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Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi

Yıl 2021, Cilt: 6 Sayı: 4, 585 - 591, 31.12.2021
https://doi.org/10.35229/jaes.993377

Öz

Nötrofil/lenfosit oranı (NEU/LYM), monosit/lenfosit oranı (MONO/LYM), ve platelet/lenfosit oranı (PLT/LYM) inflamasyonunun ucuz, tekrar kullanılabilen biyobelirteçlerini oluşturmaktadır. Bu çalışma ilk defa parvovirus enfeksiyonu (PVE) şekillenmiş köpeklerde NEU/LYM, MONO/LYM ve PLT/LYM değerlerini ortaya koymaktadır. Çalışmanın amacını ise tedavi öncesi PVE ile pozitif köpeklerin NEU/LYM, MONO/LYM ve PLT/LYM değerlerinin, sağlıklı kontrollere göre karşılaştırılması oluşturmuştur. On sekiz sahipli, 2-8 aylık, PVE pozitif köpek, çalışma grubunu oluşturmuştur. Yedi sahipli, aynı yaş aralığında sağlıklı köpek ise kontrol grubunu oluşturmuştur. Gruplar arasında tedavi öncesi NEU/LYM, MONO/LYM karşılaştırılmasında PVE pozitif grubu ortalama NEU (P<0,001), LYM (P<0,05) değerleri kontrol grubuna istatistiksel olarak düşük bulunmuştur. Bununla birlikte, PVE pozitif grubunda tedavi öncesi ortalama PLT/LYM seviyeleri kontrol grubuna göre istatistiksel olarak yüksek (P<0,001) tespit edilmiştir. PVE pozitif ve kontrol gruplarında ortalama PLT/LYM düzeyleri ise sırasıyla 1120,94 ve 135,26 olarak bulunmuştur. Sonuç olarak, bu ön çalışma PLT/LYM oranın, PVE ile doğal olarak enfekte olmuş köpeklerde kolay, uygun maliyetli, objektif ve invazif olmayan yeni bir prognostik belirteç adayı olabileceğini göstermektedir. NEU/LYM, MONO/LYM, PLT/LYM ile ilgili çalışmaların kısıtlı varlığına rağmen, özellikle veteriner hekimlikte bulaşıcı hastalıklarda daha ileri çalışmalara ihtiyaç duyulmaktadır.

