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A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection

Yıl 2022, Cilt: 7 Sayı: 4, 437 - 443, 31.12.2022
https://doi.org/10.35229/jaes.1172262

Öz

It is aimed to compare the pretreatment Neutrophil/Lymphocyte (NEU/LYM), Monocyte/Lymphocyte (MONO/LYM), and Platelet/Lymphocyte (PLT/LYM) ratios with whole blood count (WBC) of dogs naturally infected Canine Distemper Virus (CDV) with healthy individuals within this preliminary study. For this purpose, retrospectively, 22 owned, 3-12 (6.2) months old dogs diagnosed with CDV infection found to be positive with rapid test kits based up on the records of Animal Hospital, Faculty of Veterinary Medicine, constituted the study group. On the other hand, eight owned, 2-10 (8.2) months old, and healthy dogs enrolled in the control group. In the comparison of pre-treatment NEU/LYM, MONO/LYM, PLT/LYM, and WBC parameters between the groups, we found only a statistical difference (P 0.05) between median LYM, EOS, NEU%, LYM%, EOS%, BAS%, MCH, MCHC, RDWCV, PLT with NEU/LYM, MONO/LYM, PLT/LYM ratios. The median NEU/LYM, MONO/LYM, and PLT/LYM levels in the CDV positive group were 31.9, 2.33, and 391.2, respectively, while the same values of the control group were determined as 6.39, 0.37 and 187.7, respectively. The optimized cut-off points of NEU/LYM, MONO/LYM, and PLT/LYM values in estimating CDV patients were also determined as NEU/LYM =7.6, MONO/LYM=0.61 and PLT/LYM=0.852, respectively. In conclusion, this preliminary study suggests that NEU/LYM, MONO/LYM, and PLT/LYM values may be inexpensive, objective, and non-invasive new marker candidates for clinicians to support the diagnosis of CDV infected dogs in suspicious circumstances.

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Çalışmamızı destekleyen herhangi bir kurum bulunmamaktadır.

