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A case of Brucellosis with neurological and dermatological findings in a thoroughbred Arabian horse

Yıl 2024, Cilt: 9 Sayı: 1, 73 - 78, 30.04.2024

Erdoğan Uzlu Feyyaz Kaya Bilge Kaan Fatmanur Özkurşun Ziya İlhan

https://doi.org/10.31797/vetbio.1415732

Öz

Brucellosis, a zoonotic infection, exhibits varying prevalence across different geographical regions, with a notable incidence in Mediterranean countries, contributing to considerable economic losses. This study focuses on an 11-year-old purebred male Arabian horse, presenting symptoms including weight loss, weakness, environmental indifference, joint swelling, and diverse dermatological manifestations despite sufficient feed intake. A pivotal clinical observation from anamnesis and examination is the animal's inclination to lean its head against walls or fixed objects. In conjunction with hematological and biochemical analyses, the Brucella Rose Bengal plate test (RBPT) and serum agglutination test (SAT) were conducted, revealing seropositivity for brucellosis in the patient. Consequently, it is imperative for professionals in the equine breeding sector, particularly clinical veterinarians, to adhere to biosafety protocols concerning brucellosis cases exhibiting atypical clinical symptoms in horses. Proper diagnostic methods should be employed to assess suspicious cases, underscoring the significance of safeguarding both public and animal health.

