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Dirofilaria immitis enfekte köpeklerde serum cystatinC konsantrasyonlarının değerlendirilmesi

Year 2015, Volume: 62 Issue: 4, 303 - 306, 01.12.2015

Didem Pekmezci Murat Güzel Alparslan Yıldırım Gülay Çiftci Gökmen Zafer Pekmezci Mehmet Tütüncü Abdullah İnci

https://doi.org/10.1501/Vetfak_0000002696

Abstract

Glomerular filtrasyon hızının değerlendirilmesi amacı ile Dirofilaria immitis ile doğal enfekte köpeklerde yeni bir renal markır olan serum cystatinC (sCysC) konsantrasyonu kanin CysC ELISA kiti ile ölçüldü. Çalışmada yirmi mikrofilaremikseropozitif ve 20 amikrofilaremik-seronegatif köpek değerlendirildi. Her iki grupta serum üre ve kreatinin (sCre) konsantrasyonları ölçüldü. Enfekte köpeklerde ortalama sCysC konsantrasyonu 2.40 mg/L iken, kontrol grubunda 2.30 mg/L olarak bulundu. Enfekte köpeklerin ortalama serum üre konsantrasyonu 9.97 mmol/L, sCre 116.24 µmol/L bulunurken, kontrol grubunda değerler sırasıyla 11.92 mmol/L ve 128.62 µmol/L olarak tespit edildi. Gruplar arasında sCysC, sCre ile serum Urea:Cre oranları bakımından istatistiksel olarak farklılık bulunmadı. Diğer taraftan, serum üre konsantrasyonu gruplar arasında istatistiksel olarak farklı bulundu. Bu çalışma ile D. immitis ile enfekte köpeklerde sCysC konsantrasyonları değişmez gibi göründü