Proje Numarası

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Teşekkür

-

Kaynakça

  • Appel, M.J. (1970). Distemper pathogenesis in dogs. Journal of the American Veterinary Medical Association, 156, 1681-1684.
  • Becher, A., Suchodolski, J.S., Steiner, J.M. & Heilmann, R.M. (2021). Blood neutrophil-to-lymphocyte ratio (NLR) as a diagnostic marker in dogs with chronic enteropathy. The Journal of Veterinary Diagnostic Investigation, 33(3), 516–527.
  • Benvenuti, E., Pierini, A., Gori, E., Lucarelli, C., Lubas, G. & Marchetti, V. (2020). Neutrophil-to-lymphocyte ratio (nlr) in canine inflammatory bowel disease (IBD). Veterinary Sciences, 7(3),141.
  • Burton, A.G., Harris, L.A., Owens, S.D. & Jandrey, K.E. (2013). The prognostic utility of degenerative left shifts in dogs. Journal of Veterinary Internal Medicine, 27, 1517-1522.
  • Chandrashekara, S., Mukhtar Ahmad, M., Renuka, P., Anupama, K.R. & Renuka, K. (2017). Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis. International Journal of Rheumatic Diseases, 20(10), 1457-1467.
  • Conway, E.A., Del Pizzarro, C., Waugh, E.M., French, A. & Ridyard, A.E. (2021). Retrospective investigation of the neutrophil-to-lymphocyte ratio in dogs with pneumonia: 49 cases (2011-2016). Journal of Veterinary Emergency and Critical Care, 31, 490-497.
  • Çakır, K. & Pekmezci, D. (2019). Borrelia burgdorferi ile doğal enfekte köpeklerin nötrofil-lenfosit, monosit- lenfosit ve platelet-lenfosit oranlarının belirlenmesi. Etlik Veteriner Mikrobiyoloji Dergisi, 30(1), 58-63.
  • Daldaban, F., Karaca Bekdik, I., Aslan, Ö., Akyüz, B., Akçay, A., & Arslan, K. (2021). Investigation of TLR1-9 genes and miR-155 expression in dogs infected with canine distemper. Comparative Immunology, Microbiology and Infectious Diseases, Dec,79:101711.
  • Deem, S.L., Spelman, L.H., Yates, R.A. & Montali, R.J. (2000). Canine distemper in terrestrial carnivores: a review. Journal of Zoo and Wildlife Medicine, 31, 441-451.
  • Desai, D., Kalyani, I., Solanki, J., Patel, D., Makwana, P., Sharma, K., Vala, J., & Muglikar, D. (2021). Serological and nucleocapsid gene based molecular characterization of canine distemper Virus (CDV) isolated from dogs of Southern Gujarat, India. Indian Journal of Animal Research, 55(10), 1224-32.
  • Dong, A.J., Kim, T.Y., Song, D.S., Kang, B.K., & Park, B.K. (2008). An immuno-chromatography assay for rapid antemortem diagnosis of dogs suspected to have canine distemper. Journal of Virological Methods, 147(2), 244-249.
  • Ezeibe, M.C.O. & Udegbunam, R.I. (2008). Haematology of dogs infected with canine distemper virüs. Sokoto Journal of Veterinary Sciences, 7(2), 31-33.
  • Gori, E., Pierini, A., Lippi, I., Lubas, G. & Marchetti, V. (2021). Leukocytes ratios in feline systemic ınflammatory response syndrome and sepsis: a retrospective analysis of 209 cases. Animals, 6, 1644.
  • Hodgson, N., Llewellyn, E.A. & Schaeffer, D.J. (2018). Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis. Journal of the American Animal Hospital Association, 54, 351-359.
  • Huang Y, Liu A, Liang L, Jiang J, Luo H, Deng W, Lin G, Wu M, Li T & Jiang Y. (2018). Diagnostic value of blood parameters for community-acquired pneumonia. International Immunopharmacology, 64, 10-15.
  • Jenne, C.N. & Kubes, P. (2015). Platelets in inflammation and infection. Platelets, 26(4), 286-292.
  • Kartal, O. & Kartal, A.T. (2017). Value of neutrophil to lymphocyte and platelet to lymphocyte ratios in pneumonia. Bratislava Medical Journal, 118(9):513–516.
  • Kim, Y. H., Cho, K. W., Youn, H. Y., Yoo, H. S. & Han, H. R. (2001). Detection of canine distemper virus (CDV) through one-step RT-PCR combined with nested PCR. Journal of Veterinary Science, 2(1), 59-64.
  • Krakowka, S., Higgins, R.J. & Koestner, A. (1980). Canine distemper virus: review of structural and functional modulations in lymphoid tissues. American Journal of Veterinary Research, 41, 284–292.
