Derleme
BibTex RIS Kaynak Göster

YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER

Yıl 2022, Cilt: 46 Sayı: 1, 239 - 261, 29.01.2022
https://doi.org/10.33483/jfpau.1006409

Öz

Amaç: Nanopartiküler ilaç taşıyıcı sistemler, boyuta bağlı özelliklerinden dolayı giderek artan şekilde ilgi görmektedir. Bu sistemler arasında polimerik nanopartiküller ve lipozomlar en popüler nanotaşıyıcılardandır; ancak bu sistemlerde görülen düşük stabilite, kısa raf ömrü, hazırlanmasında organik çözücü kullanımı, ölçek büyütmenin zor olması gibi dezavantajların üstesinden gelmek için araştırmacılar lipit bazlı nanotaşıyıcılara yönelmiştir. Yeni nesil lipidik taşıyıcılardan olan lipid nanokapsüller (LNC), hidrofilik ve lipofilik sert bir surfaktan kabuk ile çevrelenmiş yağlı sıvı çekirdekten oluşan sistemlerdir ve polimerik nanokapsüller ile lipozomlar arasında yer alan hibrit bir yapıya sahiptirler. Bu derleme kapsamında LNC’ler hakkında genel bilgiler, hazırlama yöntemi ve uygulama yollarına ilişkin bilimsel çalışmalar sunulmuştur.
Sonuç ve Tartışma: Tüm bileşenleri FDA onaylı olan LNC'ler, organik çözücü içermeyen, düşük enerji tüketimli ve ölçek büyütmeye elverişli patentli bir üretim teknolojisi olan faz inversiyon yöntemiyle kolayca hazırlanabilmektedir. Bu yöntem ile 20-100 nm partikül büyüklüklerinde ve dar bir dağılım aralığında elde edilen LNC'ler yüksek etkin madde yükleme kapasitesine sahip olmaları, yüzey modifikasyonuna elverişli olmaları, yüzeyindeki polietilen glikol zincirleri sayesinde uzun süre kan dolaşımında kalabilmeleri ve fiziksel stabilitelerinin yüksek olması (18 aya kadar) gibi çok sayıda avantaja sahiptirler. LNC'lerin, lipofilik, amfifilik ve hidrofilik özellikteki pek çok etkin madde için oral, parenteral, topikal, pulmuner yollar gibi çeşitli uygulama yolları kullanılarak farklı farmasötik uygulamalarda kullanılması onların potansiyel ilaç taşıyıcı sistemler olduğunu göstermektedir. Sahip oldukları bu üstün özellikler sayesinde LNC’ler başta lipozomlar ve polimerik nanokapsüller olmak üzere ilaç taşıyıcı sistemlerde gözlenen dezavantajların üstesinden gelerek umut verici alternatif yeni nesil ilaç taşıyıcı sistemler olarak karşımıza çıkmaktadır.