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Kaynakça

  • Apaa, T.T., Daly, J.M. & Tarlinton, R.E. (2016). Canine parvovirus (CPV-2) variants circulating in nigerian dogs. Veterinary Record Open, 3.
  • Ayyıldız, M. & Tekin, M.E. (2021). Köpeklerin parvoviral enterit hastalığı teşhisinde bazı hemogram değerlerinin ROC eğrisi ile incelenmesi. Eurasian Journal of Veterinary Sciences, 37(2), 101-108.
  • Benvenuti, E., Pierini, A., Gori, E., Lucarelli, C., Lubas, G. & Marchetti, V. (2020). Neutrophil-to-lymphocyte ratio (nlr) in canine inflammatory bowel disease (IBD). Veterinary Sciences, 7(3),141.
  • Burton, A.G., Harris, L.A., Owens, S.D., Jandrey, K.E. (2013). The prognostic utility of degenerative left shifts in dogs. Journal of Veterinary Internal Medicine, 27, 1517-1522.
  • Cavalli, A., Desario, C., Kusi, I., Mari, V., Lorusso, E., Cirone, F. Kumbe, I., Colaianni, M.L., Buonavoglia, D. & Decaro, N. (2014). Detection and genetic characterization of canine parvovirus and canine coronavirus strains circulating in district of Tirana in Albania. Journal of Veterinary Diagnostic Investigation, 26, 563-566.
  • Chandrashekara, S., Mukhtar Ahmad, M., Renuka, P., Anupama, K.R. & Renuka, K. (2017). Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis. International Journal of Rheumatic Diseases, 20(10), 1457-1467.
  • Çakır, K. & Pekmezci, D. (2019). Borrelia burgdorferi ile doğal enfekte köpeklerin nötrofil-lenfosit, monosit- lenfosit ve platelet-lenfosit oranlarının belirlenmesi. Etlik Veteriner Mikrobiyoloji Dergisi, 30(1), 58-63.
  • Decaro, N. & Buonavoglia, C. (2012). Canine parvovirus—a review of epidemiological and diagnostic aspects, with emphasis on type 2c. Veterinary Microbiology, 155, 1-12.
  • Decaro, N., Cirone, F., Desario, C., Elia, G., Lorusso, E., Colaianni, M.L., Martella, V. & Buonavoglia, C. (2009). Severe parvovirus in a 12-year-old dog that had been repeatedly vaccinated. Veterinary Record, 164, 593-595.
  • Decaro, N., Desario, C., Billi, M., Mari, V., Elia, G., Cavalli, A., Martella, V., & Buonavoglia, C. (2011). Western European epidemiological survey for parvovirus and coronavirus infections in dogs. The Veterinary Journal, 187, 195-199.
  • Dik, I. & Şimşek, A. (2021). Comparison of different diagnostic methods in detection of canine parvovirus infection. Eurasian Journal of Veterinary Sciences, 37(2), 76-81.
  • Dossin, O., Rupassara, S.I., Weng, H.Y., Williams, D.A., Garlick, P.J. & Schoeman, J.P. (2011). Effect of parvoviral enteritis on plasma citrulline concentration in dogs. Journal of Veterinary Internal Medicine, 25(2): 215-221.
  • Duijvestijn, M., Mughini-Gras, L., Schuurman, N., Schijf, W., Wagenaar, J.A. & Egberink, H. (2016). Enteropathogen infections in canine puppies: (co-) occurrence, clinical relevance and risk factors. Veterinary Microbiology, 195, 115-122.
  • Duque-García, Y., Echeverri-Zuluaga, M., Trejos-Suarez, J. & Ruiz-Saenz, J. (2017). Prevalence and molecular epidemiology of canine parvovirus 2 in diarrheic dogs in Colombia, South America: a possible new cpv-2a is emerging? Veterinary Microbiology, 201, 56-61.
  • Filipov, C., Desario, C., Patouchas, O., Eftimov, P., Gruichev, G., Manov, V., Filipov, G., Buonavoglia, C. & Decaro, N. (2016). A ten-year molecular survey on parvoviruses infecting carnivores in Bulgaria. Transboundary and Emerging Diseases, 63, 460-464.
  • Gargari, S. (2015). Gastroenteritis semptomlu köpeklerde canine parvovirus tip-2’nin tespiti ve moleküler karakterizasyonu. Ankara Üniversitesi Sağlık Bilimleri Enstitüsü. Ankara, Türkiye.
  • Goddard, A. & Leisewitz, A.L. (2010). Canine parvovirus. Veterinary Clinics of North America: Small Animal Practice, 40, 1041-1053.
  • Gori, E., Pierini, A., Lippi, I., Lubas, G. & Marchetti, V. (2021) Leukocytes ratios in feline systemic ınflammatory response syndrome and sepsis: a retrospective analysis of 209 cases. Animals, 6, 1644.
