Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım

Aysel Taktak; Nilgün Çakar

doi:10.4274/jcp.40427

Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım

Yıl 2015, Cilt: 13 Sayı: 1, 40 - 45, 01.06.2015

Aysel Taktak Nilgün Çakar

https://doi.org/10.4274/jcp.40427

Öz

Kistik böbrek hastalıkları, kalıtımsal böbrek hastalıkları içinde en sık görülen grup olup, her biri farklı etiyoloji, patogenez, klinik prezentasyon ve prognoza sahiptir. Hastalığın tanısı aile öyküsü, klinik bulgular ve görüntüleme yöntemleriyle konulabilmektedir ancak bazı olgularda kesin tanı için genetik çalışma gerekebilir. Son on yıl içerisinde kistik böbrek hastalıklarının etyopatogeneziyle ilgili birçok yeni bilgi kazanılmıştır. Edinilen bilgiler özellikle primer siliyanın bozulmuş mekanik algılama fonksiyonu, artmış proliferasyon ve iletişim yolaklarının kist gelişiminin temelini oluşturduğunu işaret etmektedir. Bu derlemede kalıtımsal kistik böbrek hastalıklarının patogenezi, belirtileri ve tanıda genetik incelemenin yeri tartışılmıştır

Anahtar Kelimeler

Kistik böbrek hastalıkları, kalıtımsal

Kaynakça

1. Wilson PD. Polycystic kidney disease. New England Journal Of Medicine 2004;350:151-64.
2. Bergmann C, Senderek J, Kupper F, Schneider F, Dornia C, Windelen E, et al. PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD). Hum Mutat 2004;23:453- 63.
3. Sweeney WE Jr, Avner ED. Diagnosis and management of childhood polycytic kidney disease. Pediatr Nephrol 2011;26:675-92.
4. Ward CJ, Yuan D, Masyuk TV, Wang X, Punyashthiti R, Whelan S, et al. Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia. Hum Mol Genet 2003;12:2703-10.
5. Follit JA, Li L, Vucica Y, Pazour GJ. The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence. J Cell Biol 2010;188:21-28.
6. Sun L, Wang S, Hu C, Zhang X. Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-kappaB pathways. Ex Cell Res 2011;317:932-40.
7. Denamur E, Delezoide AL, Alberti C, Bourillon A, Gubler MC, Bouvier R, et al. Genotype-phenotype correlations in fetuses and neonates with autosomal recessive polycystic kidney disease. Kidney Int 2010;77:350-58.
8. Gunay-Aygun M. Liver and kidney disease in ciliopathies. Am J Med Genet C Semin Med Genet 2009;151:296-306.
9. Blickman JG, Bramson RT, Herrin JT. Autosomal recessive polycystic kidney disease: long-term sonographic findings in patients surviving the neonatal period. Am J Roentgenol 1995;164:1247-50.
10. Rosesetti S, Hariss PC. Genotype-phenotype correlations in autosomal dominant and autosomal recessive polycystic kidney disease. J Am Soc Nephrol 2007;18:1374-80.
11. Bergmann C, Senderek J, Windelen E, Kupper F, Middeldorf I, Schneider F, et al. Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD). Kidney Int 2005;67:829-48.
12. Bergmann C, Senderek J, Sedlacek B, Pegiazoglou I, Puglia P, Eggermann T, et al. Spectrum of mutations in the gene for autosomal recessive polycystic kidney disease (ARPKD/ PKHD1). J Am Soc Nephrol 2003;14:76-89.
13. Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, et al. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci USA 2006;103:5466-71.