  • Li, H., Zhou, Y., Ma, Y., Han, S. & Zhou, L. (2017). The prognostic value of the platelet-to- lymphocyte ratio in acute coronary syndrome: a systematic review and meta-analysis. Kardiologia Polska, 75(7), 666-673.
  • Loots, A.K.; Mitchell, E.; Dalton, D.L.; Kotzé, A. & Venter, E.H. (2017). Advances in canine distemper virus pathogenesis research: A wildlife perspective. Journal of General Virology, 98, 311–321.
  • Martinez-Gutierrez, M. & Ruiz-Saenz, J. (2016). Diversity of susceptible hosts in canine distemper virus infection: a systematic review and data synthesis. BMC Veterinary Research, 12, 78.
  • Moritz, A., Frisk, A. & Baumgartner, W. (2000). The evaluation of diagnostic procedures for the detection of canine distemper virus infection. The European Journal of Companion Animal Practice, 10, 37–47.
  • Neumann, S. (2021). Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in dogs and cats with acute pancreatitis. Veterinary Clinical Pathology, 50(1), 45-45.
  • Park, J., Lee, D., Yun, T., Koo, Y., Chae, Y., Kim, H., Yang, M.P. & Kang, B.T. (2022). Evaluation of the blood neutrophil-to-lymphocyte ratio as a biomarker for meningoencephalitis of unknown etiology in dogs. Journal of Veterinary Internal Medicine, Aug, 1- 7.
  • Pekmezci, D. & Çolak, Z. N. (2021). Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi. Journal of Anatolian Environmental and Animal Sciences, 6(4), 585-591.
  • Pierini, A., Gori, E., Lippi, I., Lubas, G. & Marchetti, V. (2020). Are leukocyte and platelet abnormalities and complete blood count ratios potential prognostic markers in canine sepsis? Frontiers in Veterinary Science, 7, 578846.
  • Rejec, A., Butinar, J., Gawor, J. & Petelin, M. (2017). Evaluation of complete blood count indices (NLR, PLR, MPV/PLT, and PLCRi) in healthy dogs, dogs with periodontitis and dogs with oropharyngeal tumors as potential biomarkers of systemic inflammatory response. Journal of Veterinary Dentistry, 34, 231-240.
  • Rossi, S., Basso, M., Strippoli, A., Schinzari, G., D’Argento, E., Larocca, M., Cassano, A. & Barone, C. (2017). Are markers of systemic inflammation good prognostic indicators in colorectal cancer? Clin Colorectal Cancer, 16, 264-274.
  • Troìa, R., Agnoli, C., Calipa, S., Segalina, S., Murgia, E., Gruarin, M., Dondi, F. & Giunti, M. (2017). Evaluation of the delta neutrophil index from an automated blood cell analyser in septic dogs. The Veterinary Journal, 230, 13-19.
  • Wang, Y., Fuentes, H.E., Attar, B.M., Jaiswal, P. & Demetria, M. (2017). Evaluation of the prognostic value of neutrophil to lymphocyte ratio in patients with hypertriglycer- idemia-induced acute pancreatitis. Pancreatology, 17(6), 893-897.
  • Willi, B., Spiri, A.M., Meli, M.L., Grimm, F., Beatrice, L., Riond, B., Bley, T., Jordi, R., Dennler, M. & Hofmann-Lehmann, R. (2015). Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland. BMC Veterinary Research, 16, 114-154.
  • Xiang, J., Zhou, L., Li, X., Bao, W., Chen, T., Xi, X., He, Y. & Wan, X. (2017). Preoperative Monocyte-to-Lymphocyte Ratio in Peripheral Blood Predicts Stages, Metastasis, and Histological Grades in Patients with Ovarian Cancer. Translational Oncology, Feb,10(1), 33-39.
  • Pan, Y., Liu X., Meng, L., Zhu, G., Xia, Y., Chen, J. & Takashi, Y. (2013). Pathogenesis of demyelinating encephalopathy in dogs with spontaneous acute canine distemper. Journal of Integrative Agriculture, 12(2), 334-343.
  • Yao, C., Liu, X. & Tang, Z. (2017). Prognostic role of neutrophil-lymphocyte ratio and pla- telet-lymphocyte ratio for hospital mortality in patients with AECOPD. International Journal of Chronic Obstructive Pulmonary Disease, 12, 2285-2290.
  • Zahorec, R. (2021). Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Bratislava Medical Journal, 122(7):474–488.

