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A New Perspective on Animal Breeding: METABOLOMIC

Yıl 2018, Cilt: 29 Sayı: 3, 189 - 194, 27.12.2018

Öz

In order to obtain a high
yield from animals, improvement studies were carried out by various methods.
Until 1990’s, improvement studies were carried out only with phenotypic
methods. With the rapid development of genetic science, the possibilities of
using genome analysis in improvement studies were investigated. One of the
genomic analysis sections is the functional gens. In order to be able to reveal
the efficacy of the functional gens, the possibilities of using metabolomics in
animal improvement have begun to be investigated. There are nearly 20000
metabolites in living beings. When the relationship of these metabolites with
yields, diseases and adaptations of livestock animals is revealed, the use of
metabolites in animal improvement is thought to make selection more efficient.

Kaynakça

  • Akçapınar H, Özbeyaz C (1999). Hayvan Yetiştiriciliği Temel Bilgileri. Kariyer Matbaacılık, Ankara.
  • Aksoy AR (2003). Hayvan Islahı Ders Notları. Kafkas Üniversitesi Veteriner Fakültesi, Kars.
  • Alrokayan S (2002). Purification and characterization of adenosine deaminase from camel skeletal muscle. The Inter J of Biochem&Cell Biol, 34,1608-1618.
  • Anderson ME (1998). Glutathione: an overview of biosynthesis and modulation, Chem Biol Interact, 111(112),1–4.
  • Antonic-Svetina M, Turk R, Svetina A, Geres D, Rekic B, Juretic D (2011). Lipid status,paraoxonase-1 activity and metabolic parametres in serum of heifers and lactating cows related to oxidative stress. Res in Vet Sci, 90(2), 298-300.
  • Arslan M, Erzengin M, Demir D (2011). Comparison of serum paraoxonase 1 (PON1) activities among different sheep breeds in Turkey. J of Ani Vet Adv, 10(4), 489-494.
  • Arslan M, Saçkes Z, Kaya MO (2016). An examination of Hyaluronidase enzyme activity in four different sheep breeds. FEBS J, 283, 221-221.
  • Atroshi F (1979). Phenotypic and genetic association between production/reproduction traits and blood biochemical polymorphic characters in Finn sheep. In: Thesis, Government Printing Centre, Helsinki, Finland.
  • Atroshi F, Sandholm M (1982). Red blood cell glutathione as a marker of milk production in Finn sheep. Res in Vet Sci, 33, 256-259.
  • Bahadır G (2009). Sağlıklı gebelerde adenozin deaminaz ve izoenzimlerinin değerlendirilmesi. T.C. Sağlık Bakanlığı Haseki Eğitim ve Araştırma Hastanesi Biyokimya ve Klinik Biyokimya Laboratuvarı. Tıbbi Biyokimya Uzmanlık Tezi. İstanbul.
  • Bal SH, Budak F (2013). Genomik, proteomik kavramlarına genel bakış ve uygulama alanları. UÜ Tıp Fak Derg, 39(1), 65-69.
  • Başaran E, Aras S, Duman DC. (2010). General Outlook and Applications of Genomics, Proteomics and Metabolomics. Türk Hij. ve Den. Biy. Der, 67 (2): 85-96.
  • Battistuzzi G, Iudicone P, Santolamazza P, Petrucci R (1981). Activity of adenosine deaminase allelic forms in intact erythrocytes and in lymphocytes. Ann Hum Genet, 45, 15-19.
  • Belem-Gonçalves S, Tsan P, Lancelin JM, Alves LM, Salim VM Besson F (2006). Interfacial behaviour of bovine testis Hyaluronidase. Bioche J, 398, 569-576.
  • Bildik A, Yur F, Çamaş H, Odabaşıoğlu F, Aslan M (1998). Kuzuların doğum ağırlıkları ve besi performansı ile glutatyon düzeyleri arasındaki ilişkinin araştırılması. Turk J Vet Anim Sci, 22, 521-526.
  • Boad PG, Roberts J, Evans JV (1974). The genetic control of erythrocyte reduced glutathione in Australian Merino sheep. J Agric Sci, 82, 395-398.
  • Bottini E, Carapella E, Cataldi L (1981). Adenosine deaminase polymorphism. Associations at clinical level suggest a role in cell functions and immune reactions. J Med Genet, 18, 331-334.
  • Bren L (2005). Metabolomics: Working toward personalized medicine. FDA Consum, 39, 28-33.