14. Masyuk TV, Radtke BN, Stroope AJ, Banales JM, Gradilone SA, Huang B, et al. Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver disease. Hepatology 2013;58:409- 21.
15. Pei Y, Paterson AD, Wang KR, He N, Hefferton D, Watnick T, et al. Bilineal disease and trans-heterozygotes in autosomal dominant polycystic kidney disease. Am J Hum Genet 2001;68:355-63.
16. Yoder KB, Mulroy S, Eustace H, Boucher K, Sandford R. Molecular pathogenesis of autosomal polycystic kidney disease. Expert Reviews 2006;8:1-22.
17. Gabow PA. Autosomal dominant polycystic kidney disease. N Engl J Med 1993;329:332-42.
18. Huang E, Samaniego-Picota M, McCune T, Melancon JK, Montgomery RA, Ugarte R, et al. DNA testing for live kidney donors at risk for autosomal dominant polycystic kidney disease. Transplantation 2009;87:133-7.
19. Zerres K, Rudnik-Schoneborn S, Deget F. Childhood onset autosomal dominant polycystic kidney disease in sibs: clinical picture and recurrence risk. German working group on paediatric nephrology (Arbeitsgemeinschaft fur padiatrische Nephrologie). J Med Genet 1993;30:583-8.
20. Cadnapaphornchai MA, McFann K, Strain JD, Masoumi A, Schrier RW. Increased left ventricular mass in children with autosomal dominant polycystic kidney disease and borderline hypertension. Kidney Int 2008;74:1192-6.
21. Perrone RD, Ruthazer R, Terrin NC. Survival after endstage renal disease in autosomal dominant polycystic kidney disease: contribution of extrarenal complications to mortality. Am J Kidney Dis 2001;38:777-84.
22. Fick GM, Johnson AM, Hammond WS, Gabow PA. Causes of death in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1995;5:2048-56.
23. Chaki M, Hoefele J, Allen SJ, Ramaswami G, Janssen S, Bergmann C, et al. Genotypephenotype correlation in 440 patients with NPHP-related ciliopathies. Kidney Int 2011;80:1239-45.
24. Salomon R, Saunier S, Niaudet P. Nephronophthisis. Pediatr Nephrol 2009;24:2333-44.
25. Simms RJ, Eley L, Sayer JA. Nephronophthisis. Eur J Hum Genet 2009;17:406-16.
26. Zollinger HU, Mihatsch MJ, Edefonti A, Gaboardi F, İmbasciati E, Lennert T. Nephronophthisis (medullary cystic disease of the kidney). A study using electron microscopy, immunofluorescence, and a review of the morphological findings. Helv Paediatr Acta 1980;35:509-30.
27. Hildebrandt F, Benzing T, Katsanis N. Ciliopathies. N Engl J Med 2011;364:1533-43.
28. Delous M, Hellman NE, Gaude HM, Silbermann F, Le Bivic A, Salomon R, et al. Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/ PATJ and Par6. Hum Mol Genet 2009;18:4711-23.
29. Otto EA, Hurd TW, Airik R, Chaki M, Zhou W, Stoetzel C, et al. Exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nature Genet 2010;42:840-50.
30. Ala-Mello S, Kivivuori SM, Ronnholm KA, Koskimies O, Siimes MA. Mechanism underlying early anaemia in children with familial juvenile nephronophthisis. Pediatr Nephrol 1996;10:578-81.
31. Hildebrandt F, Strahm B, Nothwang HG, Gretz N, Schnieders B, Singh-Sawhney I, et al. Molecular genetic identification of families with juvenile nephronophthisis type 1: rate of progression to renal failure. APN Study Group. Arbeitsgemeinschaft fur padiatrische Nephrologie. Kidney Int 1997;51:261-9.
32. Olbrich H, Fliegauf M, Hoefele J, Kispert A, Otto E, Volz A, et al. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nat Genet 2003;34:455-9.