Kaynakça

  • 1. Hong, Y., Rao, Y. (2019). Current status of nanoscale drug delivery systems for colorectal cancer liver metastasis. Biomedicine & Pharmacotherapy, 114, 108764. [CrossRef]
  • 2. Rogueda, P.G., Traini, D. (2007). The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects. Expert opinion on drug delivery, 4(6), 595-606. [CrossRef]
  • 3. Narvekar, M., Xue, H.Y., Eoh, J.Y., Wong, H.L. (2014). Nanocarrier for poorly water-soluble anticancer drugs—barriers of translation and solutions. Aaps Pharmscitech, 15(4), 822-833. [CrossRef]
  • 4. Sengel-Turk, C.T., Hascicek, C., Dogan, A.L., Esendagli, G., Guc, D., Gonul, N. (2014). Surface modification and evaluation of PLGA nanoparticles: the effects on cellular uptake and cell proliferation on the HT-29 cell line. Journal of Drug Delivery Science and Technology, 24(2), 166-172. [CrossRef]
  • 5. Shao, K., Singha, S., Clemente-Casares, X., Tsai, S., Yang, Y., Santamaria, P. (2015). Nanoparticle-based immunotherapy for cancer. ACS nano, 9(1), 16-30. [CrossRef]
  • 6. Bidram, E., Esmaeili, Y., Ranji-Burachaloo, H., Al-Zaubai, N., Zarrabi, A., Stewart, A., Dunstan, D.E. (2019). A concise review on cancer treatment methods and delivery systems. Journal of Drug Delivery Science and Technology, 54, 101350. [CrossRef]
  • 7. Krishnamurthy, S., Vaiyapuri, R., Zhang, L., Chan, J.M. (2015). Lipid-coated polymeric nanoparticles for cancer drug delivery. Biomaterials science, 3(7), 923-936. [CrossRef]
  • 8. Yadav, H.K., Almokdad, A.A., Sumia, I.M., Debe, M.S. (2019). Chapter 17. Polymer-based nanomaterials for drug-delivery carriers. In: Mohapatra S.S., Ranjan S., Dasgupta N., Mishra R.K., Thomas S. (Eds.), Nanocarriers for Drug Delivery, Elsevier, ISBN: 9780128140338, (pp. 531-556). [CrossRef]
  • 9. Cheow, W.S., Hadinoto, K. (2011). Factors affecting drug encapsulation and stability of lipid–polymer hybrid nanoparticles. Colloids and surfaces B: Biointerfaces, 85(2), 214-220. [CrossRef]
  • 10. Thanki, K., Gangwal, R.P., Sangamwar, A.T., Jain, S. (2013). Oral delivery of anticancer drugs: challenges and opportunities. Journal of controlled release, 170(1), 15-40. [CrossRef]
  • 11. Sengel-Turk, C.T., Gumustas, M., Uslu, B., Ozkan, S.A. (2017) Chapter 10. Nano-sized Drug Carriers for Oral Delivery of Anti-Cancer Compounds and the Place of the Chromatographic Techniques. In: Grumezescu, A.M (Ed.), Nano- and Microscale Drug Delivery Systems, 1st Edition”, Elsevier, ISBN: 9780323527279, (pp.165-195). [CrossRef]
  • 12. Dave, V., Tak, K., Sohgaura, A., Gupta, A., Sadhu, V., Reddy, K.R. (2019). Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications. Journal of microbiological methods, 160, 130-142. [CrossRef]
  • 13. Allen, T.M., Cullis, P.R. (2013). Liposomal drug delivery systems: from concept to clinical applications. Advanced drug delivery reviews, 65(1), 36-48. [CrossRef]
  • 14. Sercombe, L., Veerati, T., Moheimani, F., Wu, S.Y., Sood, A.K., Hua, S. (2015). Advances and challenges of liposome assisted drug delivery. Frontiers in pharmacology, 6, 286. [CrossRef]
  • 15. Daraee, H., Etemadi, A., Kouhi, M., Alimirzalu, S., Akbarzadeh, A. (2016). Application of liposomes in medicine and drug delivery. Artificial cells, nanomedicine, and biotechnology, 44(1), 381-391. [CrossRef]
  • 16. Badilli, U., Sengel-Turk, C.T., Onay-Besikci, A., Tarimci, N. (2015). Development of etofenamate-loaded semisolid SLN dispersions and evaluation of anti-inflammatory activity for topical application. Current Drug Delivery, 12(2), 200-209. [CrossRef]
  • 17. Teixeira, M.C., Carbone, C., Souto, E.B. (2017). Beyond liposomes: Recent advances on lipid based nanostructures for poorly soluble/poorly permeable drug delivery. Progress in lipid research, 68, 1-11. [CrossRef]
  • 18. Rassouli, A., Al-Qushawi, A. (2018). Lipid-based nanoparticles as novel drug delivery systems for antimicrobial agents. Iranian Journal of Veterinary Science and Technology, 10(2), 1-16. [CrossRef]
  • 19. Bakar-Ates, F., Ozkan, E., Sengel-Turk, C.T. (2020). Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. International Journal of Pharmaceutics, 586, 119565. [CrossRef]
  • 20. Carbone, C., Leonardi, A., Cupri, S., Puglisi, G., Pignatello, R. (2014). Pharmaceutical and biomedical applications of lipid-based nanocarriers. Pharmaceutical patent analyst, 3(2), 199-215. [CrossRef]
  • 21. Chakraborty, S., Shukla, D., Mishra, B., Singh, S. (2009). Lipid–an emerging platform for oral delivery of drugs with poor bioavailability. European Journal of Pharmaceutics and Biopharmaceutics, 73(1), 1-15. [CrossRef]
  • 22. Attama, A.A., Momoh, M.A., Builders, P.F. (2012). Chapter 5. Lipid nanoparticulate drug delivery systems: a revolution in dosage form design and development. In: Sezer, A.D (Ed.), Recent advances in novel drug carrier systems, Intech, ISBN: 9789535108108, (pp. 107-140). [CrossRef]
  • 23. Mohsen, K., Azzazy, H.M., Allam, N.K., Basalious, E.B. (2020). Intranasal lipid nanocapsules for systemic delivery of nimodipine into the brain: In vitro optimization and in vivo pharmacokinetic study. Materials Science and Engineering: C, 116, 111236. [CrossRef]
  • 24. Fernandes, P.C.L., de Moura, L.D., de Lima, F.F., da Silva, G.H.R., Souza, R.I.C., de Paula, E. (2021). Lipid nanocapsules loaded with prilocaine and lidocaine and incorporated in gel for topical application. International Journal of Pharmaceutics, 602, 120675. [CrossRef]
  • 25. Heurtault, B., Saulnier, P., Pech, B., Proust, J.E., Benoit, J.P. (2002). A novel phase inversion-based process for the preparation of lipid nanocarriers. Pharmaceutical research, 19(6), 875-880. [CrossRef]
  • 26. Lollo, G., Ullio-Gamboa, G., Fuentes, E., Matha, K., Lautram, N., Benoit, J.P. (2018). In vitro anti-cancer activity and pharmacokinetic evaluation of curcumin-loaded lipid nanocapsules. Materials Science and Engineering: C, 91, 859-867. [CrossRef]
  • 27. Paillard, A., Hindré, F., Vignes-Colombeix, C., Benoit, J.P., Garcion, E. (2010). The importance of endo-lysosomal escape with lipid nanocapsules for drug subcellular bioavailability. Biomaterials, 31(29), 7542-7554. [CrossRef]
  • 28. Saulnier, P., Benoît, J.P. (2006). Lipidic core nanocapsules as new drug delivery systems. In: Torchilin, V.P. (Ed.), In Nanoparticulates as drug carriers, (pp. 213-224). [CrossRef]
  • 29. Huynh, N.T., Passirani, C., Saulnier, P., Benoît, J.P. (2009). Lipid nanocapsules: a new platform for nanomedicine. International journal of pharmaceutics, 379(2), 201-209. [CrossRef]
  • 30. Aparicio-Blanco, J., Torres-Suárez, A.I. (2015). Glioblastoma multiforme and lipid nanocapsules: a review. Journal of biomedical nanotechnology, 11(8), 1283-1311. [CrossRef]
  • 31. Safwat, S., Hathout, R.M., Ishak, R.A., Mortada, N.D. (2017). Augmented simvastatin cytotoxicity using optimized lipid nanocapsules: a potential for breast cancer treatment. Journal of liposome research, 27(1), 1-10. [CrossRef]
  • 32. Molaahmadi, M.R., Varshosaz, J., Taymouri, S., Akbari, V. (2019). Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line. Iranian journal of pharmaceutical research: IJPR, 18(4), 1676. [CrossRef]
  • 33. Chouchou, A., Aubert-Pouëssel, A., Dorandeu, C., Zghaib, Z., Cuq, P., Devoisselle, J.M., Bonnet, P.A., Bégu S., Deleuze-Masquefa, C. (2017). Lipid nanocapsules formulation and cellular activities evaluation of a promising anticancer agent: EAPB0503. International journal of pharmaceutical investigation, 7(4), 155. [CrossRef]
  • 34. Zhao, Y.Q., Wang, L.P., Ma, C., Zhao, K., Liu, Y., Feng, N.P. (2013). Preparation and characterization of tetrandrine-phospholipid complex loaded lipid nanocapsules as potential oral carriers. International journal of nanomedicine, 8, 4169. [CrossRef]
  • 35. Lamprecht, A., Bouligand, Y., Benoit, J.P. (2002). New lipid nanocapsules exhibit sustained release properties for amiodarone. Journal of Controlled Release, 84(1-2), 59-68. [CrossRef]
  • 36. Moura, R.P., Pacheco, C., Pêgo, A.P., des Rieux, A., Sarmento, B. (2020). Lipid nanocapsules to enhance drug bioavailability to the central nervous system. Journal of Controlled Release, 322, 390-400. [CrossRef]
  • 37. Anton, N., Gayet, P., Benoit, J.P., Saulnier, P. (2007). Nano-emulsions and nanocapsules by the PIT method: an investigation on the role of the temperature cycling on the emulsion phase inversion. International Journal of Pharmaceutics, 344(1-2), 44-52. [CrossRef]
  • 38. Lamprecht, A., Benoit, J.P. (2006). Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition. Journal of Controlled Release, 112(2), 208-213. [CrossRef]
  • 39. Peltier, S., Oger, J.M., Lagarce, F., Couet, W., Benoît, J.P. (2006). Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules. Pharmaceutical research, 23(6), 1243-1250. [CrossRef]
  • 40. Lacoeuille, F., Garcion, E., Benoit, J.P., Lamprecht, A. (2007). Lipid nanocapsules for intracellular drug delivery of anticancer drugs. Journal of nanoscience and nanotechnology, 7(12), 4612-4617. [CrossRef]
  • 41. Heurtault, B., Saulnier, P., Benoit, J.P., Proust, J.E., Pech, B., Richard, J. (2011). U.S. Patent No. 8,057,823. Washington, DC: U.S. Patent and Trademark Office.
  • 42. Tsakiris, N., Papavasileiou, M., Bozzato, E., Lopes, A., Vigneron, A.M., Préat, V. (2019). Combinational drug-loaded lipid nanocapsules for the treatment of cancer. International journal of pharmaceutics, 569, 118588. [CrossRef]
  • 43. Zhai, Y., Zhao, L., Wang, Z., Zhai, G. (2016). Preparation and characterization of novel lipid nanocapsules of ropivacaine for transdermal delivery. Drug delivery, 23(2), 619-628. [CrossRef]
  • 44. Saliou, B., Thomas, O., Lautram, N., Clavreul, A., Hureaux, J., Urban, T., Benoit, J.P., Lagarce, F. (2013). Development and in vitro evaluation of a novel lipid nanocapsule formulation of etoposide. European Journal of Pharmaceutical Sciences, 50(2), 172-180. [CrossRef]
  • 45. Zhai, Y., Liu, M., Wan, M., Li, Y., Zhang, M., Zhai, G. (2015). Preparation and characterization of puerarin-loaded lipid nanocapsules. Journal of nanoscience and nanotechnology, 15(4), 2643-2649. [CrossRef]
  • 46. Unicancer Web Site. From, http://www.unicancer.fr/sites/default/files/Enjeux_defis_developpement_formes_vectorielles_JP_Benoit.pdf / Erişim tarihi: 10 Temmuz 2021
  • 47. Heurtault, B., Saulnier, P., Pech, B., Venier-Julienne, M.C., Proust, J.E., Phan-Tan-Luu, R., Benoı̂t, J.P. (2003). The influence of lipid nanocapsule composition on their size distribution. European Journal of Pharmaceutical Sciences, 18(1), 55-61. [CrossRef]
  • 48. Roger, E., Lagarce, F., Benoit, J.P. (2011). Development and characterization of a novel lipid nanocapsule formulation of Sn38 for oral administration. European journal of pharmaceutics and biopharmaceutics, 79(1), 181-188. [CrossRef]
