Abstract
This case study presents the pathomorphological description of a pulmonary trophoblastic embolism in a female chinchilla, which died due to respiratory distress. Routine necropsy examination revealed the presence of multiple small and grey coloured foci, which presented with a hyperaemic and multifocal appearance on the surface of the lungs. Samples taken from the lung tissue were subjected to routine tissue processing and stained with haematoxylin-eosin (HE) and periodic acid-Schiff (PAS) reagents. Histopathological examination demonstrated one or more giant cells with rather large nuclei and a broad cytoplasm in the alveolar capillaries, which appeared as multifocal areas. These cellular structures were positive for PAS staining. And also, lymphocytic and histiocytic inflammatory cells infiltration were observed around the alveoli and bronchi-bronchioles
Keywords
References
- 1. Billington WD, Weir BJ (1967): Deportation of trophoblast in the chinchilla. J Reprod Fert, 13, 593-595.
- 2. Burek JD, Goldberg B, Hutchins G, Strandberg JD (1979): The pregnant Syrian hamster as a model to study intravascular trophoblasts and associated maternal blood vessel changes. Vet Pathol, 16, 553-566.
- 3. Hoflehner G, Golob E (1981): Gestational trophoblastic emboli as possible cause of an acute respiratory distress syndrome. Wien Med Wochenschr, 131, 475-477.
- 4. Ikarashi T, Takeuchi, S, Ohnishi, Y (1988): Trophoblastic embolism in sudden maternal death. Nippon Sanka Fujinka Gakkai Zasshi, 40, 793-795.
- 5. Ilha MRS, Bezerra Jr. PS, Sanches AWD, Barros CSL (2000): Trophoblastic pulmonary embolism in chinchillas (Chinchilla laniger). Ciênica Rural, 30, 903-904.
- 6. Ji L, Brkić J, Liu M, Fu G, Peng C, Wang YL (2013): Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia. Mol Aspects Med, 34, 981-1023.
- 7. Knöfler M, J Pollheimer J (2013): Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling. Front Genet, 4, 1-14.
- 8. Roffman BY, Simons M (1969): Syncytial trofhoblastic embolism associated with placenta increta and preeclampsia. Am J Obst & Gynec, 104, 1218-1220.
- 9. Trotter RF, Tieche HL (1956): Maternal death due to pulmonary embolism of trophoblastic cells. Am J Obst & Gynec, 71, 1114-1118.
- 10. Wagner D (1967): Trophoblastic cells in the blood stream in normal and abnormal pregnancy. Acta Cytol, 12, 137- 139
Abstract
Bu olguda, dişi bir çinçilanın akciğerlerinde trofoblastik emboli olgusu patomorfolojik olarak tanımlandı. Klinik olarak iştahsızlık ve solunum güçlüğü görüldüğü ve tedaviye yanıt vermeyerek öldüğü bildirildi. Yapılan rutin nekropsi yöntemi sonucu akciğerlerin solgun renkte yer yer hiperemik manzarada olduğu dikkati çekti. Yüzeyinde ise kimi alanlarda çok sayıda küçük ve kırmızı renkte odakların olduğu görüldü. Akciğerlerden alınan doku örnekleri rutin doku takibine alınarak Hematoksilen-eosin (HxE) ve Periodic acid-schiff (PAS) boyamaları yapıldı. Histopatolojik olarak, multifokal alanlar halinde alveoler kapillalarda tek veya birkaç büyük çekirdekli ve geniş sitoplazmalı trofoblast hücreleri gözlendi. Bu yapıların PAS boyamasında pozitif oldukları dikkati çekti. Ayrıca, alveoller ve bronş-bronşiollerin çevresinde lenfosit ve histiyositlerden oluşan yangısal hücre infiltrasyonları görüldü
Keywords
References
- 1. Billington WD, Weir BJ (1967): Deportation of trophoblast in the chinchilla. J Reprod Fert, 13, 593-595.
- 2. Burek JD, Goldberg B, Hutchins G, Strandberg JD (1979): The pregnant Syrian hamster as a model to study intravascular trophoblasts and associated maternal blood vessel changes. Vet Pathol, 16, 553-566.
- 3. Hoflehner G, Golob E (1981): Gestational trophoblastic emboli as possible cause of an acute respiratory distress syndrome. Wien Med Wochenschr, 131, 475-477.
- 4. Ikarashi T, Takeuchi, S, Ohnishi, Y (1988): Trophoblastic embolism in sudden maternal death. Nippon Sanka Fujinka Gakkai Zasshi, 40, 793-795.
- 5. Ilha MRS, Bezerra Jr. PS, Sanches AWD, Barros CSL (2000): Trophoblastic pulmonary embolism in chinchillas (Chinchilla laniger). Ciênica Rural, 30, 903-904.
- 6. Ji L, Brkić J, Liu M, Fu G, Peng C, Wang YL (2013): Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia. Mol Aspects Med, 34, 981-1023.
- 7. Knöfler M, J Pollheimer J (2013): Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling. Front Genet, 4, 1-14.
- 8. Roffman BY, Simons M (1969): Syncytial trofhoblastic embolism associated with placenta increta and preeclampsia. Am J Obst & Gynec, 104, 1218-1220.
- 9. Trotter RF, Tieche HL (1956): Maternal death due to pulmonary embolism of trophoblastic cells. Am J Obst & Gynec, 71, 1114-1118.
- 10. Wagner D (1967): Trophoblastic cells in the blood stream in normal and abnormal pregnancy. Acta Cytol, 12, 137- 139
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA96YB62HZ |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2016 |
| Published in Issue | Year 2016 |