Abstract
In the study, a myxoid liposarcoma in the proximal region of the left humerus of a 15-year-old male, shorthair cat was described. Left arm along with scapula was amputated. The cut section of tumor was tan to white with soft multilobulated mass which contained hemorrhagic and necrotic foci as well as mucuous composition. Microscopically, the tumor was composed of roundto-polygonal cells. The cells had numerous round, variable-sized, well-defined, intracytoplasmic vacuoles. The lipid droplets in the cytoplasmic vacuoles of the tumor cells was showed with Oil Red O staining. A myxoid extracellular substance remind of mucin was stained by Alcian blue staining (pH = 2,5). Tumor cells were strongly positive for vimentin, but negative for pancytokeratin and S100. A polymerase chain reaction (PCR) assay from samples showed no evidence of feline leukemia virus (FeLV) / feline sarcomavirus (FeSV) or feline immunodeficiency virus (FIV) deoksiribonucleic acid (DNA). This case describes a first report of myxoid liposarcoma in a cat
Keywords
References
- Goldschmidt MH, Hendrick MJ (2002): Liposarcoma. 97-99. In:Tumors in Domestic Animals, DJ Meuten (Ed). 4th ed., Iowa State Press, Ames, IA.
- Hendrick MJ, Goldschmidt MH, Shofer FS, Wang YY, Somlyo AP (1992): Postvaccinal sarcomas in the cat: epidemiology and electron probe microanalytical identification of aluminum. Cancer Res, 52, 5391-5394.
- Kidney BA, Ellis JA, Haines DM, Jackson ML (2000): Evaluation of formalin-fixed paraffin-embedded tissues obtained from vaccine site-associated sarcomas of cats for DNA of feline immunodeficiency virus. Am J Vet Res, 61, 1037-1041.
- Kidney BA, Ellis JA, Haines DM, Jackson ML (2001): Comparison of endogenous feline leukemia virus RNA content in feline vaccine and nonvaccine site-associated sarcomas. Am J Vet Res, 62, 1990-1994.
- Kidney BA, Haines DM, Ellis JA, Burnham M, Jackson ML (2001): Evaluation of formalin-fixed paraffin- embedded tissues from vaccine site-associated sarcomas of cats for polyomavirus DNA and antigen. Am J Vet Res, 62, 828-832.
- Masserdotti C, Bonfanti U, De Lorenzi D, Ottolini N (2006): Use of Oil Red O stain in the cytologic diagnosis of canine liposarcoma. Vet Clin Pathol, 35, 37-41.
- Rosai J (2004): Soft Tissues. 2279-2285. In: Rosai and Ackerman's Surgical Pathology. J. Rosai. (Ed), 9th ed., Vol 2, Mosby, Inc., St Louis.
- Stephens LC, Tsai CC, Raulston GL, Jardine JH, MacKenzie WF (1983): Virus-associated liposarcoma and malignant lymphoma in a kitten. J Am Vet Med Assoc, 183, 123-125.
- Stephens LC, King GK, Jardine JH (1984): Attempted transmission of a feline virus-associated liposarcoma to newborn kittens. Vet Pathol, 21, 614-616.
- Stiles J, Bienzle D, Render JA, Buyukmihci C, Johnson EC (1999): Use of nested polymerase chain reaction (PCR) for detection of retroviruses from formalin-fixed, parafin-embedded uveal melanomas in cats. Vet Ophthalmol, 2, 113-116.
