Öz
Lethal acrodermatitis (LAD) is a rare disease affecting bull terriers and miniature bull terriers characterized by poor growth, progressive skin lesions, and immunodeficiency. A mutation in the Muskelin 1 (MKLN1) gene was determined as the causative mutation for LAD, and a genetic testing method for affected dogs has been established. A bull terrier representing symptoms similar to those of LAD was submitted to clinics, and a blood sample was taken for genetic testing. DNA was extracted, and direct mutation screening confirmed the causative mutation MKLN1:c.400+3A>C. Due to the severe progression of the disease and lack of available treatment, we have been informed that the patient was euthanised. This is the first reported case of LAD from Turkiye, and based on our findings, we strongly suggest that owners and breeders implement genetic testing before breeding to reduce and eventually eradicate this mutation from the population.
Anahtar Kelimeler
Autosomal Recessive Disease Dog Inherited Disease MKLN1 Gene Mutation
Etik Beyan
This study does not present any ethical concerns.
Teşekkür
The authors would like to thank the owners of the patient.
Kaynakça
- Bauer A, Jagannathan V, Högler S, et al (2018): MKLN1 splicing defect in dogs with lethal acrodermatitis. PLoS genetics4, e1007264.
- Bell J, Cavanagh K, Tilley L, et al (2012): Veterinary medical guide to dog and cat breeds. CRC press.
- Flaim D (2020): Bull Terrier History, Behind the Breed. Available at: https://www.akc.org/expert-advice/dog-breeds/bull-terrier-history-behind-the-breed/. (Accessed July 12, 2022).
- Hall TA (1999): BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. In: Nucleic acids symposium series. Vol. 41, pp. 95-98.
- Jezyk PF, Haskins ME, Mackay-Smith WE, et al (1986): Lethal acrodermatitis in Bull Terriers. J Am Vet Med A, 188, 833-839.
- Mauldin EA, Peters-Kennedy J (2016): Chapter 6 - Integumentary System. 509-736. In: Jubb, Kennedy, and Palmer's pathology of Domestic Animals. Elsevier, St. Louis.
- McEwan NA, Huang HP, Mellor DJ (2003): Immunoglobulin levels in Bull terriers suffering from lethal acrodermatitis. Vet Immunol Immunopathol, 96, 235–238.
- McEwan NA, McNeil PE, Thompson H, et al (2000): Diagnostic features, confirmation and dis- ease progression in 28 cases of lethal acrodermatitis of bull terriers. J Small Anim Pract, 41, 501–507.
- McEwan NA (2001): Malassezia and Candida infections in bull terriers with lethal acrodermatitis. J Small Anim Pract, 42, 291-297.
- Mena VP, Cardenas RH, Contreras LM, et al (2021): Clinical management of lethal acrodermatitis syndrome in a bull terrier. Res J Vet Pract, 9, 9-11.
- Patterson DF, Aguirre GA, Fyfe JC, et al (1989): Is this a genetic disease? J Small Anim Pract, 30, 127-139.
- Salgirli Y, Emre B, Besgul K, et al (2012): A pilot study on assessment of dog owners’ attitude towards their dogs. Ankara Univ Vet Fak Derg, 59, 11-15.
- Smits B, Croft DL, Abrams-Ogg AC (1991): Lethal acrodermatitis in bull terriers: a problem of defective zinc metabolism. Vet Dermatol, 2, 91-95.
Öz
Kaynakça
- Bauer A, Jagannathan V, Högler S, et al (2018): MKLN1 splicing defect in dogs with lethal acrodermatitis. PLoS genetics4, e1007264.
- Bell J, Cavanagh K, Tilley L, et al (2012): Veterinary medical guide to dog and cat breeds. CRC press.
- Flaim D (2020): Bull Terrier History, Behind the Breed. Available at: https://www.akc.org/expert-advice/dog-breeds/bull-terrier-history-behind-the-breed/. (Accessed July 12, 2022).
- Hall TA (1999): BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. In: Nucleic acids symposium series. Vol. 41, pp. 95-98.
- Jezyk PF, Haskins ME, Mackay-Smith WE, et al (1986): Lethal acrodermatitis in Bull Terriers. J Am Vet Med A, 188, 833-839.
- Mauldin EA, Peters-Kennedy J (2016): Chapter 6 - Integumentary System. 509-736. In: Jubb, Kennedy, and Palmer's pathology of Domestic Animals. Elsevier, St. Louis.
- McEwan NA, Huang HP, Mellor DJ (2003): Immunoglobulin levels in Bull terriers suffering from lethal acrodermatitis. Vet Immunol Immunopathol, 96, 235–238.
- McEwan NA, McNeil PE, Thompson H, et al (2000): Diagnostic features, confirmation and dis- ease progression in 28 cases of lethal acrodermatitis of bull terriers. J Small Anim Pract, 41, 501–507.
- McEwan NA (2001): Malassezia and Candida infections in bull terriers with lethal acrodermatitis. J Small Anim Pract, 42, 291-297.
- Mena VP, Cardenas RH, Contreras LM, et al (2021): Clinical management of lethal acrodermatitis syndrome in a bull terrier. Res J Vet Pract, 9, 9-11.
- Patterson DF, Aguirre GA, Fyfe JC, et al (1989): Is this a genetic disease? J Small Anim Pract, 30, 127-139.
- Salgirli Y, Emre B, Besgul K, et al (2012): A pilot study on assessment of dog owners’ attitude towards their dogs. Ankara Univ Vet Fak Derg, 59, 11-15.
- Smits B, Croft DL, Abrams-Ogg AC (1991): Lethal acrodermatitis in bull terriers: a problem of defective zinc metabolism. Vet Dermatol, 2, 91-95.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Zootekni, Genetik ve Biyoistatistik |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 2 Ocak 2024 |
| Yayımlandığı Sayı | Yıl 2024Cilt: 71 Sayı: 1 |
