Derleme
BibTex RIS Kaynak Göster

The role of inflammation in epilepsy

Yıl 2019, Cilt: 12 Sayı: 3, 525 - 533, 31.12.2019

Metin Yıldırım Ulaş Değirmenci Serap Yalın

https://doi.org/10.26559/mersinsbd.557883

Öz

Epilepsy is one of
the most common diseases worldwide and in our country. Data on the relationship
between inflammatory mediators and the production of immune cells and the
recurrence of epileptic seizures are becoming more evident in the light of
experimental and clinical studies. Therefore, the relationship between epilepsy
and inflammation is of interest.  In this
review, the relationship between epilepsy and inflammation is investigated.

Anahtar Kelimeler

Inflammation epilepsi sitokin kemokin

Kaynakça

  • 1. Devinsky O. Effects of seizures on autonomic and cardiovascular function. Epilepsy Currents. 2004;4(2):43–46.
  • 2. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia. 2014;55:475–482.
  • 3. Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522-530.
  • 4. Wiebe S, Blume WT, Girvin JP, Eliasziw MA. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N. Engl. J. Med. 2001;345(5):311-318.
  • 5. Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nat. Rev. Neurol. 2011;7(1):31-40.
  • 6. Bambal G, Cakıl D, Ekici F. Epilepsi Oluşum Mekanizmaları Konuralp Tıp Dergisi. 2011;3(3) :42-45
  • 7. Alyu F, Dikmen M. Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms. Acta Neuropsychiatr. 2017;29(1):1-16
  • 8. Choi J, Koh S. Role of brain inflammation in epileptogenesis. Yonsei Med. J. 2008;49(1):1 -18.
  • 9. Jung KH, Chu K, Lee ST, Kim JH, Kang KM, Song EC, Kim SJ, Park HK, Kim M, Lee SK, Roh JK. Region-specific plasticity in the epileptic rat brain: a hippocampal and extrahippocampal analysis. Epilepsia. 2009;50(3):537-549.
  • 10. Li G, Bauer S, Nowak M, Norwood B, Tackenberg B, Rosenow F, Knake S, Oertel WH, Hamer HM. Cytokines and epilepsy. Seizure 2011;20(3):249-256.
  • 11. Scorza CA, Marques MJG, Gomes da Silva S, Naffah-Mazzacoratti MDG, Scorza FA, Cavalheiro EA. Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis. Neurosci. Lett. 2018;668:169-173.
  • 12. Ichiyama T, Nishikawa M, Yoshitomi T, Hayashi T, Furukawa S. Tumor necrosis factor-a, interleukin-l, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures comparison with acute encephalitis/encephalopathy. Neurology. 1998;50(2):407–411.
  • 13. Rana A, Musto AE. The role of inflammation in the development of epilepsy. Journal of neuroinflammation. 2018;15:144.
  • 14. Postnikova T, Zubareva O, Kovalenko A, Kim K, Magazanik L, Zaitsev A. Status epilepticus impairs synaptic plasticity in rat hippocampus and is followed by changes in expression of NMDA receptors. Biochem Mosc. 2017;82(3):282–90
  • 15. Han T, Qin Y, Mou C, Wang M, Jiang M, Liu B. Seizure induced synaptic plasticity alteration in hippocampus is mediated by IL-1ß receptor through PI3K/Akt pathway. Am J. Transl. Res. 2016;8(10):4499-4509.
  • 16. Vezzani A, & Baram TZ. New roles for interleukin-1 beta in the mechanisms of epilepsy. Epilepsy currents. 2007;7(2):45-50.
  • 17. Hirano T, Taga T, Yamasaki K, Matsuda T, Tang B, Muraguchi A, Horii Y, Suematsu S, Hirata Y, Yawata H, et al. A multifunctional cytokine (IL-6/BSF-2) and its receptor. Int. Arch Allergy Appl. Immunol. 1989;88(1-2):29-33.
  • 18. Yasukawa K, Futatsugi K, Saito T, Yawata H, Narazaki M, Suzuki H, Taga T, Kishimoto T. Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130. Immunol. Lett. 1992;31(2):123-130.
  • 19. Müller-Newen G, Küster A, Hemmann U, Keul R, Horsten U, Martens A, Graeve L, Wijdenes J, Heinrich PC. Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 onIL-6 responses. J. Immunol. 1998;161(11):6347-6355.
