Araştırma Makalesi
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Ailesel Akdeniz Ateşi olan hastalarda dinamik tiyol / disülfid homeostazının değerlendirilmesi

Yıl 2018, Cilt: 9 Sayı: 3, 21 - 25, 06.12.2018
https://doi.org/10.22312/sdusbed.462067

Öz

Amaç:
Ailesel Akdeniz Ateşi (AAA), ateş ile birlikte tekrarlayan serozal inflamasyon
ataklarını içeren, kalıtsal bir otoinflamatuar hastalıktır. Oksidatif stresin
belirteci Tiyol / disülfid homeostazı, birçok inflamatuar hastalıkta
inflamatuar sitokinlerde artış ile ilişkilidir. Çalışmamızın amacı atak dışı
dönemde AAA olan hastalarda dinamik tiyol / disülfid homeostazisini
değerlendirmektir.



Materyal-Method: Çalışmamıza atak dışı dönemde 60 AAA' li,
60 inaktif dönemde Ankilozan Spondilit (AS)’ li hasta ve 60 yaş ve cinsiyet olarak
benzer kontrol grubu dahil edildi. Erel ve Neselioğlu yöntemi kullanılarak nativ
tiyol, total tiyol ve disülfid düzeyleri ölçüldü.



Bulgular:
AAA grubunda total tiyol ve disülfid düzeyleri sağlıklı kontrollere göre
anlamlı derecede düşük bulundu. AAA grubunda nativ tiyol düzeylerinin AS
grubuna göre anlamlı olarak yüksek olduğu saptandı. Bununla birlikte, AAA ve AS
grubu arasında total tiyol düzeylerinde anlamlı bir farklılık izlenmedi. Plazma
nativ tiyol, total tiyol ve disülfid seviyeleri kullanılarak elde edilen
oranlar, AAA, AS ve kontrol grupları arasında önemli ölçüde farklıydı.



Sonuç:
AAA hastalarında AS ve control grubuna
göre düşük tiyol düzeyi saptanması, farklı patofizyolojiye sahip hastalıklarda
tiyol / disülfid dengesinin farklı şekilde etkilendiğini düşündürmektedir.
Hastalık klinik olarak inaktif bir dönemde olmasına rağmen, farklı romatizmal
hastalıklarda inflamasyon farklı düzeylerde devam edebilir.