  • Hodgson, N., Llewellyn, E.A. & Schaeffer, D.J. (2018). Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis. Journal of the American Animal Hospital Association, 54, 351-359.
  • Hoskins, J.D. (2001). Canine viral enteritis, In: Ettinger, S.J. (Ed), Pocket Companion to Text Book of Veterinary Internal Medicine. 5th ed., 214-218p, WB Saunders Company, Philadelphia, USA.
  • Hoskins, JD. (1997). Update on canine parvoviral enteritis. Veterinary Medicine, 92(8), 694-709.
  • Huang, Z., Fu, Z., Huang, W. & Huang, K. (2020). Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis. American Journal of Emergency Medicine, 38, 641-647.
  • Hwang, S.Y., Shin, T.G., Jo, I.J., Jeon, K., Suh, G.Y., Lee, T.R., Yoon, H., Cha, W.C. & Sim, M.S. (2017). Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients. American Journal of Emergency Medicine, 35, 234-239.
  • Jenne, C.N. & Kubes, P. (2015). Platelets in inflammation and infection. Platelets, 26(4), 286-292.
  • Kalli, I., Leontides, L.S., Mylonakis, M.E., Adamama-Moraitou, K., Rallis, T. & Koutinas, A.F. (2010). Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection. Research in Veterinary Science, 89(2), 174-178.
  • Li, H., Zhou, Y., Ma, Y., Han, S. & Zhou, L. (2017). The prognostic value of the platelet-to- lymphocyte ratio in acute coronary syndrome: a systematic review and meta-analysis. Kardiologia Polska, 75(7), 666-673.
  • Ling, M., Norris, J.M., Kelman, M. & Ward, M.P. (2012). Risk factors for death from canine parvoviral related disease in Australia. Veterinary Microbiology, 158, 280-290.
  • Liu, Y., Zheng, J., Zhang, D. & Jing, L. (2019). Neutrophil-lymphocyte ratio and plasma lactate predict 28-day mortality in patients with sepsis. Journal of Clinical Laboratory Analysis, 33, e22942.
  • McClure, V., van Schoor, M., Thompson, P.N., Kjelgaard-Hansen, M. & Goddard, A. (2013). Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus. Journal of the American Veterinary Medical Association, 243(3), 361-366.
  • Min, G.T., Li, Y.M., Yao, N., Wang, J., Wang, H.P. & Chen, W. (2017). The pretreatment neutrophil-lymphocyte ratio may predict prognosis of patients with liver Cancer: meta-analysis. Clinical Transplantation, 32(1).
  • Mohr, A.J., Leisewitz, A.L., Jacobson, L.S., Steiner, J.M., Ruaux, C.G. & Williams, D.A. (2003). Effect of early enteral nutrition on intestinal permeability, intestinal protein loss, and outcome in dogs with severe parvoviral enteritis. Journal of Veterinary Internal Medicine, 17, 791-798.
  • Mylonakis, M.E., Kalli, I. & Rallis, T.S. (2016). Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention. Veterinary Medicine, 7, 91-100.
  • Naess, A., Nilssen, S.S., Mo, R., Eide, G.E. & Sjursen, H. (2017). Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever. Infection, 45, 299-307.
  • Neumann, S. (2021). Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in dogs and cats with acute pancreatitis. Veterinary Clinical Pathology, 50(1), 45-45.
  • Ni, J., Wang, H., Li, Y., Shu, Y. & Liu, Y. (2019). Neutrophil to lymphocyte ratio (NLR) as a prognostic marker for in-hospital mortality of patients with sepsis: A secondary analysis based on a single-center, retrospective, cohort study. Medicine, 98, e18029.
  • O'Sullivan, G., Durham, P.J., Smith, J.R. & Campbell, R.S. (1984). Experimentally induced severe canine parvoviral enteritis. Australian Veterinary Journal, 61(1),1-4.
  • Otto, C.M., Drobatz, K.J. & Soter, C. (1997). Endotoxemia and tumor necrosis factor activity in dogs with naturally occurring parvoviral enteritis. Journal of Veterinary Internal Medicine, 11(2): 65-70.
  • Pekmezci, D. & Çakır, K. (2020). Doğal parvovirus ile enfekte köpeklerde tedavi öncesi serum albuminin globuline oranının değerlendirilmesi. Anadolu Çevre ve Hayvancılık Dergisi, 5(2), 118-124.
