Öz
Since Ewing sarcomas are highly aggressive tumors, early diagnosis is very important for the prognosis of these patients. The aim of this case report is to raise awareness among pediatricians and dentists about the clinical, radiological and histopathological features of these aggressive tumors. A 10-year-old child patient referred to our clinic from the ENT outpatient clinic was found to have a sore throat that had been persisting for about 2-3 months. In addition, it was observed that there was an extraoral swelling in the right mandibular ramus region that had started to be noticed extraorally for the last 15 days. Panoramic radiography revealed a multilocular lesion involving the mandibular ramus. The lesion was also evaluated by conventional CT, MR and ultrasonography. The biopsy specimen obtained from the patient was examined histopathologically and diagnosed as Ewing's Sarcoma and treatment with chemotherapy was started by the Department of Pediatric Oncology.The oral findings of ewing sarcomas, which rarely affect the mandibular region, should always be considered for the possibility of confusion with periodontal diseases, odontogenic and pericoronal infections. Therefore, additional and appropriate radiographic examinations should be used to make a definitive diagnosis.
Anahtar Kelimeler
computed tomography ewing sarcoma mandible panoramic radyography ultrasonography
Kaynakça
- Ahuja US, Puri N, Gupta D, Singh S, Kumar G. (2019). Ewing's sarcoma of mandible: A case report with review. International Journal of Clinical Pediatric Dentistry, 12(5), 470.
- Balkaya E, Bozkurt C, Aksu A, Özmen S, Incesoy-Ozdemir S, Sahin G. (2017). Ewing's sarcoma of the mandible misdiagnosed as periodontal inflammation: report of three cases. Turkish Journal of Pediatrics, 59(6).
- Brazão-Silva MT, Fernandes AV, Faria PRD, Cardoso SV, Loyola AM. (2010). Ewing's sarcoma of the mandible in a young child. Brazilian Dental Journal, 21, 74-79.
- Bölling T, Hardes J, Dirksen U. (2013). Management of bone tumours in paediatric oncology. Clinical Oncology, 25(1), 19-26.
- Chaudhary M, Chaudhary S.D. (2012). Osteosarcoma of jaws. Journal of Oral and Maxillofacial Pathology, 16(2), 233.
- Davido N, Rigolet A, Kerner S, Gruffaz F, Boucher Y. (2011). Case of Ewing’s sarcoma misdiagnosed as a periapical lesion of maxillary incisor. Journal of Endodontics, 37(2), 259-264.
- Gaspar N, Hawkins DS, Dirkse, U, Lewis IJ, Ferrari S, Le Deley MC et al. (2015). Ewing sarcoma: current management and future approaches through collaboration. Journal of Clinical Oncology, 33(27), 3036-3046.
- Hatim E, Nazik A, Latifa C, Siham EH. (2022). Inhabituel localisation of Ewing sarcoma: Case report. International Journal of Surgery Case Reports, 3, 226-229.
- Huang HY, Illei PB, Zhao Z, Mazumdar M, Huvos, AG, Healey JH et al. (2005). Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse. Journal of Clinical Oncology, 23(3), 548-558.
- Lopes SL, de Almeida SM, Costa AL, Zanardi VA, Cendes F. (2007). Imaging findings of Ewing's sarcoma in the mandible. Journal of Oral Science, 49(2), 167-171.
- Margaix-Muñoz M, Bagán J, Poveda-Roda R. (2017). Ewing sarcoma of the oral cavity. A review. Journal of Clinical and Experimental Dentistry, 9(2), e294.
- Martin E, Radomski S, Harley EH. (2019). Pediatric Ewing sarcoma of the head and neck: a retrospective survival analysis. International Journal of Pediatric Otorhinolaryngology, 117, 138-142.
- Mishra MN, Patil P, Chandavarkar V, Bhargava D. (2022). Ewing's sarcoma of the mandible with multilocular radiolucency. Journal of Oral and Maxillofacial Pathology, 26(Suppl 1), S107.
- Oliveira SV, Fernandes LG, Soares LAV, Moraes MF, Almeida MTA, Pinto DS et al. (2019). Mandible Ewing sarcoma in a child: clinical, radiographic and diagnosis considerations. Oral Oncology, 98, 171-173.
