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The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline

Yıl 2018, Cilt: 11 Sayı: 3, 232 - 237, 01.09.2018
https://doi.org/10.30607/kvj.408380

Öz

The
purpose of this study was to determine the efficacy of
oxytetracycline
when applied intrapalpebral (IPa) injection to the eye, compared with
subconjunctival (SCo) injection, in the treatment of infectious bovine
keratoconjunctivitis (IBK). Twenty eyes with severe clinical signs of IBK, of
15 Holstein Friesian female cattle aged 2–4 years were evaluated in this study.
The affected animals had unilateral (n=10; 66.7%) and bilateral (n=5; 33.3%)
symptoms. Moraxella bovis were
identified in all ocular swabs samples on day 0 and all isolates were
susceptible to oxytetracycline (100%). 
Oxytetracycline (100 mg/ml) was injected IPa (n=10) and SCo (n=10) at a
total dose of 200 mg once daily on days 0, 3 and 6. After injections, the
animals were re-examined for resolution of lesions associated with IBK weekly
until the corneal ulcer healed. Microbiologic examination was repeated 3 times
at intervals of 1 week. There is no effect of injection type on healing time of
the lesion. Size and side of the lesion have a significant effect on healing
time (p<0.001). It was found that small lesions had earlier clean in terms
of the microbiologic evaluation. Lesion size has a significant effect on
microbial growth (p<0.001). In conclusion, the same therapeutic effect was
achieved in both applications. However,
oxytetracycline given by IPa
injection was comparatively easy, more comfortable and less invasive especially
for painful eyes against IBK than SCo injection under the conditions of this
study. In addition, it was enough for cattle with IBK at the dosage (200 mg,
once daily on days 0, 3 and 6) of used in the study.

Kaynakça

  • Alexander D. Infectious bovine keratoconjunctivitis: A review of cases in clinical practice. Vet Clin North Am Food Anim Pract. 2010; 26: 487-503.
  • Angelos JA, Hess JF, George LW. Cloning and characterization of a Moraxella bovis cytotoxin gene. Am J Vet Res. 2001; 62: 1222-1228.
  • Bedford PGC. Ocular diseases. 917-926. In: Andrews AH, Blowey RW, Boyd H et al. (Eds.), Bovine Medicine. 2nd ed. London, 2004; Blackwell Scientific Publications.Angelos JA. Infectious Bovine Keratoconjunctivitis (Pinkeye). Vet Clin Food Anim. 2015; 31: 61–79.
  • Cullen JN, Yuan C, Totton S, Dzikamunhenga R, Coetze JF, da Silva N, Wang C, O’Connor AM A systematic review and meta-analysis of the antibiotic treatment for infectious bovine keratoconjunctivitis: an update. Anim Health Res Rev. 2016; 17(1): 60-75.
  • Burns M, O’Connor A. Assessment of methodological quality and sources of variation in the magnitude of vaccine efficacy: a systematic review of studies from 1960 to 2005 reporting immunization with Moraxella bovis vaccines in young cattle. Vaccine. 2008; 26(2): 144-152.
  • Zielinski GC, Piscitelli HG, Perez-Monti H, Stobbs LA, Zimmermann AG. Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). Vet Ther. 2002; 3(2): 196-205.
  • Brown MH, Brightman AH, Fenwick BW, Rider MA. Infectious Bovine Keratoconjunctivitis: A Review. J Vet Intern Med. 1998; 12: 259-266.
  • McConnel CS, Shum L, House JK. Infectious bovine keratoconjunctivitis antimicrobial therapy. Aust Vet J. 2007; 85(1-2), 65-69.
  • George LW, Wilson WD, Baggot JD, Mihalyi JE. Antibiotic treatment of Moraxella bovis infection in cattle. J Am Vet Med Assoc. 1984; 185(10): 1206-1209.
  • George LW, Smith JA, Kaswan R. Distribution of oxytetracycline into ocular tissues and tears of calves. J Vet Pharmacol Ther. 1985; 8(1): 47-54.
  • Senturk S, Cetin C, Temizel M, Ozel E. Evaluation of the clinical efficacy of subconjunctival injection of clindamycin in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Vet Ophthalmol. 2007; 10(3): 186-189.
  • Quinn PJ, Cater ME, Markey BK, Carter CR. Clinical Veterinary Microbiology. London, Wolfe-Mosby. 1994; 284-286.
  • Gokce I, Citil M, Genc O, Kankavi O. A comparison of the efficacy of florfenicol and oxytetracycline in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Ir Vet J. 2002; 55(11): 573-576.
  • Pickett JP. Eye Disease. In: Howard JL, Smith RA (Eds.). Current Veterinary Therapy Food Animal Practice. 4th Ed, Saunders. 1999; 633-657.
  • Prieto C, Serra DO, Martina P, Jacobs M, Bosch AM, Yantorno OM. Evaluation of biofilm-forming capacity of Moraxella bovis, the primary causative agent of infectious bovine keratoconjunctivitis. Vet Microbiol. 2013; 166(3-4): 504-15.
  • Shryock TR, White DW, Werner CS. Antimicrobial susceptibility of Moraxella bovis. Vet Microbiol. 1998; 61: 305-309.
  • Zielinski G, Piscitelli H, Perez-Monti H, Stobbs LA. Antibiotic sensitivity of an Argentine strain collection of Moraxella bovis. Vet Ther. 2000; 1: 199-204..