  • Bucak MN, Satılmış M, Kızıl S, Karaşahin T, Akyol N (2010). Effect of antioxidants added to culture media on the in vitro development of bovine embryos. Kafkas Uni Vet Fak Derg, 16(1), 69-74.
  • Clement E, Toby B, Gail P, Lucio G (2002). Pharmaco genomic conciderations of the paraoxonase polymorphisms. Pharmacogenomics, 3, 341-348.
  • Costa L, Li W, Richter R, Shih D, Lusis A, Furlong, C (1999). The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polmorphisms. Chem Bio Inter, 429, 119-120.
  • Coşkun T (2007). Nütrisyonel genomik. Çocuk Sağlığı ve Hastalıkları. Dergisi, 50, 47-66.
  • Çevik MŞ (2005). Mikroarray teknolojisi ve bitkilerde uygulama alanları. SDÜ Fen Bil Ens Derg, 9-13.
  • Çolakoğlu HE, Yazlık MO, Kaya U, Çolakoğlu EC, Kurt S, Öz B, Bayramoğlu R, Vural MR, Küplülü Ş (2017). MDA and GSH-Px activity in transition dairy cows under seasonal variations and their relationship with reproductive performance. J Vet Res, 61, 497-502.
  • Demir AÖ, Mert N(2015). The haemoglobin transferrin ceruloplasmin and Glutathione polimorphism of native goat breeds of Turkey Angora and Hair. Animal Science Series D, vol. 58, pp. 42-49.
  • Draganov D, La DB (2004). Pharmacogenetics of paraoxonases: A brief review. Naunyn-Schmiedeberg's. Arch Pharmacol, 369(1), 78-88.
  • Erol K, Gencer N, Arslan M, Arslan O (2013). Purification, characterization and investigation of in vitro inhibition by metals of paraoxonase from different sheep breeds. Artific Cells Nanomed Biotechnol, 41(2),125-30.
  • Erzengin M, Demir D, Arslan M, Sinan S (2014). Purification and characterization of paraoxonase 1 (PON1) from Swiss Black holstein and montofon bovines. Appl Biochem Biotechnol. 173(7), 1597-1660.
  • Furlong C, Richter R, Chapline C, Crabb J (1991). Purification of rabit and human serum paraoxonase.Biochemistry, 30(42),10133-10140.
  • Garner DL, Hafez ESE (2000). Spermatozoa and seminal plasma. In: Reproduction in Farm Animals, 7th ed. Lea and Febiger, Hafez ESE (Ed), 96–109, Philadelphia.
  • German JB, Hammock BD, Watkins SM (2005). Metabolomics: Building on a century of biochemistry to guide human health. Metabolomics, 1, 3-9.
  • Giordino A, Veronesi M, Rossi G, Pezzia F, Probo M, Giori L, Paltrinieri S. (2013) Serum paraoxonase-1 activity in neonatal calves: Age related variations and comparison between healthy and sick animals. The Vet J, 197(2), 499-501.
  • Gloria-Bottini F, Pietropolli A, Coppeta L, Magrini A, Bergamaschi A, Bottini E (2008). The genetics of feto-placental development: a study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants. Reprod Biol Endocrinol, 6, 38.
  • Gürses M, Bayraktar M (2014). Moleküler markerlerin hayvan yetiştiriciliği ve genetiğinde kullanımı. F Ü Sağ Bil Vet Derg, 28(2), 99-106.
  • Han Z, Yang B, Yang Z. Xi Y (2017). Effects of 2-hydroxy-4-(methylthio) butanoic acid isopropyl ester on growth and blood components in growing Holstein steers. Ani Sci J, 88, 286–293.
  • Hershfield MS, Mitchell BS (1995). Immunodeficiency diseases caused by adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. In: The Metabolic and Molecular Basis of Inherited Diseases, Scriver CR, Beaudet WS, Valle D (Eds.), 1725–1768, McGraw-Hill, New York.
  • Hoey WA (1984). Broadmeadow ACC, Hopkins PS.A study of the peripheral utilization of sulphuraminoacids for fibreproduction in the sheep. Proc Aust Soc Ani Prod, 15, 120-123.
  • Hughes J, Capleton A, Courage CA (2002). A Review of the effects of low-level exposure to organophosphate pesticide on fetal and childhood health. Leiceter (United Kingdom): Medical Research Council Instiute for Environment and Health.
  • Kehrer JP (1993). Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol, 23(1), 21-48
  • Krishnapillai AM, Taylor KDA, Morris AEJ. Quantick, PC (1999). Characterisation of Norway lobster (Nephropsnorvegicus) hayluronidase an comparison with sheep and bovine testicular hyaluronidase. Food Chem, 65, 515-521.
