Olgu Sunumu
Yıl 2020,
Cilt: 5 Sayı: 1, 20 - 26, 30.04.2020
Öz
In
this case report, the nine-month-old male Azawakh dog was observed to ataxia, uncoordinated movements,
difficulties in walking and standing, intensive head tremors, trouble evacuating
and eating. It was
determined mild cerebellar hypoplasia at the
magnetic resonance imaging.
Symptomatic treatment was started with glucocorticoids, vitamin B1,
B6and diazepam.
But these drugs had no effect on symptoms and the dog died after
three weeks. It described a macroscopic cerebellar reduction in the necropsy and
cerebellum and granular cell hypoplasia in histopathologically.
Immunohistochemically, the atrophy of neuronal cells showing positive staining
with anti-GFAP antibody and vacuolar degeneration were identified.
Based
on clinical findings, MR imaging, histopathological and immunochemical
findings, cerebellar hypoplasia was diagnosed in the dog and this study is the first case detected in the Azawakh dog.
Anahtar Kelimeler
Kaynakça
- 1. Appel, M.J., Shek, W.R., Summers, B.A. (1982). Lymphocytemediated İmmune Cytotoxicity İn Dogs İnfected With Virulent Canine Distemper Virus. Infect. Immun, 37(2), 592- 600.
- 2. Bernardıno, F., Rentmeıster, K., Schmıdt, M.J., Bruehschweın, A., Matıasek, K., Matıasek, L.A., Lauda, A., Schoon, H.A., Fischer, A. (2015). Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia: A Retrospective and Prospective Clinical Cohort Study. Plos One, 10(2).
- 3. Choı, H., Kang, S.Y., Jeong, S., Cho, S., Lee, K., Eom, K., Lee, H., Chang, D., Yoon, J., Lee, Y. (2007). Imaging diagnosis-cerebellar vermis hypoplasia in a Miniature Schnauzer. Vet. Radiol. Ultrasound, 48(2), 129-131.
- 4. Chrısman, C., Marıanı, C., Platt, S., Clemmons, R. (2003). Neurology for the Small Animal Practitioner. USA: Teton NewMedia. 204-205.
- 5. De Lahunta, A. (1990). Abiotrophy in domestic animals: a review. Can J Vet Res, 54(1), 65-76.
- 6. Flegel, T., Matıasek, K., Henke, D., Grevel, V. (2007). Cerebellar cortical degeneration with selective granule cell loss in Bavarian mountain dogs. J Small Anim Pract, 48(8), 462-465.
- 7. Johnson, K.P., Ferguson, L.C., Byıngton, D.P., Redman, D.R. (1974). Multiple fetal malformations due to persistent viral infection. I. Abortion, intrauterine death, and gross abnormalities in fetal swine infected with hog cholera vaccine virus. Lab. Invest, 30(5), 608–617.
- 8. Lım, J.H., Kım, D.Y., Yoon, J., Kım, W.H., Kweon, O. (2008). Cerebellar vermian hypoplasia in a Cocker Spaniel. J. Vet. Sci, 9(2), 215-217.
- 9. Mackıllop, E. (2011). Magnetic resonance imaging of intracranial malformations in dogs and cats. Vet Radiol Ultrasound, 52(1), 42-51.
- 10. March, P. (1996). Degenerative brain disease. In: Bagley R (ed’s), Intracranial Disease, Vet Clinics of North America. WB Saunders, Philadelphia, PA, 945-971.
- 11. Noureddıne, C., Harder, R., Olby, N.J., Spauldıng, K., Brown, T. (2004). Ultrasonographic appearance of dandy walker-like Syndrome in a Boston terrier. Vet Radiol Ultrasound, 45(4), 336-339.
- 12. Okıta, M., Yanaı, T., Ochıkubos, F., Gemma, T., Morı, T., Masekı, T., Yamanouchı, K., Mikamı, T., Kaı, C. (1997). Histopathological features of canine distemper recently observed in Japan. J Comp Path, 116(4), 403-408.
- 13. Saberı, M., Kheırandısh, R., Azızı, S., Mohebbı, E. (2014). Cerebellar cortical abiotrophy in a Samoyed dog. Eurasian J. Vet. Sci., 30(1), 44-47.