Anahtar Kelimeler

Brucella Horse Neurology Dermatology

Kaynakça

  • Acosta-González, R. I., González-Reyes, I., & Flores-Gutiérrez, G. H. (2006). Prevalence of Brucella abortus antibodies in equines of a tropical region of Mexico. Canadian Journal of Veterinary Research, 70(4), 302-304.
  • Acosta-González, R. I., Infante, F., & Flores-Gutiérrez, G. H. (2009). Epidemiological patterns of caprine brucellosis in an unvaccinated area, Mexico. Revue Médecine Véterinaire, 160, 145-148.
  • Alexander, B., Schnurrenberger, P., & Brown, R. (1981). Numbers of Brucella abortus in the placenta, umbilicus and fetal fluid of two naturally infected cows. The Veterinary Record, 108(23),500. https://doi.org/10.1177/030098588902600609
  • Alton, G. G., Jones, L. M., Angus, R. D., & Verger, J. M. (1988). Techniques for the Brucellosis laboratory. The British Veterinary Journal, 146(2), 188. https://doi.org/10.1016/0007-1935(90)90017-W
  • Amini, M., Alamian, S., Talebhemmat, M. & Dadar, M. (2024). Equine brucellosis in Iran: serological, bacteriological and molecular analysis. Veterinary Research Communications, https://doi.org/10.1007/ s11259-024-10332-0
  • Ariza, J., Servitje, O., Pallarés, R., Fernández Viladrich, P., Rufí, G., Peyrí, J., & Gudiol, F. (1989). Characteristic cutaneous lesions in patients with brucellosis. Archives of Dermatology, 125(3), 380–383. https://doi.org/10.1001/archderm.1989.01670150070010
  • Aşkar, Ş., Mumcu, F., Ünal, N., & Yıldırım, M. (2013). Kırıkkale ve Yöresindeki Süt Sığırı ve Koyunlar ile Bunların Yetiştiricilerinde Brucella Antikoru Varlığının Araştırılması. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, 24(3), 113-116.
  • Aydın, N. (2006). Brucella infeksiyonları, In: Veteriner Mikrobiyoloji (Bakteriyel hastalıklar), N. Aydın, J. Paracıklıoğlu (Eds), (pp.145-163). İlke Emek Yayıncılık, Ankara.
  • Berger, T. G., Guill, M. A., & Goette, D. K. (1981). Cutaneous Lesions in Brucellosis. Archives of Dermatological Research, 117(1), 40-42. https://doi.org/10.1001/archderm.1981.01650010046024
  • Bodur, H., Erbay, A., Akıncı, E., Colpan, A., Cevik, M.A., & Balaban, N. (2003). Neurobrucellosis in an endemic area of brucellosis. Scandinavian Journal of Infectious Diseases, 35(2), 94-97. https://doi.org/10. 1080/0036554021000027000
  • Borchers, K., Thein, P., & Sterner-Kock, A. (2006). Pathogenesis of equine herpes- associated neurological disease: a revised explanation. Equine Veterinary Journal, 38(3), 283–287. https://doi.org/10.2746/ 042516406776866462
  • Cohn, N. O., Carter, G. K., & Mc Millan, W. C. (1992). Fistulous withers in horses: 24 cases (1984-1990). Journal of the American Veterinary Medical Association, 201(1), 121–124.
  • Corbel, M. J. (1997). Brucellosis: an overview. Emerging Infectious Diseases, 3(2), 213–221. https://doi.org/10. 3201/eid0302.970219.
  • Cvetnic, Z., Spicic, S., Curic, S., Jukic, B., Lojkic, M., Albert, D., Thiébaud, M., & Garin Bastuji, B. (2005). Isolation of Brucella suis biovar 3 from horses in Croatia. Veterinary Record, 156(18), 584–585. https://doi.org/10.1136/vr.156.18.584
  • Dorneles, E. M. S., Santana, J. A., Borges Costa, A. C. T. R., Júnior, D. G. J., Heinemann, M.B., & Lage, A.P. (2023). Equine brucellosis: Current understanding and challenges. Journal of Equine Veterinary Science, 127, 104298. https://doi.org/10.1016/j.jevs.2023.104298
  • Godfroid, J. (2002). Brucellosis in wildlife. Revue Scientifique et Technique-Office International des Epizooties, 21(2), 277–286. https://doi.org/10.20506 /rst.21.2.1333
  • Gryspeerdt, A., Vandekerckhove, A., Van Doorsselaere, J., Van de Walle, G., & Nauwynck, H. (2011). Description of an unusually large outbreak of nervous system disorders caused by equine herpesvirus 1 (EHV1) in 2009 in Belgium. Vlaams Diergeneeskundig Tijdschrift, 80(2),147–153.