Keywords

Dirofilaria immitis köpek serum cystatinC

References

  • Abramowsky CR, Powers KG, Aikawa M, Swinehart G (1981): Dirofilaria immitis. 5. Immunopathology of filarial nephropathy in dogs. Am J Pathol, 104, 1-12.
  • Acevedo RA, Ciencias L, Theis JH, et al. (1981): Combination of filtration and histochemical stain for detection and differentiation of Dirofilaria immitis and Dipetalonema reconditum in the dog. Am J Vet Res, 42, 537-540.
  • Antognoni MT, Siepi D, Porciello F, Fruganti G (2005): Use of serum cytatin C determination as a marker of renal function in the dog. Vet Res Commun, 29, 265-267.
  • Antognoni MT, Siepi D, Porciello F, et al. (2007): Serum cystatin-C evaluation in dogs affected by different diseases associated or not with renal insufficiency. Vet Res Commun, 31, 269-271.
  • Brady HR, Brenner BM (1994): Acute renal failure. 1265-1274. In: Isselbaher KJ, Braunwald E, Wilson JD (Ed), Harrison’s Principles of Internal Medicine. McGraw- Hill, Columbus.
  • Braun JP, Perxachs A, Pechereau D, De La Farge F (2002): Plasma cystatin C in the dog: reference values and variations with renal failure. Comp Clin Pathol, 11, 44-49. 7. Casey HW, Splitter GA glomerulonephritis in dogs infected with Dirofilaria immitis. Vet Pathol, 12, 111-117. (1975): Membranous
  • De Scally MP, Leisewitz AL, Lobetti RG, Thompson PN (2006): The elevated serum urea:creatinine ratio in canine babesiosis in South Africa is not of renal origin. J S Afr Vet Assoc, 77, 175-178.
  • De Scally MP, Lobetti RG, Reyers F, Humphris D (2004): Are urea and creatinine values reliable indicators of azotaemia in canine babesiosis? J S Afr Vet Assoc, 75, 121-124.
  • Di Bartola SP (2000): Clinical approach and laboratory evaluation of renal disease. 1600-1614. In: Ettinger SJ, Feldman EC (Ed), Textbook of Veterinary Internal Medicine (5th ed). WB Saunders, Philadelphia.
  • Feinfeld DA, Bargouthi H, Niaz Q, Carvounis CP (2002): Massive and disproportionate elevation of blood urea nitrogen in acute azotemia. Int Urol Nephrol, 34, 143-145.
  • Finco DR (1997): Evaluation of renal function. 216-229. In: Osborne CA, Finco DR (Ed), Canine and Feline Nephrology and Urology. Williams and Wilkins, Philadelphia, USA.
  • Grauer GF, Culham CA, Bowman DD, et al. (1988): Parasite excretory-secretory antigen and antibody to excretory-secretory antigen in body fluids and kidney tissue of Dirofilaria immitis infected dogs. Am J Trop Med Hyg, 39, 380-387.
  • Ghys L, Paepe D, Smets P, et al. (2014): Cystatin C: A new renal marker and its potential use in small animal medicine. J Vet Intern Med, doi: 10.1111/jvim.12366.
  • Lobetti R (2012): Changes in the serum urea: creatinine ratio in dogs with babesiosis, haemolytic anaemia, and experimental haemoglobinaemia. Vet J, 191, 253-256.
  • Miyagawa Y, Takemura N, Hirose H (2009): Evaluation of the measurement of serum cystatin C by an enzyme- linked immunosorbent assay for humans as a marker of the glomerular filtration rate in dogs. J Vet Med Sci, 71, 1169-1176.
  • Nakagaki K, Nogami S, Hayashi Y, et al. (1993): Dirofilaria immitis: detection of parasite-specific antigen by monoclonal antibodies in glomerulonephitis in infected dogs. Parasitol Res, 79, 49-54.
  • Oge H, Doganay A, Oge S, Yildirim A (2003): Prevalence and distribution of Dirofilaria immitis in domestic dogs from Ankara and vicinity in Turkey. Dtsch Tierarztl Wochenschr, 110, 69-72.
  • Paes-de-Almeida EC, Ferreira AMR, Labarthe NV, et al. (2003): Kidney ultrastructural lesions in dogs experimentally infected with Dirofilaria immitis (Leidy, 1856). Vet Parasitol, 113, 157-168.
  • Peribáňez MA, Lucientes J, Arce S, et al. (2001): Histochemical differentiation of Dirofilaria immitis, Dirofilaria repens and Acanthocheilonema dracunculoides microfilariae by staining with a commercial kit, Leucognost-SP. Vet Parasitol, 102, 173-175. ®
  • Polizopoulou ZS, Koutinas AF, Saridomichelakis MN, et al. (2000): Clinical and laboratory observations in 91 dogs infected with Dirofilaria immitis in northern Greece. Vet Rec, 146, 466-469.
  • Randers E, Erlandsen EJ (1999): Serum cystatin C as an endogenous marker of the renal function – A Review. Clin Chem Lab Med, 37, 389-395.
  • Randers E, Kristensen JH, Erlandsen EJ, Danielsen H (1998): Serum cystatin C as a marker of renal function. Scand J Clin Lab Investig, 58, 585-592.
  • Reyers F (1992): Is azotaemia in canine babesiosis an indication of renal disease? In: Proceedings of the 9th Faculty Day. University of Pretoria, Faculty of Veterinary Science, 17.
  • Rishniw M, Barr SC, Simpson KW, et al. (2006): Discrimination between six species of canine microfilariae by a single polymerase chain reaction. Vet Parasitol, 135, 303-314.
  • Simon F, Kramer LH, Román A, et al. (2007): Immunopathology of Dirofilaria immitis infection. Vet Res Commun, 31, 161-171.
  • Sutton RH (1988): Pathology and pathogenesis of dirofilariasis. 99-132. In: Boreham PFF, Atwell RB (Ed), Dirofilariasis. Florida, CRC Press.
  • Watts KJ, Courteny CH, Reddy GR (1999): Development of a PCR- and probe-based test for the sensitive and specific detection of the dog heartworm, Dirofilaria immitis, in its mosquito intermediate host. Mol Cell Probes, 14, 425-430.
  • Yildirim A (2004): The prevalence of filarial agents in dogs in Ankara and vicinity. Ankara Univ Vet Fak Der, 51, 35-40.

Evaluation of serum cystatinC concentrations in dogs infected withDirofilaria immitis

Year 2015, Volume: 62 Issue: 4, 303 - 306, 01.12.2015

Didem Pekmezci Murat Güzel Alparslan Yıldırım Gülay Çiftci Gökmen Zafer Pekmezci Mehmet Tütüncü Abdullah İnci

https://doi.org/10.1501/Vetfak_0000002696

Abstract

To assess glomerular filtration rate (GFR) in dogs naturally infected by D. immitis new renal marker serum cystatinC (sCysC) was measured with canine CysC ELISA kit. Twenty infected microfilaremic-seropositive and 20 amicrofilaremic and seronegative dogs evaluated in the study. Serum urea and creatinine (sCre) concentrations were measured in both groups. Mean sCysC concentrations in infected dogs were detected as 2.40 mg/L and 2.30 mg/L in controls. Mean serum urea 9.97 mmol/L and sCre 116.24 µmol/L concentrations in infected and in the uninfected group detected as 11.92 mmol/L and 128.62 µmol/L, respectively. Including mean sCysC and sCre concentrations with mean serum Urea:Cre ratio were not statistically differed between the groups. On the other hand, serum urea concentrations were statistically differed between groups. Based on the results of the present study, it is concluded that, sCysC concentrations seemed to be not altered in dogs with D. immitis infection

