Editöre Mektup
Yıl 2014,
Cilt: 61 Sayı: 1, 79 - 84, 01.03.2014
Öz
Kök hücreler organizmada farklı hücre tiplerine dönüşebilen, canlı kaldıkça yaşamlarını sürdürme özelliğine sahip ve kendi kendilerini yenileyebilen hücrelerdir. Elde edildiği yere göre embriyonal ve yetişkin kök hücresi olmak üzere 2 tip kök hücre bulunmaktadır. Blastositin iç hücre kitlesinden elde edilen embriyonal kök hücreler tüm canlıyı oluşturabilirken differensiye olmuş bir dokudan elde edilen kök hücre sınırlı bölünme ve farklılaşma potansiyeline sahiptir. Embriyonal kök hücreler ile ilgili etik sınırlamalardan dolayı çalışmalar kısıtlıdır. Mezenkimal kök hücrelerdeki çalışmalar hem elde ediliş kolaylığı hem de rejeneratif tıpta kullanım alanı bulması ile öne çıkmaktadır. İnsanlarda kök hücre çalışmaları lokalize hastalıklarda, sistemik transplantasyonda, gen tedavisi ile kombine kök hücre tedavisinde ve doku mühendisliğinde olmak üzere dört alanda başlamıştır. Veteriner hekimlikte kök hücre çalışmaları insan hastalıklarına model oluşturması açısından deney hayvanlarında başlamıştır. Klinik olarak atlarda tendo yaralanmalarında köpeklerde ise osteoartiritisin/kıkırdak hasarının tedavisinde kullanım alanı bulmaktadır
Anahtar Kelimeler
Kaynakça
- Andrades JA, Claros S, Palomo PJ, Lopez-Puerta JM, Zamora-Navas P, Guerado E, Monleon M,Araque MC, Becerra J (2011): Skeletal Regeneration by Mesenchymal Stem Cells: What Else? Regenerative Medicine and Tissue Engineering - Cells and Biomaterials.5:107-144. DOI: 10.5772/20889.
- Beksaç M (2003): Cord blood as a source of stem cells. Blood Banking Transfusion Med,1:155-158.
- Caplan AI, Dennıs JE (2006) : Mesenchymal stem cells as trophic mediators. J Cell Biochem, 98:1076-84.
- Csaki C, Matis U, Mobasheri A, Ye H (2007): Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cell: a biochemical,morphological and ultrastructural study. Histochem Cell Biol,128: 507-20.
- Dozza B, Di Bella C, Lucarelli E, Giavaresi G, Fini M, Tazzari PL, Giannini S, Donati DK (2011): Mesenchymal stem cells and platelet lysate in fibrin or collagen scaffold promote non-cemented hip prosthesis integration. J Orthop Res, 29: 961-8.
- Friedenstein AJ, Gorskaja U, Kalugina NM (1976): Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol, 4: 267-274.
- Gearhart JD, Addis RC (2010): The use of Anımals ın Human Stem Cells Research:Past,Present and Future, ILAR Journal,51:1-2.
- George B (2011): Regulations and guidelines governing stem cell based products: Clinical considerations. Perspect Clin Res, 2:94-96.
- Gruen L, Grabel L (2006) Concise review: scientific and ethical roadblocks to human embryonic stem cell therapy. Stem Cells, 24: 2162-9.
- Gul Sancak I, Bozkurt FM (2010): Yeni Zelanda Tavşanında (Oryctolagus cuniculus) kornea konjunktival transpozisyon (KKT) tekniğinin korneal iyileşmeye etkisi. Ankara Üniv Vet Fak Derg, 57: 235-240.
- Inukai T, Katagiri W, Yoshimi R, Osugi M, Kawai T, Hibi H, Ueda M (2013) Novel application of stem cell- derived factors for periodontal regeneration. Biochem Biophys Res Commun, 430:763-8.
- Karaöz E, Aksoy A, Ayhan S, Sarıboyacı AE, Kaymaz F, Kasap M (2009): Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers. Histochem Cell Biol, 132:533-46.
