Abstract
Fibrous osteodystrophy is a metabolic disease that characterized marked bone resorption with fibrous tissue proliferations, cysts formations and insufficient mineralization of immature bone. Nutritional fibrous osteodystrophy was developed in 37 goats from two different goat flocks in Isparta in Turkey. The aim of this study was to examine clinicopathological findings and treatment of this rare disease. Affected animals were between 2-4 months of age and were normal at birth. Clinical signs were started about 2 months of age and characterized by mandibular and maxillary enlargements, softening of the bones (especially facial bones), varying degrees of mouth opening and protruding tongue, dyspnea, leg deformities, exophthalmos, and mastication problems. Exophthalmos was seen in 13 kids due to enlargement of facial bones into the cavum orbita. Leg deformities were observed in 11 kids and they had walking problems. Blood calcium, phosphorus, magnesium, alkaline phosphatase, vitamin D3 and parathormone levels were examined. Affected animals had increased levels of phosphorus and parathormone, as well as higher alkaline phosphatase activity. 23 kids died from the disease and 10 of them were necropsied. At necropsy, bilateral enlargement of the maxilla and mandibula, leg deformities and incomplete rib fractures were observed in kids. Histopathologically, severe diffuse proliferation of loose connective tissue surrounded the osteoid trabeculae, many of which were partially or completely non mineralized and accompanied by numerous osteoclastic giant cells. Soil analysis of the pasture revealed marked decrease in calcium level (1%). The newly born and under the one month of age kids in the flocks (totally 527 goat kids) were treated with Ca and Vit D. No new cases were observed after treatment
References
- Andrews AH, Ingram PL, Longstaffe JA (1983): Osteodystrophia fibrosa in young goats. Vet Rec, 112, 404- 406.
- Arnold SA, Kram MA, Hintz HF, et al. (1973): Nutritional secondary hyperparathyroidism in the parakeet. Cornell Vet J, 64, 37-46.
- Aslani MR, Movassaghi AR, Mohri M, et al. (2001): Outbreak of osteodystrophia fibrosa in young goats. J Vet Med-A, 48, 385-389.
- Bandarra PM, Pavarini SP, Santos AS, et al. (2011): Nutritional fibrous osteodystrophy in goats. Pesqui Vet Bras, 31, 875-878.
- Bas S, Bas A, López I, et al. (2005): Nutritional secondary hyperparathyroidism in rabbits. Domest Anim Endocrin 28, 380-390.
- Bruckman VJ, Wriessnig K (2013): Improved soil carbonate determination by FT-IR and X-ray analysis. Environ Chem Lett, 11, 65-70.
- Chen WR, Chen YD, Shi Y, et al. (2015): Vitamin D, parathyroid hormone and risk factors for coronary artery disease in an elderly Chinese population. J Cardiovasc Med (Hagerstown), 16, 59-68.
- Clark CJ, Roeder PL, Dixon PM (1996): Nasal obstruction caused by nutritional osteodystrophia fibrosa in a group of Ethiopian horses. Vet Rec, 139, 568-570.
- Crager CS, Nachreiner RF (1993): Increased parathyroid hormone concentration in a siamese kitten with nutritional secondary hyperparathyroidism. J Am Anim Hosp Assoc, 29, 331-336.
- Dunn P (1994): The Goatkeeper's Veterinary Book. Farming Press, London.
- Kawaguchi K, Braga IS 3rd, Takahashi A, et al. (1993): Nutritional secondary hyperparathyroidism occurring in a strain of German shepherd puppies. Jpn J Vet Res, 41, 89-96.
- Luna LG (1968): Routine Staining Procedures. 32-47. In: Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology, 3rd ed. McGraw-Hill Book Company.
- Lynch MJ, Slocombe RF, Harrington KE, et al. (1999): Fibrous osteodystrophy in Dromedary Camels (Camelus dromedarius). J Zoo Wildlife Med, 30, 577-583.
- Radostits OM, Gay CC, Hinchcliff KW, et al. (2008): Bone Diseases. 632-637. In: Veterinary Medicine: A Textbook of Diseases of Cattle, Horses, Sheep, Pigs, and Goats, 10th ed. Saunders Elsevier.
- Roux P (2007): Mandibular fracture in a Lhasa Apso with secondary renal hyperparathyroidism. SAT, 149, 277-279.
- Rusenov A, Nikolov Y, Simeonov R, et al. (2009): A case of fibrous osteodystrophy in a dog with secondary renal hyperparathyroidism. Bulg J Vet Med, 12, 212-218.
- Sahinduran S, Ozmen O, Sevgisunar NS (2016): Multi- organ damage in a cow with diabetes mellitus. Vet J Ankara Univ, 63, 77-78.
- Schwarz T, Störk CK, Megahy IW, et al. (2001): Osteodystrophia fibrosa in two guinea pigs. JAVMA, 219, 63-66.