  • Gul, S. T., Khan, A., Ahmad, M., & Hussain, I. (2013). Seroprevalence of Brucellosis and associated hematobiochemical changes in Pakistani horses. Pakistan Journal of Agricultural Sciences, 50(4), 745-750.
  • Heper, Y., Yılmaz, E., Akalın, H., Mıstık, R., & Helvacı, S. (2004). Nörobruselloz: 9 olgunun irdelenmesi. Klimik Dergisi, 17(2), 99-102. https://doi.org/10.1016/j.jevs.2023.104298
  • İlhan, Z., Keskin, O., Sareyyüpoğlu, B., Kökçü, L., & Akan, M. (1999). Bir sığırcılık işletmesinde Brucella abortus epidemisi. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 46,257-262. https://doi.org/10. 1501/Vetfak_0000000814
  • Jackson, T., & Kendrick, J. (1971). Paralysis of horses associated with equine herpesvirus 1 infection. Journal of the American Veterinary Medical Association, 158(8),1351–1357.
  • Khan, M. Z., & Zahoor, M. (2018). An overview of brucellosis in cattle and humans, and its serological and molecular diagnosis in control strategies. Tropical Medicine and Infectious Disease, 3(2), 65, https://doi.org/10.3390/tropicalmed3020065
  • Lotfi, Z., Pourmahdi Borujeni, M., Ghorbanpoor, M., & Ghadrdan Mashhadi, A. R. (2022). Seroprevalence and risk factors of brucellosis in Arabian horses. Veterinary Medicine and Science, 8(3), 1056–1064. https://doi.org/10.1002/ vms3.759
  • Maji, S., Manjunath, N., Bahubali, V. H., Shome, R., Palaniappan, M., Lahiri, S., Ravikumar, R., Parthasarathi, S., & Chandrashekar, N. (2020). Neurobrucellosis: A neglected entity? An update from tertiary care Neurocentre of South East Asia. Journal of the Neurological Sciences, 411, 116683. https://doi.org/10.1016/j.jns.2020.116683
  • Ocholi, R. A., Bertu, W. J., Kwaga, J. K. P., Ajogi, I., Bale, J. O., & Okpara, J. (2004). Carpal bursitis associated with Brucella abortusin a horse in Nigeria. Veterinary Record, 155(18), 566–567. https://doi.org/10.1136/vr.155.18.566
  • Pappas, G., Papadimitriou, P., Akritidis, N., Christou, L., & Tsianos, E. V. (2006). The new global map of human brucellosis. Lancet Infectious Diseases, 6, 91–99. https://doi.org/10.1016/S1473-3099(06)70382-6
  • Quinn, P. J., Markey, B. K., Leonard, F. C., Fitzpatrick, E. S., Fanning, S., & Hartigan, P. J. (2011). Veterinary Microbiology and Microbial Disease. 2nd ed. Wiley-Blackwell, West Sussex, UK. 2011; pp. 234-341.
  • Ribeiro, M. G., Motta, R. G. & Almeida, C. A. S. (2008). Brucelose eqüina: Aspectos da doença no Brasil. Revista Brasileria de Reprodução Animal,32, 83-92
  • Rossetti, C. A., Maurizio, E., & Rossi, U. A. (2022). Comparative review of brucellosis in small domestic ruminants. Frontiers in Veterinary Science, 9, 887671. https://doi.org/10.3389/fvets.2022.887671
  • Sánchez-Villalobos, A., Rodríguez-Vargas, M., Becerra- Ramírez, L., & Cordero, R. (2010). Utilidad de las técnicas fluorescencia polarizada y del inmunoensayo enzimático de competencia para diagnóstico de brucelosis en caballos purasangre de carreras. Interciencia, 35, 131-135.
  • Silva, M. A. G., de Oliveira, T. E. F., Pereira, D. C., Galvão, S. R., Almeida, K. S., & Santos, H. D. (2022). Serological Study of Equine Brucellosis in the Legal Amazon Region. Journal of Veterinary Animal Research, 4, 104.
  • Tahamtan, Y., Namavari, M. M., Mohammadi, G., & Jula, G. M. (2010). Prevalence of brucellosis in horse North-East of Iran. Journal of Equine Veterinary Science, 30(7), 376-378. https://doi.org/10.1016/ j.jevs.2010.05.007
  • Tuncel, D., Uçmak, H., Gokce, M., & Utku, U. (2008). Neurobrucellosıs. European Journal of General Medicine, 5(4), 245-248. https://doi.org/10. 29333/ejgm/82616
  • Turgut, K. (2000). Veteriner Klinik Laboratuvar Teşhis. 2. baskı. p. 885-889. Bahçıvanlar Basım Sanayi A.Ş., Konya.
  • Van Maanen, C., Oldruitenborgh-Oosterbaan, M. M., Damen, E. A., & Derksen, A. G. (2001). Neurological disease associated with EHV-1-infection in a riding school: clinical and virological characteristics. Equine Veterinary Journal, 33(2), 191–196. https://doi.org/10. 1111/j.2042-3306.2001.tb00600.x