Kaynakça

  • 1. Özen S, Batu ED, Demir S. Familial Mediterranean Fever: Recent Developments in Pathogenesis and New Recommendations for Management. Front Immunol. 2017; 8: 253.
  • 2. Van der Hilst JCh, Moutschen M, Messiaen PE, Lauwerys BR, Vanderschueren S. Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature.Biologics. 2016; 10: 75-80.
  • 3. Ozen S, Demirkaya E, Erer B, Livneh A, Ben-Chetrit E, Giancane G, et al. EULAR recommendations for the management of familial Mediterranean fever. Ann Rheum Dis. 2016; 75(4): 644-51.
  • 4. Guzel S, Andican G, Seven A, Aslan M, Bolayirli M, Guzel EC, et al. Acute phase response and oxidative stress status in familial Mediterranean fever (FMF). Mod Rheumatol 2012; 22: 431-7.
  • 5. Yildirim K, Uzkeser H, Keles M, Karatay S, Kiziltunc A, Kaya MD, et al. Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever.Biochem Med (Zagreb). 2012; 22(1): 109-13.
  • 6. Şahin A, Erten Ş, Altunoğlu A, Işıkoğlu S, Neşelioğlu S, Ergin M, et al. Comparison of serum oxidant and antioxidant parameters in familial Mediterranean fever patients (FMF) with attack free period. Acta Reumatol Port 2014; 39: 316-21.
  • 7. Notarnicola C, Didelot MN, Seguret F, Demaille J, Touitou I. Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever. Genes Immun. 2002; 3(1): 43-5.
  • 8. Chen W, Zhao Y, Seefeldt T, Guan X. Determination of thiols and disulfides via HPLC quantification of 5-thio-2-nitrobenzoic acid. J. Pharm. Biomed. Anal. 2008; 48(5): 1375-80.
  • 9. Winther JR, Thorpe C. Quantification of thiols and disulfides. Biochim Biophys. Acta. 2014; 1840(2): 838-46.
  • 10. Giustarini D, Lorenzini S, Rossi R, Chindamo D, Di Simplicio P, Marcolongo R. Altered thiol pattern in plasma of subjects affected by rheumatoid arthritis. Clin Exp Rheumatol. 2005; 23(2): 205-12.
  • 11. Ates I, Kaplan M, Inan B, Alisik M, Erel O, Yilmaz N, et al. How does thiol/disulfide homeostasis change in prediabetic patients? Diabetes Res Clin Pract. 2015; 110(2): 166-71.
  • 12. Włodek PJ, Smolenski OB, Chwatko G, Iciek MB, Miłkowski A, Bald E, et al. Disruption of thiol homeostasis in plasma of terminal renal failure patients. Clin Chim Acta. 2006; 366(1-2): 137-45.
  • 13. Erel O, Neselioglu S. A novel and automated assay for thiol/disulfide homeostasis. Clin Biochem. 2014; 47(18): 326-32.
  • 14. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997; 40(10): 1879-85.
  • 15. Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum.1984; 27(4): 361–8.
  • 16. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: The Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994; 21(12): 2286-91.
  • 17. Baykal Y, Saglam K, Yilmaz MI, Taslipinar A, Akinci SB, Inal A. Serum sIL-2r, IL-6, IL-10 and TNF-alpha level in familial Mediterranean fever patients. Clin Rheumatol 2003; 22: 99–101.
  • 18. Aypar E, Ozen S, Okur H, Kutluk T, Besbas N, Bakkaloglu A. Th1 polarization in familial Mediterranean fever. J Rheumatol 2003; 30: 2011–3.
  • 19. Ben-Zvi I, Livneh A. Chronic infl ammation in FMF: markers, risk factors, outcomes and therapy. Nat Rev Rheumatol 2011; 7: 105-12.
  • 20. Musabak U, Sengul A, Oktenli C, Pay S, Yesilova Z, Kenar L, Sanisoglu SY, et al. Does immune activation continue during an attack-free period in familial Mediterranean fever? Clin Exp Immunol. 2004; 138(3): 526-33.
  • 21. Ates I, Altay M, Yilmaz FM, Topcuoglu C, Neselioglu S, Erel O, et al. Dynamic thiol/disulfide homeostasis in patients with autoimmune subclinical hypothyroidism. Endocr Res. 2016; 41(4): 343-9.
  • 22. Dinc ME, Ozdemir C, Ayan NN, Bozan N, Ulusoy S, Koca C, et al. Thiol/disulfide homeostasis as a novel indicator of oxidative stress in obstructive sleep apnea patients. Laryngoscope. 2017; 127(7): 244-50.
  • 23. Dogan HO, Ersan EE, Aydın H, Erdoğan S, Erşan S, Alişik M, et al. Thiol/disulphide homeostasis in schizophrenia patients using atypical antipsychotic drugs. Clin Psychopharmacol Neurosci. 2018; 16(1): 39-45.
  • 24. Cakıcı EK, Eroğlu FK, Yazılıtaş F, Bülbül M, Gür G, Aydoğ Ö, et al. Evaluation of the level of dynamic thiol/disulphide homeostasis in adolescent patients with newly diagnosed primary hypertension. Pediatr Nephrol. 2018; 33(5): 847-53.
  • 25. Altinel Acoglu E, Erel O, Yazilitas F, Bulbul M, Oguz MM, Yucel H, et al. Changes in thiol/disulfide homeostasis in patients with juvenile idiopathic arthritis. Pediatr Int. 2018. doi: 10.1111/ped.13569.
  • 26. Yucel A, Sanhal CY, Daglar K, Kara O, Uygur D, Erel O. Thiol/disulphide homeostasis in pregnant women with familial Mediterranean fever. Redox Rep 2016; 21: 287-91.
  • 27. Balta B, Erdogan M, Alisik M, Kiraz A, Akalin T, Bastug F, et al. Does thiol-disulphide balance show oxidative stress in different MEFV mutations? Rheumatol Int. 2018; 38(1): 97-104.
  • 28. Omma A, Sandikci SC, Kücüksahin O, Alisik M, Erel O. Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever? J Korean Med Sci. 2017; 32(10): 1588-94.
  • 29. Dogru A, Balkarli A, Cetin GY, Neselioglu S, Erel O, Tunc SE, et al. Thiol/disulfide homeostasis in patients with ankylosing spondylitis. Bosn J Basic Med Sci. 2016; 16(3): 187-92.

