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Genotype frequency of FecXB (Belclare) mutation of BMP15 gene in Chios (Sakiz) sheep

Yıl 2018, Cilt: 37 Sayı: 2, 87 - 91, 15.10.2018

Deniz Dinçel Sena Ardıçlı Hale Şamlı Faruk Balcı

https://doi.org/10.30782/uluvfd.413857
Cited By: 3

Öz

Ovulation rate and litter
size, varies between breeds or individulas who belong to the same breed, are
evaluated as fertility traits. Fertility traits are important for economic
values in animal breeding. However these traits exhibit only in females and they
are determined in the later stages of lifes. Hence the genetic perspective is more
effective way to confirm the fertility capacities early period of life time.
Fecundity genes such as BMP15
regulate the fertility traits by increasing the ovulation rate due to the occuring
mutations. Despite some prolific breed were investigated for FecXB mutation; the
researches carried out to determine thatmutation in Chios sheep breed are limited. The objective of the
current study was to estimate the the genotype frequencies of FecXB mutation of BMP15 gene in prolific Chios sheep. We
investigated the FecXB
mutation by PCR-RFLP method in Chios sheep (n=77). According to result, the
investigated Chios breed was found monomorphic for FecXB mutation. All individuals were digested by DdeI restriction enzyme and showed wild-type
genotype and did not carry FecXB
mutation nin present study. In conclusion it’s thought that the high
prolificacy in Chios sheep may be based on another region of BMP15 gene or different major gene. Thus
the effect of other major genes or regions/QTL’s should be investigated in
future studies with a large number of animals.

