Research Article
Investigation of serum anti-Müllerian hormone levels at follicular phase and interestrus period in queens
Abstract
The objectives of this study were: i) to report overall mean AMH serum concentrations in queens, ii) to determine relationship between serum AMH concentration with estradiol level, iii) to investigate the relationship between serum AMH with follicular phase and interestrus phase of the estrous cycle, iv) to discuss the usability of AMH as a biomarker to diagnosis of ovarian remnant syndrome in breeding season in queens. In the study, 64 healthy queens referred to clinics for routine ovariohysterectomy were used. After anamnesis, vaginal cytology, macroscopic examination of the uterus and ovaries and estradiol measurement, queens were divided into two groups: follicular phase (n: 45) and interestrus (n: 19). Estradiol and AMH levels in serum samples were determined by ELISA. In the evaluation of serum AMH concentrations, a statistical difference was determined between the follicular phase and interestrus (P˂0.05). A negative correlation was found between age and estradiol in both follicular phase (r = -0.171) and interestrus (r = -0.385) groups. A positive correlation was found between age and AMH in the interestrus (P˂0.01, r = 0.696). Serum AMH levels in the interestrus were found to be significantly higher than follicular phase (P˂0.05). It was thought that this increase in serum AMH levels during the interestrus period, which is the stage where oocytes were selected for ovulation, may be an indicator of the role of AMH in oocyte selection in queens, as in many other mammalian species.
Ethical Statement
The study was approved by the Animal Ethics Committee, University of Kırıkkale, Türkiye (Approval Number: 2019/29).
Supporting Institution
This research has been supported by Kırıkkale University Scientific Research Projects Coordination Unit. Project Number: 2019/102.
Project Number
2019/102
References
- Axnér E, Ström Holst B (2015): Concentrations of anti-Müllerian hormone in the domestic cat. Relation with spay or neuter status and serum estradiol. Theriogenology, 83, 817-21.
- Binder C, Aurich C, Reifinger M, et al (2019): Spontaneous ovulation in cats-Uterine findings and correlations with animal weight and age. Anim Reprod Sci, 209, 106167.
- Da Silva TFP, Da Silva LDM, Uchoa DC, et al (2006): Sexual characteristics of domestic queens kept in a natural equatorial photoperiod. Theriogenology, 66, 1476-1481.
- Dahiya P, Dahiya K, Dhankhar R, et al (2011): The Role of the Anti-Müllerian Hormone in Female Fertility: A Review. J Clin Diagn Res, 5, 384-387.
- Dresner EO (2018): Ovarian Remnant Sendrome. 451. In: GD Norsworthy (Ed), The Feline Patient. Wiley Blackwell, USA.
- Durlinger ALL, Visser JA, Themmen APN (2002); Regulation of ovarian function: the role of anti-Müllerian hormone. Reprod, 124, 601-609.
- Fontbonne A (2016): Ovulation in the Domestic Cat: Induced, Spontaneous or Both? Avaible at https://www.ivis.org/library/iscfr/iscfr-evssar-symposium-france-2016/ovulation-domestic-cat-induced-spontaneous-or-both. (Accessed July 15, 2022).
- Grint NJ, Murison PJ, Coe RJ, et al (2006): Assessment of the influence of surgical technique on postoperative pain and wound tenderness in cats following ovariohysterectomy. J Felin Med Surg, 8, 15-21.
- Heaps LA, Scudder CJ, Lipscomb VJ, et al (2017): Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat. JFMS Open Rep, 10, 2055116917722701.
- Hurni H (1981): Daylength and breeding in the domestic cat. Lab Anim, 15, 229-233.
- Johnston SD, Kustritz MVR, Olson PNS (2001): The Feline Estrous Cycle. 396-405. In: Canine and Feline Theriogenology. W.B. Saunders Publishing, Pennsylvania.
- Karkanaki A, Vosnakis C, Panidis D (2011): The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology. Hormones, 10, 95-103.
- Korkmaz Ö, Korkmaz D, Polat İM, et al (2016): Differences in the follicular morphology of young and aged bitches and their correlation with the anti-müllerian hormone. Kafkas Univ Vet Fak Derg, 22, 733-739.
- Kumar A, Kalra B, Patel A, et al (2010): Development of a second generation anti-Müllerian hormone (AMH) ELISA. J Immunol Methods, 362, 51-59.
- Lapuente C, Faya M, Blanco PG, et al (2023): Anti-Müllerian hormone in queens: Serum consentrations and total ovarian follicle population. Theriogenology, 197, 111-115.