Keywords

Dirofilaria immitis dog serum cystatinC

References

  • Abramowsky CR, Powers KG, Aikawa M, Swinehart G (1981): Dirofilaria immitis. 5. Immunopathology of filarial nephropathy in dogs. Am J Pathol, 104, 1-12.
  • Acevedo RA, Ciencias L, Theis JH, et al. (1981): Combination of filtration and histochemical stain for detection and differentiation of Dirofilaria immitis and Dipetalonema reconditum in the dog. Am J Vet Res, 42, 537-540.
  • Antognoni MT, Siepi D, Porciello F, Fruganti G (2005): Use of serum cytatin C determination as a marker of renal function in the dog. Vet Res Commun, 29, 265-267.
  • Antognoni MT, Siepi D, Porciello F, et al. (2007): Serum cystatin-C evaluation in dogs affected by different diseases associated or not with renal insufficiency. Vet Res Commun, 31, 269-271.
  • Brady HR, Brenner BM (1994): Acute renal failure. 1265-1274. In: Isselbaher KJ, Braunwald E, Wilson JD (Ed), Harrison’s Principles of Internal Medicine. McGraw- Hill, Columbus.
  • Braun JP, Perxachs A, Pechereau D, De La Farge F (2002): Plasma cystatin C in the dog: reference values and variations with renal failure. Comp Clin Pathol, 11, 44-49. 7. Casey HW, Splitter GA glomerulonephritis in dogs infected with Dirofilaria immitis. Vet Pathol, 12, 111-117. (1975): Membranous
  • De Scally MP, Leisewitz AL, Lobetti RG, Thompson PN (2006): The elevated serum urea:creatinine ratio in canine babesiosis in South Africa is not of renal origin. J S Afr Vet Assoc, 77, 175-178.
  • De Scally MP, Lobetti RG, Reyers F, Humphris D (2004): Are urea and creatinine values reliable indicators of azotaemia in canine babesiosis? J S Afr Vet Assoc, 75, 121-124.
  • Di Bartola SP (2000): Clinical approach and laboratory evaluation of renal disease. 1600-1614. In: Ettinger SJ, Feldman EC (Ed), Textbook of Veterinary Internal Medicine (5th ed). WB Saunders, Philadelphia.
  • Feinfeld DA, Bargouthi H, Niaz Q, Carvounis CP (2002): Massive and disproportionate elevation of blood urea nitrogen in acute azotemia. Int Urol Nephrol, 34, 143-145.
  • Finco DR (1997): Evaluation of renal function. 216-229. In: Osborne CA, Finco DR (Ed), Canine and Feline Nephrology and Urology. Williams and Wilkins, Philadelphia, USA.
  • Grauer GF, Culham CA, Bowman DD, et al. (1988): Parasite excretory-secretory antigen and antibody to excretory-secretory antigen in body fluids and kidney tissue of Dirofilaria immitis infected dogs. Am J Trop Med Hyg, 39, 380-387.
  • Ghys L, Paepe D, Smets P, et al. (2014): Cystatin C: A new renal marker and its potential use in small animal medicine. J Vet Intern Med, doi: 10.1111/jvim.12366.
  • Lobetti R (2012): Changes in the serum urea: creatinine ratio in dogs with babesiosis, haemolytic anaemia, and experimental haemoglobinaemia. Vet J, 191, 253-256.
  • Miyagawa Y, Takemura N, Hirose H (2009): Evaluation of the measurement of serum cystatin C by an enzyme- linked immunosorbent assay for humans as a marker of the glomerular filtration rate in dogs. J Vet Med Sci, 71, 1169-1176.
  • Nakagaki K, Nogami S, Hayashi Y, et al. (1993): Dirofilaria immitis: detection of parasite-specific antigen by monoclonal antibodies in glomerulonephitis in infected dogs. Parasitol Res, 79, 49-54.
  • Oge H, Doganay A, Oge S, Yildirim A (2003): Prevalence and distribution of Dirofilaria immitis in domestic dogs from Ankara and vicinity in Turkey. Dtsch Tierarztl Wochenschr, 110, 69-72.
  • Paes-de-Almeida EC, Ferreira AMR, Labarthe NV, et al. (2003): Kidney ultrastructural lesions in dogs experimentally infected with Dirofilaria immitis (Leidy, 1856). Vet Parasitol, 113, 157-168.
  • Peribáňez MA, Lucientes J, Arce S, et al. (2001): Histochemical differentiation of Dirofilaria immitis, Dirofilaria repens and Acanthocheilonema dracunculoides microfilariae by staining with a commercial kit, Leucognost-SP. Vet Parasitol, 102, 173-175. ®
  • Polizopoulou ZS, Koutinas AF, Saridomichelakis MN, et al. (2000): Clinical and laboratory observations in 91 dogs infected with Dirofilaria immitis in northern Greece. Vet Rec, 146, 466-469.
  • Randers E, Erlandsen EJ (1999): Serum cystatin C as an endogenous marker of the renal function – A Review. Clin Chem Lab Med, 37, 389-395.
  • Randers E, Kristensen JH, Erlandsen EJ, Danielsen H (1998): Serum cystatin C as a marker of renal function. Scand J Clin Lab Investig, 58, 585-592.
  • Reyers F (1992): Is azotaemia in canine babesiosis an indication of renal disease? In: Proceedings of the 9th Faculty Day. University of Pretoria, Faculty of Veterinary Science, 17.
  • Rishniw M, Barr SC, Simpson KW, et al. (2006): Discrimination between six species of canine microfilariae by a single polymerase chain reaction. Vet Parasitol, 135, 303-314.
  • Simon F, Kramer LH, Román A, et al. (2007): Immunopathology of Dirofilaria immitis infection. Vet Res Commun, 31, 161-171.
  • Sutton RH (1988): Pathology and pathogenesis of dirofilariasis. 99-132. In: Boreham PFF, Atwell RB (Ed), Dirofilariasis. Florida, CRC Press.
  • Watts KJ, Courteny CH, Reddy GR (1999): Development of a PCR- and probe-based test for the sensitive and specific detection of the dog heartworm, Dirofilaria immitis, in its mosquito intermediate host. Mol Cell Probes, 14, 425-430.
  • Yildirim A (2004): The prevalence of filarial agents in dogs in Ankara and vicinity. Ankara Univ Vet Fak Der, 51, 35-40.
There are 28 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Other ID JA66HG52JK
Journal Section Research Article
Authors