Yıl 2024, Cilt: 9 Sayı: 1, 73 - 78, 30.04.2024

Erdoğan Uzlu Feyyaz Kaya Bilge Kaan Fatmanur Özkurşun Ziya İlhan

https://doi.org/10.31797/vetbio.1415732

Öz

Kaynakça

  • Acosta-González, R. I., González-Reyes, I., & Flores-Gutiérrez, G. H. (2006). Prevalence of Brucella abortus antibodies in equines of a tropical region of Mexico. Canadian Journal of Veterinary Research, 70(4), 302-304.
  • Acosta-González, R. I., Infante, F., & Flores-Gutiérrez, G. H. (2009). Epidemiological patterns of caprine brucellosis in an unvaccinated area, Mexico. Revue Médecine Véterinaire, 160, 145-148.
  • Alexander, B., Schnurrenberger, P., & Brown, R. (1981). Numbers of Brucella abortus in the placenta, umbilicus and fetal fluid of two naturally infected cows. The Veterinary Record, 108(23),500. https://doi.org/10.1177/030098588902600609
  • Alton, G. G., Jones, L. M., Angus, R. D., & Verger, J. M. (1988). Techniques for the Brucellosis laboratory. The British Veterinary Journal, 146(2), 188. https://doi.org/10.1016/0007-1935(90)90017-W
  • Amini, M., Alamian, S., Talebhemmat, M. & Dadar, M. (2024). Equine brucellosis in Iran: serological, bacteriological and molecular analysis. Veterinary Research Communications, https://doi.org/10.1007/ s11259-024-10332-0
  • Ariza, J., Servitje, O., Pallarés, R., Fernández Viladrich, P., Rufí, G., Peyrí, J., & Gudiol, F. (1989). Characteristic cutaneous lesions in patients with brucellosis. Archives of Dermatology, 125(3), 380–383. https://doi.org/10.1001/archderm.1989.01670150070010
  • Aşkar, Ş., Mumcu, F., Ünal, N., & Yıldırım, M. (2013). Kırıkkale ve Yöresindeki Süt Sığırı ve Koyunlar ile Bunların Yetiştiricilerinde Brucella Antikoru Varlığının Araştırılması. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, 24(3), 113-116.
  • Aydın, N. (2006). Brucella infeksiyonları, In: Veteriner Mikrobiyoloji (Bakteriyel hastalıklar), N. Aydın, J. Paracıklıoğlu (Eds), (pp.145-163). İlke Emek Yayıncılık, Ankara.
  • Berger, T. G., Guill, M. A., & Goette, D. K. (1981). Cutaneous Lesions in Brucellosis. Archives of Dermatological Research, 117(1), 40-42. https://doi.org/10.1001/archderm.1981.01650010046024
  • Bodur, H., Erbay, A., Akıncı, E., Colpan, A., Cevik, M.A., & Balaban, N. (2003). Neurobrucellosis in an endemic area of brucellosis. Scandinavian Journal of Infectious Diseases, 35(2), 94-97. https://doi.org/10. 1080/0036554021000027000
  • Borchers, K., Thein, P., & Sterner-Kock, A. (2006). Pathogenesis of equine herpes- associated neurological disease: a revised explanation. Equine Veterinary Journal, 38(3), 283–287. https://doi.org/10.2746/ 042516406776866462
  • Cohn, N. O., Carter, G. K., & Mc Millan, W. C. (1992). Fistulous withers in horses: 24 cases (1984-1990). Journal of the American Veterinary Medical Association, 201(1), 121–124.
  • Corbel, M. J. (1997). Brucellosis: an overview. Emerging Infectious Diseases, 3(2), 213–221. https://doi.org/10. 3201/eid0302.970219.
  • Cvetnic, Z., Spicic, S., Curic, S., Jukic, B., Lojkic, M., Albert, D., Thiébaud, M., & Garin Bastuji, B. (2005). Isolation of Brucella suis biovar 3 from horses in Croatia. Veterinary Record, 156(18), 584–585. https://doi.org/10.1136/vr.156.18.584
  • Dorneles, E. M. S., Santana, J. A., Borges Costa, A. C. T. R., Júnior, D. G. J., Heinemann, M.B., & Lage, A.P. (2023). Equine brucellosis: Current understanding and challenges. Journal of Equine Veterinary Science, 127, 104298. https://doi.org/10.1016/j.jevs.2023.104298
  • Godfroid, J. (2002). Brucellosis in wildlife. Revue Scientifique et Technique-Office International des Epizooties, 21(2), 277–286. https://doi.org/10.20506 /rst.21.2.1333
  • Gryspeerdt, A., Vandekerckhove, A., Van Doorsselaere, J., Van de Walle, G., & Nauwynck, H. (2011). Description of an unusually large outbreak of nervous system disorders caused by equine herpesvirus 1 (EHV1) in 2009 in Belgium. Vlaams Diergeneeskundig Tijdschrift, 80(2),147–153.
  • Gul, S. T., Khan, A., Ahmad, M., & Hussain, I. (2013). Seroprevalence of Brucellosis and associated hematobiochemical changes in Pakistani horses. Pakistan Journal of Agricultural Sciences, 50(4), 745-750.
  • Heper, Y., Yılmaz, E., Akalın, H., Mıstık, R., & Helvacı, S. (2004). Nörobruselloz: 9 olgunun irdelenmesi. Klimik Dergisi, 17(2), 99-102. https://doi.org/10.1016/j.jevs.2023.104298