Anahtar Kelimeler

Sheep fertiliy mutation PCR-RFLP BMP15 gene Chios

Kaynakça

  • 1. Barakat IAH, Salem LM, Daoud NM, Khalil WKB, Mahrous KF. Genetic polymorphism of candidate genes for fecundity traits in Egyptian sheep breeds. Biomedical Research, 28 (2): 851-857, 2017.
  • 2. Bodin L, Di Pasquale E, Fabre S, Bontoux M, Monget P, Persani L, Mulsant P. A Novel Mutation in the Bone Morphogenetic Protein 15 Gene Causing Defective Protein Secretion Is Associated with Both Increased Ovulation Rate and Sterility in Lacaune Sheep. Endocrinology, 148(1): 393–40, 2007.
  • 3. Davis GH. Major genes affecting ovulation rate in sheep. Genetics Selection Evolution, 37(1):11–23, 2005.
  • 4. Demars J, Fabre S, Sarry J, Rossetti R, Gilbert H, Persan L, Tosser-Klopp G, Mulsant P, Nowak Z, Drobik W, Martyniuk E, Bodin L. Genome-Wide Association Studies Identify Two Novel BMP15 Mutations Responsible for an Atypical Hyperprolificacy Phenotype in Sheep. PLoS Genetics, 9(4): e1003482, 2013.
  • 5. Dinçel D, Ardıçlı S, Soyudal B, Er M, Alpay F, Şamlı H, Balcı F. Analysis of FecB, BMP15 and CAST gene mutations in Sakiz sheep. Kafkas Univ Vet Fak Derg, 21(4): 483-488, 2015.
  • 6. Doyle JJ, Doyle JL. A rapid DNA isolation procedure for small quantities of fresh leaf tissue. Phytochem Bull, 19:11-15, 1987.7. Drouilhet L, Lecerf F, Bodin L, Fabre S, Mulsant P. Fine mapping of the FecL locus influencing prolificacy in Lacaune sheep. Animal Genetics, doi:10.1111/j.1365-2052.2009.01919.x., 40: 804–812, 2009.
  • 8. Esen Gürsel F, Akış I, Durak H, Mengi A, Öztabak K. Determination of BMP-15, BMPR-1B and GDF-9 Gene Mutations of the Indigenous Sheep Breeds in Turkey. Kafkas Univ Vet Fak Derg, 17(5): 725-729, 2011.
  • 9. Fabre S, Pierre A, Mulsant P, Bodin L, Di Papsquale E, Persani L, Monget P, Monniaux, D. Regulation of ovulation rate in mammals: contribution of sheep genetic models. Reproductive Biology and Endocrinology, 4:20, 2006.
  • 10. Hanrahan JP, Gregan SM, Mulsant P, Mullen M, Davis GH, Powell R, Galloway SM. Mutations in the Genes for Oocyte-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclare Sheep (Ovis aries) , Biology of Reproduction, 70:900–909, 2004.
  • 11. Hanrahan JP. Evidence for single gene effects on ovulation rate in the Cambridge and Belclare breeds, In: Elsen J.M., Bodin L., Thimonier J. (Eds.). Major Genes for Reproduction in Sheep. Inra, Paris, France, pp. 93–102, 1991.
  • 12. Hatziminaoglu J, Zervas NP, Boyazoglu J. Prolific dairy sheep breeds in Greece. In : Bougler J.(Eds.), Tisserand J.-L. (Eds.). Les petits ruminants et leurs productions laitières dans la région méditerranéenne. Montpellier:CIHEAM, pp 25-30, 1990.
  • 13. Jansson T. Genes involved in ovulation rate and litter size in sheep. Resource: https://stud.epsilon.slu.se/6803/7/jansson_t_140618.pdf, Date accessed: 28.03.2018.
  • 14. Karslı T, Şahin E, Argun Karslı B, Alkan S, Balcıoğlu MS. An investigation of mutations (FecXG, FecXI, FecXH, FecXB) on BMP-15 gene in some local sheep breeds raised in Turkey. Mediterranean Agricultural Sciences, 25(1): 29-33, 2012.
  • 15. Kasiriyan MM, Hafezeyan H, Sayahzadeh H, Jamshidi R, Asghari SR, Irajeyan GH, Buesagh H. Genetic polymorphism FecB and BMP15 genes and its association with litter size in Sangsari sheep breed of Iran. J Anim Vet Adv, 8(5): 1025-1031, 2009.
  • 16. Ligda Ch. Gabriilidis G, Papadopoulos Th, Georgoudis A. Estimation of genetic parameters for production traits of Chios sheep using a multitrait animal model. Livestock Production Science, 66: 217–221, 2000.
  • 17. Marjitha IS, Rajendran R, Sudhakar A, Raja A. Screening for Galway (FecXG ), Inverdale (FecXI ) and Belclare (FecXB) mutations in BMP15 gene in Indian Nilagiri sheep. Indian Journal of Small Ruminants, 21(2): 331-334, 2015.
  • 18. Mavrogenis AP, The fecundity of Chios sheep. In: Land, R.B., Robinson, D.W. (Eds.), Genetics of Reproduction in Sheep, Butterworths, London, pp 63–67, 1985.
  • 19. Mohammadi G. Determination of FecX, FecB and FecGH mutations in Iranian Arabic sheep. Basrah Journal of Veterinary Research, 15(3): 435-445, 2016.
  • 20. Monteagudo LV, Ponz R, Tejedor MT, Lavina A, Sierra I. A 17 bp deletion in the Bone Morphogenetic Protein 15 (BMP15) gene is associated to increased prolificacy in the Rasa Ara-gonesa sheep breed. Animal Reproduction Science, 110: 139–146, 2009.
  • 21. Mullen MP, Hanrahan JP, Howard DJ, Powell R. Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecXG, FecXB) and GDF9 (FecGH) in Belclare and Cambridge Sheep. (Migaud M, ed.) PLoS ONE, 8(1):e53172, 2013, doi:10.1371/journal.pone.0053172.
  • 22. Notter DR. Genetic Aspects of Reproduction in Sheep. Reprod Dom Anim, 43(2):122–128, 2008.
  • 23. Piper LR, Bindon BM. The BooroolaMerino and the performance of medium non-peppin crosses at Armidale. In: Piper LR, Bindon BM, Nethery RD (Eds.). The Booroola Merino, Proceedings of a Workshop, Armidale, CSIRO, pp. 9–19, 1982.
  • 24. Pramod KR, Sharma SK, Kumar R, Rajan A. Genetics of ovulation rate in farm animals. Veterinary World, 6(11), 833-838, 2013.
  • 25. Shi H, Bai J, Niu Z, Esha M, Jia B. Study on candidate gene for fecundity traits in Xingjiang Cele black sheep African Journal of Biotechnology, 9(49):8498-8505, 2010.
  • 26. Theodorikis A, Ragdos A, Roustemis D, Galanopoulos K, Abas Z, Sinapis E. Assessing technical efficiency of Chios sheep farms with data envelopment analysis. Small Ruminant Research, 107: 85– 9, 2012.
  • 27. Wan Somarny WMZ, Roziatul Erin AR, Suhaimi AHMS, Nurulhuda MO, Hifzan RM. A study of major prolificacy genes in Malin and Dorper sheep in Malaysia. J Trop Agric and Fd Sc, 41(2):265-272, 2013.