Evaluation of dynamic thiol/disulfide homeostasis in patients with Familial Mediterranean Fever

Yıl 2018, Cilt: 9 Sayı: 3, 21 - 25, 06.12.2018
https://doi.org/10.22312/sdusbed.462067

Öz

Introduction: Familial Mediterranean
fever (FMF) is a hereditary autoinflammatory
disease
that includes recurrent episodes
of serosal inflammation, with accompanying fever.
Thiol/disulfide
homeostasis, marker of oxidative stress, is associated with an increase in
inflammatory cytokines in many inflammatory diseases. The aim was to
evaluate the
dynamic
thiol/disulfide homeostasis
in patients with FMF during
attack free period.

Material and method: In our study, 60 patients with FMF during
attack free period, 60 patients with
Ankylosing
Spondylitis (
AS)
during inactive period and 60 age-and sex matched controls were included. Native
thiol, total thiol and disulfide levels were measured by using the Erel and
Neselioglu method.

Result: Total thiol and disulfide levels were found to be significantly
lower in FMF group compared to healthy controls. Native thiol levels were
detected to be significantly higher in FMF group compared to AS group. However,
no significant difference was observed in total thiol levels between FMF and AS
group. Ratios obtained using plasma native thiol, total thiol, and disulfide
levels differed significantly between the FMF, AS and the control groups.







Conclusion: The lower thiol level of FMF
group compared to AS and controls suggests that the thiol / disulfide balance
is affected differently in diseases with different pathophysiology. Although
the disease is in clinically inactive period, inflammation may continue at
different levels in different rheumatic diseases.

