Araştırma Makalesi
Evaluation of the enrofloxacin excretion in Anatolian buffalo milk
Yıl 2021, Cilt: 68 Sayı: 2, 121 - 127, 31.03.2021Öz
Enrofloxacin (ENR) is a broad-spectrum fluoroquinolone antibiotic widely used in both human medicine and veterinary medicine. In this study, the milk-excretion patterns of ENR and its metabolite ciprofloxacin (CIP) were determined up to the 10th milking following the intramuscular administration of ENR (2.5mg/kg of body weight) to lactating dairy buffaloes. The milk of each animal was collected and the concentrations of ENR and CIP were detected in milk by LC-MS/MS. The detection limits of the method were determined for ENR and CIP as 0.35 μg/kg and 0.12 μg/kg, respectively. The highest total mean concentrations of ENR and its metabolite CIP was determined in the second milking after injection as 603 μg/kg. The residue level in all buffalo milk samples was found to be lower than the maximum residue limit (100 μg/kg) at the fifth milking. In addition, the employed method is successfully applied to evaluate the presence of ENR and CIP residue in 50 marketed buffalo milk samples and none of the samples contained these antibiotics. Consequently, the present study provided information on the milk excretion levels of ENR and CIP in Anatolian buffalo milks by an LC-MS/MS method.
Anahtar Kelimeler
Anatolian Buffaloes, Ciprofloxacin, Enrofloxacin, excretion, LC-MS/MS, Milk
Destekleyen Kurum
Afyon Kocatepe University Scientific Research Council
Kaynakça
- Acaroz U, Arslan-Acaroz D, Ince S (2019): A Wide Perspective on Nutrients in Beverages. 1-39. In: Grumezescu AM and Holban AM (Ed) Nutrients in Beverages. Academic Press.
- Acaroz U, Dietrich R, Knauer M, et al (2019): Development of a Generic Enzyme-Immunoassay for the Detection of Fluoro(quinolone)-Residues in Foodstuffs Based on a Highly Sensitive Monoclonal Antibody. Food Anal Methods, 13, 780-792.
- Acaroz U, Ince S, Arslan-Acaroz D, et al (2020): Determination of kanamycin residue in anatolian buffalo milk by LC-MS/MS. Kafkas Univ Vet Fak Derg, 26, 97–102.
- Chui-Shiang C, Wei-Hsien W, Chin-En T (2010): Simultaneous Determination of 18 Quinolone Residues in Marine and Livestock Products by Liquid Chromatography/ Tandem Mass Spectrometry. J Food Drug Anal, 18, 87–97.
- Cinquina AL, Roberti P, Giannetti L, et al (2003): Determination of enrofloxacin and its metabolite ciprofloxacin in goat milk by high-performance liquid chromatography with diode-array detection: Optimization and validation. J Chromatogr A, 987, 221-226.
- Cuypers WL, Jacobs J, Wong V, et al (2018): Fluoroquinolone resistance in Salmonella: Insights by wholegenome sequencing. Microb Genomics, 4, e000195.
- Du C, Deng T, Zhou Y, et al (2019): Systematic analyses for candidate genes of milk production traits in water buffalo (Bubalus Bubalis). Anim Genet, 50, 207–216.
- EU Commission Regulation (2019): Pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Available at https://ec.europa.eu/health/sites/health/files/ files/eudralex/vol-5/reg_2010_37/reg_2010_37_en.pdf. (Accessed January 20, 2020).
- Haritova A, Lashev L, Pashov D (2003): Pharmacokinetics of enrofloxacin in lactating sheep. Res Vet Sci, 74, 241–245.
- Idowu OR, Peggins JO (2004): Simple, rapid determination of enrofloxacin and ciprofloxacin in bovine milk and plasma by high-performance liquid chromatography with fluorescence detection. J Pharm Biomed Anal, 35, 143–153.
- Jank L, Martins MT, Arsand JB, et al (2015): High-throughput method for the determination of residues of β-lactam antibiotics in bovine milk by LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 32, 1992–2001.
- Kaartinen L, Salonen M, Älli L, et al (1995): Pharmacokinetics of enrofloxacin after single intravenous, intramuscular and subcutaneous injections in lactating cows. J Vet Pharmacol Ther, 18, 357–362.
- Kara R, Acaroz U, Gurler Z, et al (2018): Manda Sütlerinde ICP-MS ile Metal ve Ağır Metal Seviyelerinin Belirlenmesi. Kocatepe Vet J, 11, 1–4.
- Lei Z, Liu Q, Yang B, et al (2017): Clinical efficacy and residue depletion of 10% enrofloxacin enteric-coated granules in pigs. Front Pharmacol, 8, 1–11.