Genotype frequency of FecXB (Belclare) mutation of BMP15 gene in Chios (Sakiz) sheep

Yıl 2018, Cilt: 37 Sayı: 2, 87 - 91, 15.10.2018

Deniz Dinçel Sena Ardıçlı Hale Şamlı Faruk Balcı

https://doi.org/10.30782/uluvfd.413857
Cited By: 3

Öz

Ovulation rate and litter
size, varies between breeds or individulas who belong to the same breed, are
evaluated as fertility traits. Fertility traits are important for economic
values in animal breeding. However these traits exhibit only in females and they
are determined in the later stages of lifes. Hence the genetic perspective is more
effective way to confirm the fertility capacities early period of life time.
Fecundity genes such as BMP15
regulate the fertility traits by increasing the ovulation rate due to the occuring
mutations. Despite some prolific breed were investigated for FecXB mutation; the
researches carried out to determine thatmutation in Chios sheep breed are limited. The objective of the
current study was to estimate the the genotype frequencies of FecXB mutation of BMP15 gene in prolific Chios sheep. We
investigated the FecXB
mutation by PCR-RFLP method in Chios sheep (n=77). According to result, the
investigated Chios breed was found monomorphic for FecXB mutation. All individuals were digested by DdeI restriction enzyme and showed wild-type
genotype and did not carry FecXB
mutation nin present study. In conclusion it’s thought that the high
prolificacy in Chios sheep may be based on another region of BMP15 gene or different major gene. Thus
the effect of other major genes or regions/QTL’s should be investigated in
future studies with a large number of animals.