  • 49. Briot, T., Roger, E., Lautram, N., Verger, A., Clavreul, A., Lagarce, F. (2017). Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia. International journal of nanomedicine, 12, 8427. [CrossRef]
  • 50. Lamprecht, A., Bouligand, Y., Benoit, J.P. (2002). New lipid nanocapsules exhibit sustained release properties for amiodarone. Journal of Controlled Release, 84(1-2), 59-68. [CrossRef]
  • 51. Vakilzadeh, H., Varshosaz, J., Soghrati, S. (2021). Enhanced Solubility and Permeability of Naringenin Across Non-Everted Sacs of Rat Small Intestine by Lipid Nanocapsules. Recent Patents on Nanotechnology, 15(1), 55-69. [CrossRef]
  • 52. Basu, S.M., Yadava, S.K., Singh, R., Giri, J. (2021). Lipid nanocapsules co-encapsulating paclitaxel and salinomycin for eradicating breast cancer and cancer stem cells. Colloids and Surfaces B: Biointerfaces, 204, 111775. [CrossRef]
  • 53. Ramadan, A., Lagarce, F., Tessier-Marteau, A., Thomas, O., Legras, P., Macchi, L., Saulnier, P., Benoit, J.P. (2011). Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study. International journal of nanomedicine, 6, 2941. [CrossRef]
  • 54. Morille, M., Passirani, C., Dufort, S., Bastiat, G., Pitard, B., Coll, J.L., Benoit, J.P. (2011). Tumor transfection after systemic injection of DNA lipid nanocapsules. Biomaterials, 32(9), 2327-2333. [CrossRef]
  • 55. Messaoudi, K., Saulnier, P., Boesen, K., Benoit, J.P., Lagarce, F. (2014). Anti-epidermal growth factor receptor siRNA carried by chitosan-transacylated lipid nanocapsules increases sensitivity of glioblastoma cells to temozolomide. International journal of nanomedicine, 9, 1479. [CrossRef]
  • 56. Vrignaud, S., Hureaux, J., Wack, S., Benoit, J.P., Saulnier, P. (2012). Design, optimization and in vitro evaluation of reverse micelle-loaded lipid nanocarriers containing erlotinib hydrochloride. International journal of pharmaceutics, 436(1-2), 194-200. [CrossRef]
  • 57. Groo, A.C., Matougui, N., Umerska, A., Saulnier, P. (2018). Reverse micelle-lipid nanocapsules: a novel strategy for drug delivery of the plectasin derivate AP138 antimicrobial peptide. International journal of nanomedicine, 13, 7565. [CrossRef]
  • 58. Montigaud, Y., Ucakar, B., Krishnamachary, B., Bhujwalla, Z.M., Feron, O., Préat, V., Fabienne D., Gallez, B., Danhier, P. (2018). Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer. International journal of pharmaceutics, 551(1-2), 322-328. [CrossRef]
  • 59. Vrignaud, S., Anton, N., Gayet, P., Benoit, J. P., Saulnier, P. (2011). Reverse micelle-loaded lipid nanocarriers: a novel drug delivery system for the sustained release of doxorubicin hydrochloride. European journal of pharmaceutics and biopharmaceutics, 79(1), 197-204. [CrossRef]
  • 60. Lollo, G., Matha, K., Bocchiardo, M., Bejaud, J., Marigo, I., Virgone-Carlotta, A., Dehoux T., Rivière, C., Rieu, J.P., Briançon, S., Perrier, T., Meyer, O., Benoit, J.P. (2019). Drug delivery to tumours using a novel 5-FU derivative encapsulated into lipid nanocapsules. Journal of drug targeting, 27(5-6), 634-645. [CrossRef]
  • 61. Eldesouky, L.M., El-Moslemany, R.M., Ramadan, A.A., Morsi, M.H., Khalafallah, N.M. (2021). Cyclosporine Lipid Nanocapsules as Thermoresponsive Gel for Dry Eye Management: Promising Corneal Mucoadhesion, Biodistribution and Preclinical Efficacy in Rabbits. Pharmaceutics, 13(3), 360. [CrossRef]
  • 62. Ashour, A.A., Ramadan, A.A., Abdelmonsif, D.A., El-Kamel, A.H. (2020). Enhanced oral bioavailability of Tanshinone IIA using lipid nanocapsules: formulation, in-vitro appraisal and pharmacokinetics. International Journal of Pharmaceutics, 586, 119598. [CrossRef]
  • 63. Bapat, P., Ghadi, R., Chaudhari, D., Katiyar, S.S., Jain, S. (2019). Tocophersolan stabilized lipid nanocapsules with high drug loading to improve the permeability and oral bioavailability of curcumin. International journal of pharmaceutics, 560, 219-227. [CrossRef]
  • 64. Roger, E., Lagarce, F., Benoit, J.P. (2009). The gastrointestinal stability of lipid nanocapsules. International journal of pharmaceutics, 379(2), 260-265. [CrossRef]
  • 65. Lamprecht, A., Saumet, J.L., Roux, J., Benoit, J.P. (2004). Lipid nanocarriers as drug delivery system for ibuprofen in pain treatment. International journal of pharmaceutics, 278(2), 407-414. [CrossRef]
  • 66. Amara, R.O., Ramadan, A.A., El-Moslemany, R.M., Eissa, M.M., El-Azzouni, M.Z., El-Khordagui, L.K. (2018). Praziquantel–lipid nanocapsules: an oral nanotherapeutic with potential Schistosoma mansoni tegumental targeting. International journal of nanomedicine, 13, 4493. [CrossRef]
  • 67. Varshosaz, J., Taymouri, S., Jahanian-Najafabadi, A., Alizadeh, A. (2018). Efavirenz oral delivery via lipid nanocapsules: formulation, optimisation, and ex-vivo gut permeation study. IET nanobiotechnology, 12(6), 795-806. [CrossRef]
  • 68. Gamboa, G.V.U., Pensel, P.E., Elissondo, M.C., Bruni, S.F.S., Benoit, J.P., Palma, S.D., Allemandi, D.A. (2019). Albendazole-lipid nanocapsules: optimization, characterization and chemoprophylactic efficacy in mice infected with Echinococcus granulosus. Experimental parasitology, 198, 79-86. [CrossRef]
  • 69. Hureaux, J., Lagarce, F., Gagnadoux, F., Rousselet, M.C., Moal, V., Urban, T., Benoit, J.P. (2010). Toxicological study and efficacy of blank and paclitaxel-loaded lipid nanocapsules after iv administration in mice. Pharmaceutical research, 27(3), 421-430. [CrossRef]
  • 70. Khalid, M.N., Simard, P., Hoarau, D., Dragomir, A., Leroux, J.C. (2006). Long circulating poly (ethylene glycol)-decorated lipid nanocapsules deliver docetaxel to solid tumors. Pharmaceutical research, 23(4), 752-758. [CrossRef]
  • 71. Rahali, Y., Saulnier, P., Benoit, J.P., Bensouda, Y. (2010). Incorporating vegetal oils in parenteral nutrition using lipid nanocapsules. Journal of drug delivery science and technology, 20(6), 425-429. [CrossRef]
  • 72. Huynh, N.T., Morille, M., Bejaud, J., Legras, P., Vessieres, A., Jaouen, G., Benoit, J.P., Passirani, C. (2011). Treatment of 9L gliosarcoma in rats by ferrociphenol-loaded lipid nanocapsules based on a passive targeting strategy via the EPR effect. Pharmaceutical research, 28(12), 3189-3198. [CrossRef]
  • 73. Lainé, A.L., Adriaenssens, E., Vessières, A., Jaouen, G., Corbet, C., Desruelles, E., Pigeon, P., Toillon, R.A., Passirani, C. (2013). The in vivo performance of ferrocenyl tamoxifen lipid nanocapsules in xenografted triple negative breast cancer. Biomaterials, 34(28), 6949-6956. [CrossRef]
  • 74. Hureaux, J., Lacoeuille, F., Lagarce, F., Rousselet, M.C., Contini, A., Saulnier, P., Benoit, J.P., Urban, T. (2017). Absence of lung fibrosis after a single pulmonary delivery of lipid nanocapsules in rats. International journal of nanomedicine, 12, 8159. [CrossRef]
  • 75. Umerska, A., Mugheirbi, N.A., Kasprzak, A., Saulnier, P., Tajber, L. (2020). Carbohydrate-based Trojan microparticles as carriers for pulmonary delivery of lipid nanocapsules using dry powder inhalation. Powder Technology, 364, 507-521. [CrossRef]
  • 76. Hureaux, J., Lagarce, F., Gagnadoux, F., Vecellio, L., Clavreul, A., Roger, E., Kempf, M., Racineux, J.L., Diot, P., Benoit, J.P., Urban, T. (2009). Lipid nanocapsules: ready-to-use nanovectors for the aerosol delivery of paclitaxel. European journal of pharmaceutics and biopharmaceutics, 73(2), 239-246. [CrossRef]
  • 77. Umerska, A., Mouzouvi, C.R., Bigot, A., Saulnier, P. (2015). Formulation and nebulization of fluticasone propionate-loaded lipid nanocarriers. International journal of pharmaceutics, 493(1-2), 224-232. [CrossRef]
  • 78. Nguyen, H.T.P., Munnier, E., Perse, X., Vial, F., Yvergnaux, F., Perrier, T., Soucé, M., Chourpa, I. (2016). Qualitative and quantitative study of the potential of lipid nanocapsules of one hundred twenty nanometers for the topical administration of hydrophobic molecules. Journal of pharmaceutical sciences, 10 5(10), 3191-3198. [CrossRef]
  • 79. Zhai, Y., Yang, X., Zhao, L., Wang, Z., Zhai, G. (2014). Lipid nanocapsules for transdermal delivery of ropivacaine: in vitro and in vivo evaluation. International journal of pharmaceutics, 471(1-2), 103-111. [CrossRef]
  • 80. Varshosaz, J., Hajhashemi, V., Soltanzadeh, S. (2011). Lipid nanocapsule-based gels for enhancement of transdermal delivery of ketorolac tromethamine. Journal of drug delivery, 2011. [CrossRef]
  • 81. Abdel-Mottaleb, M.M., Neumann, D., Lamprecht, A. (2011). Lipid nanocapsules for dermal application: a comparative study of lipid-based versus polymer-based nanocarriers. European Journal of Pharmaceutics and Biopharmaceutics, 79(1), 36-42. [CrossRef]
  • 82. Hatahet, T., Morille, M., Shamseddin, A., Aubert-Pouëssel, A., Devoisselle, J.M., Bégu, S. (2017). Dermal quercetin lipid nanocapsules: Influence of the formulation on antioxidant activity and cellular protection against hydrogen peroxide. International journal of pharmaceutics, 518(1-2), 167-176. [CrossRef]
  • 83. Hatahet, T., Morille, M., Hommoss, A., Devoisselle, J.M., Müller, R.H., Begu, S. (2018). Liposomes, lipid nanocapsules and smartCrystals®: A comparative study for an effective quercetin delivery to the skin. International journal of pharmaceutics, 542(1-2), 176-185. [CrossRef]
  • 84. El-Sheridy, N.A., Ramadan, A.A., Eid, A.A., El-Khordagui, L.K. (2019). Itraconazole lipid nanocapsules gel for dermatological applications: in vitro characteristics and treatment of induced cutaneous candidiasis. Colloids and Surfaces B: Biointerfaces, 181, 623-631. [CrossRef]
  • 85. Formica, M.L., Legeay, S., Bejaud, J., Montich, G.G., Gamboa, G.V U., Benoit, J.P., Palma, S.D. (2020). Novel hybrid lipid nanocapsules loaded with a therapeutic monoclonal antibody–Bevacizumab–and Triamcinolone acetonide for combined therapy in neovascular ocular pathologies. Materials Science and Engineering: C, 119, 111398. [CrossRef]
  • 86. Sun, R., Zhang, A., Ge, Y., Gou, J., Yin, T., He, H., Wang, Y., Zhang, G., Kong, J., Shang, L., Tao, X., Zhang, Y., Tang, X. (2020). Ultra-small-size Astragaloside-IV loaded lipid nanocapsules eye drops for the effective management of dry age-related macular degeneration. Expert Opinion on Drug Delivery, 17(9), 1305-1320. [CrossRef]
  • 87. Zhang, A., Sun, R., Ran, M., Deng, Y., Ge, Y., Zhu, Y., Tao, X., Shang, L., Gou, J., He, H., Yin, T., Wang, Y., Zhang, Y., Tang, X. (2020). A Novel Eyes Topical Drug Delivery System: CsA-LNC for the Treatment of DED. Pharmaceutical Research, 37(7), 1-14. [CrossRef]
  • 88. Abozaid, D., Ramadan, A., Barakat, H., Khalafallah, N. (2018). Acyclovir lipid nanocapsules gel for oromucosal delivery: A preclinical evidence of efficacy in the chicken pouch membrane model. European Journal of Pharmaceutical Sciences, 121, 228-235. [CrossRef]

