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Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma

Yıl 2022, Cilt 69, Sayı 1, 105 - 109, 01.01.2022
https://doi.org/10.33988/auvfd.929370

Öz

Pulmonary veno-occlusive disease (PVOD) is an uncommon disease in humans and animals caused by pulmonary hypertension (PH). The aim of this study was to investigate pathomorphological findings of PVOD in a cat. A mass was detected in the right atrium with echocardiography in an 11-year-old male cat. Following treatments, necropsy of the cat was performed after death due to respiratory failure. Macroscopically, masses were detected in mesenteric lymph node, mediastinal lymph node and, heart. Congestion and consolidated areas with edema were seen in the examination of the lung. Histopathologically, neoplastic lymphoid cells were observed in intestine, lymph nodes and heart. In lung, vein lumens were almost completely occluded by mostly loose intimal fibrosis. Near affected veins, increasing in number of the capillaries was observed. While intimal fibrosis was detected by Masson’s trichrome staining, the occluded veins were demonstrated by Verhoeff-van Gieson staining. In this case report, pathomorphological evaluation of PVOD was performed and as a result of clinicopathological examinations; PVOD, intestinal lymphoma, and cardiac metastasis were described in a male cat. 

Kaynakça

  • Aupperle H, März I, Ellenberger C (2007): Primary and secondary heart tumours in dogs and cats. J Comp Pathol, 136, 18-26.
  • Hora J (1934): Zur histologie der klinischen "primaren pulmonalsklerose". Frankfurt Z Pathol, 47, 100-108.
  • Jenkins TL, Jennings RN (2017): Pulmonary capillary hemangiomatosis and hypertrophic cardiomyopathy in a Persian cat. J Vet Diagn Invest, 29, 900-903.
  • Koiwa H, Tsujino I, Ikeda D (2011): An autopsy case of pulmonary veno-occlusive disease refractory to imatinib. Eur Respir J, 37, 968-970.
  • Luna LG (1968): Manual of Histological Staining Methods of the Armed Forces Institute of Pathology. 3rd ed. McGraw Hill Book Company, New York, USA.
  • Montani D, Achouh L, Dorfmüller P, et al (2008): Pulmonary veno-occlusive disease: clinical, functional, radiologic, and hemodynamic characteristics and outcome of 24 cases confirmed by histology. Medicine (Baltimore), 87, 220-233.
  • Montani D, O'callaghan DS, Savale L, et al (2010): Pulmonary veno-occlusive disease: recent progress and current challenges. Respir Med, 104, 23-32.
  • Montani D, Prıce LC, Dorfmuller P, et al (2009): Pulmonary veno-occlusive disease. Eur Respir J, 33, 189-200.
  • Munday JS, Löhr CV, Kiupel M (2017): Tumors of the alimentary tract. P: 499-601. In: Meuten DJ (Ed), Tumors in Domestic Animals. 5th ed. Wiley-Blackwell.
  • Pietra GG, Capron F, Stewart S, et al (2004): Pathologic assessment of vasculopathies in pulmonary hypertension. J Am Coll Cardiol, 43, 25-32.
  • Ryan JJ, Thenappan T, Luo N, et al (2012): The who classification of pulmonary hypertension: A case-based imaging compendium. Pulm Circ, 2, 107-121.
  • Stein TJ, Pellin M, Steinberg H (2010): Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids. J Am Anim Hosp Assoc, 46, 413-417.
  • Stenmark KR, Krafsur GM, Tuder RM (2016): Pulmonary veno-occlusive disease and pulmonary hypertension in dogs: striking similarities to the human condition. Vet Pathol, 53, 707-710.
  • Stepien RL (2002): Hypertension in cats and dogs, Small Animal Cardiology, Waltham/OSU Symposium.
  • Vail DM, Moore AS, Ogilvie GK (1998): Feline lymphoma (145 cases): proliferation indices, cluster of differentiation 3 immunoreactivity, and their association with prognosis in 90 cats. J Vet Intern Med, 12, 349-354.
  • Wagenvoort CA, Wagenvoort N (1974): The pathology of pulmonary veno-occlusive disease. A Path Anat and Histol, 364, 69-79.
  • Waly NE, Gruffydd-Jones TJ, Stokes CR (2005): Immunohistochemical diagnosis of alimentary lymphomas and severe intestinal inflammation in cats. J Comp Pathol, 133, 253-260.
  • Williams K, Andrie K, Cartoceti A (2016): Pulmonary veno-occlusive disease: a newly recognized cause of severe pulmonary hypertension in dogs. Vet Pathol, 53, 813-822.