33. Wolf MT, Beck BB, Zaucke F, Kunze A, Misselwitz J, Ruley J, et al. The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect. Kidney Int 2007;71:574-81.
34. Wolf MT, Van Vlem B, Hennies HC, Zalewski I, Karle SM, Puetz nM, et al. Telomeric refinement of the MCKD1 locus on chromosome 1q21. Kidney Int 2004;66:580-5.
35. Hart TC, Gorry MC, Hart PS, Woodard AS, Shihabi Z, Sandhu J, et al. Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet 2002;39:882-92.
36. Kalbacova M, Baresova V, Sikora J, Blazkova H, Zivny J, Ivanek R, et al. Dominant renin gene mutations associated with earlyonset hyperuricemia, anemia, and chronic kidney failure. Am J Hum Genet 2009;85:204-13.
37. Kroiss SHK, Berthold S, Rüschendorf F, Scolari F, Caridi G, Ghiggeri GM, et al. Evidence of further genetic heterogeneity in autosomal dominant medullary cystic kidney disease. Nephro Dial Transplant 2000;15:818-21.
38. Stavrou C, Koptides M, Tombazos C, Psara E, Patsias C, Zouvani I, et al. Autosomal-dominant medullary cystic kidney disease type 1: clinical and molecular findings in six large Cypriot families. Kidney Int 2002;62:1385-94.
39. Auranen MA-MS, Turunen JA, Jarvela I. Further evidence for linkage of autosomal-dominant medullary cystic kidney disease on chromosome 1q21. Kidney Int 2001;60:1225-32.
40. Puig JG, Miranda ME, Mateos FA, Picazo ML, Jimenez ML, Calvin TS, et al. Hereditary nephropathy associated with hyperuricemia and gout. Arch Intern Med 1993;153:357-65.
41. Scolari F, Caridi G, Rampoldi L, Tardanico R, Izzi C, Pirulli D, et al. Uromodulin storage diseases: clinical aspects and mechanisms. Am J Kidney Dis 2004;44:987-99.
42. Kiser RL, Wolf MT, Martin JL, Zalewski I, Attanasio M, Hildebrandt F, et al. Medullary cystic kidney disease type 1 in a large Native-American kindred. Am J Kidney Dis 2004;44:611-7.
43. Fairbanks LD, Cameron JS, Venkat-Raman G, Rigden SP, Rees L, Van THW, et al. Early treatment with allopurinol in familial juvenile hyerpuricaemic nephropathy (FJHN) ameliorates the long-term progression of renal disease. QJM 2002;95:597-607.
44. Lennerz JK, Spence DC, Iskandar SS, Dehner LP, Liapis H. Glomerulocystic kidney: one hundred-year perspective. Arch Pathol Lab Med 2010;134:583-605.
45. Bissler JJ, Siroky BJ, Yin H. Glomerulocystic kidney disease. Pediatr Nephrol 2010;25:2049-56.
46. Borges Oliva MR, Hsing J, Rybicki FJ, Fennessy F, Mortele KJ, Ros PR. Glomerulocystic kidney disease: MRI findings. Abdom Imaging 2003;28:889-92.
47. Hiesberger T, Fiette L, Igarashi P, Yaniv M, Pontoglio M. A transcriptional network in polycystic kidney disease. EMBO J 2004;23:1657-68.
48. Coffinier C, Barra J, Babinet C, Yaniv M. Expression of the vHNF1/HNF1beta homeoprotein gene during mouse organogenesis. Mech Dev 1999;89:211-3.
49. Bingham C, Hattersley AT. Renal cysts and diabetes syndrome resulting from mutations in hepatocyte nuclear factor- 1beta. Nephrol Dial Transplant 2004;19:2703-08.
50. Heidet L, Decramer S, Pawtowski A, Moriniere V, Bandin F, Knebelmann B, et al. Spectrum of HNF1B mutations in a large cohort of patients who harbor renal diseases. Clin J Am Soc Nephrol 2010;5:1079-90.s