Anahtar Kelimeler

Sheep fertiliy mutation PCR-RFLP BMP15 gene Chios

Kaynakça

  • 1. Barakat IAH, Salem LM, Daoud NM, Khalil WKB, Mahrous KF. Genetic polymorphism of candidate genes for fecundity traits in Egyptian sheep breeds. Biomedical Research, 28 (2): 851-857, 2017.
  • 2. Bodin L, Di Pasquale E, Fabre S, Bontoux M, Monget P, Persani L, Mulsant P. A Novel Mutation in the Bone Morphogenetic Protein 15 Gene Causing Defective Protein Secretion Is Associated with Both Increased Ovulation Rate and Sterility in Lacaune Sheep. Endocrinology, 148(1): 393–40, 2007.
  • 3. Davis GH. Major genes affecting ovulation rate in sheep. Genetics Selection Evolution, 37(1):11–23, 2005.
  • 4. Demars J, Fabre S, Sarry J, Rossetti R, Gilbert H, Persan L, Tosser-Klopp G, Mulsant P, Nowak Z, Drobik W, Martyniuk E, Bodin L. Genome-Wide Association Studies Identify Two Novel BMP15 Mutations Responsible for an Atypical Hyperprolificacy Phenotype in Sheep. PLoS Genetics, 9(4): e1003482, 2013.
  • 5. Dinçel D, Ardıçlı S, Soyudal B, Er M, Alpay F, Şamlı H, Balcı F. Analysis of FecB, BMP15 and CAST gene mutations in Sakiz sheep. Kafkas Univ Vet Fak Derg, 21(4): 483-488, 2015.
  • 6. Doyle JJ, Doyle JL. A rapid DNA isolation procedure for small quantities of fresh leaf tissue. Phytochem Bull, 19:11-15, 1987.7. Drouilhet L, Lecerf F, Bodin L, Fabre S, Mulsant P. Fine mapping of the FecL locus influencing prolificacy in Lacaune sheep. Animal Genetics, doi:10.1111/j.1365-2052.2009.01919.x., 40: 804–812, 2009.
  • 8. Esen Gürsel F, Akış I, Durak H, Mengi A, Öztabak K. Determination of BMP-15, BMPR-1B and GDF-9 Gene Mutations of the Indigenous Sheep Breeds in Turkey. Kafkas Univ Vet Fak Derg, 17(5): 725-729, 2011.
  • 9. Fabre S, Pierre A, Mulsant P, Bodin L, Di Papsquale E, Persani L, Monget P, Monniaux, D. Regulation of ovulation rate in mammals: contribution of sheep genetic models. Reproductive Biology and Endocrinology, 4:20, 2006.
  • 10. Hanrahan JP, Gregan SM, Mulsant P, Mullen M, Davis GH, Powell R, Galloway SM. Mutations in the Genes for Oocyte-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclare Sheep (Ovis aries) , Biology of Reproduction, 70:900–909, 2004.
  • 11. Hanrahan JP. Evidence for single gene effects on ovulation rate in the Cambridge and Belclare breeds, In: Elsen J.M., Bodin L., Thimonier J. (Eds.). Major Genes for Reproduction in Sheep. Inra, Paris, France, pp. 93–102, 1991.
  • 12. Hatziminaoglu J, Zervas NP, Boyazoglu J. Prolific dairy sheep breeds in Greece. In : Bougler J.(Eds.), Tisserand J.-L. (Eds.). Les petits ruminants et leurs productions laitières dans la région méditerranéenne. Montpellier:CIHEAM, pp 25-30, 1990.
  • 13. Jansson T. Genes involved in ovulation rate and litter size in sheep. Resource: https://stud.epsilon.slu.se/6803/7/jansson_t_140618.pdf, Date accessed: 28.03.2018.
  • 14. Karslı T, Şahin E, Argun Karslı B, Alkan S, Balcıoğlu MS. An investigation of mutations (FecXG, FecXI, FecXH, FecXB) on BMP-15 gene in some local sheep breeds raised in Turkey. Mediterranean Agricultural Sciences, 25(1): 29-33, 2012.
  • 15. Kasiriyan MM, Hafezeyan H, Sayahzadeh H, Jamshidi R, Asghari SR, Irajeyan GH, Buesagh H. Genetic polymorphism FecB and BMP15 genes and its association with litter size in Sangsari sheep breed of Iran. J Anim Vet Adv, 8(5): 1025-1031, 2009.
  • 16. Ligda Ch. Gabriilidis G, Papadopoulos Th, Georgoudis A. Estimation of genetic parameters for production traits of Chios sheep using a multitrait animal model. Livestock Production Science, 66: 217–221, 2000.
  • 17. Marjitha IS, Rajendran R, Sudhakar A, Raja A. Screening for Galway (FecXG ), Inverdale (FecXI ) and Belclare (FecXB) mutations in BMP15 gene in Indian Nilagiri sheep. Indian Journal of Small Ruminants, 21(2): 331-334, 2015.
  • 18. Mavrogenis AP, The fecundity of Chios sheep. In: Land, R.B., Robinson, D.W. (Eds.), Genetics of Reproduction in Sheep, Butterworths, London, pp 63–67, 1985.
  • 19. Mohammadi G. Determination of FecX, FecB and FecGH mutations in Iranian Arabic sheep. Basrah Journal of Veterinary Research, 15(3): 435-445, 2016.
  • 20. Monteagudo LV, Ponz R, Tejedor MT, Lavina A, Sierra I. A 17 bp deletion in the Bone Morphogenetic Protein 15 (BMP15) gene is associated to increased prolificacy in the Rasa Ara-gonesa sheep breed. Animal Reproduction Science, 110: 139–146, 2009.
  • 21. Mullen MP, Hanrahan JP, Howard DJ, Powell R. Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecXG, FecXB) and GDF9 (FecGH) in Belclare and Cambridge Sheep. (Migaud M, ed.) PLoS ONE, 8(1):e53172, 2013, doi:10.1371/journal.pone.0053172.
  • 22. Notter DR. Genetic Aspects of Reproduction in Sheep. Reprod Dom Anim, 43(2):122–128, 2008.
  • 23. Piper LR, Bindon BM. The BooroolaMerino and the performance of medium non-peppin crosses at Armidale. In: Piper LR, Bindon BM, Nethery RD (Eds.). The Booroola Merino, Proceedings of a Workshop, Armidale, CSIRO, pp. 9–19, 1982.
  • 24. Pramod KR, Sharma SK, Kumar R, Rajan A. Genetics of ovulation rate in farm animals. Veterinary World, 6(11), 833-838, 2013.
  • 25. Shi H, Bai J, Niu Z, Esha M, Jia B. Study on candidate gene for fecundity traits in Xingjiang Cele black sheep African Journal of Biotechnology, 9(49):8498-8505, 2010.
  • 26. Theodorikis A, Ragdos A, Roustemis D, Galanopoulos K, Abas Z, Sinapis E. Assessing technical efficiency of Chios sheep farms with data envelopment analysis. Small Ruminant Research, 107: 85– 9, 2012.
  • 27. Wan Somarny WMZ, Roziatul Erin AR, Suhaimi AHMS, Nurulhuda MO, Hifzan RM. A study of major prolificacy genes in Malin and Dorper sheep in Malaysia. J Trop Agric and Fd Sc, 41(2):265-272, 2013.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Deniz Dinçel