- Kim JW, Lee JH, Lyoo YS, Jung DI, Park HM (2013) The effects of topical mesenchymal stem cell transplantation in canine experimental cutaneous wounds. Vet Dermatol, 24: 242-253.
- Lettry V, Hosoya K, Takagi S, Okumura M (2010): Coculture of equıne mesenchymal stem cells and mature equıne artıcular chondrocytes results ın ımproved chondrogenıc dıfferentıatıon of the stem cells. Jpn J Vet Res, 58: 5-15.
- Ozen A, Gul Sancak I, Koch S, Von Rechenberg B (2013): Ultrastructural characteristics of sheep and horse mesenchymal stem cells (MSCs).Microscopy Research, 1, 17-23.
- Pasquinelli G, Tazzari P, Ricci F, Vaselli C, Buzzi M, Conte R (2007): Ultrastructural Characteristics of Human Mesenchymal Stromal (Stem) Cells Derived from Bone Marrow and Term Placenta. Ultrastructural Pathology, 31: 23-31.
- Pittenger MF, Maçkay AM, Beck SC et al (1999): Multilineage potential of adult human mesenchymal stem cells. Science, 284:143-147.
- Prockop DJ (1997): Marrow stromal cells as stem cells for non-hematopoietic tissues. Science, 276: 71-74.
- Qiao SM, Chen GH, Wang Y, Wu DP (2012): Ultrastructure of human umbilical cord mesenchymal stem cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 20: 443-447.
- Ryu HH, Kang BJ, Park SS, Kim Y, Sung GJ, Woo HM, Kim WH, Kweon OK (2012), Comparison of mesenchymal stem cells derived from fat, bone marrow, Wharton's jelly, and umbilical cord blood for treating spinal cord injuries in dogs, 74: 1617-30.
- Sarraf CE, Otto WR, Eastwood M (2011): In vitro mesenchymal stem cell differentiation after mechanical stimulation. Cell Prolif, 44: 99-108.
- Takahashi K, Yamanaka S (2006): Induction of Pluripotent Stem Cells from Mouse Embriyonic and Adult fibroblast Cultures by Defined Factors. J Cell, 126: 663- 676.
- Tan B, Wei RQ, Tan MY, Luo JC, Deng L, Chen XH, Hou JL, Li XQ, Yang ZM, Xie HQ (2012) Tissue engineered esophagus by mesenchymal stem cell seeding for esophageal repair in a canine model. J Surg Res. [Epub ahead of print]
- TÜBA Kök Hücre Çalışma Grubu (2009): Kök Hücre Biyolojisi ve Klinik uygulamalar. Türkiye Bilimler Akademisi Raporları. Sayı:20, Yalçın matbaacılık, Türkiye Bilimler Akademisi Raporlar, sayı: 20, Ankara.
- Vieira NM, Valadares M, Zucconi E, Secco M, Bueno CR Jr, Brandalise V, Assoni A, Gomes J, Landini V, Andrade T, Caetano HV, Vainzof M, Zatz M (2012): Human adipose-derived mesenchymal stromal cells injected systemically into GRMD dogs without immunosuppression are able to reach the host muscle and express human dystrophin. Cell Transplant, 21: 1407-17.
- Wood JA, Chung DJ, Park SA, Zwingenberger AL, Reilly CM, Ly I, Walker NJ, Vernau W, Hayashi K, Wisner ER, Cannon MS, Kass PH, Cherry SR, Borjesson DL, Russell P, Murphy CJ (2012): Periocular and intra-articular injection of canine adipose-derived mesenchymal stem cells: an in vivo imaging and migration study. J Ocul Pharmacol, 28: 307-17.
- Anonymous (2004): Stem Cells, Proquest Information and Learning and Learning CSA. www.csa.com/discoveryguides/stemcell/overview.php. Erişim tarihi: 01.02 .2013.
- Anonymous (2001): Kök hücre nedir, Kök Hücre Derneği. www.kokhucredernegi.org.tr. Erişim tarihi: 12.02.2013.