Kanin Distemper Virus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesine Yönelik Bir Ön Çalışma

Yıl 2022, Cilt: 7 Sayı: 4, 437 - 443, 31.12.2022
https://doi.org/10.35229/jaes.1172262

Öz

Sunulan ön çalışma ile doğal olarak Kanin Distemper Virüs (KDV) ile enfekte köpeklerin tedavi öncesi Nötrofil/Lenfosit (NEU/LYM), Monosit/Lenfosit (MONO/LYM), ve Platelet/Lenfosit (PLT/LYM) oranları ile tam kan sayımı (TKS) verilerin sağlıklı bireyler ile karşılaştırılması amaçlanmıştır. Bu amaçla retrospektif olarak Veteriner Fakültesi, Hayvan Hastanesi kayıtlarında yer alan 22 adet sahipli, 3-12 (6,2) aylık, KDV enfeksiyonu tanısı almış ve hızlı test kitleri ile pozitifliği saptanan köpekler çalışma grubunu oluşturmuştur. Diğer taraftan, 8 adet sahipli, 2-10 (8,2) aylık ve sağlıklı olduğu tespit edilen köpek ise kontrol grubunu oluşturmuştur. Gruplar arasında tedavi öncesi NEU/LYM, MONO/LYM, PLT/LYM ve TKS parametrelerinin karşılaştırılmasında KDV pozitif grubu medyan NEU/LYM, MONO/LYM, PLT/LYM ile TKS değerlerinden sadece LYM, EOS, %NEU, %LYM, %EOS, %BAS, MCH, MCHC, RDWCV, PLT değerleri arasında istatistiksel fark (P 0,05) bulunmuştur. KDV pozitif grubu medyan NEU/LYM, MONO/LYM ve PLT/LYM düzeyleri ise sırasıyla 31,9, 2,33 ve 391,2 olarak bulunurken kontrol grubunun aynı değerleri sırası ile 6,39, 0,37 ve 187,7 olarak tespit edilmiştir. KDV hastalarının tahmin edilmesinde aynı zamanda NEU/LYM, MONO/LYM ve PLT/LYM değerlerinin optimize edilmiş kesim noktaları ise sırası ile NEU/LYM =7,6, MONO/LYM=0,61 ve PLT/LYM=0,852 olarak tespit edilmiştir. Sonuç olarak, bu ön çalışma NEU/LYM, MONO/LYM ve PLT/LYM değerlerinin KDV ile enfekte köpeklerin şüpheli durumlarda tanılarının desteklenmesinde klinisyenlerce kullanılabilecek ucuz, objektif ve invazif olmayan yeni belirteç adayı olabileceklerini düşündürmektedir.