Sena Ardıçlı

Hale Şamlı Bu kişi benim

Faruk Balcı

Yayımlanma Tarihi 15 Ekim 2018
Kabul Tarihi 10 Mayıs 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 37 Sayı: 2

Kaynak Göster

APA Dinçel, D., Ardıçlı, S., Şamlı, H., Balcı, F. (2018). Genotype frequency of FecXB (Belclare) mutation of BMP15 gene in Chios (Sakiz) sheep. Uludağ Üniversitesi Veteriner Fakültesi Dergisi, 37(2), 87-91. https://doi.org/10.30782/uluvfd.413857
AMA Dinçel D, Ardıçlı S, Şamlı H, Balcı F. Genotype frequency of FecXB (Belclare) mutation of BMP15 gene in Chios (Sakiz) sheep. Uludağ Üniversitesi Veteriner Fakültesi Dergisi. Ekim 2018;37(2):87-91. doi:10.30782/uluvfd.413857
Chicago Dinçel, Deniz, Sena Ardıçlı, Hale Şamlı, ve Faruk Balcı. “Genotype Frequency of FecXB (Belclare) Mutation of BMP15 Gene in Chios (Sakiz) Sheep”. Uludağ Üniversitesi Veteriner Fakültesi Dergisi 37, sy. 2 (Ekim 2018): 87-91. https://doi.org/10.30782/uluvfd.413857.
EndNote Dinçel D, Ardıçlı S, Şamlı H, Balcı F (01 Ekim 2018) Genotype frequency of FecXB (Belclare) mutation of BMP15 gene in Chios (Sakiz) sheep. Uludağ Üniversitesi Veteriner Fakültesi Dergisi 37 2 87–91.
IEEE D. Dinçel, S. Ardıçlı, H. Şamlı, ve F. Balcı, “Genotype frequency of FecXB (Belclare) mutation of BMP15 gene in Chios (Sakiz) sheep”, Uludağ Üniversitesi Veteriner Fakültesi Dergisi, c. 37, sy. 2, ss. 87–91, 2018, doi: 10.30782/uluvfd.413857.
ISNAD Dinçel, Deniz vd. “Genotype Frequency of FecXB (Belclare) Mutation of BMP15 Gene in Chios (Sakiz) Sheep”. Uludağ Üniversitesi Veteriner Fakültesi Dergisi 37/2 (Ekim 2018), 87-91. https://doi.org/10.30782/uluvfd.413857.
JAMA Dinçel D, Ardıçlı S, Şamlı H, Balcı F. Genotype frequency of FecXB (Belclare) mutation of BMP15 gene in Chios (Sakiz) sheep. Uludağ Üniversitesi Veteriner Fakültesi Dergisi. 2018;37:87–91.
MLA Dinçel, Deniz vd. “Genotype Frequency of FecXB (Belclare) Mutation of BMP15 Gene in Chios (Sakiz) Sheep”. Uludağ Üniversitesi Veteriner Fakültesi Dergisi, c. 37, sy. 2, 2018, ss. 87-91, doi:10.30782/uluvfd.413857.
Vancouver Dinçel D, Ardıçlı S, Şamlı H, Balcı F. Genotype frequency of FecXB (Belclare) mutation of BMP15 gene in Chios (Sakiz) sheep. Uludağ Üniversitesi Veteriner Fakültesi Dergisi. 2018;37(2):87-91.

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