NEW GENERATION LIPID-BASED DRUG DELIVERY SYSTEMS: LIPID NANOCAPSULES

Yıl 2022, Cilt: 46 Sayı: 1, 239 - 261, 29.01.2022
https://doi.org/10.33483/jfpau.1006409

Öz

Objective: Nanoparticulate drug delivery systems are attracting increasing attention due to their size-dependent properties. Among these systems, polymeric nanoparticles and liposomes are the most popular nanocarriers, but to overcome the disadvantages such as low stability, short shelf life, use of organic solvents in preparation, and difficulty in scale-up, researchers have turned to lipid-based nanocarriers. Lipid nanocapsules (LNCs), one of the new generation lipidic carriers, are nanoparticular systems consisting of an oily liquid core surrounded by a hydrophilic and lipophilic rigid surfactant shell. Their structure is a hybrid nature between liposomes and polymeric nanocapsules. In this review, general information about LNCs, preparation method and scientific studies on application methods are presented.
Result and Discussion: With all components FDA-approved, LNCs can be easily prepared using the phase inversion method, a patented production technology that does not contain any organic solvents, has low energy consumption and is suitable for scale-up. LNCs obtained by this method with particle sizes of 20-100 nm and a narrow size distribution range has many advantages such as having a high drug loading capacity, being suitable for surface modification, being able to stay in the blood circulation for a long time due to the polyethylene glycol chains on the surface, and high physical stability (upwards to 18 months). The use of LNCs in different pharmaceutical applications using various routes of administration such as oral, parenteral, topical, pulmonary routes for many active substances with lipophilic, amphiphilic and hydrophilic properties shows that they are potential drug delivery systems. As a result of these superior properties, LNCs emerge as promising alternative new generation drug delivery systems by overcoming the disadvantages observed in drug delivery systems, especially liposomes and polymeric nanocapsules.