  • Pierini, A., Gori, E., Lippi, I., Ceccherini, G., Lubas, G., Marchetti, V. (2019). Neutrophil-to-lymphocyte ratio, nucleated red blood cells and erythrocyte abnormalities in canine systemic inflammatory response syndrome. Research in Veterinary Science, 126, 150-154.
  • Pierini, A., Gori, E., Lippi, I., Lubas, G. & Marchetti, V. (2020) Are leukocyte and platelet abnormalities and complete blood count ratios potential prognostic markers in canine sepsis? Frontiers in Veterinary Science, 7, 578846.
  • Prittie, J. (2004). Canine parvoviral enteritis: a review of diagnosis, management, and prevention. Journal of Veterinary Internal Medicine, 14, 167-176.
  • Rejec, A., Butinar, J., Gawor, J. & Petelin, M. (2017). Evaluation of complete blood count indices (NLR, PLR, MPV/PLT, and PLCRi) in healthy dogs, dogs with periodontitis and dogs with oropharyngeal tumors as potential biomarkers of systemic inflammatory response. Journal of Veterinary Dentistry, 34, 231-240.
  • Rossi, S., Basso, M., Strippoli, A., Schinzari, G., D’Argento, E., Larocca, M., Cassano, A. & Barone, C. (2017). Are markers of systemic inflammation good prognostic indicators in colorectal cancer? Clin Colorectal Cancer, 16, 264-274.
  • Schoeman, J.P. & Herrtage, M.E. (2008). Serum thyrotropin, thyroxine and free thyroxine concentrations as predictors of mortality in critically ill puppies with parvovirus infection: a model for human paediatric critical illness? Microbes and Infection, 10(2), 203-207.
  • Schoeman, J.P., Goddard, A. & Herrtage, M.E. (2007). Serum cortisol and thyroxine concentrations as predictors of death in critically ill puppies with parvoviral diarrhea. Journal of the American Veterinary Medical Association, 231(10), 1534-1539.
  • Schoeman, J.P., Goddard, A. & Leisewitz, A.L. (2013). Biomarkers in canine parvovirus enteritis. New Zealand Veterinary Journal, 61, 217-222.
  • Shi, L., Qin, X., Wang, H., Xia, Y., Li, Y., Chen, X., Shang, L., Tai, Y.T., Feng, X., Acharya, P., Acharya, C., Xu, Y., Deng, S., Hao, M., Zou, D., Zhao, Y., Ru, K., Qiu, L. & An, G. (2017). Elevated neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio and decreased platelet-to-lymphocyte ratio are associated with poor prognosis in multiple myeloma. Oncotarget, 8(12), 18792-18801.
  • Smith-Carr, S., Macintire, D.K. & Swango, L.J. (1997). Canine parvovirus. Part I. Pathogenesis and vaccination. Compendium on Continuing Education for the Practising Veterinarian,19(2), 125-133.
  • Summers, C., Rankin, S.M., Condliffe, A.M., Singh, N., Peters, A.M. & Chilvers, E.R. (2010). Neutrophil kinetics in health and disease. Trends in Immunology, 31(8), 318-324.
  • Troìa, R., Agnoli, C., Calipa, S., Segalina, S., Murgia, E., Gruarin, M., Dondi, F. & Giunti, M. (2017). Evaluation of the delta neutrophil index from an automated blood cell analyser in septic dogs. The Veterinary Journal, 230, 13-19.
  • Wang, Y., Fuentes, H.E., Attar, B.M., Jaiswal, P. & Demetria, M. (2017). Evaluation of the prognostic value of neutrophil to lymphocyte ratio in patients with hypertriglycer- idemia-induced acute pancreatitis. Pancreatology, 17(6), 893-897.
  • Yao, C., Liu, X. & Tang, Z. (2017). Prognostic role of neutrophil-lymphocyte ratio and pla- telet-lymphocyte ratio for hospital mortality in patients with AECOPD. International Journal of Chronic Obstructive Pulmonary Disease, 12, 2285-2290.
  • Yilmaz, Z. & Senturk, S. (2007). Characterization of lipid profiles in dogs with parvoviral enteritis. Journal of Small Animal Practice, 48, 643-650.
  • Zhao, Z., Liu, H., Ding, K., Peng, C., Xue, Q., Yu, Z. & Xue, Y. (2016). Occurrence of canine parvovirus in dogs from Henan province of China in 2009–2014. BMC Veterinary Research, 12.