- Sidler-Lauff K, Boos A, Kraenzlin M, et al. (2010): Influence of different calcium supplies and a single vitamin D injection on vitamin D receptor and calbindin D9k immunoreactivities in the gastrointestinal tract of goat kids. J Anim Sci, 88, 3598-3610.
- Simesen MG (1980): Calcium, Phosphorus and Magnesium Metabolism. 610-611. In: Kaneko JJ (Ed.) Clinical Biochemistry of Domestic Animals. 3rd ed. Academic Press.
- Tasova H, Akın A (2013): Marmara bölgesi topraklarının bitki besin maddesi kapsamlarının belirlenmesi, veri tabanının oluşturulması ve haritalanması. Soil-Water J, 2, 83-95.
- Thompson K (2007): Bones and Joints. 82-88. In: Maxie MG (Ed.) Jubb, Kennedy, and Palmer´s Pathology of Domestic Animals, Vol.1. 5th ed. Elsevier.
- Tomson FN, Lotshaw RR (1978): Hyperphosphatemia and hypocalcemia in lemurs. JAVMA, 173, 1103-1106.
- Van Pelt RW, Caley MT (1974): Nutritional secondary hyperparathyroidism in Alaskan red fox kits. J Wildlife Dis, 10, 47-52.
- Weisbrode SW (2007): Bone and Joints. 1075-1076. In: Mc Gavin MD, Zachary JF (Eds.) Pathologic Basis of Veterinary Disease, 4th ed. Mosby Company.
- Woodard JC (1997): Skeletal System. 917-922. In: Jones TC, Hunt RD, King NW (Eds.), Veterinary Pathology. William and Wilkins, Baltimore.
- Yates NG, Hoffmann D, Seripto S (1987): Mandibular osteodystrophy fibrosa in Indonesian goats fed leucaena. Trop Anim Health Pro, 19, 121-126.
Abstract
Fibröz osteodistrofi belirgin kemik rezorpsiyonu ile birlikte fibröz bağ doku proliferasyonları, kist formasyonları ve olgunlaşmamış kemik dokunun yetersiz mineralizasyonu ile karakterize metabolik bir hastalıktır. Isparta ilinde iki farklı keçi sürüsündeki 37 oğlakta nutrisyonel fibröz osteodistrofi saptandı. Bu çalışmanın amacı, keçilerde nadir rastlanan fibröz osteodistrofideki klinikopatolojik bulgular ile bu hastalığın tedavisinin incelenmesidir. Hasta hayvanlar 2-4 aylıktı ve doğduklarında normal görünümdeydiler. Klinik belirtiler hayvanlar yaklaşık 2 aylıkken başlayıp; mandibular ve maksiller genişlemeler, kemiklerde (özellikle yüz kemikleri) yumuşama, ağzın değişik derecelerde açık kalması ve dilin dışarıya sarkması, nefes darlığı, bacak deformiteleri, ekzoftalmus ve çiğneme problemleri ile karakterize bir tablo ile seyrediyordu. 13 oğlakta yüz kemiklerinin orbita çukuruna doğru genişlemesi sebebiyle ekzoftalmus şekillenmişti. 11 oğlakta bacak deformiteleri oluşmuştu ve bu hayvanlarda yürüme problemleri gözlendi. Kan kalsiyum, fosfor, magnezyum, alkalen fosfataz, vitamin D3 ve parathormon seviyeleri incelendi. Hasta hayvanlarda alkalen fosfataz, fosfor ve parathormon seviyeleri yükselmişti. Hastalıktan 23 oğlak öldü ve bunlardan 10’unun nekropsisi yapıldı. Nekropside, maksilla ve mandibulada bilateral şişkinlikler, bacak deformiteleri ve kaburgalardaki kırıklarda yetersiz kaynaşmalar gözlendi. Histopatolojik olarak çoğunluğu veya tamamı nonmineralize osteoid trabekülalar çevresinde yoğun gevşek bağ doku proliferasyonları ile birlikte çok sayıda osteoklastik dev hücreler dikkati çekti. Meranın toprak analizinde toprak kalsiyum düzeyinde belirgin bir eksiklik saptandı (%1). Sürüdeki yeni doğan ve bir aylıktan küçük oğlaklar (toplam 527 oğlak) Ca ve Vit D ile tedavi edildi. Tedavi sonrası yeni vakalar saptanmadı
References
- Andrews AH, Ingram PL, Longstaffe JA (1983): Osteodystrophia fibrosa in young goats. Vet Rec, 112, 404- 406.
- Arnold SA, Kram MA, Hintz HF, et al. (1973): Nutritional secondary hyperparathyroidism in the parakeet. Cornell Vet J, 64, 37-46.
- Aslani MR, Movassaghi AR, Mohri M, et al. (2001): Outbreak of osteodystrophia fibrosa in young goats. J Vet Med-A, 48, 385-389.