  • 20. De Luca G, Di Giorgio RM, Macaione S, Calpona PR, Costantino S, Di Paola ED, De Sarro A, Ciliberto G, De Sarro G. Susceptibility to audiogenic seizure and neurotransmitter amino acid levels in different brain areas of IL-6-deficient mice. Pharmacol. Biochem. Behav. 2004;78(1):75-81.
  • 21. Stellwagen D, Malenka RC. Synaptic scaling mediated by glial TNF-αlpha. Nature. 2006;440(7087):1054-1059.
  • 22. Galic MA, Riazi K, Pittman QJ. Cytokines and brain excitability. Front. Neuroendocrino.l 2012;33(1):116-25.
  • 23. Stellwagen D, Beattie EC, Seo JY, Malenka RC. Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J. Neurosci. 2005;25(12):3219-28.
  • 24. Loetscher H, Steinmetz M, Lesslauer W. Tumor necrosis factor: receptors and inhibitors. Cancer Cells. 1991;3(6):221-6.
  • 25. Mukai Y, Shibata H, Nakamura T, Yoshioka Y, Abe Y, Nomura T, Taniai M, Ohta T, Ikemizu S, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y. Structure–function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant. J. Mol. Biol. 2009;385(4):1221-1229.
  • 26. Natoli G, Costanzo A, Moretti F, Fulco M, Balsano C, Levrero M. Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 1997;272(42):26079-26082.
  • 27. Godlevsky LS, Shandra AA, Oleinik AA, Vastyanov RS, Kostyushov VV, Timchishin OL. TNF-alpha in cerebral cortex and cerebellum is affected by amygdalar kindling but not by stimulation of cerebellum. Pol. J. Pharmacol .2002;54(6):655-660.
  • 28. Balosso S, Ravizza T, Perego C, Peschon J, Campbell IL, De Simoni MG, Vezzani A. Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors. Ann. Neurol. 2005;57(6):804-812.
  • 29. Probert L, Akassoglou K, Pasparakis M, Kontogeorgos G, Kollias G. Spontaneousinflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc. Natl. Acad Sci. 1995;92(24):11294-11298.
  • 30. Ichiyama T, Suenaga N, Kajimoto M, Tohyama J, Isumi H, Kubota M, Mori M, Furukawa S. Serum and CSF levels of cytokines in acute encephalopathy following prolonged febrile seizures. Brain. Dev. 2008;30(1):47-52.
  • 31. Bozzi Y, Caleo M. Epilepsy, Seizures, and Inflammation: Role of the C-C Motif Ligand 2 Chemokine. DNA Cell Biol. 2016;35(6):257-260.
  • 32. Fabene PF, Bramanti P, Constantin G. The emerging role for chemokines in epilepsy. J. Neuroimmunol. 2010;224(1-2):22-27.
  • 33. Li R, Ma L, Huang H, Ou S, Yuan J, Xu T, Yu X, Liu X, Yang J, Chen Y, Peng X. Altered expression of CXCL13 and CXCR5 inintractable temporal lobe epilepsy patients and pilocarpine-induced epileptic rats. Neurochem. Res. 2017;42(2):526-540.
  • 34. Viviani B, Gardoni F, Marinovich M. Cytokines and Neuronal Ion Channels in Health and Disease. Int. Rev. Neurobiol. 2007;82:247-63.
  • 35. Rantala H, Tarkka R, Uhari M. Systematic review of the role of prostaglandins and their synthetase inhibitors with respect to febrile seizures. Epilepsy. Res. 2001;46(3):251-257.
  • 36. Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D(2) is crucial for seizure suppression and postictal sleep. Exp. Neurol. 2014;253:82-90.
  • 37. Takemiya T, Matsumura K, Sugiura H, Maehara M, Yasuda S, Uematsu S, Akira S, Yamagata K. Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate. J. Neurosci Res. 2010;88(2):381-390.
  • 38. Shimada T, Takemiya T, Sugiura H, Yamagata K. Role of inflammatory mediators in the pathogenesis of epilepsy. Mediators. Inflamm. 2014;2014:901-902.
  • 39. Marchi N, Granata T, Janigro D. Inflammatory pathways of seizure disorders. Trends. Neurosci. 2014;37(2):55-65.
  • 40. Dey A, Kang X, Qiu J, Du Y, Jiang J. Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside. Trends Pharmacol. Sci. 2016;37(6):463-484.