Proje Numarası

-

Kaynakça

  • Appel, M.J. (1970). Distemper pathogenesis in dogs. Journal of the American Veterinary Medical Association, 156, 1681-1684.
  • Becher, A., Suchodolski, J.S., Steiner, J.M. & Heilmann, R.M. (2021). Blood neutrophil-to-lymphocyte ratio (NLR) as a diagnostic marker in dogs with chronic enteropathy. The Journal of Veterinary Diagnostic Investigation, 33(3), 516–527.
  • Benvenuti, E., Pierini, A., Gori, E., Lucarelli, C., Lubas, G. & Marchetti, V. (2020). Neutrophil-to-lymphocyte ratio (nlr) in canine inflammatory bowel disease (IBD). Veterinary Sciences, 7(3),141.
  • Burton, A.G., Harris, L.A., Owens, S.D. & Jandrey, K.E. (2013). The prognostic utility of degenerative left shifts in dogs. Journal of Veterinary Internal Medicine, 27, 1517-1522.
  • Chandrashekara, S., Mukhtar Ahmad, M., Renuka, P., Anupama, K.R. & Renuka, K. (2017). Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis. International Journal of Rheumatic Diseases, 20(10), 1457-1467.
  • Conway, E.A., Del Pizzarro, C., Waugh, E.M., French, A. & Ridyard, A.E. (2021). Retrospective investigation of the neutrophil-to-lymphocyte ratio in dogs with pneumonia: 49 cases (2011-2016). Journal of Veterinary Emergency and Critical Care, 31, 490-497.
  • Çakır, K. & Pekmezci, D. (2019). Borrelia burgdorferi ile doğal enfekte köpeklerin nötrofil-lenfosit, monosit- lenfosit ve platelet-lenfosit oranlarının belirlenmesi. Etlik Veteriner Mikrobiyoloji Dergisi, 30(1), 58-63.
  • Daldaban, F., Karaca Bekdik, I., Aslan, Ö., Akyüz, B., Akçay, A., & Arslan, K. (2021). Investigation of TLR1-9 genes and miR-155 expression in dogs infected with canine distemper. Comparative Immunology, Microbiology and Infectious Diseases, Dec,79:101711.
  • Deem, S.L., Spelman, L.H., Yates, R.A. & Montali, R.J. (2000). Canine distemper in terrestrial carnivores: a review. Journal of Zoo and Wildlife Medicine, 31, 441-451.
  • Desai, D., Kalyani, I., Solanki, J., Patel, D., Makwana, P., Sharma, K., Vala, J., & Muglikar, D. (2021). Serological and nucleocapsid gene based molecular characterization of canine distemper Virus (CDV) isolated from dogs of Southern Gujarat, India. Indian Journal of Animal Research, 55(10), 1224-32.
  • Dong, A.J., Kim, T.Y., Song, D.S., Kang, B.K., & Park, B.K. (2008). An immuno-chromatography assay for rapid antemortem diagnosis of dogs suspected to have canine distemper. Journal of Virological Methods, 147(2), 244-249.
  • Ezeibe, M.C.O. & Udegbunam, R.I. (2008). Haematology of dogs infected with canine distemper virüs. Sokoto Journal of Veterinary Sciences, 7(2), 31-33.
  • Gori, E., Pierini, A., Lippi, I., Lubas, G. & Marchetti, V. (2021). Leukocytes ratios in feline systemic ınflammatory response syndrome and sepsis: a retrospective analysis of 209 cases. Animals, 6, 1644.
  • Hodgson, N., Llewellyn, E.A. & Schaeffer, D.J. (2018). Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis. Journal of the American Animal Hospital Association, 54, 351-359.
  • Huang Y, Liu A, Liang L, Jiang J, Luo H, Deng W, Lin G, Wu M, Li T & Jiang Y. (2018). Diagnostic value of blood parameters for community-acquired pneumonia. International Immunopharmacology, 64, 10-15.
  • Jenne, C.N. & Kubes, P. (2015). Platelets in inflammation and infection. Platelets, 26(4), 286-292.
  • Kartal, O. & Kartal, A.T. (2017). Value of neutrophil to lymphocyte and platelet to lymphocyte ratios in pneumonia. Bratislava Medical Journal, 118(9):513–516.
  • Kim, Y. H., Cho, K. W., Youn, H. Y., Yoo, H. S. & Han, H. R. (2001). Detection of canine distemper virus (CDV) through one-step RT-PCR combined with nested PCR. Journal of Veterinary Science, 2(1), 59-64.
  • Krakowka, S., Higgins, R.J. & Koestner, A. (1980). Canine distemper virus: review of structural and functional modulations in lymphoid tissues. American Journal of Veterinary Research, 41, 284–292.
  • Li, H., Zhou, Y., Ma, Y., Han, S. & Zhou, L. (2017). The prognostic value of the platelet-to- lymphocyte ratio in acute coronary syndrome: a systematic review and meta-analysis. Kardiologia Polska, 75(7), 666-673.