  • Kulka M, Kolodziejska-Lesisz J, Klucinski W (2016). Serum paraoxonase (PON1) activity and lipid metabolism parametres changes in different production cycle periods of holstein-friesionan Polish red and Norwegian breeds. Polish J Vet Sci, 19(1), 165-73.
  • La D, Aviram M, Billecke S, Navab M, Primo-Parmo S, Sorenson RC, Standiford TJ (1999). On the physiological role(s) of the paraoxonase. Chem Biolo Interac, 119-120, 379-388.
  • La D (2002). Human serum paraoxonase/arylesterase. In: Kalow W(ed) Genetic factors influencing the metabolism of foreign compounds. International encyclopedia of pharmacology and therapeutics. 51-59, New York.
  • Lara M, Gama L, Bufarah G, Sereno J, Celegato E, De Abreu U (2002). Genetic polymorphisms at the k-casein in the pantaneiro cattle. Archi de Zootec, 51, 99-105.
  • Manat TD, Chaudhary SS, Singh VK, Patel, SB, Tyagi KK (2017). Oxidative stress profile during postpartum period in Surti goats. Indian J Anim Res, 51(5), 837-840.
  • Mert H, Karakuş K, Yılmaz A, Aygün T, Mert N, Apaydın Yıldırım B Seyhan E (2009). Effects of Genotype on Testis Semen Quality and Mineral Composition of Semen in Various Ram Breeds. Biol Trace Elem Res, vol. 132, no. 1–3, pp. 93–102.
  • Montaldo HH, Meza-Herrera CA (1998). Use of molecular markers and major genes in the genetic improvement of livestock Electron. J Biotech, 1, 83-89.Murray RK, Mayes PA, Granner DK, Rodwell VW (1993). Harper’in Biyokimyası. Barış Kitabevi, İstanbul.
  • Napolioni V (2010). ADA (22G>A) polymorphism: a possible genetic marker for predictive medicine of human reproduction? Metabol Clinic and Experiment, 59. E9–E12
  • Özcan S, Yıldırım V, Kaya L, Becher D, Hecker M, Özcengiz G (2007). Phanerochaetechrysosporium soluble proteome as a prelude for the analysis of heavy metal response. Proteomics, 7, 1249-60.
  • Reddy JM, Joyce C, Zaneveld LJD (1980). Role of hyaluronidase in fertilization – the anti-fertility activity of myocrisin, a nontoxic hyaluronidase inhibitor. J Androl, 1, 28–32.
  • Rizzi R, Caroli A, Bolla P, Acciailoi A, Pagnacco G (1998). Variabilty of reduced glutathione levels in Massage ewes and its effect on daily milk production. J Dairy Res. 55, 345-353.
  • Rose WC (1984). New aspects of glutathione biochemistry and transport-selective alteration of glutathione metabolism. Nutri Rev, 42(12), 397-410.
  • Sadek K, Saleh E, Ayoub M. (2017). Selective, reliable blood and milk bio-markers for diagnosing clinical and subclinical bovine mastitis. Trop Ani Heal and Prod, 49(2):431-437.
  • Schneider A, Correa M, Butler W (2013) Shortcommuniation: Acut phase proteins holstein cows dianosed with uterine infection. Res in Vet Sci, 95(1), 269-71
  • Stoltz DA, Ozer EA, Taft, PJ, Barry M, Liu L, Kiss PJ, Moninger TO, Persek MR, Zabner J (2008). Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1. The J Clin Invest, 118(9), 3123-3131.
  • Tabakoğlu E, Durgut R (2013). Veteriner hekimlikte oksidatif stres ve bazı önemli hastalıklarda oksidatif stresin etkileri. AVKAE Derg, 3(1), 69-75.
  • Tanyıldızı S, Bozkurt T (2002). Effects of progesterone and testosterone on the hyaluronidaseavtivities and sperm characteristics in sheep. Turk J Vet Anim Sci, 26, 1137-1143.
  • Tanyıldızı S, Bozkurt T (2003). Effects of acetylsalicylic acid and metamizol on hyaluronidase activity and sperm characteristics in rams. Ani Rep Sci, 76, 195-204.
  • Tarakçı Ü, Türel İ (2009). Halk sağlığı amaçlı kullanılan pestisitlerin (Biyosidal) güvenilirlik standartlarının karşılaştırılması.YYU Vet Fak Derg, 20(1), 11-18.
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  • Turka R, Podpecan O, Mrkun J, Kosec M, Flegar-Mestric Z, Perkov S, Straric J, Robic M, Belic M, Zrimsek P (2013). Lipid Mobilisationanved oxidative stress as metabolic adeptationprocessesin dairy heifesdurring transition period. Ani Rep Science, 141(3-4), 109-115.
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Hayvan Islahında Yeni Bir Bakış: Metabolomik

