Letter to Editor
Effects of season and altitude on biological active certain phenolic compounds levels and partial standardization of propolis
Abstract
Propolis has antibacterial, antiviral, antifungal, anti-inflammatory, antitumoral, antioxidant, immunomodulatory, tissue regeneration, anti-ulcer, analgesic, local anaesthetic, and antiseptic effects related to its chemical components. The aim of the present study was to determine certain biological active phenolic compounds and their levels in propolis collected from Bursa province, and to evaluate propolis quality and effects of altitude and season. Propolis samples were collected using propolis traps from 15 different constant apiaries at varying altitudes (between 50 and 1000 m) located in Bursa province Turkey, during the spring, summer and autumn of 2012. Fourteen flavonoid and phenolic acids in ethanolic extracts were investigated by liquid chromatography tandem-mass spectrometry (LC-MS/MS). Galangin, naringenin, pinocembrin, caffeic acid and caffeic acid phenylethyl ester were detected in all samples (45 samples) for all seasons and altitudes. Significant differences were determined for certain phenolic compounds levels across altitudes and seasons. In the present study results showed that qualitative and quantitative analysis of propolis for useful phenolic compounds may provide partial standardization of propolis depend on altitude and season
Keywords
References
- Aliyazıcıoglu R, Sahin S, Erturk O, et al. (2013): Properties of phenolic composition and biological activity of propolis from Turkey. Int J Food Prop, 16, 277-287.
- Bankova V (2005): Chemical diversity of propolis and the problem of standardization. J Ethnopharmacol, 100, 114-117.
- Bankova VS, De Castro SL, Marcucci MC (2000): Propolis: Recent advances in chemistry and plant origin. Apidologie, 31, 3-15.
- Banskota AH, Tezuka Y, Kadota S (2001): Recent progress in pharmacological research of propolis. Phytother Res, 15, 561-571.
- Barbarić M, Mišković K, Bojić M, et al. (2011): Chemical composition of the ethanolic propolis extracts and its effect on HeLa cells. J Ethnopharmacol, 135, 772-778.
- Barros MP, Lemos M, Maistro EL, et al. (2008): Evaluation of antiulcer activity of the main phenolic acids found in Brazilian green propolis. J Ethnopharmacol, 120, 372-377.
- Cam Y, Koç AN, Silici S, et al. (2009): Treatment of dermatophytosis in young cattle with propolis and Whitfield’s ointment. Veterinary Record, 165, 57-58.
- Cardoso RL, Maboni F, Machado G, et al. (2010): Antimicrobial activity of propolis extract against Staphylococcus coagulase positive and Malassezia pachydermatis of canine otitis. Vet Microbiol, 142, 432-434.
- Castro ML, Cury JA, Rosalen PL, et al. (2007): Propolis from southeastern and northeastern of Brazil: The influence of seasonality in antibacterial activity and phenolic composition. Quim Nova, 30, 1512-1516.
- Chaillou LL, Nazareno AM (2009): Chemical variability in propolis from Santiago del Estero, Argentina, related to the arboreal environment as the sources of resins. J Sci Food Agric, 89, 978-983.
- Cruz Sánchez TA, García PAE, Zamora CIL, et al. (2014): Use of propolis for topical treatment of dermatophytosis in dog. OJVM, 4, 239-245.
- Erdogan S, Ates B, Durmaz G, et al. (2011): Pressurized liquid extraction of phenolic compounds from Anatolia propolis and their radical scavenging capacities. Food Chem Toxicol, 49, 1592-1597.
- Isla MI, Zampini IC, Ordóñez RM, et al. (2009): Effect of seasonal variations and collection form on antioxidant activity of propolis from San Juan, Argentina. J Med Food, 12, 1334-1342.
- Liu R, Gao M, Yang ZH, et al. (2008): Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro. Brain Res, 24, 104-115.
- Lozina LA, Peichoto ME, Boehringer SI, et al. (2010): Efficacy of Argentine propolis formulation for topical treatment of canine otitis extern. Arq Bras Med Vet Zootec, 62, 1359-1366.