Lenfomalı Bir Kedide Pulmoner Veno-Oklüzif Hastalık

Yıl 2022, Cilt 69, Sayı 1, 105 - 109, 01.01.2022
https://doi.org/10.33988/auvfd.929370

Öz

Pulmoner Veno-Oklüzif Hastalık (PVOH) pulmoner hipertansiyonun neden olduğu, insanlarda ve hayvanlarda nadir görülen bir hastalıktır. Bu olgu ile bir kedide gözlenen Pulmoner Veno-Oklüzif Hastalık’ın patomorfolojik yönden incelenmesi amaçlanmıştır. 11 yaşlı erkek kedinin ekokardiyografisinde sağ atriumda kitle gözlendi. Tedavilerin ardından solunum güçlüğüne bağlı ölen kedinin nekropsisi yapıldı. Makroskobik olarak, mezenteriyal ve mediastinal lenf yumrularında ve kalpte kitleler ile karşılaşıldı. Akciğer muayenesinde ödem ve konjesyon ile konsolide alanlar görüldü. Histopatolojik olarak bağırsak, lenf yumruları ve kalpte neoplastik lenfoid hücreler gözlendi. Akciğerde şiddetli intimal fibrozise bağlı venlerin lümenlerinde daralma ve tıkanmalar dikkati çekti. Etkilenen çoğu damarların çevresinde kapillarizasyon gözlendi. Masson trikrom boyamasıyla intimal fibrozis tespit edilirken, tıkalı damarlar Verhoeff-van Gieson boyamasıyla gösterildi. Yapılan klinikopatolojik incelemeler sonrasında PVOD ve kardiyak metastazlı intestinal lenfoma tanıları konuldu. Bu olguda bir kedide Pulmoner Veno-Oklüzif Hastalık patomorfolojik yönden değerlendirilmiş ve PVOD ile lenfoma ile ilişkisi tartışılmıştır. Klinikopatolojik incelemeler sonucunda erkek bir kedide PVOH, intestinal lenfoma ve kardiyak metastazı tanımlanmıştır.

Kaynakça

  • Aupperle H, März I, Ellenberger C (2007): Primary and secondary heart tumours in dogs and cats. J Comp Pathol, 136, 18-26.
  • Hora J (1934): Zur histologie der klinischen "primaren pulmonalsklerose". Frankfurt Z Pathol, 47, 100-108.
  • Jenkins TL, Jennings RN (2017): Pulmonary capillary hemangiomatosis and hypertrophic cardiomyopathy in a Persian cat. J Vet Diagn Invest, 29, 900-903.
  • Koiwa H, Tsujino I, Ikeda D (2011): An autopsy case of pulmonary veno-occlusive disease refractory to imatinib. Eur Respir J, 37, 968-970.
  • Luna LG (1968): Manual of Histological Staining Methods of the Armed Forces Institute of Pathology. 3rd ed. McGraw Hill Book Company, New York, USA.
  • Montani D, Achouh L, Dorfmüller P, et al (2008): Pulmonary veno-occlusive disease: clinical, functional, radiologic, and hemodynamic characteristics and outcome of 24 cases confirmed by histology. Medicine (Baltimore), 87, 220-233.
  • Montani D, O'callaghan DS, Savale L, et al (2010): Pulmonary veno-occlusive disease: recent progress and current challenges. Respir Med, 104, 23-32.
  • Montani D, Prıce LC, Dorfmuller P, et al (2009): Pulmonary veno-occlusive disease. Eur Respir J, 33, 189-200.
  • Munday JS, Löhr CV, Kiupel M (2017): Tumors of the alimentary tract. P: 499-601. In: Meuten DJ (Ed), Tumors in Domestic Animals. 5th ed. Wiley-Blackwell.
  • Pietra GG, Capron F, Stewart S, et al (2004): Pathologic assessment of vasculopathies in pulmonary hypertension. J Am Coll Cardiol, 43, 25-32.
  • Ryan JJ, Thenappan T, Luo N, et al (2012): The who classification of pulmonary hypertension: A case-based imaging compendium. Pulm Circ, 2, 107-121.
  • Stein TJ, Pellin M, Steinberg H (2010): Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids. J Am Anim Hosp Assoc, 46, 413-417.
  • Stenmark KR, Krafsur GM, Tuder RM (2016): Pulmonary veno-occlusive disease and pulmonary hypertension in dogs: striking similarities to the human condition. Vet Pathol, 53, 707-710.
  • Stepien RL (2002): Hypertension in cats and dogs, Small Animal Cardiology, Waltham/OSU Symposium.
  • Vail DM, Moore AS, Ogilvie GK (1998): Feline lymphoma (145 cases): proliferation indices, cluster of differentiation 3 immunoreactivity, and their association with prognosis in 90 cats. J Vet Intern Med, 12, 349-354.
  • Wagenvoort CA, Wagenvoort N (1974): The pathology of pulmonary veno-occlusive disease. A Path Anat and Histol, 364, 69-79.
  • Waly NE, Gruffydd-Jones TJ, Stokes CR (2005): Immunohistochemical diagnosis of alimentary lymphomas and severe intestinal inflammation in cats. J Comp Pathol, 133, 253-260.
  • Williams K, Andrie K, Cartoceti A (2016): Pulmonary veno-occlusive disease: a newly recognized cause of severe pulmonary hypertension in dogs. Vet Pathol, 53, 813-822.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Hekimlik
Bölüm Olgu Sunumu
Yazarlar