Determination of Neutrophil/Lymphocyte, Monocyte/Lymphocyte and Platelet/Lymphocyte Ratios in Dogs with Occurring Parvovirus Infection

Yıl 2021, Cilt: 6 Sayı: 4, 585 - 591, 31.12.2021
https://doi.org/10.35229/jaes.993377

Öz

Neutrophil/lymphocyte ratio (NEU/LYM), monocyte/lymphocyte ratio (MONO/LYM), and platelet/lymphocyte ratio (PLT/LYM) are inexpensive and reproducible biomarkers of inflammation. This is the first study that explores NEU/LYM, MONO/LYM, and PLT/LYM in dogs with Parvovirus infection (PVI). This study aims to determine whether the pretreatment NEU/LYM, MONO/LYM, and PLT/LYM differs in dogs with PVI against healthy controls. Eighteen client-owned dogs aged 2-8 months that were found positive with PVI were enrolled as the study group. Seven client-owned, healthy dogs of the same age formed the control group. Pretreatment NEU/LYM, MONO/LYM, and PLT/LYM were compared between groups. The pretreatment mean NEU (P< 0.001) and LYM (P<0.05) levels were found to be significantly lower in the study group when compared to the control group. However, pretreatment mean PLT/LYM levels in the PVI positive group was significantly higher (P<0.001) than in the control group. The mean PLT/LYM levels in the PVI positive and control groups were found as 1120.94 and 135.26, respectively. In summary, this preliminary study demonstrates that pretreatment PLT/LYM in dogs with PVI positive is an easy, cost-effective, objective, and non-invasive biomarker that could be the new prognostic marker candidates in dogs naturally infected with PVI. Although limited studies on NEU/LYM, MONO/LYM, PLT/LYM are existed, especially further studies in veterinary medicine with infectious diseases are needed.

