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Does the anticholinergic drug Biperiden affect early neural tube development in chick embryos?

Yıl 2022, Cilt: 13 Sayı: 47, 267 - 272, 15.12.2022

Hilal Güzel Esra Aslan

https://doi.org/10.17944/mkutfd.986503

Öz

Objective: Biperiden (BPD) is an anticholinergic agent that acts both centrally and peripherally. It is used to counteract both extrapyramidal side effects of neuroleptic treatment and symptoms of Parkinson’s disease in clinical practice. Current study was layout to determine the potential toxic effect of different doses of Biperiden on neural tube closure in 48hr chick embryos.

Method: Sixty fertilized eggs were used in the study. All eggs were placed in the incubator and divided into four groups (15 eggs in each); Control, BPD1, BPD2 and BPD3. At 28hr of incubation, three different doses of Biperiden were administered subblastodermically in all BPD groups. At the end of 48hr of incubation, all eggs were opened and embryos were dissected and evaluated morphologically and histopathologically.

Results: According to these results, the mean crown-rump length and somite number tended to decrease proportionally with the dose. As the dose increases, the number of open neural tube and undeveloped embryos in the experimental groups also increases. There was also a significant difference between the groups in terms of Hamburger-Hamilton stages of embryos evaluated according to the number of somite. Embryos in the Control, BPD1 and BPD2 groups were observed at stage 13, and those in the BPD3 group were observed at stage 12.

Conclusion: These results showed that Biperiden even in the low dose has teratogenicity on neural tube closure in early chick embryos. The somite numbers and crown-rump length were decreased depending on the dose and Biperiden caused developmental retardation in high doses.