- 14. Schatzberg, S.J., Haley, N.J., Barr, S.C., Parrısh, C., Steıngold, S., Summers, B.A., Delahunta, A., Kornegay, J.N., Sharp, N.J.H. (2003). Polymerase Chain Reaction (PCR) Amplification of Parvoviral DNA from the Brains of Dogs and Cats with Cerebellar Hypoplasia. J. Vet. Intern. Med, 17(4), 538-544.
- 15. Sullıvan, N.D. (1985). The Nervous System. In: Jubb K.V.F., Kennedy P.C., Palmer N (ed’s), Pathology of Domestic Animals. 3th ed, Academic Press, London, 214-220.
- 16. Summers, B., Cummıngs, J., Delahunta, A. (1994). Malformations of the Central Nervous System. Veterinary Neuropathology. Mosby, St Louis, 82-86.
- 17. Summers, B.A., Cummings, J.F. (1995). De Lahunta A. Inflammatory diseases of the central nervous system. In: Duncan L, (ed’s), Veterinary Neuropathology. USA, Mosby Year Book, 102-110.
- 18. Tago, Y., Katsuta, O., Tsuchıtanı, M. (1993). Granule cell type cerebellar hypoplasia in a beagle dog. Assoc Lab Anim Sci, 27(2), 151-155.
- 19. Thompson, M.S. (2014). Small Animal Medical Differencial Diagnosis. Second Edition. Elsevier Saunders, Missouri, 227-228.
- 20. Troxel, M.T. (2012). Neurology Case of the Month: Chronic, progressive ataxia in a Labrador http://www.ivghospitals.com/specialty-services/neurology-case-of-the-month-nov-2012-chronic-progressive-ataxia-in-a-labrador/ 18.07.2019.
- 21. Yarasan, E. (2015). Kedi Köpek Hekimliği, Güneş kitapevleri.
- 22. Yarım, G.F., Yagcı, B.B. (2006). Köpek gençlik hastalığının sinirsel formundaki köpeklerin plazmasında vitamin A ve beta-karotin düzeylerindeki degişiklikler, Ankara Univ. Vet. Fak. Derg, 53, 85-90.
Yıl 2020,
Cilt: 5 Sayı: 1, 20 - 26, 30.04.2020
Öz
Bu olgu
sunumunda, dokuz aylık erkek Azawakh ırkı köpek, ataksi, koordinasyon bozukluğu,
yürüme ve ayakta durma zorluğu, başta titremeler, dışkılama ve yemek yemede
zorluk çekme şikayeti ile kliniğimize geldi. Manyetik rezonans görüntülemede
hafif serebellar hipoplazi saptandı ve semptomatik tedavi amacı ile
glukokortikoid, vitamin B1,
B6 ve diazepam kullanıldı. Ancak köpek üç hafta sonra hayatını
kaybetti. Nekropsisi yapılan köpekte makroskobik olarak cerebellar küçülme
tespit edilirken, histopatolojik olarak serebellum ve granüler hücre
hipoplazisi belirgindi. İmmünokimyasal olarak ise anti-GFAP antikoru ve vakuolar
dejenerasyonu ile pozitif boyanma gösteren nöronal hücrelerin atrofisi
belirlendi.
Klinik bulgular, MR
görüntüleme, histopatolojik ve immunokimyasal bulgular doğrultusunda köpekte
cerebellar hypoplasia teşhis edilmiş olup azawakh ırkı köpekte tespit edilen
ilk olgu olması ile çalışmamız özgündür.
Anahtar Kelimeler
Kaynakça
- 1. Appel, M.J., Shek, W.R., Summers, B.A. (1982). Lymphocytemediated İmmune Cytotoxicity İn Dogs İnfected With Virulent Canine Distemper Virus. Infect. Immun, 37(2), 592- 600.
- 2. Bernardıno, F., Rentmeıster, K., Schmıdt, M.J., Bruehschweın, A., Matıasek, K., Matıasek, L.A., Lauda, A., Schoon, H.A., Fischer, A. (2015). Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia: A Retrospective and Prospective Clinical Cohort Study. Plos One, 10(2).
- 3. Choı, H., Kang, S.Y., Jeong, S., Cho, S., Lee, K., Eom, K., Lee, H., Chang, D., Yoon, J., Lee, Y. (2007). Imaging diagnosis-cerebellar vermis hypoplasia in a Miniature Schnauzer. Vet. Radiol. Ultrasound, 48(2), 129-131.
- 4. Chrısman, C., Marıanı, C., Platt, S., Clemmons, R. (2003). Neurology for the Small Animal Practitioner. USA: Teton NewMedia. 204-205.