Gözde YÜCEL TENEKECİ (Sorumlu Yazar)
ANKARA UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF PRE-CLINICAL SCIENCES, DEPARTMENT OF PATHOLOGY
0000-0002-2586-8346
Türkiye


Osman Safa TERZİ
ANKARA UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF CLINICAL SCIENCES, DEPARTMENT OF INTERNAL MEDICINE
0000-0002-7877-8897
Türkiye


Mehmet ŞAHAL
ANKARA UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF CLINICAL SCIENCES, DEPARTMENT OF INTERNAL MEDICINE
0000-0003-3189-5778
Türkiye


Rıfkı HAZIROĞLU
ANKARA UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF PRE-CLINICAL SCIENCES, DEPARTMENT OF PATHOLOGY
0000-0002-1134-3581
Türkiye

Teşekkür This case presented at “IX. Veterinary Pathology Congress (International Participation)” in Antalya – Turkey (25-28 October 2018).
Yayımlanma Tarihi 1 Ocak 2022
Yayınlandığı Sayı Yıl 2022, Cilt 69, Sayı 1

Kaynak Göster

Bibtex @olgu sunumu { auvfd929370, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2022}, volume = {69}, pages = {105 - 109}, doi = {10.33988/auvfd.929370}, title = {Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma}, key = {cite}, author = {Yücel Tenekeci, Gözde and Terzi, Osman Safa and Şahal, Mehmet and Hazıroğlu, Rıfkı} }
APA Yücel Tenekeci, G. , Terzi, O. S. , Şahal, M. & Hazıroğlu, R. (2022). Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 69 (1) , 105-109 . DOI: 10.33988/auvfd.929370
MLA Yücel Tenekeci, G. , Terzi, O. S. , Şahal, M. , Hazıroğlu, R. "Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 (2022 ): 105-109 <http://vetjournal.ankara.edu.tr/tr/pub/issue/67711/929370>
Chicago Yücel Tenekeci, G. , Terzi, O. S. , Şahal, M. , Hazıroğlu, R. "Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma". Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 (2022 ): 105-109
RIS TY - JOUR T1 - Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma AU - Gözde Yücel Tenekeci , Osman Safa Terzi , Mehmet Şahal , Rıfkı Hazıroğlu Y1 - 2022 PY - 2022 N1 - doi: 10.33988/auvfd.929370 DO - 10.33988/auvfd.929370 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 105 EP - 109 VL - 69 IS - 1 SN - -1308-2817 M3 - doi: 10.33988/auvfd.929370 UR - https://doi.org/10.33988/auvfd.929370 Y2 - 2021 ER -
EndNote %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma %A Gözde Yücel Tenekeci , Osman Safa Terzi , Mehmet Şahal , Rıfkı Hazıroğlu %T Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma %D 2022 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P -1308-2817 %V 69 %N 1 %R doi: 10.33988/auvfd.929370 %U 10.33988/auvfd.929370
ISNAD Yücel Tenekeci, Gözde , Terzi, Osman Safa , Şahal, Mehmet , Hazıroğlu, Rıfkı . "Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma". Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 / 1 (Ocak 2022): 105-109 . https://doi.org/10.33988/auvfd.929370
AMA Yücel Tenekeci G. , Terzi O. S. , Şahal M. , Hazıroğlu R. Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma. Ankara Univ Vet Fak Derg. 2022; 69(1): 105-109.
Vancouver Yücel Tenekeci G. , Terzi O. S. , Şahal M. , Hazıroğlu R. Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2022; 69(1): 105-109.
IEEE G. Yücel Tenekeci , O. S. Terzi , M. Şahal ve R. Hazıroğlu , "Pulmonary Veno-Occlusive Disease in a Cat with Lymphoma", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 69, sayı. 1, ss. 105-109, Oca. 2022, doi:10.33988/auvfd.929370