Anahtar Kelimeler

Biperiden Chick Embryo Neural Tube

Destekleyen Kurum

-

Proje Numarası

-

Kaynakça

  • Pehl C, Wendl B, Kaess H, Pfeiffer A. Effects of two anticholinergic drugs, Trospium Chloride and Biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998;12(10):979-84. https://doi.org/10.1046/ j.1365-2036.1998.00398.x.
  • Allahverdiyev O, Nurten A, Enginar N. Assessment of rewarding and reinforcing properties of Biperiden in conditioned place preference in rats. Behav Brain Res. 2011;225(2):642-5. https://doi.org/10.1016/j.bbr.2011.07.050.
  • Coura CP de M, Fragoso VM da S, Valdez ECN, Paulino ET, Silva D, Cortez CM. Study on the interaction of three classical drugs used in psychiatry in albumin through spectrofluorimetric modeling. Spectrochim Acta - Part A Mol Biomol Spectrosc. 2021;255: 119638. https://doi.org/10.1016/j.saa.2021.119638.
  • Gjerden P, Bramness JG, Slørdal L. The use and potential abuse of anticholinergic antiparkinson drugs in Norway: A Pharmacoepidemiological Study. Br J Clin Pharmacol. 2009;67(2):228-33. https://doi.org/10.1111/j.1365- 2125.2008.03342.x.
  • Katsanoulas K, Papaioannou A, Fraidakis O, Michaloudis D. Undiagnosed Central Anticholinergic Syndrome may lead to dangerous complications. Eur J Anaesthesiol. 1999;16(11):803- 9. https://doi.org/10.1046/j.1365-2346.1999.00583.x.
  • Yap HL. Early psychosis intervention. Singapore Med J 2010;51(9):689-93.
  • Örüm MH. Biperiden dependence and differential diagnosis with Neuroleptic Malignant Syndrome: A Case Report. Istanbul Bilim Univ Florence Nightingale J Med. 2019;4: 194-6. https://doi.org/10.5606/fng.btd.2018.033.
  • Bakker C, Esdonk MJ, Stuurman R (F). E, Borghans LGJM, Kam ML, Gerven JMA et al. Biperiden challenge model in healthy elderly as proof‐of‐pharmacology tool: A Randomized, Placebo‐Controlled Trial. J Clin Pharmacol. 2021; May 21. https://doi.org/10.1002/jcph.1913.
  • Song G, Cui Y, Han ZJ, Xia HF, Ma X. Effects of Choline on Sodium Arsenite-induced neural tube defects in chick embryos. Food Chem Toxicol. 2012;50(12):4364-74. https://doi.org/10.1016/j. fct.2012.08.023.
  • Tureci E, Asan Z, Eser M, Tanriverdi T, Alkan F, Erdincler P. The effects of Valproic Acid and Levetiracetam on chicken embryos. J Clin Neurosci. 2011;18(6):816-20. https://doi. org/10.1016/j.jocn.2010.11.005.
  • Chen L, Wang S, Feng Y, Zhang J, Du Y, Zhang J et al. Utilisation of chick embryo chorioallantoic membrane as a model platform for imaging-navigated biomedical research. Cells. 2021;10(2):463. https://doi.org/10.3390/cells10020463.
  • Victorelli FD, Cardoso VM de O, Ferreira NN, Calixto GMF, Fontana CR, Baltazar F et al. Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review. Eur J Pharm Biopharm. 2020;153:273-84. https://doi.org/10.1016/j. ejpb.2020.06.010.
  • Palombo P, Engi SA, Yokoyama TS, Bezerra AG, Curado DF, Anésio A et al. Effects of Biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on Ethanol conditioned place preference in mice. Neurosci Lett. 2021;6(745):135551745. https://doi.org/10.1016/j.neulet.2020.135551.
  • Szczodry O, van der Staay FJ, Arndt SS. Modelling Alzheimer like cognitive deficits in rats using biperiden as putative cognition impairer. Behav Brain Res. 2014;1(274):307-11. https://doi.org/10.1016/j.bbr.2014.08.036.
  • Ertekin T, Bilir A, Aslan E, Koca B, Turamanlar O, Ertekin A, et al. The effect of Diclofenac Sodium on neural tube development in the early stage of chick embryos. Folia Morphol. 2019;78(2):307-13. https://doi.org/10.5603/FM.a2018.0080.
  • Atay E, Ertekin A, Bozkurt E, Aslan E. Impact of Bisphenol A on neural tube development in 48-hr chicken embryos. Birth Defects Res. 2020;112(17):1386-96. https://doi.org/10.1002/ bdr2.1791.
  • Rakip U, Bilir A, Arikan ES. Effect of Pethidine Hydrochloride on the development of neural tube: A genetic analysis study in a chick embryo model. World Neurosurg. 2021;150: e613-e620. https://doi.org/10.1016/j.wneu.2021.03.065.
  • Hamburger V, Hamilton HL. A Series of normal stages in the development of the chick embryo. J Morphol. 1951;88(1): 49- 92. https://doi.org/10.1002/jmor.1050880104.
  • Wunsch MJ, Stanard V, Schnoll SH. Treatment of pain in pregnancy. Clin J Pain. 2003;19(3): 148-55. https://doi. org/10.1097/00002508-200305000-00002.
  • Van De Velde M, De Buck F. Anesthesia for non-obstetric surgery in the pregnant patient. Minerva Anestesiol 2007;73(4):235-40.
  • de Carvalho FB, de Gomes MG, Savall ASP, Fidelis EM, Pinton S, Ribeiro ACF, Munieweg FR et al. Evaluation of curcumin loaded polymeric nanocapsules with different coatings in chick embryo model: Influence on angiogenesis, teratogenesis and oxidative stress. Pharmacol Reports. 2021;73(2):563-73. https://doi.org/10.1007/s43440-021-00218-2
  • Sayin M, Gurgen GS, Sayin SS, Guvenc G, Yuceer N. Does the anti migraine drug rizatriptan affect early neural tube development in chick embryos? Turk Neurosurg. 2019;29(1):106-9. https://doi.org/10.5137/1019-5149.JTN.23431-18.1.
  • Ovalioglu TC, Canaz G, Arslan S, Ovalioglu AO, Sar M, Aydin AE et al. Effects of Quetiapine on neural tube development in the early stage of chicken embryos. Turk Neurosurg. 2021;31(1): 137-41. https://doi.org/10.5137/1019-5149.JTN.32887-20.1.
  • Stamilio, David M. “Drugs for Pregnant and Lactating Women.” (2004): 408. https://doi.org/10.7326/0003-4819-140- 5-200403020-00030
  • Baskak B, Atbasoglu EC, Ozguven HD, Saka MC, Gogus AK. The effectiveness of intramuscular Biperiden in acute akathisia: A double-blind, randomized, placebo-controlled study. J Clin Psychopharmacol. 2007;27(3):289-94. https://doi. org/10.1097/jcp.0b013e3180582439.
  • Toto S, Hefner G, Hahn M, Hiemke C, Roll SC, Wolff J et al. Current use of anticholinergic medications in a large naturalistic sample of psychiatric patients. J Neural Transm. 2021;128(2): 263-72. https://doi.org/10.1007/s00702-020- 02298-5.
  • Hirose S. Insomnia related to Biperiden withdrawal in two schizophrenic patients. Int Clin Psychopharmacol. 2000;15(6):357-9. https://doi.org/10.1097/00004850- 200015060-00007.
  • Wang HE. Street drug toxicity resulting from opiates combined with anticholinergics. Prehospital Emerg Care. 2002;6 (3):351- 4. https://doi.org/10.1080/10903120290938463.
  • Espi Martinez F, Espi Forcen F, Shapov A, Martinez Moya A. Biperiden dependence: Case report and literature review. Case Rep Psychiatry. 2012;2012: 949256. https://doi. org/10.1155/2012/949256.
  • Sambeth A, Riedel WJ, Klinkenberg I, Kähkönen S, Blokland A. Biperiden selectively induces memory impairment in healthy volunteers: No interaction with citalopram. Psychopharmacology (Berl). 2015;232(11):1887-97. https:// doi.org/10.1007/s00213-014-3822-9.
  • Guvenc Y, Dalgic A, Billur D, Karaoglu D, Aydin S, Daglioglu E et al. The Effects of Levetiracetam on neural tube development in the early stage of chick embryos. Turk Neurosurg. 2013;23(5):617-22. https://doi.org/10.5137/1019-5149. JTN.7471-13.0.