- Lizondo M, Pons M, Gallardo M, et al (1997): Physicochemical properties of enrofloxacin. J Pharm Biomed Anal, 15, 1845–1849.
- Lv YK, L Yang, XH Liu, et al (2013): Preparation and evaluation of a novel molecularly imprinted hybrid composite monolithic column for on-line solid-phase extraction coupled with HPLC to detect trace fluoroquinolone residues in milk. Anal Methods, 5, 1848–1855.
- Mahmood T, Abbas M, Ilyas S, et al (2016): Quantification of fluoroquinolone (enrofloxacin, norfloxacin and ciprofloxacin) residues in cow milk. IJCBS, 10, 10–15.
- Malbe M, Salonen M, Fang W, et al (1996): Disposition of enrofloxacin (Baytril) into the udder after intravenous and intra-arterial injections into dairy cows. J Vet Med A, 43, 377–386.
- Mohammed HA, Abdou AM, Eid AM, et al (2016): Rapid tests for detection of enrofloxacin residues in liquid milk. Benha Vet Med J, 30, 97–103.
- Naeem A, Badshah SL, Muska M, et al (2016): The current case of quinolones: Synthetic approaches and antibacterial activity. Molecules, 21, 268.
- Nirala RK, Anjana K, Mandal KG, et al (2017): Persistence of antibiotic residue in milk under region of Bihar, India. Int J Curr Microbiol App Sci, 6, 2296–2299.
- Piñero MY, Fuenmayor M, Arce L, et al (2013): A simple sample treatment for the determination of enrofloxacin and ciprofloxacin in raw goat milk. Microchem J, 110, 533–537.
- Rath S, Padhy RN (2015): Prevalence of fluoroquinolone resistance in Escherichia coli in an Indian teaching hospital and adjoining communities. J Taibah Univ Med Sci, 10, 504–508.
- Sierra-Arguello YM, Furian TQ, Perdoncini G, et al (2018): Fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli from poultry and human samples assessed by PCR-restriction fragment length polymorphism assay. PLoS One, 13, 1–9.
- Talpade J (2018): pharmacokinetic study of single dose intravenous administration of enrofloxacin in Barbari goats. J Anim Res, 8, 609–611.
- Tian H (2011): Determination of chloramphenicol, enrofloxacin and 29pesticides residues in bovine milk by liquid chromatography-tandem mass spectrometry. Chemosphere, 83, 349–355.
- Tian Z, Gao JJ, Qin W (2018): Determination of fluoroquinolones in milk by ionic liquid-mediated two phase extraction followed by capillary electrophoresis analysis. Madridge J Anal Sci Instrum, 3, 62–67.
- Trouchon T, Lefebvre S (2016): A review of enrofloxacin for veterinary use. Open J Vet Med, 6, 40–58.
- Ziv G (1994): Pharmacokinetics of Antibacterial Fluoroquinolones in Small and Large Animal Practice. 194-196. In: Proceedings of the 6th Congress of EAVPT Congress, Edinburgh.
Yıl 2021, Cilt: 68 Sayı: 2, 121 - 127, 31.03.2021
Öz
Kaynakça
- Acaroz U, Arslan-Acaroz D, Ince S (2019): A Wide Perspective on Nutrients in Beverages. 1-39. In: Grumezescu AM and Holban AM (Ed) Nutrients in Beverages. Academic Press.
- Acaroz U, Dietrich R, Knauer M, et al (2019): Development of a Generic Enzyme-Immunoassay for the Detection of Fluoro(quinolone)-Residues in Foodstuffs Based on a Highly Sensitive Monoclonal Antibody. Food Anal Methods, 13, 780-792.
- Acaroz U, Ince S, Arslan-Acaroz D, et al (2020): Determination of kanamycin residue in anatolian buffalo milk by LC-MS/MS. Kafkas Univ Vet Fak Derg, 26, 97–102.
- Chui-Shiang C, Wei-Hsien W, Chin-En T (2010): Simultaneous Determination of 18 Quinolone Residues in Marine and Livestock Products by Liquid Chromatography/ Tandem Mass Spectrometry. J Food Drug Anal, 18, 87–97.
- Cinquina AL, Roberti P, Giannetti L, et al (2003): Determination of enrofloxacin and its metabolite ciprofloxacin in goat milk by high-performance liquid chromatography with diode-array detection: Optimization and validation. J Chromatogr A, 987, 221-226.