Didem Pekmezci

Murat Güzel

Alparslan Yıldırım

Gülay Çiftci

Gökmen Zafer Pekmezci

Mehmet Tütüncü

Abdullah İnci

Publication Date December 1, 2015
Published in Issue Year 2015Volume: 62 Issue: 4

Cite

APA Pekmezci, D., Güzel, M., Yıldırım, A., Çiftci, G., et al. (2015). Evaluation of serum cystatinC concentrations in dogs infected withDirofilaria immitis. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 62(4), 303-306. https://doi.org/10.1501/Vetfak_0000002696
AMA Pekmezci D, Güzel M, Yıldırım A, Çiftci G, Pekmezci GZ, Tütüncü M, İnci A. Evaluation of serum cystatinC concentrations in dogs infected withDirofilaria immitis. Ankara Univ Vet Fak Derg. December 2015;62(4):303-306. doi:10.1501/Vetfak_0000002696
Chicago Pekmezci, Didem, Murat Güzel, Alparslan Yıldırım, Gülay Çiftci, Gökmen Zafer Pekmezci, Mehmet Tütüncü, and Abdullah İnci. “Evaluation of Serum CystatinC Concentrations in Dogs Infected WithDirofilaria Immitis”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 62, no. 4 (December 2015): 303-6. https://doi.org/10.1501/Vetfak_0000002696.
EndNote Pekmezci D, Güzel M, Yıldırım A, Çiftci G, Pekmezci GZ, Tütüncü M, İnci A (December 1, 2015) Evaluation of serum cystatinC concentrations in dogs infected withDirofilaria immitis. Ankara Üniversitesi Veteriner Fakültesi Dergisi 62 4 303–306.
IEEE D. Pekmezci, M. Güzel, A. Yıldırım, G. Çiftci, G. Z. Pekmezci, M. Tütüncü, and A. İnci, “Evaluation of serum cystatinC concentrations in dogs infected withDirofilaria immitis”, Ankara Univ Vet Fak Derg, vol. 62, no. 4, pp. 303–306, 2015, doi: 10.1501/Vetfak_0000002696.
ISNAD Pekmezci, Didem et al. “Evaluation of Serum CystatinC Concentrations in Dogs Infected WithDirofilaria Immitis”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 62/4 (December 2015), 303-306. https://doi.org/10.1501/Vetfak_0000002696.
JAMA Pekmezci D, Güzel M, Yıldırım A, Çiftci G, Pekmezci GZ, Tütüncü M, İnci A. Evaluation of serum cystatinC concentrations in dogs infected withDirofilaria immitis. Ankara Univ Vet Fak Derg. 2015;62:303–306.
MLA Pekmezci, Didem et al. “Evaluation of Serum CystatinC Concentrations in Dogs Infected WithDirofilaria Immitis”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 62, no. 4, 2015, pp. 303-6, doi:10.1501/Vetfak_0000002696.
Vancouver Pekmezci D, Güzel M, Yıldırım A, Çiftci G, Pekmezci GZ, Tütüncü M, İnci A. Evaluation of serum cystatinC concentrations in dogs infected withDirofilaria immitis. Ankara Univ Vet Fak Derg. 2015;62(4):303-6.