Kaynakça

  • 1. Hong, Y., Rao, Y. (2019). Current status of nanoscale drug delivery systems for colorectal cancer liver metastasis. Biomedicine & Pharmacotherapy, 114, 108764. [CrossRef]
  • 2. Rogueda, P.G., Traini, D. (2007). The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects. Expert opinion on drug delivery, 4(6), 595-606. [CrossRef]
  • 3. Narvekar, M., Xue, H.Y., Eoh, J.Y., Wong, H.L. (2014). Nanocarrier for poorly water-soluble anticancer drugs—barriers of translation and solutions. Aaps Pharmscitech, 15(4), 822-833. [CrossRef]
  • 4. Sengel-Turk, C.T., Hascicek, C., Dogan, A.L., Esendagli, G., Guc, D., Gonul, N. (2014). Surface modification and evaluation of PLGA nanoparticles: the effects on cellular uptake and cell proliferation on the HT-29 cell line. Journal of Drug Delivery Science and Technology, 24(2), 166-172. [CrossRef]
  • 5. Shao, K., Singha, S., Clemente-Casares, X., Tsai, S., Yang, Y., Santamaria, P. (2015). Nanoparticle-based immunotherapy for cancer. ACS nano, 9(1), 16-30. [CrossRef]
  • 6. Bidram, E., Esmaeili, Y., Ranji-Burachaloo, H., Al-Zaubai, N., Zarrabi, A., Stewart, A., Dunstan, D.E. (2019). A concise review on cancer treatment methods and delivery systems. Journal of Drug Delivery Science and Technology, 54, 101350. [CrossRef]
  • 7. Krishnamurthy, S., Vaiyapuri, R., Zhang, L., Chan, J.M. (2015). Lipid-coated polymeric nanoparticles for cancer drug delivery. Biomaterials science, 3(7), 923-936. [CrossRef]
  • 8. Yadav, H.K., Almokdad, A.A., Sumia, I.M., Debe, M.S. (2019). Chapter 17. Polymer-based nanomaterials for drug-delivery carriers. In: Mohapatra S.S., Ranjan S., Dasgupta N., Mishra R.K., Thomas S. (Eds.), Nanocarriers for Drug Delivery, Elsevier, ISBN: 9780128140338, (pp. 531-556). [CrossRef]
  • 9. Cheow, W.S., Hadinoto, K. (2011). Factors affecting drug encapsulation and stability of lipid–polymer hybrid nanoparticles. Colloids and surfaces B: Biointerfaces, 85(2), 214-220. [CrossRef]
  • 10. Thanki, K., Gangwal, R.P., Sangamwar, A.T., Jain, S. (2013). Oral delivery of anticancer drugs: challenges and opportunities. Journal of controlled release, 170(1), 15-40. [CrossRef]
  • 11. Sengel-Turk, C.T., Gumustas, M., Uslu, B., Ozkan, S.A. (2017) Chapter 10. Nano-sized Drug Carriers for Oral Delivery of Anti-Cancer Compounds and the Place of the Chromatographic Techniques. In: Grumezescu, A.M (Ed.), Nano- and Microscale Drug Delivery Systems, 1st Edition”, Elsevier, ISBN: 9780323527279, (pp.165-195). [CrossRef]
  • 12. Dave, V., Tak, K., Sohgaura, A., Gupta, A., Sadhu, V., Reddy, K.R. (2019). Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications. Journal of microbiological methods, 160, 130-142. [CrossRef]
  • 13. Allen, T.M., Cullis, P.R. (2013). Liposomal drug delivery systems: from concept to clinical applications. Advanced drug delivery reviews, 65(1), 36-48. [CrossRef]
  • 14. Sercombe, L., Veerati, T., Moheimani, F., Wu, S.Y., Sood, A.K., Hua, S. (2015). Advances and challenges of liposome assisted drug delivery. Frontiers in pharmacology, 6, 286. [CrossRef]
  • 15. Daraee, H., Etemadi, A., Kouhi, M., Alimirzalu, S., Akbarzadeh, A. (2016). Application of liposomes in medicine and drug delivery. Artificial cells, nanomedicine, and biotechnology, 44(1), 381-391. [CrossRef]
  • 16. Badilli, U., Sengel-Turk, C.T., Onay-Besikci, A., Tarimci, N. (2015). Development of etofenamate-loaded semisolid SLN dispersions and evaluation of anti-inflammatory activity for topical application. Current Drug Delivery, 12(2), 200-209. [CrossRef]
  • 17. Teixeira, M.C., Carbone, C., Souto, E.B. (2017). Beyond liposomes: Recent advances on lipid based nanostructures for poorly soluble/poorly permeable drug delivery. Progress in lipid research, 68, 1-11. [CrossRef]
  • 18. Rassouli, A., Al-Qushawi, A. (2018). Lipid-based nanoparticles as novel drug delivery systems for antimicrobial agents. Iranian Journal of Veterinary Science and Technology, 10(2), 1-16. [CrossRef]
  • 19. Bakar-Ates, F., Ozkan, E., Sengel-Turk, C.T. (2020). Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. International Journal of Pharmaceutics, 586, 119565. [CrossRef]
  • 20. Carbone, C., Leonardi, A., Cupri, S., Puglisi, G., Pignatello, R. (2014). Pharmaceutical and biomedical applications of lipid-based nanocarriers. Pharmaceutical patent analyst, 3(2), 199-215. [CrossRef]
  • 21. Chakraborty, S., Shukla, D., Mishra, B., Singh, S. (2009). Lipid–an emerging platform for oral delivery of drugs with poor bioavailability. European Journal of Pharmaceutics and Biopharmaceutics, 73(1), 1-15. [CrossRef]
  • 22. Attama, A.A., Momoh, M.A., Builders, P.F. (2012). Chapter 5. Lipid nanoparticulate drug delivery systems: a revolution in dosage form design and development. In: Sezer, A.D (Ed.), Recent advances in novel drug carrier systems, Intech, ISBN: 9789535108108, (pp. 107-140). [CrossRef]
  • 23. Mohsen, K., Azzazy, H.M., Allam, N.K., Basalious, E.B. (2020). Intranasal lipid nanocapsules for systemic delivery of nimodipine into the brain: In vitro optimization and in vivo pharmacokinetic study. Materials Science and Engineering: C, 116, 111236. [CrossRef]
  • 24. Fernandes, P.C.L., de Moura, L.D., de Lima, F.F., da Silva, G.H.R., Souza, R.I.C., de Paula, E. (2021). Lipid nanocapsules loaded with prilocaine and lidocaine and incorporated in gel for topical application. International Journal of Pharmaceutics, 602, 120675. [CrossRef]
  • 25. Heurtault, B., Saulnier, P., Pech, B., Proust, J.E., Benoit, J.P. (2002). A novel phase inversion-based process for the preparation of lipid nanocarriers. Pharmaceutical research, 19(6), 875-880. [CrossRef]
  • 26. Lollo, G., Ullio-Gamboa, G., Fuentes, E., Matha, K., Lautram, N., Benoit, J.P. (2018). In vitro anti-cancer activity and pharmacokinetic evaluation of curcumin-loaded lipid nanocapsules. Materials Science and Engineering: C, 91, 859-867. [CrossRef]
  • 27. Paillard, A., Hindré, F., Vignes-Colombeix, C., Benoit, J.P., Garcion, E. (2010). The importance of endo-lysosomal escape with lipid nanocapsules for drug subcellular bioavailability. Biomaterials, 31(29), 7542-7554. [CrossRef]
  • 28. Saulnier, P., Benoît, J.P. (2006). Lipidic core nanocapsules as new drug delivery systems. In: Torchilin, V.P. (Ed.), In Nanoparticulates as drug carriers, (pp. 213-224). [CrossRef]
  • 29. Huynh, N.T., Passirani, C., Saulnier, P., Benoît, J.P. (2009). Lipid nanocapsules: a new platform for nanomedicine. International journal of pharmaceutics, 379(2), 201-209. [CrossRef]
  • 30. Aparicio-Blanco, J., Torres-Suárez, A.I. (2015). Glioblastoma multiforme and lipid nanocapsules: a review. Journal of biomedical nanotechnology, 11(8), 1283-1311. [CrossRef]
  • 31. Safwat, S., Hathout, R.M., Ishak, R.A., Mortada, N.D. (2017). Augmented simvastatin cytotoxicity using optimized lipid nanocapsules: a potential for breast cancer treatment. Journal of liposome research, 27(1), 1-10. [CrossRef]
  • 32. Molaahmadi, M.R., Varshosaz, J., Taymouri, S., Akbari, V. (2019). Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line. Iranian journal of pharmaceutical research: IJPR, 18(4), 1676. [CrossRef]
