Case Report
Diagnosis of white muscle disease in two goat kids: combining pathological evaluation with ICP-MS based trace element analysis
Abstract
White muscle disease, commonly observed in young ruminants, is a myopathy caused by selenium (Se)/vitamin E deficiency. In this case, white muscle disease was diagnosed in two goat kids following multiple kid mortalities in a hair goat herd in the Gördes district of Manisa province. The disease was diagnosed based on the farmer’s anamnesis, detailed pathological examination, and measurement of Se concentrations in blood and tissue samples using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). In addition to the clinical and pathological findings, the diagnosis of white muscle disease was further supported by the detection of markedly low Se concentrations in the blood, liver, and muscle tissues of the kids. This case report highlights the importance of trace element analysis in the differential diagnosis of white muscle disease from other myopathies in small ruminants.
References
- Anderson P (1983): Selenium Deficiency in Farm Livestock in Britain. Cambridge University Press, Cambridge.
- Beytut E, Karataş F, Beytut E (2002): Lambs with white muscle disease and selenium content of soil and meadow hay in the region of Kars. Vet J, 163, 214-217.
- Cooper BJ, Valentine BA (2016): Muscle and tendon. 214-218. In: Maxie MG (Ed), Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1, Elsevier, China.
- Değer Y, Mert H, Mert N, et al (2008): Serum selenium, vitamin E, and sialic acids concentrations in lambs with white muscle disease. Biol Trace Elem Res, 121, 39-43.
- Helmer C, Hannemann R, Humann-Ziehank E, et al (2021): A case of concurrent molybdenosis, secondary copper, cobalt and selenium deficiency in a small sheep herd in northern Germany. Animals, 11, 1864.
- Hosnedlová B, Kępińska M, Skalická S, et al (2017): A summary of new findings on the biological effects of selenium in selected animal species—a critical review. Int J Mol Sci, 18, 2209.
- Irak K, Mert H, Mert N, et al (2021): Evaluation of various biochemical parameters in the serum and tissues of lambs with white muscle disease. Indian J Anim Res, 55, 1293-1297.
- Milli UH, Hazıroğlu R (2000): Veteriner Patoloji. Özkan Matbaacılık, Ankara.
- Özdemir Ö, Çiftçi MK, Hatipoğlu F, et al (2016): Bir köşekte (C. dromedarius) nutrisyonel kardiyomiyopati. Eurasian J Vet Sci, 32, 52-54.
- Puls R (1994): Mineral Levels in Animal Health: Diagnostic Data. Sherpa International, Clearbrook.
- Rammell CG, Thompson KG, Bentley GR, et al (1989): Selenium, vitamin E and polyunsaturated fatty acid concentrations in goat kids with and without nutritional myodegeneration. NZ Vet J, 37, 4-6.
- Rodriguez AM, Schild CO, Cantón GJ, et al (2018): White muscle disease in three selenium deficient beef and dairy calves in Argentina and Uruguay. Ciência Rural, 48, e20170733
- Semenenko MP, Grin VA, Kuzminova EV, et al (2021): Pharmacological therapy of white muscle disease in lambs with selenium preparations in a comparative aspect. 042020. In: Proceedings of IOP Conference Series: Earth and Environmental Science, IOP Publishing.
- Underwood EJ, Suttle NF (1999): The Mineral Nutrition of Livestock. CAB International, Wallingford.
- Yavuz O (2018): The pathological investigations on nutritional myopathy causing lamb deaths in neonatal period. Bahri Dağdaş Hayv Araş Derg, 6, 1-8.
Abstract
References
- Anderson P (1983): Selenium Deficiency in Farm Livestock in Britain. Cambridge University Press, Cambridge.
- Beytut E, Karataş F, Beytut E (2002): Lambs with white muscle disease and selenium content of soil and meadow hay in the region of Kars. Vet J, 163, 214-217.
- Cooper BJ, Valentine BA (2016): Muscle and tendon. 214-218. In: Maxie MG (Ed), Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1, Elsevier, China.
- Değer Y, Mert H, Mert N, et al (2008): Serum selenium, vitamin E, and sialic acids concentrations in lambs with white muscle disease. Biol Trace Elem Res, 121, 39-43.
- Helmer C, Hannemann R, Humann-Ziehank E, et al (2021): A case of concurrent molybdenosis, secondary copper, cobalt and selenium deficiency in a small sheep herd in northern Germany. Animals, 11, 1864.
- Hosnedlová B, Kępińska M, Skalická S, et al (2017): A summary of new findings on the biological effects of selenium in selected animal species—a critical review. Int J Mol Sci, 18, 2209.
- Irak K, Mert H, Mert N, et al (2021): Evaluation of various biochemical parameters in the serum and tissues of lambs with white muscle disease. Indian J Anim Res, 55, 1293-1297.
- Milli UH, Hazıroğlu R (2000): Veteriner Patoloji. Özkan Matbaacılık, Ankara.
- Özdemir Ö, Çiftçi MK, Hatipoğlu F, et al (2016): Bir köşekte (C. dromedarius) nutrisyonel kardiyomiyopati. Eurasian J Vet Sci, 32, 52-54.
- Puls R (1994): Mineral Levels in Animal Health: Diagnostic Data. Sherpa International, Clearbrook.
- Rammell CG, Thompson KG, Bentley GR, et al (1989): Selenium, vitamin E and polyunsaturated fatty acid concentrations in goat kids with and without nutritional myodegeneration. NZ Vet J, 37, 4-6.
- Rodriguez AM, Schild CO, Cantón GJ, et al (2018): White muscle disease in three selenium deficient beef and dairy calves in Argentina and Uruguay. Ciência Rural, 48, e20170733
- Semenenko MP, Grin VA, Kuzminova EV, et al (2021): Pharmacological therapy of white muscle disease in lambs with selenium preparations in a comparative aspect. 042020. In: Proceedings of IOP Conference Series: Earth and Environmental Science, IOP Publishing.
- Underwood EJ, Suttle NF (1999): The Mineral Nutrition of Livestock. CAB International, Wallingford.
- Yavuz O (2018): The pathological investigations on nutritional myopathy causing lamb deaths in neonatal period. Bahri Dağdaş Hayv Araş Derg, 6, 1-8.
There are 15 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Biochemistry, Veterinary Pathology, Veterinary Diagnosis and Diagnostics |
| Journal Section | Case Report |
| Authors | |
| Early Pub Date | August 6, 2025 |
| Publication Date | September 1, 2025 |
| Submission Date | April 14, 2025 |
| Acceptance Date | July 19, 2025 |
| Published in Issue | Year 2025 Accepted Papers |