Antikolinerjik ilaçlardan Biperiden civciv embriyolarında erken dönemde nöral tüp gelişimini etkiler mi?

Yıl 2022, Cilt: 13 Sayı: 47, 267 - 272, 15.12.2022

Hilal Güzel Esra Aslan

https://doi.org/10.17944/mkutfd.986503

Öz

Amaç: Biperiden, hem merkezi hem de periferik olarak etki gösteren antikolinerjik bir ajandır. Klinik uygulamada hem nöroleptik tedavinin ekstrapiramidal yan etkilerine hem de Parkinson hastalığının semptomlarına karşı kullanılır. Mevcut çalışmanın amacı farklı dozlarda Biperiden uygulamasının 48 saatlik civciv embriyolarında nöral tüp kapanması üzerindeki potansiyel toksik etkisini belirlemektir.

Yöntem: Çalışmada 60 adet döllenmiş yumurta kullanıldı. Tüm yumurtalar kuluçka makinesine yerleştirildi ve her grupta 15 yumurta olacak şekilde dört gruba ayrıldı: Kontrol, BPD1, BPD2 ve BPD3. Yirmi sekiz saatlik inkübasyonda, Biperiden gruplarına subblastodermik olarak üç farklı Biperiden dozu uygulandı. 48 saatlik inkübasyonun sonunda tüm yumurtalar açılarak embriyolar diseke edildi. Embriyolar morfolojik ve histopatolojik olarak değerlendirildi.

Bulgular: Mevcut çalışmanın sonuçlarına göre ortalama baş-popo uzunluğu ve somit sayısı dozla orantılı olarak azalma eğilimindeydi. Doz arttıkça deney gruplarında açık nöral tüp ve gelişmemiş embriyo sayısı istatistiksel olarak anlamlı şekilde artmıştır. Somit sayısına göre değerlendirilen embriyoların Hamburger-Hamilton evreleri açısından da gruplar arasında anlamlı fark vardı. Kontrol, BPD1 ve BPD2 gruplarındaki embriyolar evre 13’te, BPD3 grubundakiler ise evre 12’de gözlendi.

Sonuç: Çalışmamızda erken civciv embriyolarında Biperiden’in düşük dozda bile nöral tüp kapanmasında teratojeniteye neden olduğunu gösterilmiştir. Doza bağlı olarak somit sayısı ve baş-popo uzunluğu azalmış, yüksek dozda ise gelişim geriliğine neden olmuştur.

