Letter to Editor
The association between insulin-like growth factors I, II and bovine papillomavirus type-1 expressions in naturally occuring bovine fibropapilloma cases
Abstract
In this study, we hypothesized that insulin-like growth factors (IGFs) may have a combine effect together with BPV-1 in the etiopathogenesis of fibropapilloma. With this aim, macroscopic and histopathological findings of the fibropapillomatous changes were described in masses collected from the skin of neck, hindlimbs and abdominal region of 15 cattle, ranging from 14 to 23 months old. In several cases, hyperkeratosis (n=7) and/or parakeratosis (n=8), acanthosis (n=15), degenerative changes (n=15) and inflammatory cell infiltrations (n=9), and also vascularization (n=15) were accompanied to the neoplastic cells comprising paranchyme and stroma. In terms of virus entity in collected samples, L1 and L2 genes of BPV-1 were found to be positive by PCR. Immunohistochemically, BPV-1, IGF-I and IGF II expressions were found parallel. IGF-I positivities were stronger and more common in the epidermal cells and connective tissue components when compared with IGF-II positivity. In general, immunolocalization of both IGF-I and IGF-II were seen in the cytoplasm and membranes of all cell layers in the epidermis and only in the fibrocytes and fibroblasts in addition to collagen bundles. We concluded that IGF-I and IGF-II could have an effect as much as BPV-1 in pathogenesis of fibropapillomatous changes in the epidermis and dermis
References
- Baege AC, Disbrow GL, Schlegel R (2004): IGFBP-3, a marker of cellular senescence, is overexpressed in human papillomavirus-immortalized cervical cells and enhances IGF-I induced mitogenesis. J Virol, 78 (11), 5720-5727.
- Barreca A, De Luca M, Del Monte P et al. (1992): In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors. J Cell Physiol, 151, 262-268.
- Borzacchiello G, Roperto papillomavirus, papillomas and cancer in cattle. Vet Res, 39 (5), 45. F (2008): Bovine
- Campo MS (1997): Bovine Papillomavirus and Cancer. Vet Journal, 154, 175-188.
- Cheville NF, Olson C (1964): Epithelial and Fibroblast Proliferation in Bovine Cutenous Papillomatosis. Epithelial and fibroblastic proliferation in bovine cutenous papillomatosis. Path Vet, 1, 248-257.
- Clemmons DR (1997): Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev, 8, 45-62.
- Daughaday WH, Rotwein P (1989): Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev, 10, 68–91.
- Ergunay K, Mısırlıoğlu M, Fırat P, et al. (2008): Detection and typing of human papilloma virus by polimerase chain reaction and hybridization assay in cervical samples with cytological abnormalities. Microbiol Bull, 42 (2), 273-282.
- Ergunay K, Mısırlıoğlu M, Pınar F, et al. (2007): Human papilloma virus DNA in cervical samples with cytological abnormalities and typing of the virus. Microbiol Bull, 41 (2), 219-226.
- Goldshcmidt MH, Hendrick MJ (2002): Tumors of the skin. Chapter 11. In: D.J. Meuten (Ed), Tumors in Domestic Animals. Fourth Edition, Iowa State Press, USA, pp 47-50. 11. Gülbahar
- MY, Yüksel H, Aslan L (2003): Angiokeratomatous papillomavirus in a calf. Vet Path, 40 (5), 582-586.
- Harris TG, Burk RD, Yu H, et al. (2008): Insulin-like growth factor axis and oncogenic human papillomavirus natural history. Cancer Epidemiol Biomarkers Prev, 17 (1), 245-248.
- Hatama S, Ishihara R, Ueda Y, et al. (2011): Detection of a novel bovine papillomavirus type 11 (BPV-11) using xipapillomavirus consensus polymerase chain reaction primers. Arch Virol, 156 (7), 1281-1285.
- Jarrett WFH (1985): The natural history of bovine papillomavirus infections. In: G Klein (Ed): Advances in Viral Oncology, vol 5, Raven Press, New York, pp 83-101.
- Jelinek F, Tachezy R (2005): Cutenous Papillomatosis in Cattle. J Comp Path, 132, 70-81.
- Jones JI, Clemmons DR (1995): Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev, 16, 3–34.
- Jozefiak A, Pacholska-Bogalska J, Myga-Nowak M, et al. (2008): Serum and tissue levels of insulin-like growth factor-I in women with dysplasia and HPV-positive cervical cancer. Mol Med Rep, 1 (2), 231-237.
- Kuramoto H, Hongo A, Liu YX, et al. (2008): Immunohistochemical evaluation of insulin-like growth factor I receptor status in cervical cancer specimens. Acta Med Okayama, 62 (4), 251-259.