Proje Numarası

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Kaynakça

  • Apaa, T.T., Daly, J.M. & Tarlinton, R.E. (2016). Canine parvovirus (CPV-2) variants circulating in nigerian dogs. Veterinary Record Open, 3.
  • Ayyıldız, M. & Tekin, M.E. (2021). Köpeklerin parvoviral enterit hastalığı teşhisinde bazı hemogram değerlerinin ROC eğrisi ile incelenmesi. Eurasian Journal of Veterinary Sciences, 37(2), 101-108.
  • Benvenuti, E., Pierini, A., Gori, E., Lucarelli, C., Lubas, G. & Marchetti, V. (2020). Neutrophil-to-lymphocyte ratio (nlr) in canine inflammatory bowel disease (IBD). Veterinary Sciences, 7(3),141.
  • Burton, A.G., Harris, L.A., Owens, S.D., Jandrey, K.E. (2013). The prognostic utility of degenerative left shifts in dogs. Journal of Veterinary Internal Medicine, 27, 1517-1522.
  • Cavalli, A., Desario, C., Kusi, I., Mari, V., Lorusso, E., Cirone, F. Kumbe, I., Colaianni, M.L., Buonavoglia, D. & Decaro, N. (2014). Detection and genetic characterization of canine parvovirus and canine coronavirus strains circulating in district of Tirana in Albania. Journal of Veterinary Diagnostic Investigation, 26, 563-566.
  • Chandrashekara, S., Mukhtar Ahmad, M., Renuka, P., Anupama, K.R. & Renuka, K. (2017). Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis. International Journal of Rheumatic Diseases, 20(10), 1457-1467.
  • Çakır, K. & Pekmezci, D. (2019). Borrelia burgdorferi ile doğal enfekte köpeklerin nötrofil-lenfosit, monosit- lenfosit ve platelet-lenfosit oranlarının belirlenmesi. Etlik Veteriner Mikrobiyoloji Dergisi, 30(1), 58-63.
  • Decaro, N. & Buonavoglia, C. (2012). Canine parvovirus—a review of epidemiological and diagnostic aspects, with emphasis on type 2c. Veterinary Microbiology, 155, 1-12.
  • Decaro, N., Cirone, F., Desario, C., Elia, G., Lorusso, E., Colaianni, M.L., Martella, V. & Buonavoglia, C. (2009). Severe parvovirus in a 12-year-old dog that had been repeatedly vaccinated. Veterinary Record, 164, 593-595.
  • Decaro, N., Desario, C., Billi, M., Mari, V., Elia, G., Cavalli, A., Martella, V., & Buonavoglia, C. (2011). Western European epidemiological survey for parvovirus and coronavirus infections in dogs. The Veterinary Journal, 187, 195-199.
  • Dik, I. & Şimşek, A. (2021). Comparison of different diagnostic methods in detection of canine parvovirus infection. Eurasian Journal of Veterinary Sciences, 37(2), 76-81.
  • Dossin, O., Rupassara, S.I., Weng, H.Y., Williams, D.A., Garlick, P.J. & Schoeman, J.P. (2011). Effect of parvoviral enteritis on plasma citrulline concentration in dogs. Journal of Veterinary Internal Medicine, 25(2): 215-221.
  • Duijvestijn, M., Mughini-Gras, L., Schuurman, N., Schijf, W., Wagenaar, J.A. & Egberink, H. (2016). Enteropathogen infections in canine puppies: (co-) occurrence, clinical relevance and risk factors. Veterinary Microbiology, 195, 115-122.
  • Duque-García, Y., Echeverri-Zuluaga, M., Trejos-Suarez, J. & Ruiz-Saenz, J. (2017). Prevalence and molecular epidemiology of canine parvovirus 2 in diarrheic dogs in Colombia, South America: a possible new cpv-2a is emerging? Veterinary Microbiology, 201, 56-61.
  • Filipov, C., Desario, C., Patouchas, O., Eftimov, P., Gruichev, G., Manov, V., Filipov, G., Buonavoglia, C. & Decaro, N. (2016). A ten-year molecular survey on parvoviruses infecting carnivores in Bulgaria. Transboundary and Emerging Diseases, 63, 460-464.
  • Gargari, S. (2015). Gastroenteritis semptomlu köpeklerde canine parvovirus tip-2’nin tespiti ve moleküler karakterizasyonu. Ankara Üniversitesi Sağlık Bilimleri Enstitüsü. Ankara, Türkiye.
  • Goddard, A. & Leisewitz, A.L. (2010). Canine parvovirus. Veterinary Clinics of North America: Small Animal Practice, 40, 1041-1053.
  • Gori, E., Pierini, A., Lippi, I., Lubas, G. & Marchetti, V. (2021) Leukocytes ratios in feline systemic ınflammatory response syndrome and sepsis: a retrospective analysis of 209 cases. Animals, 6, 1644.
  • Hodgson, N., Llewellyn, E.A. & Schaeffer, D.J. (2018). Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis. Journal of the American Animal Hospital Association, 54, 351-359.