- Cuypers WL, Jacobs J, Wong V, et al (2018): Fluoroquinolone resistance in Salmonella: Insights by wholegenome sequencing. Microb Genomics, 4, e000195.
- Du C, Deng T, Zhou Y, et al (2019): Systematic analyses for candidate genes of milk production traits in water buffalo (Bubalus Bubalis). Anim Genet, 50, 207–216.
- EU Commission Regulation (2019): Pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Available at https://ec.europa.eu/health/sites/health/files/ files/eudralex/vol-5/reg_2010_37/reg_2010_37_en.pdf. (Accessed January 20, 2020).
- Haritova A, Lashev L, Pashov D (2003): Pharmacokinetics of enrofloxacin in lactating sheep. Res Vet Sci, 74, 241–245.
- Idowu OR, Peggins JO (2004): Simple, rapid determination of enrofloxacin and ciprofloxacin in bovine milk and plasma by high-performance liquid chromatography with fluorescence detection. J Pharm Biomed Anal, 35, 143–153.
- Jank L, Martins MT, Arsand JB, et al (2015): High-throughput method for the determination of residues of β-lactam antibiotics in bovine milk by LC-MS/MS. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess, 32, 1992–2001.
- Kaartinen L, Salonen M, Älli L, et al (1995): Pharmacokinetics of enrofloxacin after single intravenous, intramuscular and subcutaneous injections in lactating cows. J Vet Pharmacol Ther, 18, 357–362.
- Kara R, Acaroz U, Gurler Z, et al (2018): Manda Sütlerinde ICP-MS ile Metal ve Ağır Metal Seviyelerinin Belirlenmesi. Kocatepe Vet J, 11, 1–4.
- Lei Z, Liu Q, Yang B, et al (2017): Clinical efficacy and residue depletion of 10% enrofloxacin enteric-coated granules in pigs. Front Pharmacol, 8, 1–11.
- Lizondo M, Pons M, Gallardo M, et al (1997): Physicochemical properties of enrofloxacin. J Pharm Biomed Anal, 15, 1845–1849.
- Lv YK, L Yang, XH Liu, et al (2013): Preparation and evaluation of a novel molecularly imprinted hybrid composite monolithic column for on-line solid-phase extraction coupled with HPLC to detect trace fluoroquinolone residues in milk. Anal Methods, 5, 1848–1855.
- Mahmood T, Abbas M, Ilyas S, et al (2016): Quantification of fluoroquinolone (enrofloxacin, norfloxacin and ciprofloxacin) residues in cow milk. IJCBS, 10, 10–15.
- Malbe M, Salonen M, Fang W, et al (1996): Disposition of enrofloxacin (Baytril) into the udder after intravenous and intra-arterial injections into dairy cows. J Vet Med A, 43, 377–386.
- Mohammed HA, Abdou AM, Eid AM, et al (2016): Rapid tests for detection of enrofloxacin residues in liquid milk. Benha Vet Med J, 30, 97–103.
- Naeem A, Badshah SL, Muska M, et al (2016): The current case of quinolones: Synthetic approaches and antibacterial activity. Molecules, 21, 268.
- Nirala RK, Anjana K, Mandal KG, et al (2017): Persistence of antibiotic residue in milk under region of Bihar, India. Int J Curr Microbiol App Sci, 6, 2296–2299.
- Piñero MY, Fuenmayor M, Arce L, et al (2013): A simple sample treatment for the determination of enrofloxacin and ciprofloxacin in raw goat milk. Microchem J, 110, 533–537.
- Rath S, Padhy RN (2015): Prevalence of fluoroquinolone resistance in Escherichia coli in an Indian teaching hospital and adjoining communities. J Taibah Univ Med Sci, 10, 504–508.
- Sierra-Arguello YM, Furian TQ, Perdoncini G, et al (2018): Fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli from poultry and human samples assessed by PCR-restriction fragment length polymorphism assay. PLoS One, 13, 1–9.
- Talpade J (2018): pharmacokinetic study of single dose intravenous administration of enrofloxacin in Barbari goats. J Anim Res, 8, 609–611.
- Tian H (2011): Determination of chloramphenicol, enrofloxacin and 29pesticides residues in bovine milk by liquid chromatography-tandem mass spectrometry. Chemosphere, 83, 349–355.
- Tian Z, Gao JJ, Qin W (2018): Determination of fluoroquinolones in milk by ionic liquid-mediated two phase extraction followed by capillary electrophoresis analysis. Madridge J Anal Sci Instrum, 3, 62–67.
- Trouchon T, Lefebvre S (2016): A review of enrofloxacin for veterinary use. Open J Vet Med, 6, 40–58.