- Lindsey CL, Almeida ME, Vicari CF, et al. (2009): Bovine papillomavirus DNA in milk, blood, urine, semen, and spermatozoa of bovine papillomavirus-infected animals. Genet Mol Res, 8 (1), 310-318.
- Lunardi M, Alfieri AA, Otonel RA, et al. (2013): Genetic characterization of a novel bovine papillomavirus member of the Deltapapillomavirus genus. Vet Microbiol, 162 (1), 207-213.
- Minshall C, Arkins S, Straza J, et al. (1997): IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors. J Immunol, 159 (3), 1225–1232.
- Morrione A, Deangelis T, Baserga R (1995): Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes. J Virol, 69 (9), 5300-5303.
- Parrizas M, Leroith D (1997): Insulin-like growth factor- 1 inhibition of apoptosis is associated with increased expression of the Bcl-xL gene product. Endocrinology, 138, 1355–1358.
- Rosenfeld RG, Lamson G, Pham H, et al. (1990): Insulin like growth factor-binding proteins. Recent Prog Horm Res, 46, 99–159.
- Rubini M, Hongo A, DʼAmbrosio C, et al. (1997): The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp Cell Res, 230, 284-292.
- Sara VR, Hall K (1990): Insulin-like growth factors and their binding proteins. Physiol Rev, 70, 591–614.
- Stewart CE, Rotwein P (1996): Growth, differentiation, and survival:multiple physiological functions for insulin- like growth factors. Physiol Rev, 76, 1005–1026.
- Tan MT, Yıldırım Y, Sözmen M, et al. (2012): Histopathological, Immunohistochemical and Molecular Study of Cutaneous Bovine Papillomatosis. Kafkas Univ Vet Fak Derg, 18 (5), 739-744.
- Yu H, Rohan T (2000): Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst, 29, 1472-1481.
- Zur Hausen H (1996): Papillomavirus infections—a major cause of human cancers. Biochim Biophys Acta, 1288 (2), 55-78.
- Zur Hausen H (2000): Papillomavirus causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst, 92 (9), 690-698.
Doğal gelişen sığır fibropapilloma olgularında insülin-benzeri büyüme faktörü I, II ve sığırpapillomavirus tip-1 ekspresyonları arasındaki ilişki
Abstract
Bu çalışmada, insülin benzeri büyüme faktörlerinin (IGF'ler) fibropapillomanın etiyopatogenezinde BPV-1 ile birlikte kombine bir etkisinin olabileceği ileri sürülmüştür. Bu amaçla, yaşları 14-23 ay arasında değişen toplam 15 sığırda boyun, arka bacaklar ve abdominal bölgede fibropapillomatöz değişikliklere ait makroskopik ve histopatolojik bulgular tanımlanmıştır. Tümörün paranşim ve stromasını oluşturan neoplazik hücrelere çeşitli olgularda hiperkeratozis (n=7), ve/veya parakeratozis (n=8), acanthosis (n=15), dejeneratif değişiklikler (n=15), yangısal hücre infiltrasyonları (n=9) ve vaskülarizasyon (n=15)'un eşlik ettiği dikkati çekmiştir. Toplanan örneklerde virusun varlığı, BPV-1'in L1 ve L2 genlerine PCR ile bakılarak pozitif olduğu bulunmuştur. İmmunohistokimyasal olarak BPV-1, IGF-I ve IGF-II ekspresyonlarının birbirine paralel olduğu belirlenmiştir. IGF-I pozitivitelerinin, IGF-II ile karşılaştırıldığında epidermal ve bağ doku hücrelerinde daha şiddetli ve yaygın olduğu gözlenmiştir. Hem IGF-I hem de IGF-II için immunpozitiflikler genelde epidermisin tüm katmanlarındaki hücrelerin sitoplazma ve membranlarında, kollajen demetlerin yanı sıra fibrosit ile fibroblastlarda gözlenmiştir. Fibropapillomalarda epidermis ve dermisteki fibropapillomatöz değişikliklerin patogenezisinde IGF-I and IGF-II'nin en az BPV-1 kadar etkili olabileceği sonucuna varılmıştır
References
- Baege AC, Disbrow GL, Schlegel R (2004): IGFBP-3, a marker of cellular senescence, is overexpressed in human papillomavirus-immortalized cervical cells and enhances IGF-I induced mitogenesis. J Virol, 78 (11), 5720-5727.
- Barreca A, De Luca M, Del Monte P et al. (1992): In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors. J Cell Physiol, 151, 262-268.
- Borzacchiello G, Roperto papillomavirus, papillomas and cancer in cattle. Vet Res, 39 (5), 45. F (2008): Bovine
- Campo MS (1997): Bovine Papillomavirus and Cancer. Vet Journal, 154, 175-188.