Yıl 2018, Cilt: 29 Sayı: 3, 189 - 194, 27.12.2018

Öz

Hayvanlardan yüksek düzeyde verim elde edebilmek
için çeşitli yöntemlerle ıslah çalışmaları uygulanmıştır. 1990’lı yıllara kadar
sadece fenotipik yöntemlerle ıslah çalışmaları yapılmıştır. Genetik biliminde
hızlı gelişimle birlikte ıslah çalışmalarında genom analizlerinin kullanılma
olanakları araştırılmıştır. Genomik analiz bölümlerinden birisi işlevsel
genlerdir. İşlevsel genlerin etkinliğinin ortaya konabilmesi için hayvan
ıslahında metabolitlerin kullanılma imkânları araştırılmaya başlanmıştır.
Canlılarda 20.000’e yakın metabolit bulunmaktadır. Bu metabolitlerin çiftlik
hayvanlarının verimleri, hastalıkları ve adaptasyonlarıyla ilgili ilişkileri
ortaya konulduğunda, hayvan ıslahında metabolitlerin kullanılmasının
seleksiyonu daha etkin yapacağı düşünülmektedir.

Kaynakça

  • Akçapınar H, Özbeyaz C (1999). Hayvan Yetiştiriciliği Temel Bilgileri. Kariyer Matbaacılık, Ankara.
  • Aksoy AR (2003). Hayvan Islahı Ders Notları. Kafkas Üniversitesi Veteriner Fakültesi, Kars.
  • Alrokayan S (2002). Purification and characterization of adenosine deaminase from camel skeletal muscle. The Inter J of Biochem&Cell Biol, 34,1608-1618.
  • Anderson ME (1998). Glutathione: an overview of biosynthesis and modulation, Chem Biol Interact, 111(112),1–4.
  • Antonic-Svetina M, Turk R, Svetina A, Geres D, Rekic B, Juretic D (2011). Lipid status,paraoxonase-1 activity and metabolic parametres in serum of heifers and lactating cows related to oxidative stress. Res in Vet Sci, 90(2), 298-300.
  • Arslan M, Erzengin M, Demir D (2011). Comparison of serum paraoxonase 1 (PON1) activities among different sheep breeds in Turkey. J of Ani Vet Adv, 10(4), 489-494.
  • Arslan M, Saçkes Z, Kaya MO (2016). An examination of Hyaluronidase enzyme activity in four different sheep breeds. FEBS J, 283, 221-221.
  • Atroshi F (1979). Phenotypic and genetic association between production/reproduction traits and blood biochemical polymorphic characters in Finn sheep. In: Thesis, Government Printing Centre, Helsinki, Finland.
  • Atroshi F, Sandholm M (1982). Red blood cell glutathione as a marker of milk production in Finn sheep. Res in Vet Sci, 33, 256-259.
  • Bahadır G (2009). Sağlıklı gebelerde adenozin deaminaz ve izoenzimlerinin değerlendirilmesi. T.C. Sağlık Bakanlığı Haseki Eğitim ve Araştırma Hastanesi Biyokimya ve Klinik Biyokimya Laboratuvarı. Tıbbi Biyokimya Uzmanlık Tezi. İstanbul.
  • Bal SH, Budak F (2013). Genomik, proteomik kavramlarına genel bakış ve uygulama alanları. UÜ Tıp Fak Derg, 39(1), 65-69.
  • Başaran E, Aras S, Duman DC. (2010). General Outlook and Applications of Genomics, Proteomics and Metabolomics. Türk Hij. ve Den. Biy. Der, 67 (2): 85-96.
  • Battistuzzi G, Iudicone P, Santolamazza P, Petrucci R (1981). Activity of adenosine deaminase allelic forms in intact erythrocytes and in lymphocytes. Ann Hum Genet, 45, 15-19.
  • Belem-Gonçalves S, Tsan P, Lancelin JM, Alves LM, Salim VM Besson F (2006). Interfacial behaviour of bovine testis Hyaluronidase. Bioche J, 398, 569-576.