  • 33. Chouchou, A., Aubert-Pouëssel, A., Dorandeu, C., Zghaib, Z., Cuq, P., Devoisselle, J.M., Bonnet, P.A., Bégu S., Deleuze-Masquefa, C. (2017). Lipid nanocapsules formulation and cellular activities evaluation of a promising anticancer agent: EAPB0503. International journal of pharmaceutical investigation, 7(4), 155. [CrossRef]
  • 34. Zhao, Y.Q., Wang, L.P., Ma, C., Zhao, K., Liu, Y., Feng, N.P. (2013). Preparation and characterization of tetrandrine-phospholipid complex loaded lipid nanocapsules as potential oral carriers. International journal of nanomedicine, 8, 4169. [CrossRef]
  • 35. Lamprecht, A., Bouligand, Y., Benoit, J.P. (2002). New lipid nanocapsules exhibit sustained release properties for amiodarone. Journal of Controlled Release, 84(1-2), 59-68. [CrossRef]
  • 36. Moura, R.P., Pacheco, C., Pêgo, A.P., des Rieux, A., Sarmento, B. (2020). Lipid nanocapsules to enhance drug bioavailability to the central nervous system. Journal of Controlled Release, 322, 390-400. [CrossRef]
  • 37. Anton, N., Gayet, P., Benoit, J.P., Saulnier, P. (2007). Nano-emulsions and nanocapsules by the PIT method: an investigation on the role of the temperature cycling on the emulsion phase inversion. International Journal of Pharmaceutics, 344(1-2), 44-52. [CrossRef]
  • 38. Lamprecht, A., Benoit, J.P. (2006). Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition. Journal of Controlled Release, 112(2), 208-213. [CrossRef]
  • 39. Peltier, S., Oger, J.M., Lagarce, F., Couet, W., Benoît, J.P. (2006). Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules. Pharmaceutical research, 23(6), 1243-1250. [CrossRef]
  • 40. Lacoeuille, F., Garcion, E., Benoit, J.P., Lamprecht, A. (2007). Lipid nanocapsules for intracellular drug delivery of anticancer drugs. Journal of nanoscience and nanotechnology, 7(12), 4612-4617. [CrossRef]
  • 41. Heurtault, B., Saulnier, P., Benoit, J.P., Proust, J.E., Pech, B., Richard, J. (2011). U.S. Patent No. 8,057,823. Washington, DC: U.S. Patent and Trademark Office.
  • 42. Tsakiris, N., Papavasileiou, M., Bozzato, E., Lopes, A., Vigneron, A.M., Préat, V. (2019). Combinational drug-loaded lipid nanocapsules for the treatment of cancer. International journal of pharmaceutics, 569, 118588. [CrossRef]
  • 43. Zhai, Y., Zhao, L., Wang, Z., Zhai, G. (2016). Preparation and characterization of novel lipid nanocapsules of ropivacaine for transdermal delivery. Drug delivery, 23(2), 619-628. [CrossRef]
  • 44. Saliou, B., Thomas, O., Lautram, N., Clavreul, A., Hureaux, J., Urban, T., Benoit, J.P., Lagarce, F. (2013). Development and in vitro evaluation of a novel lipid nanocapsule formulation of etoposide. European Journal of Pharmaceutical Sciences, 50(2), 172-180. [CrossRef]
  • 45. Zhai, Y., Liu, M., Wan, M., Li, Y., Zhang, M., Zhai, G. (2015). Preparation and characterization of puerarin-loaded lipid nanocapsules. Journal of nanoscience and nanotechnology, 15(4), 2643-2649. [CrossRef]
  • 46. Unicancer Web Site. From, http://www.unicancer.fr/sites/default/files/Enjeux_defis_developpement_formes_vectorielles_JP_Benoit.pdf / Erişim tarihi: 10 Temmuz 2021
  • 47. Heurtault, B., Saulnier, P., Pech, B., Venier-Julienne, M.C., Proust, J.E., Phan-Tan-Luu, R., Benoı̂t, J.P. (2003). The influence of lipid nanocapsule composition on their size distribution. European Journal of Pharmaceutical Sciences, 18(1), 55-61. [CrossRef]
  • 48. Roger, E., Lagarce, F., Benoit, J.P. (2011). Development and characterization of a novel lipid nanocapsule formulation of Sn38 for oral administration. European journal of pharmaceutics and biopharmaceutics, 79(1), 181-188. [CrossRef]
  • 49. Briot, T., Roger, E., Lautram, N., Verger, A., Clavreul, A., Lagarce, F. (2017). Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia. International journal of nanomedicine, 12, 8427. [CrossRef]
  • 50. Lamprecht, A., Bouligand, Y., Benoit, J.P. (2002). New lipid nanocapsules exhibit sustained release properties for amiodarone. Journal of Controlled Release, 84(1-2), 59-68. [CrossRef]
  • 51. Vakilzadeh, H., Varshosaz, J., Soghrati, S. (2021). Enhanced Solubility and Permeability of Naringenin Across Non-Everted Sacs of Rat Small Intestine by Lipid Nanocapsules. Recent Patents on Nanotechnology, 15(1), 55-69. [CrossRef]
  • 52. Basu, S.M., Yadava, S.K., Singh, R., Giri, J. (2021). Lipid nanocapsules co-encapsulating paclitaxel and salinomycin for eradicating breast cancer and cancer stem cells. Colloids and Surfaces B: Biointerfaces, 204, 111775. [CrossRef]
  • 53. Ramadan, A., Lagarce, F., Tessier-Marteau, A., Thomas, O., Legras, P., Macchi, L., Saulnier, P., Benoit, J.P. (2011). Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study. International journal of nanomedicine, 6, 2941. [CrossRef]
  • 54. Morille, M., Passirani, C., Dufort, S., Bastiat, G., Pitard, B., Coll, J.L., Benoit, J.P. (2011). Tumor transfection after systemic injection of DNA lipid nanocapsules. Biomaterials, 32(9), 2327-2333. [CrossRef]
  • 55. Messaoudi, K., Saulnier, P., Boesen, K., Benoit, J.P., Lagarce, F. (2014). Anti-epidermal growth factor receptor siRNA carried by chitosan-transacylated lipid nanocapsules increases sensitivity of glioblastoma cells to temozolomide. International journal of nanomedicine, 9, 1479. [CrossRef]
  • 56. Vrignaud, S., Hureaux, J., Wack, S., Benoit, J.P., Saulnier, P. (2012). Design, optimization and in vitro evaluation of reverse micelle-loaded lipid nanocarriers containing erlotinib hydrochloride. International journal of pharmaceutics, 436(1-2), 194-200. [CrossRef]
  • 57. Groo, A.C., Matougui, N., Umerska, A., Saulnier, P. (2018). Reverse micelle-lipid nanocapsules: a novel strategy for drug delivery of the plectasin derivate AP138 antimicrobial peptide. International journal of nanomedicine, 13, 7565. [CrossRef]
  • 58. Montigaud, Y., Ucakar, B., Krishnamachary, B., Bhujwalla, Z.M., Feron, O., Préat, V., Fabienne D., Gallez, B., Danhier, P. (2018). Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer. International journal of pharmaceutics, 551(1-2), 322-328. [CrossRef]
  • 59. Vrignaud, S., Anton, N., Gayet, P., Benoit, J. P., Saulnier, P. (2011). Reverse micelle-loaded lipid nanocarriers: a novel drug delivery system for the sustained release of doxorubicin hydrochloride. European journal of pharmaceutics and biopharmaceutics, 79(1), 197-204. [CrossRef]
  • 60. Lollo, G., Matha, K., Bocchiardo, M., Bejaud, J., Marigo, I., Virgone-Carlotta, A., Dehoux T., Rivière, C., Rieu, J.P., Briançon, S., Perrier, T., Meyer, O., Benoit, J.P. (2019). Drug delivery to tumours using a novel 5-FU derivative encapsulated into lipid nanocapsules. Journal of drug targeting, 27(5-6), 634-645. [CrossRef]
  • 61. Eldesouky, L.M., El-Moslemany, R.M., Ramadan, A.A., Morsi, M.H., Khalafallah, N.M. (2021). Cyclosporine Lipid Nanocapsules as Thermoresponsive Gel for Dry Eye Management: Promising Corneal Mucoadhesion, Biodistribution and Preclinical Efficacy in Rabbits. Pharmaceutics, 13(3), 360. [CrossRef]
  • 62. Ashour, A.A., Ramadan, A.A., Abdelmonsif, D.A., El-Kamel, A.H. (2020). Enhanced oral bioavailability of Tanshinone IIA using lipid nanocapsules: formulation, in-vitro appraisal and pharmacokinetics. International Journal of Pharmaceutics, 586, 119598. [CrossRef]