- Ziv G (1994): Pharmacokinetics of Antibacterial Fluoroquinolones in Small and Large Animal Practice. 194-196. In: Proceedings of the 6th Congress of EAVPT Congress, Edinburgh.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Bölüm | Araştırma Makalesi |
| Yazarlar |
|
| Proje Numarası | 17.VF.08 |
| Yayımlanma Tarihi | 31 Mart 2021 |
| Yayınlandığı Sayı | Yıl 2021Cilt: 68 Sayı: 2 |
Kaynak Göster
| Bibtex | @araştırma makalesi { auvfd706602, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2021}, volume = {68}, number = {2}, pages = {121 - 127}, doi = {10.33988/auvfd.706602}, title = {Evaluation of the enrofloxacin excretion in Anatolian buffalo milk}, key = {cite}, author = {Acaröz, Ulaş and İnce, Sinan and Arslan Acaröz, Damla and Gürler, Zeki and Kara, Recep and Küçükkurt, İsmail and Eryavuz, Abdullah} } |
| APA | Acaröz, U. , İnce, S. , Arslan Acaröz, D. , Gürler, Z. , Kara, R. , Küçükkurt, İ. & Eryavuz, A. (2021). Evaluation of the enrofloxacin excretion in Anatolian buffalo milk . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 68 (2) , 121-127 . DOI: 10.33988/auvfd.706602 |
| MLA | Acaröz, U. , İnce, S. , Arslan Acaröz, D. , Gürler, Z. , Kara, R. , Küçükkurt, İ. , Eryavuz, A. "Evaluation of the enrofloxacin excretion in Anatolian buffalo milk" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 68 (2021 ): 121-127 <http://vetjournal.ankara.edu.tr/tr/pub/issue/60673/706602> |
| Chicago | Acaröz, U. , İnce, S. , Arslan Acaröz, D. , Gürler, Z. , Kara, R. , Küçükkurt, İ. , Eryavuz, A. "Evaluation of the enrofloxacin excretion in Anatolian buffalo milk". Ankara Üniversitesi Veteriner Fakültesi Dergisi 68 (2021 ): 121-127 |
| RIS | TY - JOUR T1 - Evaluation of the enrofloxacin excretion in Anatolian buffalo milk AU - UlaşAcaröz, Sinanİnce, DamlaArslan Acaröz, ZekiGürler, RecepKara, İsmailKüçükkurt, AbdullahEryavuz Y1 - 2021 PY - 2021 N1 - doi: 10.33988/auvfd.706602 DO - 10.33988/auvfd.706602 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 121 EP - 127 VL - 68 IS - 2 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.706602 UR - https://doi.org/10.33988/auvfd.706602 Y2 - 2020 ER - |
| EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Evaluation of the enrofloxacin excretion in Anatolian buffalo milk %A Ulaş Acaröz , Sinan İnce , Damla Arslan Acaröz , Zeki Gürler , Recep Kara , İsmail Küçükkurt , Abdullah Eryavuz %T Evaluation of the enrofloxacin excretion in Anatolian buffalo milk %D 2021 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 68 %N 2 %R doi: 10.33988/auvfd.706602 %U 10.33988/auvfd.706602 |
| ISNAD | Acaröz, Ulaş , İnce, Sinan , Arslan Acaröz, Damla , Gürler, Zeki , Kara, Recep , Küçükkurt, İsmail , Eryavuz, Abdullah . "Evaluation of the enrofloxacin excretion in Anatolian buffalo milk". Ankara Üniversitesi Veteriner Fakültesi Dergisi 68 / 2 (Mart 2021): 121-127 . https://doi.org/10.33988/auvfd.706602 |
| AMA | Acaröz U. , İnce S. , Arslan Acaröz D. , Gürler Z. , Kara R. , Küçükkurt İ. , Eryavuz A. Evaluation of the enrofloxacin excretion in Anatolian buffalo milk. Ankara Univ Vet Fak Derg. 2021; 68(2): 121-127. |
| Vancouver | Acaröz U. , İnce S. , Arslan Acaröz D. , Gürler Z. , Kara R. , Küçükkurt İ. , Eryavuz A. Evaluation of the enrofloxacin excretion in Anatolian buffalo milk. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2021; 68(2): 121-127. |
| IEEE | U. Acaröz , S. İnce , D. Arslan Acaröz , Z. Gürler , R. Kara , İ. Küçükkurt ve A. Eryavuz , "Evaluation of the enrofloxacin excretion in Anatolian buffalo milk", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 68, sayı. 2, ss. 121-127, Mar. 2021, doi:10.33988/auvfd.706602 |