  • Bildik A, Yur F, Çamaş H, Odabaşıoğlu F, Aslan M (1998). Kuzuların doğum ağırlıkları ve besi performansı ile glutatyon düzeyleri arasındaki ilişkinin araştırılması. Turk J Vet Anim Sci, 22, 521-526.
  • Boad PG, Roberts J, Evans JV (1974). The genetic control of erythrocyte reduced glutathione in Australian Merino sheep. J Agric Sci, 82, 395-398.
  • Bottini E, Carapella E, Cataldi L (1981). Adenosine deaminase polymorphism. Associations at clinical level suggest a role in cell functions and immune reactions. J Med Genet, 18, 331-334.
  • Bren L (2005). Metabolomics: Working toward personalized medicine. FDA Consum, 39, 28-33.
  • Bucak MN, Satılmış M, Kızıl S, Karaşahin T, Akyol N (2010). Effect of antioxidants added to culture media on the in vitro development of bovine embryos. Kafkas Uni Vet Fak Derg, 16(1), 69-74.
  • Clement E, Toby B, Gail P, Lucio G (2002). Pharmaco genomic conciderations of the paraoxonase polymorphisms. Pharmacogenomics, 3, 341-348.
  • Costa L, Li W, Richter R, Shih D, Lusis A, Furlong, C (1999). The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polmorphisms. Chem Bio Inter, 429, 119-120.
  • Coşkun T (2007). Nütrisyonel genomik. Çocuk Sağlığı ve Hastalıkları. Dergisi, 50, 47-66.
  • Çevik MŞ (2005). Mikroarray teknolojisi ve bitkilerde uygulama alanları. SDÜ Fen Bil Ens Derg, 9-13.
  • Çolakoğlu HE, Yazlık MO, Kaya U, Çolakoğlu EC, Kurt S, Öz B, Bayramoğlu R, Vural MR, Küplülü Ş (2017). MDA and GSH-Px activity in transition dairy cows under seasonal variations and their relationship with reproductive performance. J Vet Res, 61, 497-502.
  • Demir AÖ, Mert N(2015). The haemoglobin transferrin ceruloplasmin and Glutathione polimorphism of native goat breeds of Turkey Angora and Hair. Animal Science Series D, vol. 58, pp. 42-49.
  • Draganov D, La DB (2004). Pharmacogenetics of paraoxonases: A brief review. Naunyn-Schmiedeberg's. Arch Pharmacol, 369(1), 78-88.
  • Erol K, Gencer N, Arslan M, Arslan O (2013). Purification, characterization and investigation of in vitro inhibition by metals of paraoxonase from different sheep breeds. Artific Cells Nanomed Biotechnol, 41(2),125-30.
  • Erzengin M, Demir D, Arslan M, Sinan S (2014). Purification and characterization of paraoxonase 1 (PON1) from Swiss Black holstein and montofon bovines. Appl Biochem Biotechnol. 173(7), 1597-1660.
  • Furlong C, Richter R, Chapline C, Crabb J (1991). Purification of rabit and human serum paraoxonase.Biochemistry, 30(42),10133-10140.
  • Garner DL, Hafez ESE (2000). Spermatozoa and seminal plasma. In: Reproduction in Farm Animals, 7th ed. Lea and Febiger, Hafez ESE (Ed), 96–109, Philadelphia.
  • German JB, Hammock BD, Watkins SM (2005). Metabolomics: Building on a century of biochemistry to guide human health. Metabolomics, 1, 3-9.
  • Giordino A, Veronesi M, Rossi G, Pezzia F, Probo M, Giori L, Paltrinieri S. (2013) Serum paraoxonase-1 activity in neonatal calves: Age related variations and comparison between healthy and sick animals. The Vet J, 197(2), 499-501.
  • Gloria-Bottini F, Pietropolli A, Coppeta L, Magrini A, Bergamaschi A, Bottini E (2008). The genetics of feto-placental development: a study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants. Reprod Biol Endocrinol, 6, 38.