- Anonymous (2011): Kök hücreler, Hacettepe Üniversitesi. yunus.hacettepe.edu.tr/~mergen/derleme/d_stem.pdf. Erişim tarihi: 15.02.2013. Geliş tarihi: 26.04.2013 / Kabul tarihi: 01.07.2013
Yıl 2014,
Cilt: 61 Sayı: 1, 79 - 84, 01.03.2014
Öz
In the living organism stem cells differentiate into diverse specialized cell types, capable of sustaining viability and self-renewal. Stem cells can be categorized as embryonal, and adult due to its origin. Embryonic stem cells obtained from the inner cell mass of the blastocyst has the ability to create the whole organism, differentiated tissue-derived stem cells have the limited growth and differentiation potential and tend to turn into the tissue from which they originated. Due to ethical limitations studies in the embryonic stem cells are limited. Ease of obtaining and common use of the cells in regenerative medicine makes mesenchymal stem cells favorable for studies. In humans; localized disease, systemic transplantations, stem cell therapy in combination with gene therapy and tissue engineering are the four areas of work to be started on stem cells. Stem cell research in veterinary medicine started in experimental animals in terms of being a good model for human diseases. Clinically mesenchymal stem cells are broadly used in horses for tendon injuries and in dogs for osteoartiritis/ injury of the cartilage
Anahtar Kelimeler
Kaynakça
- Andrades JA, Claros S, Palomo PJ, Lopez-Puerta JM, Zamora-Navas P, Guerado E, Monleon M,Araque MC, Becerra J (2011): Skeletal Regeneration by Mesenchymal Stem Cells: What Else? Regenerative Medicine and Tissue Engineering - Cells and Biomaterials.5:107-144. DOI: 10.5772/20889.
- Beksaç M (2003): Cord blood as a source of stem cells. Blood Banking Transfusion Med,1:155-158.
- Caplan AI, Dennıs JE (2006) : Mesenchymal stem cells as trophic mediators. J Cell Biochem, 98:1076-84.
- Csaki C, Matis U, Mobasheri A, Ye H (2007): Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cell: a biochemical,morphological and ultrastructural study. Histochem Cell Biol,128: 507-20.
- Dozza B, Di Bella C, Lucarelli E, Giavaresi G, Fini M, Tazzari PL, Giannini S, Donati DK (2011): Mesenchymal stem cells and platelet lysate in fibrin or collagen scaffold promote non-cemented hip prosthesis integration. J Orthop Res, 29: 961-8.
- Friedenstein AJ, Gorskaja U, Kalugina NM (1976): Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol, 4: 267-274.
- Gearhart JD, Addis RC (2010): The use of Anımals ın Human Stem Cells Research:Past,Present and Future, ILAR Journal,51:1-2.
- George B (2011): Regulations and guidelines governing stem cell based products: Clinical considerations. Perspect Clin Res, 2:94-96.
- Gruen L, Grabel L (2006) Concise review: scientific and ethical roadblocks to human embryonic stem cell therapy. Stem Cells, 24: 2162-9.
- Gul Sancak I, Bozkurt FM (2010): Yeni Zelanda Tavşanında (Oryctolagus cuniculus) kornea konjunktival transpozisyon (KKT) tekniğinin korneal iyileşmeye etkisi. Ankara Üniv Vet Fak Derg, 57: 235-240.
- Inukai T, Katagiri W, Yoshimi R, Osugi M, Kawai T, Hibi H, Ueda M (2013) Novel application of stem cell- derived factors for periodontal regeneration. Biochem Biophys Res Commun, 430:763-8.
- Karaöz E, Aksoy A, Ayhan S, Sarıboyacı AE, Kaymaz F, Kasap M (2009): Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers. Histochem Cell Biol, 132:533-46.
- Kim JW, Lee JH, Lyoo YS, Jung DI, Park HM (2013) The effects of topical mesenchymal stem cell transplantation in canine experimental cutaneous wounds. Vet Dermatol, 24: 242-253.
- Lettry V, Hosoya K, Takagi S, Okumura M (2010): Coculture of equıne mesenchymal stem cells and mature equıne artıcular chondrocytes results ın ımproved chondrogenıc dıfferentıatıon of the stem cells. Jpn J Vet Res, 58: 5-15.
