Investigation of hereditary cholesterol deficiency (CD) in Holstein Cattle at the state farms in Türkiye

Ceyhan Özbeyaz; Melike Özcan

doi:10.33988/auvfd.1295330

Research Article

Investigation of hereditary cholesterol deficiency (CD) in Holstein Cattle at the state farms in Türkiye

Year 2024, , 321 - 328, 10.07.2024

Ceyhan Özbeyaz , Melike Özcan

https://doi.org/10.33988/auvfd.1295330

Abstract

Türkiye is exposed to international animal and semen movements. For this reason, Türkiye is very affected by diseases and hereditary disorders. State Farms is a state organization that raises and distributes breeding cattle. This study was aimed at investigating the presence and distribution of mutant alleles causing cholesterol deficiency (CD) disorder in Holstein cattle on state farms. For this purpose, blood and sperm samples were collected from 466 Holstein cattle. The real-time PCR method was used for genotyping. A total of seven cattle were found to be heterozygous. The frequency of the mutant allele was determined to be 0.75%. The kinship of four cattle carrying the mutant allele with Mauglin Storm, the bull in which this disease was first detected, was determined. The presence of cattle carrying the mutant allele in Türkiye is quite low compared to other countries. The Apolipoprotein-B (APOB) mutant allele was found at low frequencies and detected for the first time at the State Farms in Türkiye. Therefore, it is necessary to develop control programs by screening other Holstein herds.

Keywords

Apolipoprotein-B, Cattle, Cholestrol Deficiency, Holstein, Mutation

Ethical Statement

This study was carried out after the animal experiment was approved by Ankara University Local Ethics Committee (Decision number: 2017-10-88).

Supporting Institution

This research was supported by Ankara University BAP (Scientific Research Projects) with project number 18L0239012.

Project Number

18L0239012

Thanks

This article was produced from the PhD thesis of the second author under the consultation of the first author. The authors wish to thank the General Directorate of Agricultural Enterprises, Republic of Türkiye Ministry of Agriculture and Forestry. We thank Prof. Dr. Metin Erdoğan for his contributions to genetic analysis.

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