  • Gürses M, Bayraktar M (2014). Moleküler markerlerin hayvan yetiştiriciliği ve genetiğinde kullanımı. F Ü Sağ Bil Vet Derg, 28(2), 99-106.
  • Han Z, Yang B, Yang Z. Xi Y (2017). Effects of 2-hydroxy-4-(methylthio) butanoic acid isopropyl ester on growth and blood components in growing Holstein steers. Ani Sci J, 88, 286–293.
  • Hershfield MS, Mitchell BS (1995). Immunodeficiency diseases caused by adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. In: The Metabolic and Molecular Basis of Inherited Diseases, Scriver CR, Beaudet WS, Valle D (Eds.), 1725–1768, McGraw-Hill, New York.
  • Hoey WA (1984). Broadmeadow ACC, Hopkins PS.A study of the peripheral utilization of sulphuraminoacids for fibreproduction in the sheep. Proc Aust Soc Ani Prod, 15, 120-123.
  • Hughes J, Capleton A, Courage CA (2002). A Review of the effects of low-level exposure to organophosphate pesticide on fetal and childhood health. Leiceter (United Kingdom): Medical Research Council Instiute for Environment and Health.
  • Kehrer JP (1993). Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol, 23(1), 21-48
  • Krishnapillai AM, Taylor KDA, Morris AEJ. Quantick, PC (1999). Characterisation of Norway lobster (Nephropsnorvegicus) hayluronidase an comparison with sheep and bovine testicular hyaluronidase. Food Chem, 65, 515-521.
  • Kulka M, Kolodziejska-Lesisz J, Klucinski W (2016). Serum paraoxonase (PON1) activity and lipid metabolism parametres changes in different production cycle periods of holstein-friesionan Polish red and Norwegian breeds. Polish J Vet Sci, 19(1), 165-73.
  • La D, Aviram M, Billecke S, Navab M, Primo-Parmo S, Sorenson RC, Standiford TJ (1999). On the physiological role(s) of the paraoxonase. Chem Biolo Interac, 119-120, 379-388.
  • La D (2002). Human serum paraoxonase/arylesterase. In: Kalow W(ed) Genetic factors influencing the metabolism of foreign compounds. International encyclopedia of pharmacology and therapeutics. 51-59, New York.
  • Lara M, Gama L, Bufarah G, Sereno J, Celegato E, De Abreu U (2002). Genetic polymorphisms at the k-casein in the pantaneiro cattle. Archi de Zootec, 51, 99-105.
  • Manat TD, Chaudhary SS, Singh VK, Patel, SB, Tyagi KK (2017). Oxidative stress profile during postpartum period in Surti goats. Indian J Anim Res, 51(5), 837-840.
  • Mert H, Karakuş K, Yılmaz A, Aygün T, Mert N, Apaydın Yıldırım B Seyhan E (2009). Effects of Genotype on Testis Semen Quality and Mineral Composition of Semen in Various Ram Breeds. Biol Trace Elem Res, vol. 132, no. 1–3, pp. 93–102.
  • Montaldo HH, Meza-Herrera CA (1998). Use of molecular markers and major genes in the genetic improvement of livestock Electron. J Biotech, 1, 83-89.Murray RK, Mayes PA, Granner DK, Rodwell VW (1993). Harper’in Biyokimyası. Barış Kitabevi, İstanbul.
  • Napolioni V (2010). ADA (22G>A) polymorphism: a possible genetic marker for predictive medicine of human reproduction? Metabol Clinic and Experiment, 59. E9–E12