- Medana C, Carbone F, Aigotti R, et al. (2008): Selective analysis of phenolic compounds in propolis by HPLC- MS/MS. Phytochem Anal, 19, 32-39.
- Pellati F, Orlandini G, Pinetti D, et al. (2011): HPLC- DAD and HPLC-ESI-MS/MS methods for metabolite profiling of propolis extracts. J Pharm Biomed Anal, 55, 934-48.
- Popova MP, Bankova VS, Bogdanov S, et al. (2007): Chemical characteristics of poplar type propolis of different geographic origin. Apidologie, 38, 306-311.
- Raina K, Rajamanickam S, Deep G, et al. (2008): Chemo preventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice. Mol Cancer Ther, 7, 1258-1267.
- Salonen A, Saarnio S, Julkunen-Tiitto R (2012): Phenolic compounds of propolis from the boreal coniferous zone. J Apic Sci, 56, 13-22.
- Sforcin JM, Fernandes JA, Lopes CA, et al. (2000): Seasonal effect on Brazilian propolis antibacterial activity. J Ethnopharmacol, 73, 243-249.
- Stan L, Mărghitaş LA, Dezmirean D (2011): Quality criteria for propolis standardization. J Anim Sci Biotechnol, 44, 137-140.
- Trusheva B, Trunkova D, Bankova V (2007): Different extraction methods of biologically active components from propolis: A preliminary study. Chem Cen J, 7, 1-13.
- Velazquez C, Navarro M, Acosta A, et al. (2007): Antibacterial and free-radical scavenging activities of Sonoran propolis. J Appl Microbiol, 103, 1747-1756.
- Žižić JB, Vuković NL, Jadranin MB, et al. (2013): Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. J Sci Food Agric, 93, 3001-3009.
Mevsim ve rakımın propolisteki biyolojik olarak aktif belirli fenolik bileşiklerin düzeylerine etkisi vepropolisin kısmi standardizasyonu
Abstract
Propolis kimyasal içeriğine bağlı olarak antibakteriyel, antiviral, antifungal, anti-inflamatuar, antitumoral, antioksidan, immunmodulator, doku yenileyici, antiülser, analjezik, lokal anastezik ve antiseptik etkilere sahiptir. Bu çalışmanın amacı, Bursa ilinden toplanan propolislerde biyolojik olarak etkisi bulunan fenolik bileşiklerin nitel ve nicel olarak saptanması, kalitesinin belirlenmesi ve bunda yükseklik ve mevsimin etkisinin değerlendirilmesidir. Propolis numuneleri, 2012 yılında ilkbahar, yaz, sonbahar mevsimlerinde, Bursa ilinde değişen rakımlarda bulunan (50-1000 m arası), 15 sabit aralıktan, propolis tuzakları kullanılarak toplandı. Propolislerde, 14 flavanoid ve fenolik asit sıvı kromatografi kütle/kütle spektrometresi (LC-MS/MS) ile analiz edildi. Galangin, naringenin, pinosembrin, kafeik asit ve kafeik asit feniletil ester tüm numunelerde (45 numune), tüm mevsim ve rakımlarda tespit edildi. Bazı fenolik bileşiklerin miktarlarında rakım ve mevsime bağlı olarak anlamlı değişiklikler tespit edilmiş olup, bu bulguların propolisin kısmi standardizasyonun yapılmasına yardımcı olabilecek nitelikte olduğu sonucuna varıldı
Keywords
References
- Aliyazıcıoglu R, Sahin S, Erturk O, et al. (2013): Properties of phenolic composition and biological activity of propolis from Turkey. Int J Food Prop, 16, 277-287.
- Bankova V (2005): Chemical diversity of propolis and the problem of standardization. J Ethnopharmacol, 100, 114-117.
- Bankova VS, De Castro SL, Marcucci MC (2000): Propolis: Recent advances in chemistry and plant origin. Apidologie, 31, 3-15.
- Banskota AH, Tezuka Y, Kadota S (2001): Recent progress in pharmacological research of propolis. Phytother Res, 15, 561-571.
