Letter to Editor
Immunohistochemical investigation of the damage to and repair of myelin, and astrocyte activity in small ruminants resulting from with natural meningoencephalitic listeriosis
Abstract
Meningoencephalitic listeriosis is a significant bacterial disease in various species. Common characteristics include microabscesses in the brainstem, midbrain and cerebellum. Many aspects of damage to the central nervous system caused by the disease remain obscure. We investigated central nervous system damage by assessing the presence of biomarkers such as galactocerebroside (GAL-C), glial fibrilary acidic protein (GFAP) and myelin basic protein (MBP) in brain tissues of sheep and goats of various ages, which naturally infected with listeriosis. We examined sections of pons, medulla oblongata, rostral colliculus, cerebellum, thalamus and cornu ammonis and found increased MBP (P<0.01), GAL-C (P<0.01) and GFAP (P<0.01) expression. This study showed that myelin damage in meningoencephalitic listeriosis was an important neuropathological finding. The most prominent finding of this study is the beginning of the regeneration as soon as myelin damage occurs
Keywords
References
- Akiyama Y, Asahi O, Hosoda T (1957): Studies on the mechanism of infection of the brain with Listeria monocytogenes. Am J Vet Res, 18, 147-157.
- Altimira J, Prats N, Lopez S, et al. (2000): Effect of selenium deficiency on the development of central nervous system lesions in murine listeriosis. J Comp Pathol, 123, 104-109.
- Campero CM, Odeon AC, Cipolla AL, et al. (2002): Demonstration immunohistochemistry in formalin-fixed brain tissues from natural cases of ovine and bovine encephalitis. J Vet Med B Infect Dis Vet Publ Health, 49, 379-383. by
- Cordy DR, Osebold JW (1959): The neuropathogenesis of Listeria encephalomyelitis in sheep and mice. J Infect Dis, 104, 164-173.
- Dinçel GC, Kul O (2015): Increased expressions of ADAMTS-13, neuronal nitric oxide synthase, and neurofilament correlate with severity of neuropathology in Border disease virus-infected small ruminants. PLoS One. 2015 Mar 23;10 (3): e0120005.
- Dinçel GC, Kul O (2015): eNOS and iNOS trigger apoptosis in the brains of sheep and goats naturally infected with the border disease virus. Histol Histopathol, 30, 1233- 42.
- Dons L, Jin Y, Kristensson K, et al. (2007): Axonal transport of Listeria monocytogenes and nerve-cell-induced bacterial killing. J Neurosci Res, 85, 2529-37.
- Dramsi S, Lévi S, Triller A, et al. (1998): Entry of Listeria monocytogenes into neurons occurs by cell-to-cell spread: an in vitro study. Infect Immun, 66, 4461-68.
- Hazıroğlu R (2000): Listeriosis, 308-310. In: R Hazıoğlu and ÜH Milli (Ed.) Veteriner Patoloji. I. Cilt, Özkan Matbaacılık, Ankara.
- Henke D, Rupp S, Gaschen V, et al. (2015): Listeria monocytogenes spreads within the brain by actin-based intra-axonal migration. Infect Immun, 83, 2409-19.
- Innes JRM, Saunders LZ (1962): X. Bacterial Infection, III Listeriosis, 508-510. In: LZ Saunders (Ed) Comparative Neuropathology, Academic Press, New York and London.
- Kabakci N, Yarim M (2004): The expression of CD 14 antigen in experimental encephalitic listeriosis in rabbits. Rev Med Vet, 155, 151-155.
- Krueger N, Low C, Donachie W (1995): Phenotypic characterization of the cells of the inflammatory response in ovine encephalitic listeriosis. J Comp Pathol, 113, 263- 275. 14. Lecuit M (2005): Understanding how Listeria monocytogenes targets and crosses host barriers. Clin Microbiol Infect, 11, 427-513.
- Luna GL (1968): Manuel of histologic staining methods of the Armed Forces Institute of Pathology.3rd ed., McGraw Hill, New York.
- Olafson P (2016): Listerial encephalitis (circling disease) of sheep, cattle and goats. Cornell Vet, 30, 141-150.
- Orndorff PE, Hamrick TS, Smoak IW, et al. (2006): Host and bacterial factors in listeriosis pathogenesis. Vet Microbiol, 114, 1-15.
- Pensinger DA, Aliota MT, Schaenzer AJ, et al. (2014): Selective pharmacologic inhibition of a PASTA kinase increases Listeria monocytogenes susceptibility to β-lactam antibiotics. Antimicrob Agents Chemother, 58, 4486-94.
- Summers BA, Cummings JF, De Lahunta A (1995): Inflammatory disease of the central nervous system, 133- 136. Veterinary Neuropathology. Mosby-Year Book, St. Louis, Missouri.
- Wardrope DD, Macleod NS (1983): Outbreak of listeria meningoencephalitis in young lambs. Vet Rec, 113, 213- 214.