  • Özcan S, Yıldırım V, Kaya L, Becher D, Hecker M, Özcengiz G (2007). Phanerochaetechrysosporium soluble proteome as a prelude for the analysis of heavy metal response. Proteomics, 7, 1249-60.
  • Reddy JM, Joyce C, Zaneveld LJD (1980). Role of hyaluronidase in fertilization – the anti-fertility activity of myocrisin, a nontoxic hyaluronidase inhibitor. J Androl, 1, 28–32.
  • Rizzi R, Caroli A, Bolla P, Acciailoi A, Pagnacco G (1998). Variabilty of reduced glutathione levels in Massage ewes and its effect on daily milk production. J Dairy Res. 55, 345-353.
  • Rose WC (1984). New aspects of glutathione biochemistry and transport-selective alteration of glutathione metabolism. Nutri Rev, 42(12), 397-410.
  • Sadek K, Saleh E, Ayoub M. (2017). Selective, reliable blood and milk bio-markers for diagnosing clinical and subclinical bovine mastitis. Trop Ani Heal and Prod, 49(2):431-437.
  • Schneider A, Correa M, Butler W (2013) Shortcommuniation: Acut phase proteins holstein cows dianosed with uterine infection. Res in Vet Sci, 95(1), 269-71
  • Stoltz DA, Ozer EA, Taft, PJ, Barry M, Liu L, Kiss PJ, Moninger TO, Persek MR, Zabner J (2008). Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1. The J Clin Invest, 118(9), 3123-3131.
  • Tabakoğlu E, Durgut R (2013). Veteriner hekimlikte oksidatif stres ve bazı önemli hastalıklarda oksidatif stresin etkileri. AVKAE Derg, 3(1), 69-75.
  • Tanyıldızı S, Bozkurt T (2002). Effects of progesterone and testosterone on the hyaluronidaseavtivities and sperm characteristics in sheep. Turk J Vet Anim Sci, 26, 1137-1143.
  • Tanyıldızı S, Bozkurt T (2003). Effects of acetylsalicylic acid and metamizol on hyaluronidase activity and sperm characteristics in rams. Ani Rep Sci, 76, 195-204.
  • Tarakçı Ü, Türel İ (2009). Halk sağlığı amaçlı kullanılan pestisitlerin (Biyosidal) güvenilirlik standartlarının karşılaştırılması.YYU Vet Fak Derg, 20(1), 11-18.
  • Tiryaki O, Temur C (2010). The fate of pesticide in the enviroment. J Biol Environ Sci, 4(10), 29-38.
  • Turka R, Podpecan O, Mrkun J, Kosec M, Flegar-Mestric Z, Perkov S, Straric J, Robic M, Belic M, Zrimsek P (2013). Lipid Mobilisationanved oxidative stress as metabolic adeptationprocessesin dairy heifesdurring transition period. Ani Rep Science, 141(3-4), 109-115.
  • Ungerer JP, Oosthuizen HM, Bissbort SH, Vermaak WJ (1992). Serum adenosine deaminase: isoenzymes and diagnostic application. Clin Chem, 38, 1322-1326.
  • Ünsal EM (2013). Mikro İktisada Giriş. İmajYayınları, Ankara.
  • Valko M, Leibfritz D, Moncol J, Cronin M, Mazur M, Telser J (2007). Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol, 39, 44–84.
  • Varga GM (2004). Proteomics principles and challenges. Pure Appl Chem, 76(4), 829-837.
  • Venter JC (2003). A part of the human genome sequence. Science. 299, 1183-1184.
  • Vera LF, Cunha B, Ana R, Marcelo V, Paulo S, Jose A, Ferraz L, Jayma CB (1998). Paraoxonase activity in sera from Piaractus mesapotamicusholmberg (Characidae) and Hypostomuspunctatusvalenciennes (Siluridae). Rev Brasiel de Zoolog, 15(3), 665-675.
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Toplam 69 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm Makaleler
Yazarlar