  • Hoskins, J.D. (2001). Canine viral enteritis, In: Ettinger, S.J. (Ed), Pocket Companion to Text Book of Veterinary Internal Medicine. 5th ed., 214-218p, WB Saunders Company, Philadelphia, USA.
  • Hoskins, JD. (1997). Update on canine parvoviral enteritis. Veterinary Medicine, 92(8), 694-709.
  • Huang, Z., Fu, Z., Huang, W. & Huang, K. (2020). Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis. American Journal of Emergency Medicine, 38, 641-647.
  • Hwang, S.Y., Shin, T.G., Jo, I.J., Jeon, K., Suh, G.Y., Lee, T.R., Yoon, H., Cha, W.C. & Sim, M.S. (2017). Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients. American Journal of Emergency Medicine, 35, 234-239.
  • Jenne, C.N. & Kubes, P. (2015). Platelets in inflammation and infection. Platelets, 26(4), 286-292.
  • Kalli, I., Leontides, L.S., Mylonakis, M.E., Adamama-Moraitou, K., Rallis, T. & Koutinas, A.F. (2010). Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection. Research in Veterinary Science, 89(2), 174-178.
  • Li, H., Zhou, Y., Ma, Y., Han, S. & Zhou, L. (2017). The prognostic value of the platelet-to- lymphocyte ratio in acute coronary syndrome: a systematic review and meta-analysis. Kardiologia Polska, 75(7), 666-673.
  • Ling, M., Norris, J.M., Kelman, M. & Ward, M.P. (2012). Risk factors for death from canine parvoviral related disease in Australia. Veterinary Microbiology, 158, 280-290.
  • Liu, Y., Zheng, J., Zhang, D. & Jing, L. (2019). Neutrophil-lymphocyte ratio and plasma lactate predict 28-day mortality in patients with sepsis. Journal of Clinical Laboratory Analysis, 33, e22942.
  • McClure, V., van Schoor, M., Thompson, P.N., Kjelgaard-Hansen, M. & Goddard, A. (2013). Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus. Journal of the American Veterinary Medical Association, 243(3), 361-366.
  • Min, G.T., Li, Y.M., Yao, N., Wang, J., Wang, H.P. & Chen, W. (2017). The pretreatment neutrophil-lymphocyte ratio may predict prognosis of patients with liver Cancer: meta-analysis. Clinical Transplantation, 32(1).
  • Mohr, A.J., Leisewitz, A.L., Jacobson, L.S., Steiner, J.M., Ruaux, C.G. & Williams, D.A. (2003). Effect of early enteral nutrition on intestinal permeability, intestinal protein loss, and outcome in dogs with severe parvoviral enteritis. Journal of Veterinary Internal Medicine, 17, 791-798.
  • Mylonakis, M.E., Kalli, I. & Rallis, T.S. (2016). Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention. Veterinary Medicine, 7, 91-100.
  • Naess, A., Nilssen, S.S., Mo, R., Eide, G.E. & Sjursen, H. (2017). Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever. Infection, 45, 299-307.
  • Neumann, S. (2021). Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in dogs and cats with acute pancreatitis. Veterinary Clinical Pathology, 50(1), 45-45.
  • Ni, J., Wang, H., Li, Y., Shu, Y. & Liu, Y. (2019). Neutrophil to lymphocyte ratio (NLR) as a prognostic marker for in-hospital mortality of patients with sepsis: A secondary analysis based on a single-center, retrospective, cohort study. Medicine, 98, e18029.
  • O'Sullivan, G., Durham, P.J., Smith, J.R. & Campbell, R.S. (1984). Experimentally induced severe canine parvoviral enteritis. Australian Veterinary Journal, 61(1),1-4.
  • Otto, C.M., Drobatz, K.J. & Soter, C. (1997). Endotoxemia and tumor necrosis factor activity in dogs with naturally occurring parvoviral enteritis. Journal of Veterinary Internal Medicine, 11(2): 65-70.
  • Pekmezci, D. & Çakır, K. (2020). Doğal parvovirus ile enfekte köpeklerde tedavi öncesi serum albuminin globuline oranının değerlendirilmesi. Anadolu Çevre ve Hayvancılık Dergisi, 5(2), 118-124.
  • Pierini, A., Gori, E., Lippi, I., Ceccherini, G., Lubas, G., Marchetti, V. (2019). Neutrophil-to-lymphocyte ratio, nucleated red blood cells and erythrocyte abnormalities in canine systemic inflammatory response syndrome. Research in Veterinary Science, 126, 150-154.