  • 63. Bapat, P., Ghadi, R., Chaudhari, D., Katiyar, S.S., Jain, S. (2019). Tocophersolan stabilized lipid nanocapsules with high drug loading to improve the permeability and oral bioavailability of curcumin. International journal of pharmaceutics, 560, 219-227. [CrossRef]
  • 64. Roger, E., Lagarce, F., Benoit, J.P. (2009). The gastrointestinal stability of lipid nanocapsules. International journal of pharmaceutics, 379(2), 260-265. [CrossRef]
  • 65. Lamprecht, A., Saumet, J.L., Roux, J., Benoit, J.P. (2004). Lipid nanocarriers as drug delivery system for ibuprofen in pain treatment. International journal of pharmaceutics, 278(2), 407-414. [CrossRef]
  • 66. Amara, R.O., Ramadan, A.A., El-Moslemany, R.M., Eissa, M.M., El-Azzouni, M.Z., El-Khordagui, L.K. (2018). Praziquantel–lipid nanocapsules: an oral nanotherapeutic with potential Schistosoma mansoni tegumental targeting. International journal of nanomedicine, 13, 4493. [CrossRef]
  • 67. Varshosaz, J., Taymouri, S., Jahanian-Najafabadi, A., Alizadeh, A. (2018). Efavirenz oral delivery via lipid nanocapsules: formulation, optimisation, and ex-vivo gut permeation study. IET nanobiotechnology, 12(6), 795-806. [CrossRef]
  • 68. Gamboa, G.V.U., Pensel, P.E., Elissondo, M.C., Bruni, S.F.S., Benoit, J.P., Palma, S.D., Allemandi, D.A. (2019). Albendazole-lipid nanocapsules: optimization, characterization and chemoprophylactic efficacy in mice infected with Echinococcus granulosus. Experimental parasitology, 198, 79-86. [CrossRef]
  • 69. Hureaux, J., Lagarce, F., Gagnadoux, F., Rousselet, M.C., Moal, V., Urban, T., Benoit, J.P. (2010). Toxicological study and efficacy of blank and paclitaxel-loaded lipid nanocapsules after iv administration in mice. Pharmaceutical research, 27(3), 421-430. [CrossRef]
  • 70. Khalid, M.N., Simard, P., Hoarau, D., Dragomir, A., Leroux, J.C. (2006). Long circulating poly (ethylene glycol)-decorated lipid nanocapsules deliver docetaxel to solid tumors. Pharmaceutical research, 23(4), 752-758. [CrossRef]
  • 71. Rahali, Y., Saulnier, P., Benoit, J.P., Bensouda, Y. (2010). Incorporating vegetal oils in parenteral nutrition using lipid nanocapsules. Journal of drug delivery science and technology, 20(6), 425-429. [CrossRef]
  • 72. Huynh, N.T., Morille, M., Bejaud, J., Legras, P., Vessieres, A., Jaouen, G., Benoit, J.P., Passirani, C. (2011). Treatment of 9L gliosarcoma in rats by ferrociphenol-loaded lipid nanocapsules based on a passive targeting strategy via the EPR effect. Pharmaceutical research, 28(12), 3189-3198. [CrossRef]
  • 73. Lainé, A.L., Adriaenssens, E., Vessières, A., Jaouen, G., Corbet, C., Desruelles, E., Pigeon, P., Toillon, R.A., Passirani, C. (2013). The in vivo performance of ferrocenyl tamoxifen lipid nanocapsules in xenografted triple negative breast cancer. Biomaterials, 34(28), 6949-6956. [CrossRef]
  • 74. Hureaux, J., Lacoeuille, F., Lagarce, F., Rousselet, M.C., Contini, A., Saulnier, P., Benoit, J.P., Urban, T. (2017). Absence of lung fibrosis after a single pulmonary delivery of lipid nanocapsules in rats. International journal of nanomedicine, 12, 8159. [CrossRef]
  • 75. Umerska, A., Mugheirbi, N.A., Kasprzak, A., Saulnier, P., Tajber, L. (2020). Carbohydrate-based Trojan microparticles as carriers for pulmonary delivery of lipid nanocapsules using dry powder inhalation. Powder Technology, 364, 507-521. [CrossRef]
  • 76. Hureaux, J., Lagarce, F., Gagnadoux, F., Vecellio, L., Clavreul, A., Roger, E., Kempf, M., Racineux, J.L., Diot, P., Benoit, J.P., Urban, T. (2009). Lipid nanocapsules: ready-to-use nanovectors for the aerosol delivery of paclitaxel. European journal of pharmaceutics and biopharmaceutics, 73(2), 239-246. [CrossRef]
  • 77. Umerska, A., Mouzouvi, C.R., Bigot, A., Saulnier, P. (2015). Formulation and nebulization of fluticasone propionate-loaded lipid nanocarriers. International journal of pharmaceutics, 493(1-2), 224-232. [CrossRef]
  • 78. Nguyen, H.T.P., Munnier, E., Perse, X., Vial, F., Yvergnaux, F., Perrier, T., Soucé, M., Chourpa, I. (2016). Qualitative and quantitative study of the potential of lipid nanocapsules of one hundred twenty nanometers for the topical administration of hydrophobic molecules. Journal of pharmaceutical sciences, 10 5(10), 3191-3198. [CrossRef]
  • 79. Zhai, Y., Yang, X., Zhao, L., Wang, Z., Zhai, G. (2014). Lipid nanocapsules for transdermal delivery of ropivacaine: in vitro and in vivo evaluation. International journal of pharmaceutics, 471(1-2), 103-111. [CrossRef]
  • 80. Varshosaz, J., Hajhashemi, V., Soltanzadeh, S. (2011). Lipid nanocapsule-based gels for enhancement of transdermal delivery of ketorolac tromethamine. Journal of drug delivery, 2011. [CrossRef]
  • 81. Abdel-Mottaleb, M.M., Neumann, D., Lamprecht, A. (2011). Lipid nanocapsules for dermal application: a comparative study of lipid-based versus polymer-based nanocarriers. European Journal of Pharmaceutics and Biopharmaceutics, 79(1), 36-42. [CrossRef]
  • 82. Hatahet, T., Morille, M., Shamseddin, A., Aubert-Pouëssel, A., Devoisselle, J.M., Bégu, S. (2017). Dermal quercetin lipid nanocapsules: Influence of the formulation on antioxidant activity and cellular protection against hydrogen peroxide. International journal of pharmaceutics, 518(1-2), 167-176. [CrossRef]
  • 83. Hatahet, T., Morille, M., Hommoss, A., Devoisselle, J.M., Müller, R.H., Begu, S. (2018). Liposomes, lipid nanocapsules and smartCrystals®: A comparative study for an effective quercetin delivery to the skin. International journal of pharmaceutics, 542(1-2), 176-185. [CrossRef]
  • 84. El-Sheridy, N.A., Ramadan, A.A., Eid, A.A., El-Khordagui, L.K. (2019). Itraconazole lipid nanocapsules gel for dermatological applications: in vitro characteristics and treatment of induced cutaneous candidiasis. Colloids and Surfaces B: Biointerfaces, 181, 623-631. [CrossRef]
  • 85. Formica, M.L., Legeay, S., Bejaud, J., Montich, G.G., Gamboa, G.V U., Benoit, J.P., Palma, S.D. (2020). Novel hybrid lipid nanocapsules loaded with a therapeutic monoclonal antibody–Bevacizumab–and Triamcinolone acetonide for combined therapy in neovascular ocular pathologies. Materials Science and Engineering: C, 119, 111398. [CrossRef]
  • 86. Sun, R., Zhang, A., Ge, Y., Gou, J., Yin, T., He, H., Wang, Y., Zhang, G., Kong, J., Shang, L., Tao, X., Zhang, Y., Tang, X. (2020). Ultra-small-size Astragaloside-IV loaded lipid nanocapsules eye drops for the effective management of dry age-related macular degeneration. Expert Opinion on Drug Delivery, 17(9), 1305-1320. [CrossRef]
  • 87. Zhang, A., Sun, R., Ran, M., Deng, Y., Ge, Y., Zhu, Y., Tao, X., Shang, L., Gou, J., He, H., Yin, T., Wang, Y., Zhang, Y., Tang, X. (2020). A Novel Eyes Topical Drug Delivery System: CsA-LNC for the Treatment of DED. Pharmaceutical Research, 37(7), 1-14. [CrossRef]
  • 88. Abozaid, D., Ramadan, A., Barakat, H., Khalafallah, N. (2018). Acyclovir lipid nanocapsules gel for oromucosal delivery: A preclinical evidence of efficacy in the chicken pouch membrane model. European Journal of Pharmaceutical Sciences, 121, 228-235. [CrossRef]
Toplam 88 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Eczacılık ve İlaç Bilimleri
Bölüm Derleme
Yazarlar