Approach to Inherited Cystic Kidney Disease

Yıl 2015, Cilt: 13 Sayı: 1, 40 - 45, 01.06.2015

Aysel Taktak Nilgün Çakar

https://doi.org/10.4274/jcp.40427

Öz

Cystic kidney diseases are the most frequent form of inherited kidney diseases which have different etiology, pathogenesis, clinical presentation and prognosis. Although diagnosis based on, family history, clinical presentation and imaging modalities, in some circumstances genetic testing can be required. In the last decade a lot of new information about the pathogenesis of cystic kidney diseases have been reported. It has been showed that, deteriorated mechanical sensing function of primary cilia, increased proliferation and signaling pathways constitute the basis of cyst development. In this review the pathogenesis, clinical presentation and genetic evaluation of inherited cystic kidney diseases have been discussed

Anahtar Kelimeler

Cystic kidney disease, inherited

Kaynakça

1. Wilson PD. Polycystic kidney disease. New England Journal Of Medicine 2004;350:151-64.
2. Bergmann C, Senderek J, Kupper F, Schneider F, Dornia C, Windelen E, et al. PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD). Hum Mutat 2004;23:453- 63.
3. Sweeney WE Jr, Avner ED. Diagnosis and management of childhood polycytic kidney disease. Pediatr Nephrol 2011;26:675-92.
4. Ward CJ, Yuan D, Masyuk TV, Wang X, Punyashthiti R, Whelan S, et al. Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia. Hum Mol Genet 2003;12:2703-10.
5. Follit JA, Li L, Vucica Y, Pazour GJ. The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence. J Cell Biol 2010;188:21-28.
6. Sun L, Wang S, Hu C, Zhang X. Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-kappaB pathways. Ex Cell Res 2011;317:932-40.
7. Denamur E, Delezoide AL, Alberti C, Bourillon A, Gubler MC, Bouvier R, et al. Genotype-phenotype correlations in fetuses and neonates with autosomal recessive polycystic kidney disease. Kidney Int 2010;77:350-58.
8. Gunay-Aygun M. Liver and kidney disease in ciliopathies. Am J Med Genet C Semin Med Genet 2009;151:296-306.
9. Blickman JG, Bramson RT, Herrin JT. Autosomal recessive polycystic kidney disease: long-term sonographic findings in patients surviving the neonatal period. Am J Roentgenol 1995;164:1247-50.
10. Rosesetti S, Hariss PC. Genotype-phenotype correlations in autosomal dominant and autosomal recessive polycystic kidney disease. J Am Soc Nephrol 2007;18:1374-80.
11. Bergmann C, Senderek J, Windelen E, Kupper F, Middeldorf I, Schneider F, et al. Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD). Kidney Int 2005;67:829-48.
12. Bergmann C, Senderek J, Sedlacek B, Pegiazoglou I, Puglia P, Eggermann T, et al. Spectrum of mutations in the gene for autosomal recessive polycystic kidney disease (ARPKD/ PKHD1). J Am Soc Nephrol 2003;14:76-89.
13. Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, et al. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci USA 2006;103:5466-71.
14. Masyuk TV, Radtke BN, Stroope AJ, Banales JM, Gradilone SA, Huang B, et al. Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver disease. Hepatology 2013;58:409- 21.
15. Pei Y, Paterson AD, Wang KR, He N, Hefferton D, Watnick T, et al. Bilineal disease and trans-heterozygotes in autosomal dominant polycystic kidney disease. Am J Hum Genet 2001;68:355-63.
16. Yoder KB, Mulroy S, Eustace H, Boucher K, Sandford R. Molecular pathogenesis of autosomal polycystic kidney disease. Expert Reviews 2006;8:1-22.
17. Gabow PA. Autosomal dominant polycystic kidney disease. N Engl J Med 1993;329:332-42.
18. Huang E, Samaniego-Picota M, McCune T, Melancon JK, Montgomery RA, Ugarte R, et al. DNA testing for live kidney donors at risk for autosomal dominant polycystic kidney disease. Transplantation 2009;87:133-7.
19. Zerres K, Rudnik-Schoneborn S, Deget F. Childhood onset autosomal dominant polycystic kidney disease in sibs: clinical picture and recurrence risk. German working group on paediatric nephrology (Arbeitsgemeinschaft fur padiatrische Nephrologie). J Med Genet 1993;30:583-8.
20. Cadnapaphornchai MA, McFann K, Strain JD, Masoumi A, Schrier RW. Increased left ventricular mass in children with autosomal dominant polycystic kidney disease and borderline hypertension. Kidney Int 2008;74:1192-6.
21. Perrone RD, Ruthazer R, Terrin NC. Survival after endstage renal disease in autosomal dominant polycystic kidney disease: contribution of extrarenal complications to mortality. Am J Kidney Dis 2001;38:777-84.
22. Fick GM, Johnson AM, Hammond WS, Gabow PA. Causes of death in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1995;5:2048-56.
23. Chaki M, Hoefele J, Allen SJ, Ramaswami G, Janssen S, Bergmann C, et al. Genotypephenotype correlation in 440 patients with NPHP-related ciliopathies. Kidney Int 2011;80:1239-45.
