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İshal Kaynaklı Sepsisli Neonatal Buzağılarda Hematoloji, Bazı Klinik Biyokimyasal Parametreler ve Mineral Düzeylerinin Değişimi

Yıl 2022, Cilt: 33 Sayı: 1, 26 - 30, 27.03.2022

Enes Akyüz Mert Sezer Mushap Kuru Amir Naseri

https://doi.org/10.36483/vanvetj.1066050

Öz

Sunulan çalışmada ishal kaynaklı neonatal sepsisli buzağılarda hematolojik, klinik biyokimyasal parametreler ve bazı mineral düzeylerinin değerlendirilmesi amaçlanmıştır. Çalışmanın hayvan materyalini 0-10 günlük yaşta, herhangi bir tedavi uygulanmamış ve sepsis kriterlerini sağlayan 30 ishalli buzağı sepsisli grubu ve aynı yaş grubunda bulunan 20 sağlıklı buzağı kontrol grubunu oluşturdu. Sepsisli buzağılardan tedavi öncesi ve sağlıklı buzağılardan bir kez venöz kan örnekleri alındı. Sepsisli buzağıların dakikadaki kalp frekansı ve solunum sayıları kontrol grubuna göre yüksek olduğu belirlendi. Hematolojik analizlerde sepsisli grupta nötrofil sayısı kontrole göre yüksek bulunurken, eritrosit sayısı ve ortalama eritrosit hacmi düşük bulundu. Biyokimyasal analizlerde ise sepsisli grupta alanin aminotransferaz, aspartat aminotransferaz, üre ve kreatinin düzeyleri kontrol grubuna göre istatistiksel olarak önemli oranda yüksek, magnezyum konsantrasyonları düşüktü (p<0.05). Sonuç olarak ishal kaynaklı sepsisli neonatal buzağılarda karaciğer ve böbrek disfonksiyonu ile ilişkili olarak biyokimyasal parametrelerin yükseldiği, minaral düzeylerinin düştüğü belirlendi. Elde edilen verilerin ortaya çıkmasında ishal kaynaklı dehidrasyonun etkili olabileceği öngörülmüştür. Bu nedenle tedavide özellikle seviyesi düşen minerallerin eklenmesi ve uygun sıvı tedavisi yapılarak normal doku perfüzyonunun sağlanması önemlidir. Doku perfüzyonu sağlanarak, enzim seviyelerinin normale döndürülmesi ile sepsisli buzağıların yaşama şansının artacağını düşünmekteyiz.

Anahtar Kelimeler

Buzağı Mineraller Yenidoğan Sepsisi.