Epilepside inflamasyonun rolü

Yıl 2019, Cilt: 12 Sayı: 3, 525 - 533, 31.12.2019

Metin Yıldırım Ulaş Değirmenci Serap Yalın

https://doi.org/10.26559/mersinsbd.557883

Öz

Epilepsi, dünya çapında ve ülkemizde oldukça
yaygın görülen hastalıklardan biridir. İnflamatuvar mediatörler ve immün
hücrelerin üretilmesi ile epileptik nöbetlerin tekrarı arasındaki ilişki
hakkında gün geçtikçe deneysel ve klinik çalışmaların ışığında birbirini
destekleyen veriler ortaya çıkmaktadır. Bundan dolayı epilepsi ve inflamasyon
ilişkisi ilgi çekmektedir. Bu derlemede epilepsi ile inflamasyon ilişkisi
incelenmiştir.

Anahtar Kelimeler

İnflamasyon Epilepsi Sitokin Kemokin

Kaynakça

  • 1. Devinsky O. Effects of seizures on autonomic and cardiovascular function. Epilepsy Currents. 2004;4(2):43–46.
  • 2. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia. 2014;55:475–482.
  • 3. Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522-530.
  • 4. Wiebe S, Blume WT, Girvin JP, Eliasziw MA. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N. Engl. J. Med. 2001;345(5):311-318.
  • 5. Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nat. Rev. Neurol. 2011;7(1):31-40.
  • 6. Bambal G, Cakıl D, Ekici F. Epilepsi Oluşum Mekanizmaları Konuralp Tıp Dergisi. 2011;3(3) :42-45
  • 7. Alyu F, Dikmen M. Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms. Acta Neuropsychiatr. 2017;29(1):1-16
  • 8. Choi J, Koh S. Role of brain inflammation in epileptogenesis. Yonsei Med. J. 2008;49(1):1 -18.
  • 9. Jung KH, Chu K, Lee ST, Kim JH, Kang KM, Song EC, Kim SJ, Park HK, Kim M, Lee SK, Roh JK. Region-specific plasticity in the epileptic rat brain: a hippocampal and extrahippocampal analysis. Epilepsia. 2009;50(3):537-549.
  • 10. Li G, Bauer S, Nowak M, Norwood B, Tackenberg B, Rosenow F, Knake S, Oertel WH, Hamer HM. Cytokines and epilepsy. Seizure 2011;20(3):249-256.
  • 11. Scorza CA, Marques MJG, Gomes da Silva S, Naffah-Mazzacoratti MDG, Scorza FA, Cavalheiro EA. Status epilepticus does not induce acute brain inflammatory response in the Amazon rodent Proechimys, an animal model resistant to epileptogenesis. Neurosci. Lett. 2018;668:169-173.
  • 12. Ichiyama T, Nishikawa M, Yoshitomi T, Hayashi T, Furukawa S. Tumor necrosis factor-a, interleukin-l, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures comparison with acute encephalitis/encephalopathy. Neurology. 1998;50(2):407–411.
  • 13. Rana A, Musto AE. The role of inflammation in the development of epilepsy. Journal of neuroinflammation. 2018;15:144.
  • 14. Postnikova T, Zubareva O, Kovalenko A, Kim K, Magazanik L, Zaitsev A. Status epilepticus impairs synaptic plasticity in rat hippocampus and is followed by changes in expression of NMDA receptors. Biochem Mosc. 2017;82(3):282–90
  • 15. Han T, Qin Y, Mou C, Wang M, Jiang M, Liu B. Seizure induced synaptic plasticity alteration in hippocampus is mediated by IL-1ß receptor through PI3K/Akt pathway. Am J. Transl. Res. 2016;8(10):4499-4509.
  • 16. Vezzani A, & Baram TZ. New roles for interleukin-1 beta in the mechanisms of epilepsy. Epilepsy currents. 2007;7(2):45-50.
  • 17. Hirano T, Taga T, Yamasaki K, Matsuda T, Tang B, Muraguchi A, Horii Y, Suematsu S, Hirata Y, Yawata H, et al. A multifunctional cytokine (IL-6/BSF-2) and its receptor. Int. Arch Allergy Appl. Immunol. 1989;88(1-2):29-33.
  • 18. Yasukawa K, Futatsugi K, Saito T, Yawata H, Narazaki M, Suzuki H, Taga T, Kishimoto T. Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130. Immunol. Lett. 1992;31(2):123-130.
  • 19. Müller-Newen G, Küster A, Hemmann U, Keul R, Horsten U, Martens A, Graeve L, Wijdenes J, Heinrich PC. Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 onIL-6 responses. J. Immunol. 1998;161(11):6347-6355.
