auvfd.492765 |
ISNAD | Ercan, Nazlı , Yüksel, Murat , Koçkaya, Mustafa . "Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour". Ankara Üniversitesi Veteriner Fakültesi Dergisi 67 / 2 (Mart 2020): 121-125 . https://doi.org/10.33988/auvfd.492765 |
AMA | Ercan N. , Yüksel M. , Koçkaya M. Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour. Ankara Univ Vet Fak Derg. 2020; 67(2): 121-125. |
Vancouver | Ercan N. , Yüksel M. , Koçkaya M. Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2020; 67(2): 121-125. |
IEEE | N. Ercan , M. Yüksel ve M. Koçkaya , "Determination of 8-hydroxy-2’deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 67, sayı. 2, ss. 121-125, Mar. 2020, doi:10.33988/auvfd.492765 |