Kaynakça

  • 1. Özen S, Batu ED, Demir S. Familial Mediterranean Fever: Recent Developments in Pathogenesis and New Recommendations for Management. Front Immunol. 2017; 8: 253.
  • 2. Van der Hilst JCh, Moutschen M, Messiaen PE, Lauwerys BR, Vanderschueren S. Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature.Biologics. 2016; 10: 75-80.
  • 3. Ozen S, Demirkaya E, Erer B, Livneh A, Ben-Chetrit E, Giancane G, et al. EULAR recommendations for the management of familial Mediterranean fever. Ann Rheum Dis. 2016; 75(4): 644-51.
  • 4. Guzel S, Andican G, Seven A, Aslan M, Bolayirli M, Guzel EC, et al. Acute phase response and oxidative stress status in familial Mediterranean fever (FMF). Mod Rheumatol 2012; 22: 431-7.
  • 5. Yildirim K, Uzkeser H, Keles M, Karatay S, Kiziltunc A, Kaya MD, et al. Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever.Biochem Med (Zagreb). 2012; 22(1): 109-13.
  • 6. Şahin A, Erten Ş, Altunoğlu A, Işıkoğlu S, Neşelioğlu S, Ergin M, et al. Comparison of serum oxidant and antioxidant parameters in familial Mediterranean fever patients (FMF) with attack free period. Acta Reumatol Port 2014; 39: 316-21.
  • 7. Notarnicola C, Didelot MN, Seguret F, Demaille J, Touitou I. Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever. Genes Immun. 2002; 3(1): 43-5.
  • 8. Chen W, Zhao Y, Seefeldt T, Guan X. Determination of thiols and disulfides via HPLC quantification of 5-thio-2-nitrobenzoic acid. J. Pharm. Biomed. Anal. 2008; 48(5): 1375-80.
  • 9. Winther JR, Thorpe C. Quantification of thiols and disulfides. Biochim Biophys. Acta. 2014; 1840(2): 838-46.
  • 10. Giustarini D, Lorenzini S, Rossi R, Chindamo D, Di Simplicio P, Marcolongo R. Altered thiol pattern in plasma of subjects affected by rheumatoid arthritis. Clin Exp Rheumatol. 2005; 23(2): 205-12.
  • 11. Ates I, Kaplan M, Inan B, Alisik M, Erel O, Yilmaz N, et al. How does thiol/disulfide homeostasis change in prediabetic patients? Diabetes Res Clin Pract. 2015; 110(2): 166-71.
  • 12. Włodek PJ, Smolenski OB, Chwatko G, Iciek MB, Miłkowski A, Bald E, et al. Disruption of thiol homeostasis in plasma of terminal renal failure patients. Clin Chim Acta. 2006; 366(1-2): 137-45.
  • 13. Erel O, Neselioglu S. A novel and automated assay for thiol/disulfide homeostasis. Clin Biochem. 2014; 47(18): 326-32.
  • 14. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997; 40(10): 1879-85.
  • 15. Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum.1984; 27(4): 361–8.
  • 16. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: The Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994; 21(12): 2286-91.
  • 17. Baykal Y, Saglam K, Yilmaz MI, Taslipinar A, Akinci SB, Inal A. Serum sIL-2r, IL-6, IL-10 and TNF-alpha level in familial Mediterranean fever patients. Clin Rheumatol 2003; 22: 99–101.
  • 18. Aypar E, Ozen S, Okur H, Kutluk T, Besbas N, Bakkaloglu A. Th1 polarization in familial Mediterranean fever. J Rheumatol 2003; 30: 2011–3.
  • 19. Ben-Zvi I, Livneh A. Chronic infl ammation in FMF: markers, risk factors, outcomes and therapy. Nat Rev Rheumatol 2011; 7: 105-12.
  • 20. Musabak U, Sengul A, Oktenli C, Pay S, Yesilova Z, Kenar L, Sanisoglu SY, et al. Does immune activation continue during an attack-free period in familial Mediterranean fever? Clin Exp Immunol. 2004; 138(3): 526-33.
  • 21. Ates I, Altay M, Yilmaz FM, Topcuoglu C, Neselioglu S, Erel O, et al. Dynamic thiol/disulfide homeostasis in patients with autoimmune subclinical hypothyroidism. Endocr Res. 2016; 41(4): 343-9.
  • 22. Dinc ME, Ozdemir C, Ayan NN, Bozan N, Ulusoy S, Koca C, et al. Thiol/disulfide homeostasis as a novel indicator of oxidative stress in obstructive sleep apnea patients. Laryngoscope. 2017; 127(7): 244-50.
  • 23. Dogan HO, Ersan EE, Aydın H, Erdoğan S, Erşan S, Alişik M, et al. Thiol/disulphide homeostasis in schizophrenia patients using atypical antipsychotic drugs. Clin Psychopharmacol Neurosci. 2018; 16(1): 39-45.
  • 24. Cakıcı EK, Eroğlu FK, Yazılıtaş F, Bülbül M, Gür G, Aydoğ Ö, et al. Evaluation of the level of dynamic thiol/disulphide homeostasis in adolescent patients with newly diagnosed primary hypertension. Pediatr Nephrol. 2018; 33(5): 847-53.
  • 25. Altinel Acoglu E, Erel O, Yazilitas F, Bulbul M, Oguz MM, Yucel H, et al. Changes in thiol/disulfide homeostasis in patients with juvenile idiopathic arthritis. Pediatr Int. 2018. doi: 10.1111/ped.13569.
  • 26. Yucel A, Sanhal CY, Daglar K, Kara O, Uygur D, Erel O. Thiol/disulphide homeostasis in pregnant women with familial Mediterranean fever. Redox Rep 2016; 21: 287-91.
  • 27. Balta B, Erdogan M, Alisik M, Kiraz A, Akalin T, Bastug F, et al. Does thiol-disulphide balance show oxidative stress in different MEFV mutations? Rheumatol Int. 2018; 38(1): 97-104.
  • 28. Omma A, Sandikci SC, Kücüksahin O, Alisik M, Erel O. Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever? J Korean Med Sci. 2017; 32(10): 1588-94.
  • 29. Dogru A, Balkarli A, Cetin GY, Neselioglu S, Erel O, Tunc SE, et al. Thiol/disulfide homeostasis in patients with ankylosing spondylitis. Bosn J Basic Med Sci. 2016; 16(3): 187-92.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makaleleri
Yazarlar

Atalay Doğru 0000-0002-9797-1182

Ayşe Balkarlı 0000-0002-9545-0084

Gözde Yıldırım Çetin 0000-0001-9680-7535

Salim Neşelioğlu Bu kişi benim 0000-0002-0974-5717

Özcan Erel 0000-0002-2996-3236

Mehmet Şahin 0000-0001-7367-4274

Yayımlanma Tarihi 6 Aralık 2018
Gönderilme Tarihi 21 Eylül 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 9 Sayı: 3

Kaynak Göster

Vancouver Doğru A, Balkarlı A, Yıldırım Çetin G, Neşelioğlu S, Erel Ö, Şahin M. Evaluation of dynamic thiol/disulfide homeostasis in patients with Familial Mediterranean Fever. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2018;9(3):21-5.

SDÜ Sağlık Bilimleri Dergisi, makalenin gönderilmesi ve yayınlanması dahil olmak üzere hiçbir aşamada herhangi bir ücret talep etmemektedir. Dergimiz, bilimsel araştırmaları okuyucuya ücretsiz sunmanın bilginin küresel paylaşımını artıracağı ilkesini benimseyerek, içeriğine anında açık erişim sağlamaktadır.