  • 20. De Luca G, Di Giorgio RM, Macaione S, Calpona PR, Costantino S, Di Paola ED, De Sarro A, Ciliberto G, De Sarro G. Susceptibility to audiogenic seizure and neurotransmitter amino acid levels in different brain areas of IL-6-deficient mice. Pharmacol. Biochem. Behav. 2004;78(1):75-81.
  • 21. Stellwagen D, Malenka RC. Synaptic scaling mediated by glial TNF-αlpha. Nature. 2006;440(7087):1054-1059.
  • 22. Galic MA, Riazi K, Pittman QJ. Cytokines and brain excitability. Front. Neuroendocrino.l 2012;33(1):116-25.
  • 23. Stellwagen D, Beattie EC, Seo JY, Malenka RC. Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J. Neurosci. 2005;25(12):3219-28.
  • 24. Loetscher H, Steinmetz M, Lesslauer W. Tumor necrosis factor: receptors and inhibitors. Cancer Cells. 1991;3(6):221-6.
  • 25. Mukai Y, Shibata H, Nakamura T, Yoshioka Y, Abe Y, Nomura T, Taniai M, Ohta T, Ikemizu S, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y. Structure–function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant. J. Mol. Biol. 2009;385(4):1221-1229.
  • 26. Natoli G, Costanzo A, Moretti F, Fulco M, Balsano C, Levrero M. Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 1997;272(42):26079-26082.
  • 27. Godlevsky LS, Shandra AA, Oleinik AA, Vastyanov RS, Kostyushov VV, Timchishin OL. TNF-alpha in cerebral cortex and cerebellum is affected by amygdalar kindling but not by stimulation of cerebellum. Pol. J. Pharmacol .2002;54(6):655-660.
  • 28. Balosso S, Ravizza T, Perego C, Peschon J, Campbell IL, De Simoni MG, Vezzani A. Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors. Ann. Neurol. 2005;57(6):804-812.
  • 29. Probert L, Akassoglou K, Pasparakis M, Kontogeorgos G, Kollias G. Spontaneousinflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc. Natl. Acad Sci. 1995;92(24):11294-11298.
  • 30. Ichiyama T, Suenaga N, Kajimoto M, Tohyama J, Isumi H, Kubota M, Mori M, Furukawa S. Serum and CSF levels of cytokines in acute encephalopathy following prolonged febrile seizures. Brain. Dev. 2008;30(1):47-52.
  • 31. Bozzi Y, Caleo M. Epilepsy, Seizures, and Inflammation: Role of the C-C Motif Ligand 2 Chemokine. DNA Cell Biol. 2016;35(6):257-260.
  • 32. Fabene PF, Bramanti P, Constantin G. The emerging role for chemokines in epilepsy. J. Neuroimmunol. 2010;224(1-2):22-27.
  • 33. Li R, Ma L, Huang H, Ou S, Yuan J, Xu T, Yu X, Liu X, Yang J, Chen Y, Peng X. Altered expression of CXCL13 and CXCR5 inintractable temporal lobe epilepsy patients and pilocarpine-induced epileptic rats. Neurochem. Res. 2017;42(2):526-540.
  • 34. Viviani B, Gardoni F, Marinovich M. Cytokines and Neuronal Ion Channels in Health and Disease. Int. Rev. Neurobiol. 2007;82:247-63.
  • 35. Rantala H, Tarkka R, Uhari M. Systematic review of the role of prostaglandins and their synthetase inhibitors with respect to febrile seizures. Epilepsy. Res. 2001;46(3):251-257.
  • 36. Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D(2) is crucial for seizure suppression and postictal sleep. Exp. Neurol. 2014;253:82-90.
  • 37. Takemiya T, Matsumura K, Sugiura H, Maehara M, Yasuda S, Uematsu S, Akira S, Yamagata K. Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate. J. Neurosci Res. 2010;88(2):381-390.
  • 38. Shimada T, Takemiya T, Sugiura H, Yamagata K. Role of inflammatory mediators in the pathogenesis of epilepsy. Mediators. Inflamm. 2014;2014:901-902.
  • 39. Marchi N, Granata T, Janigro D. Inflammatory pathways of seizure disorders. Trends. Neurosci. 2014;37(2):55-65.
  • 40. Dey A, Kang X, Qiu J, Du Y, Jiang J. Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside. Trends Pharmacol. Sci. 2016;37(6):463-484.
Toplam 40 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Metin Yıldırım 0000-0003-1346-312X

Ulaş Değirmenci 0000-0001-5208-6430

Serap Yalın 0000-0002-1286-2172

Yayımlanma Tarihi 31 Aralık 2019
Gönderilme Tarihi 25 Nisan 2019
Kabul Tarihi 8 Temmuz 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 12 Sayı: 3