Destekleyen Kurum

destekleyen kurum yok

Proje Numarası

destekleyen kurum yok

Kaynakça

  • Akyüz E, Coşkun A, Şen, İ (2016). Deneysel endotoksemi oluşturulan buzağılarda sıvı tedavisinin hemodinamik parametreler üzerine etkisi. Eurasian J Vet Sci, 32 (4), 246-254.
  • Akyüz E, Naseri A, Erkılıç EE et al. (2017). Neonatal buzaği ishalleri ve sepsis. KAUFBED, 10 (2), 181-191.
  • Akyüz E, Uzlu E, Sezer M, Kuru M, Gökce G (2019). Changes in calcium, phosphorus and magnesium concentratons in neonatal sepsis suspected calves. 4th International Congress on Advances of Veterinary Sciences and Techniques (ICAVST), Kiev, Ukraine.
  • Akyüz E (2020). Kars Bölgesindeki Neonatal Buzağılarda Sıklıkla Karşılaşılan İshal Kaynaklı Sepsis Nedenleri.
  • Ayvazoğlu Demir P (Ed). Tüm Yönleri İle Kuzey Doğu Anadolu Bölgesinde Hayvancılık (s. 401-423). İksad Yayınevi, Ankara, Türkiye.
  • Akyüz E, Gökce G (2021). Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis. Trop Anim Health Prod, 53 (3), 354.
  • Akyüz E, Kükürt A (2021). Evaluation of oxidative stress index and some biochemical parameters in neonatal calves with diarrhea. Acta Sci Vet Sci, 3 (9), 58-63.
  • Aydogdu U, Yildiz R, Guzelbektes H et al. (2018). Effect of combinations of intravenous small-volume hypertonic sodium chloride, acetate Ringer, sodium bicarbonate, and lactate Ringer solutions along with oral fluid on the treatment of calf diarrhea. Pol J Vet Sci, 21 (2), 273-280.
  • Aldridge BM, Garry FB, Adams R (1993). Neonatal septicemia in calves: 25 cases (1985-1990). J Am Vet Med Assoc, 203 (9), 1324-1329.
  • Başer DF, Civelek T (2013). Akut ishalli neonatal buzağılarda venöz asit baz durumu ve renal fonksiyon arası korelasyon. Kocatepe Vet J, 6 (1), 25-31.
  • Basoglu A, Sen I, Meoni G, Tenori L, Naseri A (2018). NMR-Based plasma metabolomics at set intervals in newborn dairy calves with severe sepsis. Mediat Inflamm, 2018:8016510, 1-12.
  • Beydilli Y, Gökçe H (2019). Sepsisli Neonatal buzağılarda bazı hematolojik ve biyokimyasal parametrelerin araştırılması. Mehmet Akif Ersoy Univ Sağlık Bilim Enst Derg, 7 (2), 55-67.
  • Bonelli F, Meucci, V, Divers TJ et al. (2018). Plasma procalcitonin concentration in healthy calves and those with septic systemic inflammatory response syndrome. Vet J, 234, 61-65.
  • Bozukluhan K, Merhan O, Gokce HI et al. (2017). Alterations in lipid profile in neonatal calves affected by diarrhea. Vet World, 10 (7), 786-789.
  • Chatre L, Verdonk F, Rocheteau P et al. (2017). A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis. Biochim Biophys Acta-Mol Basis Dis, 1863 (10), 2546-2553.
  • Çitil M, Gökçe E (2013). Neonatal septisemi. Türkiye Klinik Vet Bil Derg, 4 (1), 62-70.
  • Dratwa-Chalupnık A, Herosımczyk A, Lepczyńskı A, Skrzypcazk WF (2012). Calves with diarrhea and a water-electrolyte balance. Med Weter, 68 (1), 5-8.
  • Erkılıç EE, Merhan O, Kırmızıgül AH et al. (2019). Salivary and serum levels of serum amyloid a, haptoglobin, ceruloplasmin and albumin in neonatal calves with diarrhoea. Kafkas Univ Vet Fak Derg, 25 (4), 583-586.
  • Elin RJ (1994). Magnesium: the fifth but forgotten electrolyte. Am J Clin Pathol. 102 (5), 616-622.
  • Fecteau G, Paré J, Van Metre DC et al. (1997). Use of a clinical sepsis score for predicting bacteremia in neonatal dairy calves on a calf rearing farm. Can Vet J, 38 (2), 101-104.
  • Fecteau G, Smith PB, George LW (2009). Septicemia and meningitis in newborn calf. Vet Clin North Am Food Anim Pract, 25 (1), 195-208.
  • Fisher EW, De la Fuente GH (1972). Water and electrolyte studies in newborn calves with particular reference to effects of diarrhoea. Res Vet Sci, 13 (4), 315-322.
  • Gökce HI, Woldehivet Z (1999). The effects of ehrlichia (cytoecetes) phagochytophila on the clinical chemistry of sheep and goats. J Vet Med, 46 (2), 93-103.
  • House JK, Smith GW, McGuirk SM, Gunn AA, Izzo M (2015). Manifestations and Management of Disease in Neonatal Ruminants. Smith BP. (Ed.). Large Animal Internal Medicine 5th (s. 302-338). Elsevier Saunders, St. Louis, USA.
  • Lorenz I, Fagan J, More SJ (2011). Calf health from birth to weaning. II. management of diarrhoea in pre-weaned calves. Irish Vet J, 64 (9), 1-6.
  • Martin SW, Lumsden JH (1987). The relationship of hematology and serum biochemistry parameters to treatment for respiratory disease and weight gain in ontario feedlot calves. Can J Vet Res, 51 (4), 499-505.
  • Naseri A (2017). Doğal gelişen şiddetli sepsisli ve septik şoklu buzağılarda sol ventriküler sistolik fonksiyonların ve bu fonksiyonların uygulanan tedaviye bağlı değişimlerin ekokardiyografi ile değerlendirilmesi; longitudinal çalışma. Doktora Tezi, Selçuk Üniversitesi, Sağlık Bilimleri Enstitüsü, Konya.
  • Naseri A, Sen I, Turgut K, Guzelbektes H, Constable PD (2019). Echocardiographic assessment of left ventricular systolic function in neonatal calves with naturally occurring sepsis or septic shock due to diarrhea. Res Vet Sci, 126, 103-112.
  • Naseri A, Ider M (2021). Comparison of blood gases, hematological and monitorization parameters and determine prognostic importance of selected variables in hypotensive and non-hypotensive calves with sepsis. Eurasian J Vet Sci, 37 (1), 1-8.
  • Novelli G, Ferretti G, Poli L et al. (2010). Clinical results of treatment of postsurgical endotoxin-mediated sepsis with polymyxin-b direct hemoperfusion. Transplant Proc, 42 (4), 1021-1024.
  • Ok M, Güler L, Turgut K et al. (2009). The studies on the etiology of diarrhae in neonatal calves and determination of virulence gene markers of Escherichia coli strains by multiplex PCR. Zoonoses Public Health, 56 (2), 94-101.
  • Sen I, Constable PD (2013). General overview to treatment of strong ion (metabolic) acidosis in neonatal calves with diarrhea. Eurasian J Vet Sci, 29 (3), 114-120.
  • Trefz FM, Lorch A, Feist M, Sauter-Louis C, Lorenz I (2013). The prevalence and clinical relevance of hyperkalaemia in calves with neonatal diarrhoea. Vet J, 195 (3), 350-356.
  • Tyler JW, Hancock D, Thorne JG, Clive CG, Gay JM (1999). Partitioning the mortality risk associated with inadequate passive transfer of colostral immunoglobulins in dairy calves. J Vet Intern Med, 13 (4), 335-357.
  • Uzlu E, Karapehlivan M, Çitil M, Gökçe E, Erdoğan HM (2010). İshal semptomu belirlenen buzağılarda serum sialik asit ile bazı biyokimyasal parametrelerin araştırılması. YYÜ Vet Fak Derg, 21 (2), 83-86.
  • Yıldız R, Beslek M, Beydilli Y, Özçelik M, Biçici Ö (2018). Evaluation of platelet activating factor in neonatal calves with sepsis. Vet Hekim Der Derg, 89 (2), 66-73.

Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves with Sepsis due to Diarrhea

Yıl 2022, Cilt: 33 Sayı: 1, 26 - 30, 27.03.2022

Enes Akyüz Mert Sezer Mushap Kuru Amir Naseri

https://doi.org/10.36483/vanvetj.1066050

Öz

In this study, it was aimed to evaluate hematology, some clinical and biochemical parameters, as well as mineral levels in calves with neonatal sepsis caused by diarrhea. In this study, 30 calves that were 0-10 days old, who did not receive any treatment and who met the criteria for diarrhea and sepsis within 24 hours at the latest, constitute the sepsis group, and 20 healthy calves in the same age group constitute the control group. Venous blood samples were taken from calves with sepsis before treatment and once from healthy calves. The mean heart rate per minute and respiratory rate were determined higher in the group with sepsis than in the control group. In addition, neutrophil counts were found to be higher in the sepsis group compared to the control group. Erythrocyte count and mean erythrocyte volume were found to be low. While the levels of alanine aminotransferase, aspartate aminotransferase, urea and creatinine were statistically significantly higher in the group with sepsis compared to the control group, magnesium concentrations were lower (p<0.05). As a result, it was determined that biochemical parameters increased and mineral levels decreased in relation to liver and kidney dysfunction in neonatal calves with diarrhea-induced sepsis. The reason for these data to appear may be the result of dehydration from diarrhea. For this reason, it is important in the treatment to ensure normal tissue perfusion, especially by adding minerals with low levels and performing appropriate fluid therapy. We think that the chance of survival of calves with sepsis will increase by ensuring tissue perfusion and restoring enzyme levels to normal.

Anahtar Kelimeler

Calf Minerals Neonatal sepsis.