Mikail Arslan

Orhan Yılmaz

Adem Kabasakal

Yayımlanma Tarihi 27 Aralık 2018
Gönderilme Tarihi 27 Ekim 2018
Kabul Tarihi 24 Aralık 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 29 Sayı: 3

Kaynak Göster

APA Arslan, M., Yılmaz, O., & Kabasakal, A. (2018). A New Perspective on Animal Breeding: METABOLOMIC. Van Veterinary Journal, 29(3), 189-194.
AMA Arslan M, Yılmaz O, Kabasakal A. A New Perspective on Animal Breeding: METABOLOMIC. Van Vet J. Aralık 2018;29(3):189-194.
Chicago Arslan, Mikail, Orhan Yılmaz, ve Adem Kabasakal. “A New Perspective on Animal Breeding: METABOLOMIC”. Van Veterinary Journal 29, sy. 3 (Aralık 2018): 189-94.
EndNote Arslan M, Yılmaz O, Kabasakal A (01 Aralık 2018) A New Perspective on Animal Breeding: METABOLOMIC. Van Veterinary Journal 29 3 189–194.
IEEE M. Arslan, O. Yılmaz, ve A. Kabasakal, “A New Perspective on Animal Breeding: METABOLOMIC”, Van Vet J, c. 29, sy. 3, ss. 189–194, 2018.
ISNAD Arslan, Mikail vd. “A New Perspective on Animal Breeding: METABOLOMIC”. Van Veterinary Journal 29/3 (Aralık 2018), 189-194.
JAMA Arslan M, Yılmaz O, Kabasakal A. A New Perspective on Animal Breeding: METABOLOMIC. Van Vet J. 2018;29:189–194.
MLA Arslan, Mikail vd. “A New Perspective on Animal Breeding: METABOLOMIC”. Van Veterinary Journal, c. 29, sy. 3, 2018, ss. 189-94.
Vancouver Arslan M, Yılmaz O, Kabasakal A. A New Perspective on Animal Breeding: METABOLOMIC. Van Vet J. 2018;29(3):189-94.

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