Kaynak Göster

APA Yıldırım, M., Değirmenci, U., & Yalın, S. (2019). Epilepside inflamasyonun rolü. Mersin Üniversitesi Sağlık Bilimleri Dergisi, 12(3), 525-533. https://doi.org/10.26559/mersinsbd.557883
AMA Yıldırım M, Değirmenci U, Yalın S. Epilepside inflamasyonun rolü. Mersin Univ Saglık Bilim Derg. Aralık 2019;12(3):525-533. doi:10.26559/mersinsbd.557883
Chicago Yıldırım, Metin, Ulaş Değirmenci, ve Serap Yalın. “Epilepside Inflamasyonun Rolü”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 12, sy. 3 (Aralık 2019): 525-33. https://doi.org/10.26559/mersinsbd.557883.
EndNote Yıldırım M, Değirmenci U, Yalın S (01 Aralık 2019) Epilepside inflamasyonun rolü. Mersin Üniversitesi Sağlık Bilimleri Dergisi 12 3 525–533.
IEEE M. Yıldırım, U. Değirmenci, ve S. Yalın, “Epilepside inflamasyonun rolü”, Mersin Univ Saglık Bilim Derg, c. 12, sy. 3, ss. 525–533, 2019, doi: 10.26559/mersinsbd.557883.
ISNAD Yıldırım, Metin vd. “Epilepside Inflamasyonun Rolü”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 12/3 (Aralık 2019), 525-533. https://doi.org/10.26559/mersinsbd.557883.
JAMA Yıldırım M, Değirmenci U, Yalın S. Epilepside inflamasyonun rolü. Mersin Univ Saglık Bilim Derg. 2019;12:525–533.
MLA Yıldırım, Metin vd. “Epilepside Inflamasyonun Rolü”. Mersin Üniversitesi Sağlık Bilimleri Dergisi, c. 12, sy. 3, 2019, ss. 525-33, doi:10.26559/mersinsbd.557883.
Vancouver Yıldırım M, Değirmenci U, Yalın S. Epilepside inflamasyonun rolü. Mersin Univ Saglık Bilim Derg. 2019;12(3):525-33.

MEÜ Sağlık Bilimleri Dergisi Doç.Dr. Gönül Aslan'ın Editörlüğünde Mersin Üniversitesi Sağlık Bilimleri Enstitüsüne bağlı olarak 2008 yılında yayımlanmaya başlanmıştır. Prof.Dr. Gönül Aslan Mart 2015 tarihinde Başeditörlük görevine Prof.Dr. Caferi Tayyar Şaşmaz'a devretmiştir. 01 Ocak 2023 tarihinde Prof.Dr. C. Tayyar Şaşmaz Başeditörlük görevini Prof.Dr. Özlem İzci Ay'a devretmiştir. 

Yılda üç sayı olarak (Nisan - Ağustos - Aralık) yayımlanan dergi multisektöryal hakemli bir bilimsel dergidir. Dergide araştırma makaleleri yanında derleme, olgu sunumu ve editöre mektup tipinde bilimsel yazılar yayımlanmaktadır. Yayın hayatına başladığı günden beri eposta yoluyla yayın alan ve hem online hem de basılı olarak yayımlanan dergimiz, Mayıs 2014 sayısından itibaren sadece online olarak yayımlanmaya başlamıştır. TÜBİTAK-ULAKBİM Dergi Park ile Nisan 2015 tarihinde yapılan Katılım Sözleşmesi sonrasında online yayın kabul ve değerlendirme sürecine geçmiştir.

Mersin Üniversitesi Sağlık Bilimleri Dergisi 16 Kasım 2011'dan beri Türkiye Atıf Dizini tarafından indekslenmektedir.

Mersin Üniversitesi Sağlık Bilimleri Dergisi 2016 birinci sayıdan itibaren ULAKBİM Tıp Veri Tabanı tarafından indekslenmektedir.

Mersin Üniversitesi Sağlık Bilimleri Dergisi 02 Ekim 2019'dan beri DOAJ tarafından indekslenmektedir.

Mersin Üniversitesi Sağlık Bilimleri Dergisi 23 Mart 2021'den beri EBSCO tarafından indekslenmektedir.


Dergimiz açık erişim politikasını benimsemiş olup, dergimizde makale başvuru, değerlendirme ve yayınlanma aşamasında ücret talep edilmemektedir. Dergimizde yayımlanan makalelerin tamamına ücretsiz olarak Arşivden erişilebilmektedir.

154561545815459   

Bu eser Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı  ile lisanslanmıştır.