Proje Numarası

destekleyen kurum yok

Kaynakça

  • Akyüz E, Coşkun A, Şen, İ (2016). Deneysel endotoksemi oluşturulan buzağılarda sıvı tedavisinin hemodinamik parametreler üzerine etkisi. Eurasian J Vet Sci, 32 (4), 246-254.
  • Akyüz E, Naseri A, Erkılıç EE et al. (2017). Neonatal buzaği ishalleri ve sepsis. KAUFBED, 10 (2), 181-191.
  • Akyüz E, Uzlu E, Sezer M, Kuru M, Gökce G (2019). Changes in calcium, phosphorus and magnesium concentratons in neonatal sepsis suspected calves. 4th International Congress on Advances of Veterinary Sciences and Techniques (ICAVST), Kiev, Ukraine.
  • Akyüz E (2020). Kars Bölgesindeki Neonatal Buzağılarda Sıklıkla Karşılaşılan İshal Kaynaklı Sepsis Nedenleri.
  • Ayvazoğlu Demir P (Ed). Tüm Yönleri İle Kuzey Doğu Anadolu Bölgesinde Hayvancılık (s. 401-423). İksad Yayınevi, Ankara, Türkiye.
  • Akyüz E, Gökce G (2021). Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis. Trop Anim Health Prod, 53 (3), 354.
  • Akyüz E, Kükürt A (2021). Evaluation of oxidative stress index and some biochemical parameters in neonatal calves with diarrhea. Acta Sci Vet Sci, 3 (9), 58-63.
  • Aydogdu U, Yildiz R, Guzelbektes H et al. (2018). Effect of combinations of intravenous small-volume hypertonic sodium chloride, acetate Ringer, sodium bicarbonate, and lactate Ringer solutions along with oral fluid on the treatment of calf diarrhea. Pol J Vet Sci, 21 (2), 273-280.
  • Aldridge BM, Garry FB, Adams R (1993). Neonatal septicemia in calves: 25 cases (1985-1990). J Am Vet Med Assoc, 203 (9), 1324-1329.
  • Başer DF, Civelek T (2013). Akut ishalli neonatal buzağılarda venöz asit baz durumu ve renal fonksiyon arası korelasyon. Kocatepe Vet J, 6 (1), 25-31.
  • Basoglu A, Sen I, Meoni G, Tenori L, Naseri A (2018). NMR-Based plasma metabolomics at set intervals in newborn dairy calves with severe sepsis. Mediat Inflamm, 2018:8016510, 1-12.
  • Beydilli Y, Gökçe H (2019). Sepsisli Neonatal buzağılarda bazı hematolojik ve biyokimyasal parametrelerin araştırılması. Mehmet Akif Ersoy Univ Sağlık Bilim Enst Derg, 7 (2), 55-67.
  • Bonelli F, Meucci, V, Divers TJ et al. (2018). Plasma procalcitonin concentration in healthy calves and those with septic systemic inflammatory response syndrome. Vet J, 234, 61-65.
  • Bozukluhan K, Merhan O, Gokce HI et al. (2017). Alterations in lipid profile in neonatal calves affected by diarrhea. Vet World, 10 (7), 786-789.
  • Chatre L, Verdonk F, Rocheteau P et al. (2017). A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis. Biochim Biophys Acta-Mol Basis Dis, 1863 (10), 2546-2553.
  • Çitil M, Gökçe E (2013). Neonatal septisemi. Türkiye Klinik Vet Bil Derg, 4 (1), 62-70.
  • Dratwa-Chalupnık A, Herosımczyk A, Lepczyńskı A, Skrzypcazk WF (2012). Calves with diarrhea and a water-electrolyte balance. Med Weter, 68 (1), 5-8.
  • Erkılıç EE, Merhan O, Kırmızıgül AH et al. (2019). Salivary and serum levels of serum amyloid a, haptoglobin, ceruloplasmin and albumin in neonatal calves with diarrhoea. Kafkas Univ Vet Fak Derg, 25 (4), 583-586.
  • Elin RJ (1994). Magnesium: the fifth but forgotten electrolyte. Am J Clin Pathol. 102 (5), 616-622.
  • Fecteau G, Paré J, Van Metre DC et al. (1997). Use of a clinical sepsis score for predicting bacteremia in neonatal dairy calves on a calf rearing farm. Can Vet J, 38 (2), 101-104.