- Little SE (2012): Female reproduction. Available at https://dx.doi.org/10.1016%2FB978-1-4377-0660-4.00040-5. (Accessed December 25, 2022).
- Nagashima J, Hansen BS, Songsasen N, et al (2016): Anti-Müllerian Hormone in the Domestic Dog during the Anestrus to Oestrous Transition. Reprod Domest Anim, 51, 158-164.
- Pir Yağcı İ, Polat İM, Pekcan M (2016): Evaluation of Age Releated Anti-Müllerian Hormone Variations in Domestic Cat. Kafkas Univ Vet Fak Derg, 22, 729-732.
- Pir Yagci İ, Pekcan M, Polat İM, et al (2016): Does serum anti‐Müllerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kits. Reprod Domest Anim, 51, 910-915.
- Place NJ, Hansen BS, Cheraskin JL, et al (2011): Measurement of serum anti-Müllerian hormone concentration in female dogs and cats before and after ovariohysterectomy. J Vet Diagn Invest, 23, 524-527.
- Rico C, Médigue C, Fabre S, et al (2011): Regulation of anti-Müllerian hormone production in the cow: a multiscale study at endocrine, ovarian, follicular, and granulosa cell levels. Biol Reprod, 84, 560-571.
- Schmidt PM, Chakraborty PK, Wildt DE (1983): Ovarian activity, circulating hormones and sexual behavior in the cat. II. Relationships during pregnancy, parturition, lactation and the postpartum estrus. Biol Reprod, 28, 657-671.
- Shille VM, Lundström KE, Stabenfeldt GH (1979): Follicular function in the domestic cat as determined by estradiol-17 β concentrations in plasma: relation to estrous behavior and cornification of exfoliated vaginal epithelium. Biol Reprod, 21, 953-963.
- Snoeck F, Sarrazin S, Wydooghe E, et al (2017): Age and anti- Müllerian hormone levels predict the success of in vitro maturation of cat oocytes. Reprod Dom Anim, 52, 98–102.
- Stephens S (2001): Reproduction Problems-Failure to Conseive. 297-305. In: MR Lappin, D Greco (Eds), Feline Internal Medicine Secret. Hanley&Belfus INC, Philadelphia.
- Turna Yilmaz Ö, Toydemir TS, Kırşan İ, et al (2015): Anti-Müllerian hormone as a diagnostic tool for ovarian remnant syndrome in bitches. Vet Res Commun, 39, 159-62.
- Visser JA, De Jong FH, Laven JS, et al (2006): Anti-Mullerian hormone: a new marker for ovarian function. Reprod, 131, 1-9.
- Walter B, Feulner H, Otzdorff C, et al (2019). Changes in anti-Mullerian hormone concentrations in bitches throughout the oestrous cycle. Theriogenology, 127, 114–119.
Year 2024,
, 225 - 229, 01.04.2024
Abstract
Supporting Institution
Kırıkkale Üniversitesi Bilimsel Araştırmalar Proje Ofisi
Project Number
2019/102
References
- Axnér E, Ström Holst B (2015): Concentrations of anti-Müllerian hormone in the domestic cat. Relation with spay or neuter status and serum estradiol. Theriogenology, 83, 817-21.
- Binder C, Aurich C, Reifinger M, et al (2019): Spontaneous ovulation in cats-Uterine findings and correlations with animal weight and age. Anim Reprod Sci, 209, 106167.
- Da Silva TFP, Da Silva LDM, Uchoa DC, et al (2006): Sexual characteristics of domestic queens kept in a natural equatorial photoperiod. Theriogenology, 66, 1476-1481.
- Dahiya P, Dahiya K, Dhankhar R, et al (2011): The Role of the Anti-Müllerian Hormone in Female Fertility: A Review. J Clin Diagn Res, 5, 384-387.
- Dresner EO (2018): Ovarian Remnant Sendrome. 451. In: GD Norsworthy (Ed), The Feline Patient. Wiley Blackwell, USA.
- Durlinger ALL, Visser JA, Themmen APN (2002); Regulation of ovarian function: the role of anti-Müllerian hormone. Reprod, 124, 601-609.
- Fontbonne A (2016): Ovulation in the Domestic Cat: Induced, Spontaneous or Both? Avaible at https://www.ivis.org/library/iscfr/iscfr-evssar-symposium-france-2016/ovulation-domestic-cat-induced-spontaneous-or-both. (Accessed July 15, 2022).