- Bandarra PM, Pavarini SP, Santos AS, et al. (2011): Nutritional fibrous osteodystrophy in goats. Pesqui Vet Bras, 31, 875-878.
- Bas S, Bas A, López I, et al. (2005): Nutritional secondary hyperparathyroidism in rabbits. Domest Anim Endocrin 28, 380-390.
- Bruckman VJ, Wriessnig K (2013): Improved soil carbonate determination by FT-IR and X-ray analysis. Environ Chem Lett, 11, 65-70.
- Chen WR, Chen YD, Shi Y, et al. (2015): Vitamin D, parathyroid hormone and risk factors for coronary artery disease in an elderly Chinese population. J Cardiovasc Med (Hagerstown), 16, 59-68.
- Clark CJ, Roeder PL, Dixon PM (1996): Nasal obstruction caused by nutritional osteodystrophia fibrosa in a group of Ethiopian horses. Vet Rec, 139, 568-570.
- Crager CS, Nachreiner RF (1993): Increased parathyroid hormone concentration in a siamese kitten with nutritional secondary hyperparathyroidism. J Am Anim Hosp Assoc, 29, 331-336.
- Dunn P (1994): The Goatkeeper's Veterinary Book. Farming Press, London.
- Kawaguchi K, Braga IS 3rd, Takahashi A, et al. (1993): Nutritional secondary hyperparathyroidism occurring in a strain of German shepherd puppies. Jpn J Vet Res, 41, 89-96.
- Luna LG (1968): Routine Staining Procedures. 32-47. In: Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology, 3rd ed. McGraw-Hill Book Company.
- Lynch MJ, Slocombe RF, Harrington KE, et al. (1999): Fibrous osteodystrophy in Dromedary Camels (Camelus dromedarius). J Zoo Wildlife Med, 30, 577-583.
- Radostits OM, Gay CC, Hinchcliff KW, et al. (2008): Bone Diseases. 632-637. In: Veterinary Medicine: A Textbook of Diseases of Cattle, Horses, Sheep, Pigs, and Goats, 10th ed. Saunders Elsevier.
- Roux P (2007): Mandibular fracture in a Lhasa Apso with secondary renal hyperparathyroidism. SAT, 149, 277-279.
- Rusenov A, Nikolov Y, Simeonov R, et al. (2009): A case of fibrous osteodystrophy in a dog with secondary renal hyperparathyroidism. Bulg J Vet Med, 12, 212-218.
- Sahinduran S, Ozmen O, Sevgisunar NS (2016): Multi- organ damage in a cow with diabetes mellitus. Vet J Ankara Univ, 63, 77-78.
- Schwarz T, Störk CK, Megahy IW, et al. (2001): Osteodystrophia fibrosa in two guinea pigs. JAVMA, 219, 63-66.
- Sidler-Lauff K, Boos A, Kraenzlin M, et al. (2010): Influence of different calcium supplies and a single vitamin D injection on vitamin D receptor and calbindin D9k immunoreactivities in the gastrointestinal tract of goat kids. J Anim Sci, 88, 3598-3610.
- Simesen MG (1980): Calcium, Phosphorus and Magnesium Metabolism. 610-611. In: Kaneko JJ (Ed.) Clinical Biochemistry of Domestic Animals. 3rd ed. Academic Press.
- Tasova H, Akın A (2013): Marmara bölgesi topraklarının bitki besin maddesi kapsamlarının belirlenmesi, veri tabanının oluşturulması ve haritalanması. Soil-Water J, 2, 83-95.
- Thompson K (2007): Bones and Joints. 82-88. In: Maxie MG (Ed.) Jubb, Kennedy, and Palmer´s Pathology of Domestic Animals, Vol.1. 5th ed. Elsevier.
- Tomson FN, Lotshaw RR (1978): Hyperphosphatemia and hypocalcemia in lemurs. JAVMA, 173, 1103-1106.
- Van Pelt RW, Caley MT (1974): Nutritional secondary hyperparathyroidism in Alaskan red fox kits. J Wildlife Dis, 10, 47-52.
- Weisbrode SW (2007): Bone and Joints. 1075-1076. In: Mc Gavin MD, Zachary JF (Eds.) Pathologic Basis of Veterinary Disease, 4th ed. Mosby Company.
- Woodard JC (1997): Skeletal System. 917-922. In: Jones TC, Hunt RD, King NW (Eds.), Veterinary Pathology. William and Wilkins, Baltimore.
- Yates NG, Hoffmann D, Seripto S (1987): Mandibular osteodystrophy fibrosa in Indonesian goats fed leucaena. Trop Anim Health Pro, 19, 121-126.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Other ID | JA74CD58MK |
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 1, 2017 |
| Published in Issue | Year 2017Volume: 64 Issue: 1 |