Hatice Demirtaş 0000-0001-6626-2538

Ceyda Sengel-turk 0000-0003-4123-7226

Yayımlanma Tarihi 29 Ocak 2022
Gönderilme Tarihi 8 Ekim 2021
Kabul Tarihi 9 Kasım 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 46 Sayı: 1

Kaynak Göster

APA Demirtaş, H., & Sengel-turk, C. (2022). YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER. Journal of Faculty of Pharmacy of Ankara University, 46(1), 239-261. https://doi.org/10.33483/jfpau.1006409
AMA Demirtaş H, Sengel-turk C. YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER. Ankara Ecz. Fak. Derg. Ocak 2022;46(1):239-261. doi:10.33483/jfpau.1006409
Chicago Demirtaş, Hatice, ve Ceyda Sengel-turk. “YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER”. Journal of Faculty of Pharmacy of Ankara University 46, sy. 1 (Ocak 2022): 239-61. https://doi.org/10.33483/jfpau.1006409.
EndNote Demirtaş H, Sengel-turk C (01 Ocak 2022) YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER. Journal of Faculty of Pharmacy of Ankara University 46 1 239–261.
IEEE H. Demirtaş ve C. Sengel-turk, “YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER”, Ankara Ecz. Fak. Derg., c. 46, sy. 1, ss. 239–261, 2022, doi: 10.33483/jfpau.1006409.
ISNAD Demirtaş, Hatice - Sengel-turk, Ceyda. “YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER”. Journal of Faculty of Pharmacy of Ankara University 46/1 (Ocak 2022), 239-261. https://doi.org/10.33483/jfpau.1006409.
JAMA Demirtaş H, Sengel-turk C. YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER. Ankara Ecz. Fak. Derg. 2022;46:239–261.
MLA Demirtaş, Hatice ve Ceyda Sengel-turk. “YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER”. Journal of Faculty of Pharmacy of Ankara University, c. 46, sy. 1, 2022, ss. 239-61, doi:10.33483/jfpau.1006409.
Vancouver Demirtaş H, Sengel-turk C. YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER. Ankara Ecz. Fak. Derg. 2022;46(1):239-61.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.