  • Loots, A.K.; Mitchell, E.; Dalton, D.L.; Kotzé, A. & Venter, E.H. (2017). Advances in canine distemper virus pathogenesis research: A wildlife perspective. Journal of General Virology, 98, 311–321.
  • Martinez-Gutierrez, M. & Ruiz-Saenz, J. (2016). Diversity of susceptible hosts in canine distemper virus infection: a systematic review and data synthesis. BMC Veterinary Research, 12, 78.
  • Moritz, A., Frisk, A. & Baumgartner, W. (2000). The evaluation of diagnostic procedures for the detection of canine distemper virus infection. The European Journal of Companion Animal Practice, 10, 37–47.
  • Neumann, S. (2021). Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in dogs and cats with acute pancreatitis. Veterinary Clinical Pathology, 50(1), 45-45.
  • Park, J., Lee, D., Yun, T., Koo, Y., Chae, Y., Kim, H., Yang, M.P. & Kang, B.T. (2022). Evaluation of the blood neutrophil-to-lymphocyte ratio as a biomarker for meningoencephalitis of unknown etiology in dogs. Journal of Veterinary Internal Medicine, Aug, 1- 7.
  • Pekmezci, D. & Çolak, Z. N. (2021). Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi. Journal of Anatolian Environmental and Animal Sciences, 6(4), 585-591.
  • Pierini, A., Gori, E., Lippi, I., Lubas, G. & Marchetti, V. (2020). Are leukocyte and platelet abnormalities and complete blood count ratios potential prognostic markers in canine sepsis? Frontiers in Veterinary Science, 7, 578846.
  • Rejec, A., Butinar, J., Gawor, J. & Petelin, M. (2017). Evaluation of complete blood count indices (NLR, PLR, MPV/PLT, and PLCRi) in healthy dogs, dogs with periodontitis and dogs with oropharyngeal tumors as potential biomarkers of systemic inflammatory response. Journal of Veterinary Dentistry, 34, 231-240.
  • Rossi, S., Basso, M., Strippoli, A., Schinzari, G., D’Argento, E., Larocca, M., Cassano, A. & Barone, C. (2017). Are markers of systemic inflammation good prognostic indicators in colorectal cancer? Clin Colorectal Cancer, 16, 264-274.
  • Troìa, R., Agnoli, C., Calipa, S., Segalina, S., Murgia, E., Gruarin, M., Dondi, F. & Giunti, M. (2017). Evaluation of the delta neutrophil index from an automated blood cell analyser in septic dogs. The Veterinary Journal, 230, 13-19.
  • Wang, Y., Fuentes, H.E., Attar, B.M., Jaiswal, P. & Demetria, M. (2017). Evaluation of the prognostic value of neutrophil to lymphocyte ratio in patients with hypertriglycer- idemia-induced acute pancreatitis. Pancreatology, 17(6), 893-897.
  • Willi, B., Spiri, A.M., Meli, M.L., Grimm, F., Beatrice, L., Riond, B., Bley, T., Jordi, R., Dennler, M. & Hofmann-Lehmann, R. (2015). Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland. BMC Veterinary Research, 16, 114-154.
  • Xiang, J., Zhou, L., Li, X., Bao, W., Chen, T., Xi, X., He, Y. & Wan, X. (2017). Preoperative Monocyte-to-Lymphocyte Ratio in Peripheral Blood Predicts Stages, Metastasis, and Histological Grades in Patients with Ovarian Cancer. Translational Oncology, Feb,10(1), 33-39.
  • Pan, Y., Liu X., Meng, L., Zhu, G., Xia, Y., Chen, J. & Takashi, Y. (2013). Pathogenesis of demyelinating encephalopathy in dogs with spontaneous acute canine distemper. Journal of Integrative Agriculture, 12(2), 334-343.
  • Yao, C., Liu, X. & Tang, Z. (2017). Prognostic role of neutrophil-lymphocyte ratio and pla- telet-lymphocyte ratio for hospital mortality in patients with AECOPD. International Journal of Chronic Obstructive Pulmonary Disease, 12, 2285-2290.
  • Zahorec, R. (2021). Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Bratislava Medical Journal, 122(7):474–488.
Toplam 36 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Didem Pekmezci 0000-0003-2072-8165

Gamze Nur Konaçoğlu 0000-0002-1883-3428

Zeynep Nurselin Çolak 0000-0002-0631-5471

Proje Numarası -
Erken Görünüm Tarihi 16 Aralık 2022
Yayımlanma Tarihi 31 Aralık 2022
Gönderilme Tarihi 8 Eylül 2022
Kabul Tarihi 18 Kasım 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 7 Sayı: 4

Kaynak Göster

APA Pekmezci, D., Konaçoğlu, G. N., & Çolak, Z. N. (2022). A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection. Journal of Anatolian Environmental and Animal Sciences, 7(4), 437-443. https://doi.org/10.35229/jaes.1172262


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