  • Fecteau G, Smith PB, George LW (2009). Septicemia and meningitis in newborn calf. Vet Clin North Am Food Anim Pract, 25 (1), 195-208.
  • Fisher EW, De la Fuente GH (1972). Water and electrolyte studies in newborn calves with particular reference to effects of diarrhoea. Res Vet Sci, 13 (4), 315-322.
  • Gökce HI, Woldehivet Z (1999). The effects of ehrlichia (cytoecetes) phagochytophila on the clinical chemistry of sheep and goats. J Vet Med, 46 (2), 93-103.
  • House JK, Smith GW, McGuirk SM, Gunn AA, Izzo M (2015). Manifestations and Management of Disease in Neonatal Ruminants. Smith BP. (Ed.). Large Animal Internal Medicine 5th (s. 302-338). Elsevier Saunders, St. Louis, USA.
  • Lorenz I, Fagan J, More SJ (2011). Calf health from birth to weaning. II. management of diarrhoea in pre-weaned calves. Irish Vet J, 64 (9), 1-6.
  • Martin SW, Lumsden JH (1987). The relationship of hematology and serum biochemistry parameters to treatment for respiratory disease and weight gain in ontario feedlot calves. Can J Vet Res, 51 (4), 499-505.
  • Naseri A (2017). Doğal gelişen şiddetli sepsisli ve septik şoklu buzağılarda sol ventriküler sistolik fonksiyonların ve bu fonksiyonların uygulanan tedaviye bağlı değişimlerin ekokardiyografi ile değerlendirilmesi; longitudinal çalışma. Doktora Tezi, Selçuk Üniversitesi, Sağlık Bilimleri Enstitüsü, Konya.
  • Naseri A, Sen I, Turgut K, Guzelbektes H, Constable PD (2019). Echocardiographic assessment of left ventricular systolic function in neonatal calves with naturally occurring sepsis or septic shock due to diarrhea. Res Vet Sci, 126, 103-112.
  • Naseri A, Ider M (2021). Comparison of blood gases, hematological and monitorization parameters and determine prognostic importance of selected variables in hypotensive and non-hypotensive calves with sepsis. Eurasian J Vet Sci, 37 (1), 1-8.
  • Novelli G, Ferretti G, Poli L et al. (2010). Clinical results of treatment of postsurgical endotoxin-mediated sepsis with polymyxin-b direct hemoperfusion. Transplant Proc, 42 (4), 1021-1024.
  • Ok M, Güler L, Turgut K et al. (2009). The studies on the etiology of diarrhae in neonatal calves and determination of virulence gene markers of Escherichia coli strains by multiplex PCR. Zoonoses Public Health, 56 (2), 94-101.
  • Sen I, Constable PD (2013). General overview to treatment of strong ion (metabolic) acidosis in neonatal calves with diarrhea. Eurasian J Vet Sci, 29 (3), 114-120.
  • Trefz FM, Lorch A, Feist M, Sauter-Louis C, Lorenz I (2013). The prevalence and clinical relevance of hyperkalaemia in calves with neonatal diarrhoea. Vet J, 195 (3), 350-356.
  • Tyler JW, Hancock D, Thorne JG, Clive CG, Gay JM (1999). Partitioning the mortality risk associated with inadequate passive transfer of colostral immunoglobulins in dairy calves. J Vet Intern Med, 13 (4), 335-357.
  • Uzlu E, Karapehlivan M, Çitil M, Gökçe E, Erdoğan HM (2010). İshal semptomu belirlenen buzağılarda serum sialik asit ile bazı biyokimyasal parametrelerin araştırılması. YYÜ Vet Fak Derg, 21 (2), 83-86.
  • Yıldız R, Beslek M, Beydilli Y, Özçelik M, Biçici Ö (2018). Evaluation of platelet activating factor in neonatal calves with sepsis. Vet Hekim Der Derg, 89 (2), 66-73.
Toplam 36 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm Araştırma Makaleleri
Yazarlar