- Owosho AA, Ko E, Rosenberg HI, Yom SK, Antonescu CR, Huryn JM et al. (2016). Primary Ewing family of tumors of the jaw has a better prognosis compared to tumors of extragnathic sites. Journal of Oral and Maxillofacial Surgery, 74(5), 973-981.
- Pampori R, Ul Shamas I, Malik A. (2011). Ewings sarcoma of maxilla: A case report. Journal of Postgraduate Medical Institute, 25(2).
- Sinha DK, Jha NK, Yadav SK, Yadav J, Sinha R. (2014). Ewing’s sarcoma of mandible: a very rare disease and review of Indian literature. Indian Journal of Surgical Oncology, 5, 81-84.
- Soni K, Elhence P, Kesarwani A, Rajan N. (2019). Primary Ewing's sarcoma of zygoma. Annals of Maxillofacial Surgery, 9(2), 419. Suhag V, Sunita BS, Jaiswal P, Kishore K, Rautray D, Piplani S. (2012). Primitive neuroectodermal tumor (PNET) of the mandible in a 64-year-old female: A rare case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 24(3), 162-164.
- Takami Y, Aga F, Mitamura K, Norikane T, Okuda H, Yamamoto Y et al. (2020). A case of Ewing sarcoma of the mandible on 18F-FDG PET/CT. Asia Oceania Journal of Nuclear Medicine and Biology, 8(1), 84.
- Yogesh TL, Shetty A, Keswani H, Rishi D. (2018). Aggressive high-grade Ewing's sarcoma of maxilla: A rare case report. Journal of Oral and Maxillofacial Pathology, 22(Suppl 1), S48
Öz
Ewing sarkomları oldukça agresif tümörler olduğundan, erken tanı bu hastaların prognozu için çok önemlidir. Bu olgu sunumunun amacı, çocuk doktorları ve diş hekimleri arasında bu agresif tümörlerin klinik, radyolojik ve histopatolojik özellikleri hakkında farkındalık yaratmaktır. KBB polikliniğinden kliniğimize sevk edilen 10 yaşındaki çocuk hastanın yaklaşık 2-3 aydır devam eden boğaz ağrısı olduğu tespit edildi. Ayrıca sağ mandibular ramus bölgesinde son 15 gündür ekstraoral olarak fark edilmeye başlanan bir şişlik olduğu gözlendi. Panoramik radyografide mandibular ramusu tutan multiloküler bir lezyon görüldü. Lezyon konvansiyonel BT, MR ve ultrasonografi ile de değerlendirildi. Hastadan alınan biyopsi örneği histopatolojik olarak incelendi ve Ewing Sarkomu tanısı konularak Pediatrik Onkoloji Bölümü tarafından kemoterapi tedavisi başlandı.Nadiren mandibular bölgeyi etkileyen ewing sarkomlarının ağız içi bulguları periodontal hastalıklar, odontojenik ve perikoronal enfeksiyonlarla karışabilme olasılığı açısından her zaman göz önünde bulundurulmalıdır. Bu nedenle kesin tanı koymak için ek ve uygun radyografik incelemeler kullanılmalıdır.
Anahtar Kelimeler
bilgisayarlı tomografi ewing sarkoma mandibula panoramik radyografi ultrason
Kaynakça
- Ahuja US, Puri N, Gupta D, Singh S, Kumar G. (2019). Ewing's sarcoma of mandible: A case report with review. International Journal of Clinical Pediatric Dentistry, 12(5), 470.
- Balkaya E, Bozkurt C, Aksu A, Özmen S, Incesoy-Ozdemir S, Sahin G. (2017). Ewing's sarcoma of the mandible misdiagnosed as periodontal inflammation: report of three cases. Turkish Journal of Pediatrics, 59(6).
- Brazão-Silva MT, Fernandes AV, Faria PRD, Cardoso SV, Loyola AM. (2010). Ewing's sarcoma of the mandible in a young child. Brazilian Dental Journal, 21, 74-79.
- Bölling T, Hardes J, Dirksen U. (2013). Management of bone tumours in paediatric oncology. Clinical Oncology, 25(1), 19-26.