- Wang FI, Liang SL, Eng HL, Jeng CR, Pang VF (2005): Disseminated liposarcoma in a dog. J Vet Diagn Invest, 17, 291-294. Geliş tarihi: 25.03.2010 / Kabul tarihi: 26.07.2010 Corresponding author Yonca Betil Kabak University of Ondokuz Mayis, Faculty of Veterinary Medicine, Department of Pathology, Kurupelit 55139 Samsun-Turkey Tel: +90 362 3121919 ext.3914 Fax: +90 362 4576922 E-mail: yoncakabak@hotmail.com or ybkabak@omu.edu.tr
Abstract
Bu çalışmada, 15 yaşlı erkek bir kedinin sol humerusunun proksimal bölgesindeki miksoid liposarkom tanımlanmıştır. Skapula ile birlikte sol kol ampute edildi. Tümörün kesit yüzü krem- beyaz renkte, müköz yapı yanında hemorajik ve nekrotik odaklar içeren yumuşak loplu bir yapıdaydı. Mikroskobik olarak tümör, yuvarlak– polygonal hücreler içeriyordu. Hücreler çok sayıda yuvarlak, değişik büyüklüklerde, belirgin intrasitoplazmik vakullere sahipti. Oil Red O boyası ile tümör hücrelerinin sitoplazmik vakuollerindeki yağ damlacıkları gösterildi. Müsini akla getiren ekstrasellüler miksoid yapı Alcian blue boyası ile boyandı. Tümör hücreleri vimentin pozitif fakat pansitokeratin ve S-100 negatifti. Örneklerde polimeraz zincir reaksiyonu (PZR) ile feline leukemia virus (FeLV), feline sarcomavirus (FeSV) veya feline immunodeficiency virus (FIV) deoksiribonükleik asit (DNA)’leri görülemedi. Bu vaka, kedilerdeki miksoid liposarkomu tanımlayan ilk raporudur
Keywords
References
- Goldschmidt MH, Hendrick MJ (2002): Liposarcoma. 97-99. In:Tumors in Domestic Animals, DJ Meuten (Ed). 4th ed., Iowa State Press, Ames, IA.
- Hendrick MJ, Goldschmidt MH, Shofer FS, Wang YY, Somlyo AP (1992): Postvaccinal sarcomas in the cat: epidemiology and electron probe microanalytical identification of aluminum. Cancer Res, 52, 5391-5394.
- Kidney BA, Ellis JA, Haines DM, Jackson ML (2000): Evaluation of formalin-fixed paraffin-embedded tissues obtained from vaccine site-associated sarcomas of cats for DNA of feline immunodeficiency virus. Am J Vet Res, 61, 1037-1041.
- Kidney BA, Ellis JA, Haines DM, Jackson ML (2001): Comparison of endogenous feline leukemia virus RNA content in feline vaccine and nonvaccine site-associated sarcomas. Am J Vet Res, 62, 1990-1994.
- Kidney BA, Haines DM, Ellis JA, Burnham M, Jackson ML (2001): Evaluation of formalin-fixed paraffin- embedded tissues from vaccine site-associated sarcomas of cats for polyomavirus DNA and antigen. Am J Vet Res, 62, 828-832.
- Masserdotti C, Bonfanti U, De Lorenzi D, Ottolini N (2006): Use of Oil Red O stain in the cytologic diagnosis of canine liposarcoma. Vet Clin Pathol, 35, 37-41.
- Rosai J (2004): Soft Tissues. 2279-2285. In: Rosai and Ackerman's Surgical Pathology. J. Rosai. (Ed), 9th ed., Vol 2, Mosby, Inc., St Louis.
- Stephens LC, Tsai CC, Raulston GL, Jardine JH, MacKenzie WF (1983): Virus-associated liposarcoma and malignant lymphoma in a kitten. J Am Vet Med Assoc, 183, 123-125.
- Stephens LC, King GK, Jardine JH (1984): Attempted transmission of a feline virus-associated liposarcoma to newborn kittens. Vet Pathol, 21, 614-616.
- Stiles J, Bienzle D, Render JA, Buyukmihci C, Johnson EC (1999): Use of nested polymerase chain reaction (PCR) for detection of retroviruses from formalin-fixed, parafin-embedded uveal melanomas in cats. Vet Ophthalmol, 2, 113-116.
- Wang FI, Liang SL, Eng HL, Jeng CR, Pang VF (2005): Disseminated liposarcoma in a dog. J Vet Diagn Invest, 17, 291-294. Geliş tarihi: 25.03.2010 / Kabul tarihi: 26.07.2010 Corresponding author Yonca Betil Kabak University of Ondokuz Mayis, Faculty of Veterinary Medicine, Department of Pathology, Kurupelit 55139 Samsun-Turkey Tel: +90 362 3121919 ext.3914 Fax: +90 362 4576922 E-mail: yoncakabak@hotmail.com or ybkabak@omu.edu.tr
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA63VB62ZT |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2011 |
| Published in Issue | Year 2011 |