- Ozen A, Gul Sancak I, Koch S, Von Rechenberg B (2013): Ultrastructural characteristics of sheep and horse mesenchymal stem cells (MSCs).Microscopy Research, 1, 17-23.
- Pasquinelli G, Tazzari P, Ricci F, Vaselli C, Buzzi M, Conte R (2007): Ultrastructural Characteristics of Human Mesenchymal Stromal (Stem) Cells Derived from Bone Marrow and Term Placenta. Ultrastructural Pathology, 31: 23-31.
- Pittenger MF, Maçkay AM, Beck SC et al (1999): Multilineage potential of adult human mesenchymal stem cells. Science, 284:143-147.
- Prockop DJ (1997): Marrow stromal cells as stem cells for non-hematopoietic tissues. Science, 276: 71-74.
- Qiao SM, Chen GH, Wang Y, Wu DP (2012): Ultrastructure of human umbilical cord mesenchymal stem cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 20: 443-447.
- Ryu HH, Kang BJ, Park SS, Kim Y, Sung GJ, Woo HM, Kim WH, Kweon OK (2012), Comparison of mesenchymal stem cells derived from fat, bone marrow, Wharton's jelly, and umbilical cord blood for treating spinal cord injuries in dogs, 74: 1617-30.
- Sarraf CE, Otto WR, Eastwood M (2011): In vitro mesenchymal stem cell differentiation after mechanical stimulation. Cell Prolif, 44: 99-108.
- Takahashi K, Yamanaka S (2006): Induction of Pluripotent Stem Cells from Mouse Embriyonic and Adult fibroblast Cultures by Defined Factors. J Cell, 126: 663- 676.
- Tan B, Wei RQ, Tan MY, Luo JC, Deng L, Chen XH, Hou JL, Li XQ, Yang ZM, Xie HQ (2012) Tissue engineered esophagus by mesenchymal stem cell seeding for esophageal repair in a canine model. J Surg Res. [Epub ahead of print]
- TÜBA Kök Hücre Çalışma Grubu (2009): Kök Hücre Biyolojisi ve Klinik uygulamalar. Türkiye Bilimler Akademisi Raporları. Sayı:20, Yalçın matbaacılık, Türkiye Bilimler Akademisi Raporlar, sayı: 20, Ankara.
- Vieira NM, Valadares M, Zucconi E, Secco M, Bueno CR Jr, Brandalise V, Assoni A, Gomes J, Landini V, Andrade T, Caetano HV, Vainzof M, Zatz M (2012): Human adipose-derived mesenchymal stromal cells injected systemically into GRMD dogs without immunosuppression are able to reach the host muscle and express human dystrophin. Cell Transplant, 21: 1407-17.
- Wood JA, Chung DJ, Park SA, Zwingenberger AL, Reilly CM, Ly I, Walker NJ, Vernau W, Hayashi K, Wisner ER, Cannon MS, Kass PH, Cherry SR, Borjesson DL, Russell P, Murphy CJ (2012): Periocular and intra-articular injection of canine adipose-derived mesenchymal stem cells: an in vivo imaging and migration study. J Ocul Pharmacol, 28: 307-17.
- Anonymous (2004): Stem Cells, Proquest Information and Learning and Learning CSA. www.csa.com/discoveryguides/stemcell/overview.php. Erişim tarihi: 01.02 .2013.
- Anonymous (2001): Kök hücre nedir, Kök Hücre Derneği. www.kokhucredernegi.org.tr. Erişim tarihi: 12.02.2013.
- Anonymous (2011): Kök hücreler, Hacettepe Üniversitesi. yunus.hacettepe.edu.tr/~mergen/derleme/d_stem.pdf. Erişim tarihi: 15.02.2013. Geliş tarihi: 26.04.2013 / Kabul tarihi: 01.07.2013
Toplam 29 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Diğer ID | JA59AH92ST |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2014 |
| Yayımlandığı Sayı | Yıl 2014Cilt: 61 Sayı: 1 |