  • İlhan, Z., Keskin, O., Sareyyüpoğlu, B., Kökçü, L., & Akan, M. (1999). Bir sığırcılık işletmesinde Brucella abortus epidemisi. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 46,257-262. https://doi.org/10. 1501/Vetfak_0000000814
  • Jackson, T., & Kendrick, J. (1971). Paralysis of horses associated with equine herpesvirus 1 infection. Journal of the American Veterinary Medical Association, 158(8),1351–1357.
  • Khan, M. Z., & Zahoor, M. (2018). An overview of brucellosis in cattle and humans, and its serological and molecular diagnosis in control strategies. Tropical Medicine and Infectious Disease, 3(2), 65, https://doi.org/10.3390/tropicalmed3020065
  • Lotfi, Z., Pourmahdi Borujeni, M., Ghorbanpoor, M., & Ghadrdan Mashhadi, A. R. (2022). Seroprevalence and risk factors of brucellosis in Arabian horses. Veterinary Medicine and Science, 8(3), 1056–1064. https://doi.org/10.1002/ vms3.759
  • Maji, S., Manjunath, N., Bahubali, V. H., Shome, R., Palaniappan, M., Lahiri, S., Ravikumar, R., Parthasarathi, S., & Chandrashekar, N. (2020). Neurobrucellosis: A neglected entity? An update from tertiary care Neurocentre of South East Asia. Journal of the Neurological Sciences, 411, 116683. https://doi.org/10.1016/j.jns.2020.116683
  • Ocholi, R. A., Bertu, W. J., Kwaga, J. K. P., Ajogi, I., Bale, J. O., & Okpara, J. (2004). Carpal bursitis associated with Brucella abortusin a horse in Nigeria. Veterinary Record, 155(18), 566–567. https://doi.org/10.1136/vr.155.18.566
  • Pappas, G., Papadimitriou, P., Akritidis, N., Christou, L., & Tsianos, E. V. (2006). The new global map of human brucellosis. Lancet Infectious Diseases, 6, 91–99. https://doi.org/10.1016/S1473-3099(06)70382-6
  • Quinn, P. J., Markey, B. K., Leonard, F. C., Fitzpatrick, E. S., Fanning, S., & Hartigan, P. J. (2011). Veterinary Microbiology and Microbial Disease. 2nd ed. Wiley-Blackwell, West Sussex, UK. 2011; pp. 234-341.
  • Ribeiro, M. G., Motta, R. G. & Almeida, C. A. S. (2008). Brucelose eqüina: Aspectos da doença no Brasil. Revista Brasileria de Reprodução Animal,32, 83-92
  • Rossetti, C. A., Maurizio, E., & Rossi, U. A. (2022). Comparative review of brucellosis in small domestic ruminants. Frontiers in Veterinary Science, 9, 887671. https://doi.org/10.3389/fvets.2022.887671
  • Sánchez-Villalobos, A., Rodríguez-Vargas, M., Becerra- Ramírez, L., & Cordero, R. (2010). Utilidad de las técnicas fluorescencia polarizada y del inmunoensayo enzimático de competencia para diagnóstico de brucelosis en caballos purasangre de carreras. Interciencia, 35, 131-135.
  • Silva, M. A. G., de Oliveira, T. E. F., Pereira, D. C., Galvão, S. R., Almeida, K. S., & Santos, H. D. (2022). Serological Study of Equine Brucellosis in the Legal Amazon Region. Journal of Veterinary Animal Research, 4, 104.
  • Tahamtan, Y., Namavari, M. M., Mohammadi, G., & Jula, G. M. (2010). Prevalence of brucellosis in horse North-East of Iran. Journal of Equine Veterinary Science, 30(7), 376-378. https://doi.org/10.1016/ j.jevs.2010.05.007
  • Tuncel, D., Uçmak, H., Gokce, M., & Utku, U. (2008). Neurobrucellosıs. European Journal of General Medicine, 5(4), 245-248. https://doi.org/10. 29333/ejgm/82616
  • Turgut, K. (2000). Veteriner Klinik Laboratuvar Teşhis. 2. baskı. p. 885-889. Bahçıvanlar Basım Sanayi A.Ş., Konya.
  • Van Maanen, C., Oldruitenborgh-Oosterbaan, M. M., Damen, E. A., & Derksen, A. G. (2001). Neurological disease associated with EHV-1-infection in a riding school: clinical and virological characteristics. Equine Veterinary Journal, 33(2), 191–196. https://doi.org/10. 1111/j.2042-3306.2001.tb00600.x
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Tanı ve Teşhis
Bölüm Olgu Sunumu
Yazarlar

Erdoğan Uzlu 0000-0002-3064-6633

Feyyaz Kaya 0000-0001-8820-1509

Bilge Kaan 0000-0002-7755-9190

Fatmanur Özkurşun 0000-0002-8113-7011

Ziya İlhan 0000-0003-3638-9196

Erken Görünüm Tarihi 22 Nisan 2024
Yayımlanma Tarihi 30 Nisan 2024
Gönderilme Tarihi 6 Ocak 2024
Kabul Tarihi 22 Mart 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 9 Sayı: 1

Kaynak Göster

APA Uzlu, E., Kaya, F., Kaan, B., Özkurşun, F., vd. (2024). A case of Brucellosis with neurological and dermatological findings in a thoroughbred Arabian horse. Journal of Advances in VetBio Science and Techniques, 9(1), 73-78. https://doi.org/10.31797/vetbio.1415732
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