  • Pierini, A., Gori, E., Lippi, I., Lubas, G. & Marchetti, V. (2020) Are leukocyte and platelet abnormalities and complete blood count ratios potential prognostic markers in canine sepsis? Frontiers in Veterinary Science, 7, 578846.
  • Prittie, J. (2004). Canine parvoviral enteritis: a review of diagnosis, management, and prevention. Journal of Veterinary Internal Medicine, 14, 167-176.
  • Rejec, A., Butinar, J., Gawor, J. & Petelin, M. (2017). Evaluation of complete blood count indices (NLR, PLR, MPV/PLT, and PLCRi) in healthy dogs, dogs with periodontitis and dogs with oropharyngeal tumors as potential biomarkers of systemic inflammatory response. Journal of Veterinary Dentistry, 34, 231-240.
  • Rossi, S., Basso, M., Strippoli, A., Schinzari, G., D’Argento, E., Larocca, M., Cassano, A. & Barone, C. (2017). Are markers of systemic inflammation good prognostic indicators in colorectal cancer? Clin Colorectal Cancer, 16, 264-274.
  • Schoeman, J.P. & Herrtage, M.E. (2008). Serum thyrotropin, thyroxine and free thyroxine concentrations as predictors of mortality in critically ill puppies with parvovirus infection: a model for human paediatric critical illness? Microbes and Infection, 10(2), 203-207.
  • Schoeman, J.P., Goddard, A. & Herrtage, M.E. (2007). Serum cortisol and thyroxine concentrations as predictors of death in critically ill puppies with parvoviral diarrhea. Journal of the American Veterinary Medical Association, 231(10), 1534-1539.
  • Schoeman, J.P., Goddard, A. & Leisewitz, A.L. (2013). Biomarkers in canine parvovirus enteritis. New Zealand Veterinary Journal, 61, 217-222.
  • Shi, L., Qin, X., Wang, H., Xia, Y., Li, Y., Chen, X., Shang, L., Tai, Y.T., Feng, X., Acharya, P., Acharya, C., Xu, Y., Deng, S., Hao, M., Zou, D., Zhao, Y., Ru, K., Qiu, L. & An, G. (2017). Elevated neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio and decreased platelet-to-lymphocyte ratio are associated with poor prognosis in multiple myeloma. Oncotarget, 8(12), 18792-18801.
  • Smith-Carr, S., Macintire, D.K. & Swango, L.J. (1997). Canine parvovirus. Part I. Pathogenesis and vaccination. Compendium on Continuing Education for the Practising Veterinarian,19(2), 125-133.
  • Summers, C., Rankin, S.M., Condliffe, A.M., Singh, N., Peters, A.M. & Chilvers, E.R. (2010). Neutrophil kinetics in health and disease. Trends in Immunology, 31(8), 318-324.
  • Troìa, R., Agnoli, C., Calipa, S., Segalina, S., Murgia, E., Gruarin, M., Dondi, F. & Giunti, M. (2017). Evaluation of the delta neutrophil index from an automated blood cell analyser in septic dogs. The Veterinary Journal, 230, 13-19.
  • Wang, Y., Fuentes, H.E., Attar, B.M., Jaiswal, P. & Demetria, M. (2017). Evaluation of the prognostic value of neutrophil to lymphocyte ratio in patients with hypertriglycer- idemia-induced acute pancreatitis. Pancreatology, 17(6), 893-897.
  • Yao, C., Liu, X. & Tang, Z. (2017). Prognostic role of neutrophil-lymphocyte ratio and pla- telet-lymphocyte ratio for hospital mortality in patients with AECOPD. International Journal of Chronic Obstructive Pulmonary Disease, 12, 2285-2290.
  • Yilmaz, Z. & Senturk, S. (2007). Characterization of lipid profiles in dogs with parvoviral enteritis. Journal of Small Animal Practice, 48, 643-650.
  • Zhao, Z., Liu, H., Ding, K., Peng, C., Xue, Q., Yu, Z. & Xue, Y. (2016). Occurrence of canine parvovirus in dogs from Henan province of China in 2009–2014. BMC Veterinary Research, 12.
Toplam 54 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Didem Pekmezci 0000-0003-2072-8165

Zeynep Nurselin Çolak 0000-0002-0631-5471

Proje Numarası -
Erken Görünüm Tarihi 30 Aralık 2021
Yayımlanma Tarihi 31 Aralık 2021
Gönderilme Tarihi 9 Eylül 2021
Kabul Tarihi 25 Ekim 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 6 Sayı: 4

Kaynak Göster

APA Pekmezci, D., & Çolak, Z. N. (2021). Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi. Journal of Anatolian Environmental and Animal Sciences, 6(4), 585-591. https://doi.org/10.35229/jaes.993377


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