- Chaudhary M, Chaudhary S.D. (2012). Osteosarcoma of jaws. Journal of Oral and Maxillofacial Pathology, 16(2), 233.
- Davido N, Rigolet A, Kerner S, Gruffaz F, Boucher Y. (2011). Case of Ewing’s sarcoma misdiagnosed as a periapical lesion of maxillary incisor. Journal of Endodontics, 37(2), 259-264.
- Gaspar N, Hawkins DS, Dirkse, U, Lewis IJ, Ferrari S, Le Deley MC et al. (2015). Ewing sarcoma: current management and future approaches through collaboration. Journal of Clinical Oncology, 33(27), 3036-3046.
- Hatim E, Nazik A, Latifa C, Siham EH. (2022). Inhabituel localisation of Ewing sarcoma: Case report. International Journal of Surgery Case Reports, 3, 226-229.
- Huang HY, Illei PB, Zhao Z, Mazumdar M, Huvos, AG, Healey JH et al. (2005). Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse. Journal of Clinical Oncology, 23(3), 548-558.
- Lopes SL, de Almeida SM, Costa AL, Zanardi VA, Cendes F. (2007). Imaging findings of Ewing's sarcoma in the mandible. Journal of Oral Science, 49(2), 167-171.
- Margaix-Muñoz M, Bagán J, Poveda-Roda R. (2017). Ewing sarcoma of the oral cavity. A review. Journal of Clinical and Experimental Dentistry, 9(2), e294.
- Martin E, Radomski S, Harley EH. (2019). Pediatric Ewing sarcoma of the head and neck: a retrospective survival analysis. International Journal of Pediatric Otorhinolaryngology, 117, 138-142.
- Mishra MN, Patil P, Chandavarkar V, Bhargava D. (2022). Ewing's sarcoma of the mandible with multilocular radiolucency. Journal of Oral and Maxillofacial Pathology, 26(Suppl 1), S107.
- Oliveira SV, Fernandes LG, Soares LAV, Moraes MF, Almeida MTA, Pinto DS et al. (2019). Mandible Ewing sarcoma in a child: clinical, radiographic and diagnosis considerations. Oral Oncology, 98, 171-173.
- Owosho AA, Ko E, Rosenberg HI, Yom SK, Antonescu CR, Huryn JM et al. (2016). Primary Ewing family of tumors of the jaw has a better prognosis compared to tumors of extragnathic sites. Journal of Oral and Maxillofacial Surgery, 74(5), 973-981.
- Pampori R, Ul Shamas I, Malik A. (2011). Ewings sarcoma of maxilla: A case report. Journal of Postgraduate Medical Institute, 25(2).
- Sinha DK, Jha NK, Yadav SK, Yadav J, Sinha R. (2014). Ewing’s sarcoma of mandible: a very rare disease and review of Indian literature. Indian Journal of Surgical Oncology, 5, 81-84.
- Soni K, Elhence P, Kesarwani A, Rajan N. (2019). Primary Ewing's sarcoma of zygoma. Annals of Maxillofacial Surgery, 9(2), 419. Suhag V, Sunita BS, Jaiswal P, Kishore K, Rautray D, Piplani S. (2012). Primitive neuroectodermal tumor (PNET) of the mandible in a 64-year-old female: A rare case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 24(3), 162-164.
- Takami Y, Aga F, Mitamura K, Norikane T, Okuda H, Yamamoto Y et al. (2020). A case of Ewing sarcoma of the mandible on 18F-FDG PET/CT. Asia Oceania Journal of Nuclear Medicine and Biology, 8(1), 84.
- Yogesh TL, Shetty A, Keswani H, Rishi D. (2018). Aggressive high-grade Ewing's sarcoma of maxilla: A rare case report. Journal of Oral and Maxillofacial Pathology, 22(Suppl 1), S48
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Diş Hekimliği |
| Bölüm | Olgu sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Ağustos 2023 |
| Gönderilme Tarihi | 6 Nisan 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 16 Sayı: 2 |
Van Health Sciences Journal (Van Sağlık Bilimleri Dergisi) başlıklı eser bu Creative Commons Atıf-Gayri Ticari 4.0 Uluslararası Lisansı ile lisanslanmıştır.