Enes Akyüz 0000-0002-3288-2058

Mert Sezer Bu kişi benim 0000-0003-1691-7764

Mushap Kuru 0000-0003-4409-251X

Amir Naseri 0000-0001-9140-5879

Proje Numarası destekleyen kurum yok
Yayımlanma Tarihi 27 Mart 2022
Gönderilme Tarihi 31 Ocak 2022
Kabul Tarihi 6 Mart 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 33 Sayı: 1

Kaynak Göster

APA Akyüz, E., Sezer, M., Kuru, M., Naseri, A. (2022). Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves with Sepsis due to Diarrhea. Van Veterinary Journal, 33(1), 26-30. https://doi.org/10.36483/vanvetj.1066050
AMA Akyüz E, Sezer M, Kuru M, Naseri A. Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves with Sepsis due to Diarrhea. Van Vet J. Mart 2022;33(1):26-30. doi:10.36483/vanvetj.1066050
Chicago Akyüz, Enes, Mert Sezer, Mushap Kuru, ve Amir Naseri. “Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves With Sepsis Due to Diarrhea”. Van Veterinary Journal 33, sy. 1 (Mart 2022): 26-30. https://doi.org/10.36483/vanvetj.1066050.
EndNote Akyüz E, Sezer M, Kuru M, Naseri A (01 Mart 2022) Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves with Sepsis due to Diarrhea. Van Veterinary Journal 33 1 26–30.
IEEE E. Akyüz, M. Sezer, M. Kuru, ve A. Naseri, “Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves with Sepsis due to Diarrhea”, Van Vet J, c. 33, sy. 1, ss. 26–30, 2022, doi: 10.36483/vanvetj.1066050.
ISNAD Akyüz, Enes vd. “Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves With Sepsis Due to Diarrhea”. Van Veterinary Journal 33/1 (Mart 2022), 26-30. https://doi.org/10.36483/vanvetj.1066050.
JAMA Akyüz E, Sezer M, Kuru M, Naseri A. Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves with Sepsis due to Diarrhea. Van Vet J. 2022;33:26–30.
MLA Akyüz, Enes vd. “Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves With Sepsis Due to Diarrhea”. Van Veterinary Journal, c. 33, sy. 1, 2022, ss. 26-30, doi:10.36483/vanvetj.1066050.
Vancouver Akyüz E, Sezer M, Kuru M, Naseri A. Changes in Hematology, Some Clinical Biochemical Parameters and Mineral Levels in Neonatal Calves with Sepsis due to Diarrhea. Van Vet J. 2022;33(1):26-30.
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