Saha Koşullarında Enfeksiyöz Bovine Keratokonjuktivitis’in Sağaltımı: Subkonjuktival Oksitetrasiklin Enjeksiyonuna Karşı İntrapalpebral Enjeksiyon

Yıl 2018, Cilt: 11 Sayı: 3, 232 - 237, 01.09.2018
https://doi.org/10.30607/kvj.408380

Öz



Bu çalışmanın amacı,
infeksiyöz bovine keratokonjuktivitis (IBK)’in sağaltımında, göze
intrapalpebral (IPa) enjeksiyon ile uygulanılan oksitetrasiklin’in,
subkonjuktival (SCo) enjeksiyon ile karşılaştırıldığındaki etkinliğini
belirlemekti. Çalışmada, IBK’nın şiddetli klinik bulguları bulunan 2-4
yaşındaki, dişi, 15 Holstein Friesian sığıra ait 20 göz değerlendirildi.
Etkilenen hayvanlar unilateral (n=10; % 66,7) ve bilateral (n=5; % 33,3)
semptomlara sahipti. 0. günde tüm oküler swab örneklerinden Morexella bovis izole edildi ve
oksitetrasikline duyarlı idi (% 100). 0, 3 ve 6. günlerde günde bir kez toplam
200 mg dozda oksitetrasiklin (100 mg/ml) IPa (n=10) ve SCo (n=10) olarak
enjekte edildi. Enjeksiyonlardan sonra, korneal ülser iyileşmesi şekilleninceye
kadar haftalık olarak IBK ile ilişkili lezyonlar yönünden hayvanlar tekrar muayene
edildi. Mikrobiyolojik muayene birer hafta ara ile 3 kez tekrarlandı. Lezyonun
iyileşme zamanı üzerine enjeksiyon tipinin etkisi yoktu. Lezyonun büyüklüğü ve
bulunduğu tarafın iyileşme zamanı üzerine belirgin etkisi vardı (p<0.001).
Küçük lezyonlar mikrobiyolojik değerlendirmede daha erken dönemde temiz
bulundu. Lezyon büyüklüğü mikrobiyal gelişimi belirgin olarak etkiledi
(p<0.001). Sonuç olarak, her iki uygulama ile aynı terapötik etki sağlandı.
Bununla birlikte, bu çalışmada saha koşullarında özellikle ağrılı gözlerde IPa
enjeksiyon yolu ile verilen oksitetrasiklin, SCo enjeksiyondan nispeten daha
kolay, daha rahat ve daha az invazivdi. İlave olarak, bu çalışmada kullanılan
doz (0, 3 ve 6. günlerde günde bir kez 200 mg) IBK’lı sığırlar için yeterli
idi.