- Barbarić M, Mišković K, Bojić M, et al. (2011): Chemical composition of the ethanolic propolis extracts and its effect on HeLa cells. J Ethnopharmacol, 135, 772-778.
- Barros MP, Lemos M, Maistro EL, et al. (2008): Evaluation of antiulcer activity of the main phenolic acids found in Brazilian green propolis. J Ethnopharmacol, 120, 372-377.
- Cam Y, Koç AN, Silici S, et al. (2009): Treatment of dermatophytosis in young cattle with propolis and Whitfield’s ointment. Veterinary Record, 165, 57-58.
- Cardoso RL, Maboni F, Machado G, et al. (2010): Antimicrobial activity of propolis extract against Staphylococcus coagulase positive and Malassezia pachydermatis of canine otitis. Vet Microbiol, 142, 432-434.
- Castro ML, Cury JA, Rosalen PL, et al. (2007): Propolis from southeastern and northeastern of Brazil: The influence of seasonality in antibacterial activity and phenolic composition. Quim Nova, 30, 1512-1516.
- Chaillou LL, Nazareno AM (2009): Chemical variability in propolis from Santiago del Estero, Argentina, related to the arboreal environment as the sources of resins. J Sci Food Agric, 89, 978-983.
- Cruz Sánchez TA, García PAE, Zamora CIL, et al. (2014): Use of propolis for topical treatment of dermatophytosis in dog. OJVM, 4, 239-245.
- Erdogan S, Ates B, Durmaz G, et al. (2011): Pressurized liquid extraction of phenolic compounds from Anatolia propolis and their radical scavenging capacities. Food Chem Toxicol, 49, 1592-1597.
- Isla MI, Zampini IC, Ordóñez RM, et al. (2009): Effect of seasonal variations and collection form on antioxidant activity of propolis from San Juan, Argentina. J Med Food, 12, 1334-1342.
- Liu R, Gao M, Yang ZH, et al. (2008): Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro. Brain Res, 24, 104-115.
- Lozina LA, Peichoto ME, Boehringer SI, et al. (2010): Efficacy of Argentine propolis formulation for topical treatment of canine otitis extern. Arq Bras Med Vet Zootec, 62, 1359-1366.
- Medana C, Carbone F, Aigotti R, et al. (2008): Selective analysis of phenolic compounds in propolis by HPLC- MS/MS. Phytochem Anal, 19, 32-39.
- Pellati F, Orlandini G, Pinetti D, et al. (2011): HPLC- DAD and HPLC-ESI-MS/MS methods for metabolite profiling of propolis extracts. J Pharm Biomed Anal, 55, 934-48.
- Popova MP, Bankova VS, Bogdanov S, et al. (2007): Chemical characteristics of poplar type propolis of different geographic origin. Apidologie, 38, 306-311.
- Raina K, Rajamanickam S, Deep G, et al. (2008): Chemo preventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice. Mol Cancer Ther, 7, 1258-1267.
- Salonen A, Saarnio S, Julkunen-Tiitto R (2012): Phenolic compounds of propolis from the boreal coniferous zone. J Apic Sci, 56, 13-22.
- Sforcin JM, Fernandes JA, Lopes CA, et al. (2000): Seasonal effect on Brazilian propolis antibacterial activity. J Ethnopharmacol, 73, 243-249.
- Stan L, Mărghitaş LA, Dezmirean D (2011): Quality criteria for propolis standardization. J Anim Sci Biotechnol, 44, 137-140.
- Trusheva B, Trunkova D, Bankova V (2007): Different extraction methods of biologically active components from propolis: A preliminary study. Chem Cen J, 7, 1-13.
- Velazquez C, Navarro M, Acosta A, et al. (2007): Antibacterial and free-radical scavenging activities of Sonoran propolis. J Appl Microbiol, 103, 1747-1756.
- Žižić JB, Vuković NL, Jadranin MB, et al. (2013): Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. J Sci Food Agric, 93, 3001-3009.
There are 25 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA89RG76HA |
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 1, 2017 |
| Published in Issue | Year 2017 |