Anahtar Kelimeler

Biperiden Civciv Embriyosu Nöral tüp

Proje Numarası

-

Kaynakça

  • Pehl C, Wendl B, Kaess H, Pfeiffer A. Effects of two anticholinergic drugs, Trospium Chloride and Biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998;12(10):979-84. https://doi.org/10.1046/ j.1365-2036.1998.00398.x.
  • Allahverdiyev O, Nurten A, Enginar N. Assessment of rewarding and reinforcing properties of Biperiden in conditioned place preference in rats. Behav Brain Res. 2011;225(2):642-5. https://doi.org/10.1016/j.bbr.2011.07.050.
  • Coura CP de M, Fragoso VM da S, Valdez ECN, Paulino ET, Silva D, Cortez CM. Study on the interaction of three classical drugs used in psychiatry in albumin through spectrofluorimetric modeling. Spectrochim Acta - Part A Mol Biomol Spectrosc. 2021;255: 119638. https://doi.org/10.1016/j.saa.2021.119638.
  • Gjerden P, Bramness JG, Slørdal L. The use and potential abuse of anticholinergic antiparkinson drugs in Norway: A Pharmacoepidemiological Study. Br J Clin Pharmacol. 2009;67(2):228-33. https://doi.org/10.1111/j.1365- 2125.2008.03342.x.
  • Katsanoulas K, Papaioannou A, Fraidakis O, Michaloudis D. Undiagnosed Central Anticholinergic Syndrome may lead to dangerous complications. Eur J Anaesthesiol. 1999;16(11):803- 9. https://doi.org/10.1046/j.1365-2346.1999.00583.x.
  • Yap HL. Early psychosis intervention. Singapore Med J 2010;51(9):689-93.
  • Örüm MH. Biperiden dependence and differential diagnosis with Neuroleptic Malignant Syndrome: A Case Report. Istanbul Bilim Univ Florence Nightingale J Med. 2019;4: 194-6. https://doi.org/10.5606/fng.btd.2018.033.
  • Bakker C, Esdonk MJ, Stuurman R (F). E, Borghans LGJM, Kam ML, Gerven JMA et al. Biperiden challenge model in healthy elderly as proof‐of‐pharmacology tool: A Randomized, Placebo‐Controlled Trial. J Clin Pharmacol. 2021; May 21. https://doi.org/10.1002/jcph.1913.
  • Song G, Cui Y, Han ZJ, Xia HF, Ma X. Effects of Choline on Sodium Arsenite-induced neural tube defects in chick embryos. Food Chem Toxicol. 2012;50(12):4364-74. https://doi.org/10.1016/j. fct.2012.08.023.
  • Tureci E, Asan Z, Eser M, Tanriverdi T, Alkan F, Erdincler P. The effects of Valproic Acid and Levetiracetam on chicken embryos. J Clin Neurosci. 2011;18(6):816-20. https://doi. org/10.1016/j.jocn.2010.11.005.
  • Chen L, Wang S, Feng Y, Zhang J, Du Y, Zhang J et al. Utilisation of chick embryo chorioallantoic membrane as a model platform for imaging-navigated biomedical research. Cells. 2021;10(2):463. https://doi.org/10.3390/cells10020463.
  • Victorelli FD, Cardoso VM de O, Ferreira NN, Calixto GMF, Fontana CR, Baltazar F et al. Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review. Eur J Pharm Biopharm. 2020;153:273-84. https://doi.org/10.1016/j. ejpb.2020.06.010.
  • Palombo P, Engi SA, Yokoyama TS, Bezerra AG, Curado DF, Anésio A et al. Effects of Biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on Ethanol conditioned place preference in mice. Neurosci Lett. 2021;6(745):135551745. https://doi.org/10.1016/j.neulet.2020.135551.
  • Szczodry O, van der Staay FJ, Arndt SS. Modelling Alzheimer like cognitive deficits in rats using biperiden as putative cognition impairer. Behav Brain Res. 2014;1(274):307-11. https://doi.org/10.1016/j.bbr.2014.08.036.
  • Ertekin T, Bilir A, Aslan E, Koca B, Turamanlar O, Ertekin A, et al. The effect of Diclofenac Sodium on neural tube development in the early stage of chick embryos. Folia Morphol. 2019;78(2):307-13. https://doi.org/10.5603/FM.a2018.0080.
  • Atay E, Ertekin A, Bozkurt E, Aslan E. Impact of Bisphenol A on neural tube development in 48-hr chicken embryos. Birth Defects Res. 2020;112(17):1386-96. https://doi.org/10.1002/ bdr2.1791.
