Abstract
References
- Adamo PF, Cantile C, Steinberg H (2003): Evaluation of progesterone and estrogen receptor expression in 15 meningiomas of dogs and cats. Am J Vet Res, 64, 1310-1318.
- Barnhart KF, Wojcieszyn J, Storts RW (2002): Immunohistochemical staining patterns of canine meningiomas and correlation with published immunophenotypes. Vet Pathol, 39, 311-321.
- Goldschmidt MH, Dunstan RW, Stannard AA, et al (1998): Histological Classification of Epithelial and Melanocytic Tumors of the Skin of Domestic Animals. 2nd ser, vol. 3, Armed Forces Institute of Pathology, Washington, DC.
- Gross TL, Ihrke PJ, Walder EJ, et al (2005): Skin Diseases of the Dog and Cat. 2nd ed., Blackwell Publishing, Oxford.
- Jabara AG, Finnie JW (1978): Four cases of clear-cell hidradenocarcinomas in the dog. J Comp Pathol, 88, 525-532.
- Latouche EL, Arena CB, Ivey JW, et al (2018): High-frequency irreversible electroporation for intracranial meningioma: a feasibility study in a spontaneous canine tumor model. Technol Cancer Res Treat, 17, 1533033818785285.
- Mikaelian I, Wong V (2003): Follicular stem cell carcinoma: Histologic, immunohistochemical, ultrastructural, and clinical characterization in 30 dogs. Vet Pathol, 40, 433-444.
- Montoliu P, Anor S, Vidal E, et al (2006): Histological and immunohistochemical study of 30 cases of canine meningioma. J Comp Pathol, 135, 200-207.
- Piviani M, Sánchez MD, Patel RT (2012): Cytologic features of clear cell adnexal carcinoma in 3 dogs. Vet Clin Pathol, 41, 405-411.
- Ramos-Vara JA, Miller MA, Gilbreath E, et al (2010): Immunohistochemical detection of CD34, E-cadherin, claudin-1, glucose transporter 1, laminin, and protein gene product 9.5 in 28 canine and 8 feline meningiomas. Vet Pathol, 47, 725-737.
- Schulman FY, Lipscomb TP, Atkin TJ (2005): Canine cutaneous clear cell adnexal carcinoma: histopathology, immunohistochemistry, and biologic behavior of 26 cases. J Vet Diagnostic Investig, 17, 403-411.
- Sharif M, Reinacher M (2006): Clear cell trichoblastomas in two dogs. J Vet Med Ser A Physiol Pathol Clin Med, 53, 352-354.
- Yasuno K, Nishiyama S, Suetsugu F, et al (2009): Shirota K. Cutaneous clear cell adnexal carcinoma in a dog: special reference to cytokeratin expression. J Vet Med Sci, 71, 1513-1517.
- Zimmerman KL, Bender HS, Daniel Boon G, et al (2000): A comparison of the cytologic and histologic features of meningiomas in four dogs. Vet Clin Pathol, 29, 29-34.
Abstract
In this study, cases of cutaneous clear cell adnexal carcinoma were diagnosed on the right forepaw of a 6-year-old female dog and on the right hind paw of an 8-year-old male dog. On the cytological examination, scattered cell groups were seen on the hemorrhagic background, whose cytoplasmic borders could hardly be distinguished. Although the cells showed marked pleomorphism, but were generally oval, round, or spindle-shaped. Anisokaryosis, karyomegaly, and one or more prominent nucleoli were noted in the nuclei. Pseudoinclusions were found in some cell nuclei. Histologically, it was centrally necrotic, expansive growth consisting of lobular areas in the dermis. The neoplastic cells consisted of oval round-shaped epithelioid cells with clear cytoplasm showing marked anisocytosis, anisorkaryosis and karyomegaly. Nuclei were oval or round in shape with prominent nucleoli. Cystic changes and calcified areas in layers (psammoma bodies) were noted in these areas. Few mitoses were found. In the immunohistochemical examination, tumor cells were positive for vimentin, S-100, MART1 (Melan A), and cytokeratin (MNF116) and negative for glial fibrillary acidic protein (GFAP) and smooth muscle actin (SMA). Based on these findings and results, the tumors were diagnosed as canine clear cell adnexal carcinoma. According to the literature review, this is the first case in which we found psammoma bodies and nuclear pseudo inclusions on microscopic examination of canine cutaneous clear cell adnexal carcinoma.
References
- Adamo PF, Cantile C, Steinberg H (2003): Evaluation of progesterone and estrogen receptor expression in 15 meningiomas of dogs and cats. Am J Vet Res, 64, 1310-1318.
- Barnhart KF, Wojcieszyn J, Storts RW (2002): Immunohistochemical staining patterns of canine meningiomas and correlation with published immunophenotypes. Vet Pathol, 39, 311-321.
- Goldschmidt MH, Dunstan RW, Stannard AA, et al (1998): Histological Classification of Epithelial and Melanocytic Tumors of the Skin of Domestic Animals. 2nd ser, vol. 3, Armed Forces Institute of Pathology, Washington, DC.
- Gross TL, Ihrke PJ, Walder EJ, et al (2005): Skin Diseases of the Dog and Cat. 2nd ed., Blackwell Publishing, Oxford.
- Jabara AG, Finnie JW (1978): Four cases of clear-cell hidradenocarcinomas in the dog. J Comp Pathol, 88, 525-532.
- Latouche EL, Arena CB, Ivey JW, et al (2018): High-frequency irreversible electroporation for intracranial meningioma: a feasibility study in a spontaneous canine tumor model. Technol Cancer Res Treat, 17, 1533033818785285.
- Mikaelian I, Wong V (2003): Follicular stem cell carcinoma: Histologic, immunohistochemical, ultrastructural, and clinical characterization in 30 dogs. Vet Pathol, 40, 433-444.
- Montoliu P, Anor S, Vidal E, et al (2006): Histological and immunohistochemical study of 30 cases of canine meningioma. J Comp Pathol, 135, 200-207.
- Piviani M, Sánchez MD, Patel RT (2012): Cytologic features of clear cell adnexal carcinoma in 3 dogs. Vet Clin Pathol, 41, 405-411.
- Ramos-Vara JA, Miller MA, Gilbreath E, et al (2010): Immunohistochemical detection of CD34, E-cadherin, claudin-1, glucose transporter 1, laminin, and protein gene product 9.5 in 28 canine and 8 feline meningiomas. Vet Pathol, 47, 725-737.
- Schulman FY, Lipscomb TP, Atkin TJ (2005): Canine cutaneous clear cell adnexal carcinoma: histopathology, immunohistochemistry, and biologic behavior of 26 cases. J Vet Diagnostic Investig, 17, 403-411.
- Sharif M, Reinacher M (2006): Clear cell trichoblastomas in two dogs. J Vet Med Ser A Physiol Pathol Clin Med, 53, 352-354.
- Yasuno K, Nishiyama S, Suetsugu F, et al (2009): Shirota K. Cutaneous clear cell adnexal carcinoma in a dog: special reference to cytokeratin expression. J Vet Med Sci, 71, 1513-1517.
- Zimmerman KL, Bender HS, Daniel Boon G, et al (2000): A comparison of the cytologic and histologic features of meningiomas in four dogs. Vet Clin Pathol, 29, 29-34.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Case Report |
| Authors | |
| Publication Date | December 30, 2022 |
| Published in Issue | Year 2023 |