24. Salomon R, Saunier S, Niaudet P. Nephronophthisis. Pediatr Nephrol 2009;24:2333-44.
25. Simms RJ, Eley L, Sayer JA. Nephronophthisis. Eur J Hum Genet 2009;17:406-16.
26. Zollinger HU, Mihatsch MJ, Edefonti A, Gaboardi F, İmbasciati E, Lennert T. Nephronophthisis (medullary cystic disease of the kidney). A study using electron microscopy, immunofluorescence, and a review of the morphological findings. Helv Paediatr Acta 1980;35:509-30.
27. Hildebrandt F, Benzing T, Katsanis N. Ciliopathies. N Engl J Med 2011;364:1533-43.
28. Delous M, Hellman NE, Gaude HM, Silbermann F, Le Bivic A, Salomon R, et al. Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/ PATJ and Par6. Hum Mol Genet 2009;18:4711-23.
29. Otto EA, Hurd TW, Airik R, Chaki M, Zhou W, Stoetzel C, et al. Exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nature Genet 2010;42:840-50.
30. Ala-Mello S, Kivivuori SM, Ronnholm KA, Koskimies O, Siimes MA. Mechanism underlying early anaemia in children with familial juvenile nephronophthisis. Pediatr Nephrol 1996;10:578-81.
31. Hildebrandt F, Strahm B, Nothwang HG, Gretz N, Schnieders B, Singh-Sawhney I, et al. Molecular genetic identification of families with juvenile nephronophthisis type 1: rate of progression to renal failure. APN Study Group. Arbeitsgemeinschaft fur padiatrische Nephrologie. Kidney Int 1997;51:261-9.
32. Olbrich H, Fliegauf M, Hoefele J, Kispert A, Otto E, Volz A, et al. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nat Genet 2003;34:455-9.
33. Wolf MT, Beck BB, Zaucke F, Kunze A, Misselwitz J, Ruley J, et al. The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect. Kidney Int 2007;71:574-81.
34. Wolf MT, Van Vlem B, Hennies HC, Zalewski I, Karle SM, Puetz nM, et al. Telomeric refinement of the MCKD1 locus on chromosome 1q21. Kidney Int 2004;66:580-5.
35. Hart TC, Gorry MC, Hart PS, Woodard AS, Shihabi Z, Sandhu J, et al. Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet 2002;39:882-92.
36. Kalbacova M, Baresova V, Sikora J, Blazkova H, Zivny J, Ivanek R, et al. Dominant renin gene mutations associated with earlyonset hyperuricemia, anemia, and chronic kidney failure. Am J Hum Genet 2009;85:204-13.
37. Kroiss SHK, Berthold S, Rüschendorf F, Scolari F, Caridi G, Ghiggeri GM, et al. Evidence of further genetic heterogeneity in autosomal dominant medullary cystic kidney disease. Nephro Dial Transplant 2000;15:818-21.
38. Stavrou C, Koptides M, Tombazos C, Psara E, Patsias C, Zouvani I, et al. Autosomal-dominant medullary cystic kidney disease type 1: clinical and molecular findings in six large Cypriot families. Kidney Int 2002;62:1385-94.
39. Auranen MA-MS, Turunen JA, Jarvela I. Further evidence for linkage of autosomal-dominant medullary cystic kidney disease on chromosome 1q21. Kidney Int 2001;60:1225-32.
40. Puig JG, Miranda ME, Mateos FA, Picazo ML, Jimenez ML, Calvin TS, et al. Hereditary nephropathy associated with hyperuricemia and gout. Arch Intern Med 1993;153:357-65.
41. Scolari F, Caridi G, Rampoldi L, Tardanico R, Izzi C, Pirulli D, et al. Uromodulin storage diseases: clinical aspects and mechanisms. Am J Kidney Dis 2004;44:987-99.
42. Kiser RL, Wolf MT, Martin JL, Zalewski I, Attanasio M, Hildebrandt F, et al. Medullary cystic kidney disease type 1 in a large Native-American kindred. Am J Kidney Dis 2004;44:611-7.
43. Fairbanks LD, Cameron JS, Venkat-Raman G, Rigden SP, Rees L, Van THW, et al. Early treatment with allopurinol in familial juvenile hyerpuricaemic nephropathy (FJHN) ameliorates the long-term progression of renal disease. QJM 2002;95:597-607.
44. Lennerz JK, Spence DC, Iskandar SS, Dehner LP, Liapis H. Glomerulocystic kidney: one hundred-year perspective. Arch Pathol Lab Med 2010;134:583-605.
45. Bissler JJ, Siroky BJ, Yin H. Glomerulocystic kidney disease. Pediatr Nephrol 2010;25:2049-56.
46. Borges Oliva MR, Hsing J, Rybicki FJ, Fennessy F, Mortele KJ, Ros PR. Glomerulocystic kidney disease: MRI findings. Abdom Imaging 2003;28:889-92.
47. Hiesberger T, Fiette L, Igarashi P, Yaniv M, Pontoglio M. A transcriptional network in polycystic kidney disease. EMBO J 2004;23:1657-68.
48. Coffinier C, Barra J, Babinet C, Yaniv M. Expression of the vHNF1/HNF1beta homeoprotein gene during mouse organogenesis. Mech Dev 1999;89:211-3.
49. Bingham C, Hattersley AT. Renal cysts and diabetes syndrome resulting from mutations in hepatocyte nuclear factor- 1beta. Nephrol Dial Transplant 2004;19:2703-08.
50. Heidet L, Decramer S, Pawtowski A, Moriniere V, Bandin F, Knebelmann B, et al. Spectrum of HNF1B mutations in a large cohort of patients who harbor renal diseases. Clin J Am Soc Nephrol 2010;5:1079-90.s