  • Rakip U, Bilir A, Arikan ES. Effect of Pethidine Hydrochloride on the development of neural tube: A genetic analysis study in a chick embryo model. World Neurosurg. 2021;150: e613-e620. https://doi.org/10.1016/j.wneu.2021.03.065.
  • Hamburger V, Hamilton HL. A Series of normal stages in the development of the chick embryo. J Morphol. 1951;88(1): 49- 92. https://doi.org/10.1002/jmor.1050880104.
  • Wunsch MJ, Stanard V, Schnoll SH. Treatment of pain in pregnancy. Clin J Pain. 2003;19(3): 148-55. https://doi. org/10.1097/00002508-200305000-00002.
  • Van De Velde M, De Buck F. Anesthesia for non-obstetric surgery in the pregnant patient. Minerva Anestesiol 2007;73(4):235-40.
  • de Carvalho FB, de Gomes MG, Savall ASP, Fidelis EM, Pinton S, Ribeiro ACF, Munieweg FR et al. Evaluation of curcumin loaded polymeric nanocapsules with different coatings in chick embryo model: Influence on angiogenesis, teratogenesis and oxidative stress. Pharmacol Reports. 2021;73(2):563-73. https://doi.org/10.1007/s43440-021-00218-2
  • Sayin M, Gurgen GS, Sayin SS, Guvenc G, Yuceer N. Does the anti migraine drug rizatriptan affect early neural tube development in chick embryos? Turk Neurosurg. 2019;29(1):106-9. https://doi.org/10.5137/1019-5149.JTN.23431-18.1.
  • Ovalioglu TC, Canaz G, Arslan S, Ovalioglu AO, Sar M, Aydin AE et al. Effects of Quetiapine on neural tube development in the early stage of chicken embryos. Turk Neurosurg. 2021;31(1): 137-41. https://doi.org/10.5137/1019-5149.JTN.32887-20.1.
  • Stamilio, David M. “Drugs for Pregnant and Lactating Women.” (2004): 408. https://doi.org/10.7326/0003-4819-140- 5-200403020-00030
  • Baskak B, Atbasoglu EC, Ozguven HD, Saka MC, Gogus AK. The effectiveness of intramuscular Biperiden in acute akathisia: A double-blind, randomized, placebo-controlled study. J Clin Psychopharmacol. 2007;27(3):289-94. https://doi. org/10.1097/jcp.0b013e3180582439.
  • Toto S, Hefner G, Hahn M, Hiemke C, Roll SC, Wolff J et al. Current use of anticholinergic medications in a large naturalistic sample of psychiatric patients. J Neural Transm. 2021;128(2): 263-72. https://doi.org/10.1007/s00702-020- 02298-5.
  • Hirose S. Insomnia related to Biperiden withdrawal in two schizophrenic patients. Int Clin Psychopharmacol. 2000;15(6):357-9. https://doi.org/10.1097/00004850- 200015060-00007.
  • Wang HE. Street drug toxicity resulting from opiates combined with anticholinergics. Prehospital Emerg Care. 2002;6 (3):351- 4. https://doi.org/10.1080/10903120290938463.
  • Espi Martinez F, Espi Forcen F, Shapov A, Martinez Moya A. Biperiden dependence: Case report and literature review. Case Rep Psychiatry. 2012;2012: 949256. https://doi. org/10.1155/2012/949256.
  • Sambeth A, Riedel WJ, Klinkenberg I, Kähkönen S, Blokland A. Biperiden selectively induces memory impairment in healthy volunteers: No interaction with citalopram. Psychopharmacology (Berl). 2015;232(11):1887-97. https:// doi.org/10.1007/s00213-014-3822-9.
  • Guvenc Y, Dalgic A, Billur D, Karaoglu D, Aydin S, Daglioglu E et al. The Effects of Levetiracetam on neural tube development in the early stage of chick embryos. Turk Neurosurg. 2013;23(5):617-22. https://doi.org/10.5137/1019-5149. JTN.7471-13.0.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Original Articles
Yazarlar

Hilal Güzel 0000-0001-7692-8890

Esra Aslan 0000-0002-3191-4978

Proje Numarası -
Yayımlanma Tarihi 15 Aralık 2022
Gönderilme Tarihi 24 Ağustos 2021
Kabul Tarihi 18 Haziran 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 13 Sayı: 47

Kaynak Göster

Vancouver Güzel H, Aslan E. Does the anticholinergic drug Biperiden affect early neural tube development in chick embryos?. mkutfd. 2022;13(47):267-72.
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