- 5. De Lahunta, A. (1990). Abiotrophy in domestic animals: a review. Can J Vet Res, 54(1), 65-76.
- 6. Flegel, T., Matıasek, K., Henke, D., Grevel, V. (2007). Cerebellar cortical degeneration with selective granule cell loss in Bavarian mountain dogs. J Small Anim Pract, 48(8), 462-465.
- 7. Johnson, K.P., Ferguson, L.C., Byıngton, D.P., Redman, D.R. (1974). Multiple fetal malformations due to persistent viral infection. I. Abortion, intrauterine death, and gross abnormalities in fetal swine infected with hog cholera vaccine virus. Lab. Invest, 30(5), 608–617.
- 8. Lım, J.H., Kım, D.Y., Yoon, J., Kım, W.H., Kweon, O. (2008). Cerebellar vermian hypoplasia in a Cocker Spaniel. J. Vet. Sci, 9(2), 215-217.
- 9. Mackıllop, E. (2011). Magnetic resonance imaging of intracranial malformations in dogs and cats. Vet Radiol Ultrasound, 52(1), 42-51.
- 10. March, P. (1996). Degenerative brain disease. In: Bagley R (ed’s), Intracranial Disease, Vet Clinics of North America. WB Saunders, Philadelphia, PA, 945-971.
- 11. Noureddıne, C., Harder, R., Olby, N.J., Spauldıng, K., Brown, T. (2004). Ultrasonographic appearance of dandy walker-like Syndrome in a Boston terrier. Vet Radiol Ultrasound, 45(4), 336-339.
- 12. Okıta, M., Yanaı, T., Ochıkubos, F., Gemma, T., Morı, T., Masekı, T., Yamanouchı, K., Mikamı, T., Kaı, C. (1997). Histopathological features of canine distemper recently observed in Japan. J Comp Path, 116(4), 403-408.
- 13. Saberı, M., Kheırandısh, R., Azızı, S., Mohebbı, E. (2014). Cerebellar cortical abiotrophy in a Samoyed dog. Eurasian J. Vet. Sci., 30(1), 44-47.
- 14. Schatzberg, S.J., Haley, N.J., Barr, S.C., Parrısh, C., Steıngold, S., Summers, B.A., Delahunta, A., Kornegay, J.N., Sharp, N.J.H. (2003). Polymerase Chain Reaction (PCR) Amplification of Parvoviral DNA from the Brains of Dogs and Cats with Cerebellar Hypoplasia. J. Vet. Intern. Med, 17(4), 538-544.
- 15. Sullıvan, N.D. (1985). The Nervous System. In: Jubb K.V.F., Kennedy P.C., Palmer N (ed’s), Pathology of Domestic Animals. 3th ed, Academic Press, London, 214-220.
- 16. Summers, B., Cummıngs, J., Delahunta, A. (1994). Malformations of the Central Nervous System. Veterinary Neuropathology. Mosby, St Louis, 82-86.
- 17. Summers, B.A., Cummings, J.F. (1995). De Lahunta A. Inflammatory diseases of the central nervous system. In: Duncan L, (ed’s), Veterinary Neuropathology. USA, Mosby Year Book, 102-110.
- 18. Tago, Y., Katsuta, O., Tsuchıtanı, M. (1993). Granule cell type cerebellar hypoplasia in a beagle dog. Assoc Lab Anim Sci, 27(2), 151-155.
- 19. Thompson, M.S. (2014). Small Animal Medical Differencial Diagnosis. Second Edition. Elsevier Saunders, Missouri, 227-228.
- 20. Troxel, M.T. (2012). Neurology Case of the Month: Chronic, progressive ataxia in a Labrador http://www.ivghospitals.com/specialty-services/neurology-case-of-the-month-nov-2012-chronic-progressive-ataxia-in-a-labrador/ 18.07.2019.
- 21. Yarasan, E. (2015). Kedi Köpek Hekimliği, Güneş kitapevleri.
- 22. Yarım, G.F., Yagcı, B.B. (2006). Köpek gençlik hastalığının sinirsel formundaki köpeklerin plazmasında vitamin A ve beta-karotin düzeylerindeki degişiklikler, Ankara Univ. Vet. Fak. Derg, 53, 85-90.
Toplam 22 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Bilimleri |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Nisan 2020 |
| Gönderilme Tarihi | 20 Eylül 2019 |
| Kabul Tarihi | 8 Nisan 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 5 Sayı: 1 |