- Grint NJ, Murison PJ, Coe RJ, et al (2006): Assessment of the influence of surgical technique on postoperative pain and wound tenderness in cats following ovariohysterectomy. J Felin Med Surg, 8, 15-21.
- Heaps LA, Scudder CJ, Lipscomb VJ, et al (2017): Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat. JFMS Open Rep, 10, 2055116917722701.
- Hurni H (1981): Daylength and breeding in the domestic cat. Lab Anim, 15, 229-233.
- Johnston SD, Kustritz MVR, Olson PNS (2001): The Feline Estrous Cycle. 396-405. In: Canine and Feline Theriogenology. W.B. Saunders Publishing, Pennsylvania.
- Karkanaki A, Vosnakis C, Panidis D (2011): The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology. Hormones, 10, 95-103.
- Korkmaz Ö, Korkmaz D, Polat İM, et al (2016): Differences in the follicular morphology of young and aged bitches and their correlation with the anti-müllerian hormone. Kafkas Univ Vet Fak Derg, 22, 733-739.
- Kumar A, Kalra B, Patel A, et al (2010): Development of a second generation anti-Müllerian hormone (AMH) ELISA. J Immunol Methods, 362, 51-59.
- Lapuente C, Faya M, Blanco PG, et al (2023): Anti-Müllerian hormone in queens: Serum consentrations and total ovarian follicle population. Theriogenology, 197, 111-115.
- Little SE (2012): Female reproduction. Available at https://dx.doi.org/10.1016%2FB978-1-4377-0660-4.00040-5. (Accessed December 25, 2022).
- Nagashima J, Hansen BS, Songsasen N, et al (2016): Anti-Müllerian Hormone in the Domestic Dog during the Anestrus to Oestrous Transition. Reprod Domest Anim, 51, 158-164.
- Pir Yağcı İ, Polat İM, Pekcan M (2016): Evaluation of Age Releated Anti-Müllerian Hormone Variations in Domestic Cat. Kafkas Univ Vet Fak Derg, 22, 729-732.
- Pir Yagci İ, Pekcan M, Polat İM, et al (2016): Does serum anti‐Müllerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kits. Reprod Domest Anim, 51, 910-915.
- Place NJ, Hansen BS, Cheraskin JL, et al (2011): Measurement of serum anti-Müllerian hormone concentration in female dogs and cats before and after ovariohysterectomy. J Vet Diagn Invest, 23, 524-527.
- Rico C, Médigue C, Fabre S, et al (2011): Regulation of anti-Müllerian hormone production in the cow: a multiscale study at endocrine, ovarian, follicular, and granulosa cell levels. Biol Reprod, 84, 560-571.
- Schmidt PM, Chakraborty PK, Wildt DE (1983): Ovarian activity, circulating hormones and sexual behavior in the cat. II. Relationships during pregnancy, parturition, lactation and the postpartum estrus. Biol Reprod, 28, 657-671.
- Shille VM, Lundström KE, Stabenfeldt GH (1979): Follicular function in the domestic cat as determined by estradiol-17 β concentrations in plasma: relation to estrous behavior and cornification of exfoliated vaginal epithelium. Biol Reprod, 21, 953-963.
- Snoeck F, Sarrazin S, Wydooghe E, et al (2017): Age and anti- Müllerian hormone levels predict the success of in vitro maturation of cat oocytes. Reprod Dom Anim, 52, 98–102.
- Stephens S (2001): Reproduction Problems-Failure to Conseive. 297-305. In: MR Lappin, D Greco (Eds), Feline Internal Medicine Secret. Hanley&Belfus INC, Philadelphia.
- Turna Yilmaz Ö, Toydemir TS, Kırşan İ, et al (2015): Anti-Müllerian hormone as a diagnostic tool for ovarian remnant syndrome in bitches. Vet Res Commun, 39, 159-62.
- Visser JA, De Jong FH, Laven JS, et al (2006): Anti-Mullerian hormone: a new marker for ovarian function. Reprod, 131, 1-9.
- Walter B, Feulner H, Otzdorff C, et al (2019). Changes in anti-Mullerian hormone concentrations in bitches throughout the oestrous cycle. Theriogenology, 127, 114–119.
There are 28 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Biochemistry, Veterinary Obstetrics and Gynecology |
| Journal Section | Research Article |
| Authors | |
| Project Number | 2019/102 |
| Early Pub Date | September 21, 2023 |
| Publication Date | April 1, 2024 |
| Published in Issue | Year 2024 |