Given the role of the interaction between gut microbiome with dermatological diseases, namely “gut-skin axis”, the present author proved that gut restoration should alleviate canine atopic dermatitis (CAD), which was the purpose of the study. A 4-week, open-label, non-controlled case series involved 8 -owned dogs with CAD which had received no previous treatment. Evaluations included Canine Atopic Dermatitis Extent and Severity Index version 4 (CADESI-04 scores), Visual Analog Scale (VAS) pruritus scores and Polycheck in vitro allergen specific tests. Faecal samples were analysed by dual indexing one-step PCR and 16S rRNA targeted metagenomics for detecting gut microbiota alterations before and after fecal microbiota transplantation (FMT) capsule treatment twice daily for 4 weeks. All cases were presenting pruritus and all of those dogs showed elevated IgE levels. CADESI scores decreased on days 28 (4-21) compared to day 0 initial values (50-128). Similarly, decreased VAS scores were detected on days 28 (0-2) in contrast to prior values (6-10). Regarding epidermal barrier functioning epidermal hydration (55-100 vs. 4-24) and pH (6.-7.8 vs. 4.2-5.7) values were elevated after FMT treatment in contrast to prior ranges, respectively. Alpha diversity revaled both richness and diversity of gut microbiota were improved for all cases on day 28. Furthermore at the end of trial Firmicutes: Bacteroidetes ratio was 8, the benchmark detected for healthy dogs. The present study supports a potential benefit of FMT capsule treatment against CAD. This safe and tolerant treatment modality directed against CAD shifted the gut microbiome composition towards a healthy state for all 8 dogs enrolled.
This research received no grant from any funding agency/sector. The author would like to thank RDA Group, Istanbul for purchasing test samples.
Birincil Dil | İngilizce |
---|---|
Konular | Veteriner Cerrahi |
Bölüm | Araştırma Makalesi |
Yazarlar | |
Yayımlanma Tarihi | 25 Mart 2022 |
Yayınlandığı Sayı | Yıl 2022Cilt: 69 Sayı: 2 |
Bibtex | @araştırma makalesi { auvfd822971, journal = {Ankara Üniversitesi Veteriner Fakültesi Dergisi}, issn = {1300-0861}, eissn = {1308-2817}, address = {}, publisher = {Ankara Üniversitesi}, year = {2022}, volume = {69}, number = {2}, pages = {211 - 219}, doi = {10.33988/auvfd.822971}, title = {Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs}, key = {cite}, author = {Ural, Kerem} } |
APA | Ural, K. (2022). Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 69 (2) , 211-219 . DOI: 10.33988/auvfd.822971 |
MLA | Ural, K. "Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs" . Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 (2022 ): 211-219 <http://vetjournal.ankara.edu.tr/tr/pub/issue/69048/822971> |
Chicago | Ural, K. "Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs". Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 (2022 ): 211-219 |
RIS | TY - JOUR T1 - Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs AU - KeremUral Y1 - 2022 PY - 2022 N1 - doi: 10.33988/auvfd.822971 DO - 10.33988/auvfd.822971 T2 - Ankara Üniversitesi Veteriner Fakültesi Dergisi JF - Journal JO - JOR SP - 211 EP - 219 VL - 69 IS - 2 SN - 1300-0861-1308-2817 M3 - doi: 10.33988/auvfd.822971 UR - https://doi.org/10.33988/auvfd.822971 Y2 - 2021 ER - |
EndNote | %0 Ankara Üniversitesi Veteriner Fakültesi Dergisi Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs %A Kerem Ural %T Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs %D 2022 %J Ankara Üniversitesi Veteriner Fakültesi Dergisi %P 1300-0861-1308-2817 %V 69 %N 2 %R doi: 10.33988/auvfd.822971 %U 10.33988/auvfd.822971 |
ISNAD | Ural, Kerem . "Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs". Ankara Üniversitesi Veteriner Fakültesi Dergisi 69 / 2 (Mart 2022): 211-219 . https://doi.org/10.33988/auvfd.822971 |
AMA | Ural K. Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs. Ankara Univ Vet Fak Derg. 2022; 69(2): 211-219. |
Vancouver | Ural K. Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2022; 69(2): 211-219. |
IEEE | K. Ural , "Fecal microbiota transplantation capsule therapy via oral route for combatting atopic dermatitis in dogs", Ankara Üniversitesi Veteriner Fakültesi Dergisi, c. 69, sayı. 2, ss. 211-219, Mar. 2022, doi:10.33988/auvfd.822971 |