Toplam 50 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Bölüm	Collection
Yazarlar	Aysel Taktak Nilgün Çakar Bu kişi benim
Yayımlanma Tarihi	1 Haziran 2015
Yayımlandığı Sayı	Yıl 2015 Cilt: 13 Sayı: 1

Kaynak Göster

APA	Taktak, A., & Çakar, N. (2015). Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım. Güncel Pediatri, 13(1), 40-45. https://doi.org/10.4274/jcp.40427
AMA	Taktak A, Çakar N. Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım. Güncel Pediatri. Haziran 2015;13(1):40-45. doi:10.4274/jcp.40427
Chicago	Taktak, Aysel, ve Nilgün Çakar. “Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım”. Güncel Pediatri 13, sy. 1 (Haziran 2015): 40-45. https://doi.org/10.4274/jcp.40427.
EndNote	Taktak A, Çakar N (01 Haziran 2015) Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım. Güncel Pediatri 13 1 40–45.
IEEE	A. Taktak ve N. Çakar, “Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım”, Güncel Pediatri, c. 13, sy. 1, ss. 40–45, 2015, doi: 10.4274/jcp.40427.
ISNAD	Taktak, Aysel - Çakar, Nilgün. “Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım”. Güncel Pediatri 13/1 (Haziran 2015), 40-45. https://doi.org/10.4274/jcp.40427.
JAMA	Taktak A, Çakar N. Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım. Güncel Pediatri. 2015;13:40–45.
MLA	Taktak, Aysel ve Nilgün Çakar. “Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım”. Güncel Pediatri, c. 13, sy. 1, 2015, ss. 40-45, doi:10.4274/jcp.40427.
Vancouver	Taktak A, Çakar N. Kalıtımsal Kistik Böbrek Hastalıklarına Yaklaşım. Güncel Pediatri. 2015;13(1):40-5.

Makale Dosyaları

Tam Metin