- Cheville NF, Olson C (1964): Epithelial and Fibroblast Proliferation in Bovine Cutenous Papillomatosis. Epithelial and fibroblastic proliferation in bovine cutenous papillomatosis. Path Vet, 1, 248-257.
- Clemmons DR (1997): Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev, 8, 45-62.
- Daughaday WH, Rotwein P (1989): Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev, 10, 68–91.
- Ergunay K, Mısırlıoğlu M, Fırat P, et al. (2008): Detection and typing of human papilloma virus by polimerase chain reaction and hybridization assay in cervical samples with cytological abnormalities. Microbiol Bull, 42 (2), 273-282.
- Ergunay K, Mısırlıoğlu M, Pınar F, et al. (2007): Human papilloma virus DNA in cervical samples with cytological abnormalities and typing of the virus. Microbiol Bull, 41 (2), 219-226.
- Goldshcmidt MH, Hendrick MJ (2002): Tumors of the skin. Chapter 11. In: D.J. Meuten (Ed), Tumors in Domestic Animals. Fourth Edition, Iowa State Press, USA, pp 47-50. 11. Gülbahar
- MY, Yüksel H, Aslan L (2003): Angiokeratomatous papillomavirus in a calf. Vet Path, 40 (5), 582-586.
- Harris TG, Burk RD, Yu H, et al. (2008): Insulin-like growth factor axis and oncogenic human papillomavirus natural history. Cancer Epidemiol Biomarkers Prev, 17 (1), 245-248.
- Hatama S, Ishihara R, Ueda Y, et al. (2011): Detection of a novel bovine papillomavirus type 11 (BPV-11) using xipapillomavirus consensus polymerase chain reaction primers. Arch Virol, 156 (7), 1281-1285.
- Jarrett WFH (1985): The natural history of bovine papillomavirus infections. In: G Klein (Ed): Advances in Viral Oncology, vol 5, Raven Press, New York, pp 83-101.
- Jelinek F, Tachezy R (2005): Cutenous Papillomatosis in Cattle. J Comp Path, 132, 70-81.
- Jones JI, Clemmons DR (1995): Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev, 16, 3–34.
- Jozefiak A, Pacholska-Bogalska J, Myga-Nowak M, et al. (2008): Serum and tissue levels of insulin-like growth factor-I in women with dysplasia and HPV-positive cervical cancer. Mol Med Rep, 1 (2), 231-237.
- Kuramoto H, Hongo A, Liu YX, et al. (2008): Immunohistochemical evaluation of insulin-like growth factor I receptor status in cervical cancer specimens. Acta Med Okayama, 62 (4), 251-259.
- Lindsey CL, Almeida ME, Vicari CF, et al. (2009): Bovine papillomavirus DNA in milk, blood, urine, semen, and spermatozoa of bovine papillomavirus-infected animals. Genet Mol Res, 8 (1), 310-318.
- Lunardi M, Alfieri AA, Otonel RA, et al. (2013): Genetic characterization of a novel bovine papillomavirus member of the Deltapapillomavirus genus. Vet Microbiol, 162 (1), 207-213.
- Minshall C, Arkins S, Straza J, et al. (1997): IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors. J Immunol, 159 (3), 1225–1232.
- Morrione A, Deangelis T, Baserga R (1995): Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes. J Virol, 69 (9), 5300-5303.
- Parrizas M, Leroith D (1997): Insulin-like growth factor- 1 inhibition of apoptosis is associated with increased expression of the Bcl-xL gene product. Endocrinology, 138, 1355–1358.
- Rosenfeld RG, Lamson G, Pham H, et al. (1990): Insulin like growth factor-binding proteins. Recent Prog Horm Res, 46, 99–159.
- Rubini M, Hongo A, DʼAmbrosio C, et al. (1997): The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp Cell Res, 230, 284-292.
- Sara VR, Hall K (1990): Insulin-like growth factors and their binding proteins. Physiol Rev, 70, 591–614.
- Stewart CE, Rotwein P (1996): Growth, differentiation, and survival:multiple physiological functions for insulin- like growth factors. Physiol Rev, 76, 1005–1026.
- Tan MT, Yıldırım Y, Sözmen M, et al. (2012): Histopathological, Immunohistochemical and Molecular Study of Cutaneous Bovine Papillomatosis. Kafkas Univ Vet Fak Derg, 18 (5), 739-744.
- Yu H, Rohan T (2000): Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst, 29, 1472-1481.
- Zur Hausen H (1996): Papillomavirus infections—a major cause of human cancers. Biochim Biophys Acta, 1288 (2), 55-78.
- Zur Hausen H (2000): Papillomavirus causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst, 92 (9), 690-698.
There are 31 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA37MD42KR |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2018 |
| Published in Issue | Year 2018 |