- Weinstock D, Horton SB, Rowland PH (1995): Rapid diagnosis immunohistochemistry in formalin-fixed brain tissue. Vet Pathol, 32, 193-195. monocytogenes by Geliş tarihi: 09.11.2016 / Kabul tarihi: 22.01.2017 Address for correspondence: Güngör Çağdaş DİNÇEL Aksaray University, Laboratory and Veterinary Science, Eskil Vocational High School, 68800, Eskil, Aksaray, Turkey. gcdincel@yahoo.com.tr
Küçük ruminantlardaki doğal meningoensefalitik listerioziste miyelin hasar ve onarımı ile astrositaktivitesinin immunohistokimyasal olarak incelenmesi
Abstract
Meningoencephalitic listeriosis çeşitli türlerde önemli bir bakteriyel hastalıktır. Hastalığın karakteristik özelliği beyin sapı, orta beyin ve beyincikte görülen mikroapselerdir. Hastalık sebebiyle merkezi sinir sisteminde meydana gelen hasarlar birçok açıdan hala belirsizliğini korumaktadır. Bu çalışmada, listeriozis ile doğal enfekte değişik yaşlardaki küçük ruminantların merkezi sinir sistemlerinde görülen hasarın varlığı, galaktoserebrosid (GAL-C), glial fibrilary asidik protein (GFAP) ve miyelin temel protein (MBP) gibi biyolojik belirteçlerle araştırıldı. Pons, medulla oblongata, colliculus rostralis, cerebellum, thalamus ve cornu ammonis gibi bölümler incelendi ve beyin hasarını gösteren MBP (P<0.01) ve GFAP (P<0.01) ile birlikte GAL-C (P<0.01) ekspresyonlarının da arttığı görüldü. Bu çalışma, meningoensefalitik listeriyozisdeki miyelin hasarının önemli bir nöropatolojik bulgu olduğunu gösterdi. Araştırmanın en belirgin bulgusu, miyelin hasarı meydana gelirken rejenerasyonun da başladığının gösterilmesidir
Keywords
References
- Akiyama Y, Asahi O, Hosoda T (1957): Studies on the mechanism of infection of the brain with Listeria monocytogenes. Am J Vet Res, 18, 147-157.
- Altimira J, Prats N, Lopez S, et al. (2000): Effect of selenium deficiency on the development of central nervous system lesions in murine listeriosis. J Comp Pathol, 123, 104-109.
- Campero CM, Odeon AC, Cipolla AL, et al. (2002): Demonstration immunohistochemistry in formalin-fixed brain tissues from natural cases of ovine and bovine encephalitis. J Vet Med B Infect Dis Vet Publ Health, 49, 379-383. by
- Cordy DR, Osebold JW (1959): The neuropathogenesis of Listeria encephalomyelitis in sheep and mice. J Infect Dis, 104, 164-173.
- Dinçel GC, Kul O (2015): Increased expressions of ADAMTS-13, neuronal nitric oxide synthase, and neurofilament correlate with severity of neuropathology in Border disease virus-infected small ruminants. PLoS One. 2015 Mar 23;10 (3): e0120005.
- Dinçel GC, Kul O (2015): eNOS and iNOS trigger apoptosis in the brains of sheep and goats naturally infected with the border disease virus. Histol Histopathol, 30, 1233- 42.
- Dons L, Jin Y, Kristensson K, et al. (2007): Axonal transport of Listeria monocytogenes and nerve-cell-induced bacterial killing. J Neurosci Res, 85, 2529-37.
- Dramsi S, Lévi S, Triller A, et al. (1998): Entry of Listeria monocytogenes into neurons occurs by cell-to-cell spread: an in vitro study. Infect Immun, 66, 4461-68.
- Hazıroğlu R (2000): Listeriosis, 308-310. In: R Hazıoğlu and ÜH Milli (Ed.) Veteriner Patoloji. I. Cilt, Özkan Matbaacılık, Ankara.
- Henke D, Rupp S, Gaschen V, et al. (2015): Listeria monocytogenes spreads within the brain by actin-based intra-axonal migration. Infect Immun, 83, 2409-19.
- Innes JRM, Saunders LZ (1962): X. Bacterial Infection, III Listeriosis, 508-510. In: LZ Saunders (Ed) Comparative Neuropathology, Academic Press, New York and London.
- Kabakci N, Yarim M (2004): The expression of CD 14 antigen in experimental encephalitic listeriosis in rabbits. Rev Med Vet, 155, 151-155.
- Krueger N, Low C, Donachie W (1995): Phenotypic characterization of the cells of the inflammatory response in ovine encephalitic listeriosis. J Comp Pathol, 113, 263- 275. 14. Lecuit M (2005): Understanding how Listeria monocytogenes targets and crosses host barriers. Clin Microbiol Infect, 11, 427-513.
- Luna GL (1968): Manuel of histologic staining methods of the Armed Forces Institute of Pathology.3rd ed., McGraw Hill, New York.
- Olafson P (2016): Listerial encephalitis (circling disease) of sheep, cattle and goats. Cornell Vet, 30, 141-150.
- Orndorff PE, Hamrick TS, Smoak IW, et al. (2006): Host and bacterial factors in listeriosis pathogenesis. Vet Microbiol, 114, 1-15.
- Pensinger DA, Aliota MT, Schaenzer AJ, et al. (2014): Selective pharmacologic inhibition of a PASTA kinase increases Listeria monocytogenes susceptibility to β-lactam antibiotics. Antimicrob Agents Chemother, 58, 4486-94.
- Summers BA, Cummings JF, De Lahunta A (1995): Inflammatory disease of the central nervous system, 133- 136. Veterinary Neuropathology. Mosby-Year Book, St. Louis, Missouri.
- Wardrope DD, Macleod NS (1983): Outbreak of listeria meningoencephalitis in young lambs. Vet Rec, 113, 213- 214.
- Weinstock D, Horton SB, Rowland PH (1995): Rapid diagnosis immunohistochemistry in formalin-fixed brain tissue. Vet Pathol, 32, 193-195. monocytogenes by Geliş tarihi: 09.11.2016 / Kabul tarihi: 22.01.2017 Address for correspondence: Güngör Çağdaş DİNÇEL Aksaray University, Laboratory and Veterinary Science, Eskil Vocational High School, 68800, Eskil, Aksaray, Turkey. gcdincel@yahoo.com.tr
There are 20 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA34FC47JV |
| Journal Section | Research Article |
| Authors | |
| Publication Date | September 1, 2018 |
| Published in Issue | Year 2018 |