Kaynakça

  • Alexander D. Infectious bovine keratoconjunctivitis: A review of cases in clinical practice. Vet Clin North Am Food Anim Pract. 2010; 26: 487-503.
  • Angelos JA, Hess JF, George LW. Cloning and characterization of a Moraxella bovis cytotoxin gene. Am J Vet Res. 2001; 62: 1222-1228.
  • Bedford PGC. Ocular diseases. 917-926. In: Andrews AH, Blowey RW, Boyd H et al. (Eds.), Bovine Medicine. 2nd ed. London, 2004; Blackwell Scientific Publications.Angelos JA. Infectious Bovine Keratoconjunctivitis (Pinkeye). Vet Clin Food Anim. 2015; 31: 61–79.
  • Cullen JN, Yuan C, Totton S, Dzikamunhenga R, Coetze JF, da Silva N, Wang C, O’Connor AM A systematic review and meta-analysis of the antibiotic treatment for infectious bovine keratoconjunctivitis: an update. Anim Health Res Rev. 2016; 17(1): 60-75.
  • Burns M, O’Connor A. Assessment of methodological quality and sources of variation in the magnitude of vaccine efficacy: a systematic review of studies from 1960 to 2005 reporting immunization with Moraxella bovis vaccines in young cattle. Vaccine. 2008; 26(2): 144-152.
  • Zielinski GC, Piscitelli HG, Perez-Monti H, Stobbs LA, Zimmermann AG. Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). Vet Ther. 2002; 3(2): 196-205.
  • Brown MH, Brightman AH, Fenwick BW, Rider MA. Infectious Bovine Keratoconjunctivitis: A Review. J Vet Intern Med. 1998; 12: 259-266.
  • McConnel CS, Shum L, House JK. Infectious bovine keratoconjunctivitis antimicrobial therapy. Aust Vet J. 2007; 85(1-2), 65-69.
  • George LW, Wilson WD, Baggot JD, Mihalyi JE. Antibiotic treatment of Moraxella bovis infection in cattle. J Am Vet Med Assoc. 1984; 185(10): 1206-1209.
  • George LW, Smith JA, Kaswan R. Distribution of oxytetracycline into ocular tissues and tears of calves. J Vet Pharmacol Ther. 1985; 8(1): 47-54.
  • Senturk S, Cetin C, Temizel M, Ozel E. Evaluation of the clinical efficacy of subconjunctival injection of clindamycin in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Vet Ophthalmol. 2007; 10(3): 186-189.
  • Quinn PJ, Cater ME, Markey BK, Carter CR. Clinical Veterinary Microbiology. London, Wolfe-Mosby. 1994; 284-286.
  • Gokce I, Citil M, Genc O, Kankavi O. A comparison of the efficacy of florfenicol and oxytetracycline in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Ir Vet J. 2002; 55(11): 573-576.
  • Pickett JP. Eye Disease. In: Howard JL, Smith RA (Eds.). Current Veterinary Therapy Food Animal Practice. 4th Ed, Saunders. 1999; 633-657.
  • Prieto C, Serra DO, Martina P, Jacobs M, Bosch AM, Yantorno OM. Evaluation of biofilm-forming capacity of Moraxella bovis, the primary causative agent of infectious bovine keratoconjunctivitis. Vet Microbiol. 2013; 166(3-4): 504-15.
  • Shryock TR, White DW, Werner CS. Antimicrobial susceptibility of Moraxella bovis. Vet Microbiol. 1998; 61: 305-309.
  • Zielinski G, Piscitelli H, Perez-Monti H, Stobbs LA. Antibiotic sensitivity of an Argentine strain collection of Moraxella bovis. Vet Ther. 2000; 1: 199-204..
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm ARAŞTIRMA MAKALESİ
Yazarlar

Göksen Çeçen

İbrahim Akın

Ayşe Ebru Borum

Yayımlanma Tarihi 1 Eylül 2018
Kabul Tarihi 5 Haziran 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 11 Sayı: 3

Kaynak Göster

APA Çeçen, G., Akın, İ., & Borum, A. E. (2018). The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline. Kocatepe Veterinary Journal, 11(3), 232-237. https://doi.org/10.30607/kvj.408380
AMA Çeçen G, Akın İ, Borum AE. The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline. kvj. Eylül 2018;11(3):232-237. doi:10.30607/kvj.408380
Chicago Çeçen, Göksen, İbrahim Akın, ve Ayşe Ebru Borum. “The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline”. Kocatepe Veterinary Journal 11, sy. 3 (Eylül 2018): 232-37. https://doi.org/10.30607/kvj.408380.
EndNote Çeçen G, Akın İ, Borum AE (01 Eylül 2018) The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline. Kocatepe Veterinary Journal 11 3 232–237.
IEEE G. Çeçen, İ. Akın, ve A. E. Borum, “The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline”, kvj, c. 11, sy. 3, ss. 232–237, 2018, doi: 10.30607/kvj.408380.
ISNAD Çeçen, Göksen vd. “The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline”. Kocatepe Veterinary Journal 11/3 (Eylül 2018), 232-237. https://doi.org/10.30607/kvj.408380.
JAMA Çeçen G, Akın İ, Borum AE. The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline. kvj. 2018;11:232–237.
MLA Çeçen, Göksen vd. “The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline”. Kocatepe Veterinary Journal, c. 11, sy. 3, 2018, ss. 232-7, doi:10.30607/kvj.408380.
Vancouver Çeçen G, Akın İ, Borum AE. The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline. kvj. 2018;11(3):232-7.

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